Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology

Pharmacology and Therapeutics

Volumn 130, Issue 1, 2011, Pages 1-8

  Yoo, Byoung Kwon ^a   Emdad, Luni ^b   Lee, Seok Geun ^c   Su, Zao Zhong ^a   Santhekadur, Prasanna ^a   Chen, Dong ^a   Gredler, Rachel ^a   Fisher, Paul B ^a,d   Sarkar, Devanand ^a,d  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c Kyung Hee University   (South Korea)

^d VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Angiogenesis; Astrocyte elevated gene 1 (AEG 1); Chemoresistance; Metastasis; Neurodegeneration; Oncogene

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; WNT PROTEIN;

ANGIOGENESIS; ARTICLE; ASTROCYTE ELEVATED GENE 1; CANCER INVASION; CARCINOGENESIS; CELL PROLIFERATION; GENE EXPRESSION; GENE FUNCTION; GENE INTERACTION; GENE STRUCTURE; MOLECULAR CLONING; ONCOGENE; PRIORITY JOURNAL;

EID: 79951850570     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2011.01.008     Document Type: Review

References (61)

1. V. Anttila, H. Stefansson, M. Kallela, U. Todt, G.M. Terwindt, and M.S. Calafato Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1 Nat Genet 42 2010 869 873
2. S.C. Ash, D.Q. Yang, and D.E. Britt Lyric/AEG-1 overexpression modulates BCCIPα protein levels in prostate tumor cells Biochem Biophys Res Commun 371 2008 333 338
3. A. Bergamaschi, Y.H. Kim, P. Wang, T. Sørlie, T. Hernandez-Boussard, and P.E. Lonning Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer Genes Chromosom Cancer 45 2006 1033 1040 (Pubitemid 44435537)
4. D.E. Britt, D.F. Yang, D.Q. Yang, D. Flanagan, H. Callanan, and Y.P. Lim Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells Exp Cell Res 300 2004 134 148 (Pubitemid 39286223)
5. D.M. Brown, and E. Ruoslahti Metadherin, a cell surface protein in breast tumors that mediates lung metastasis Cancer Cell 5 2004 365 374 (Pubitemid 38482072)
6. A. Carnemolla, E. Fossale, E. Agostoni, S. Michelazzi, R. Calligaris, and L. De Maso Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease J Biol Chem 284 2009 18167 18173
7. A.A. Caudy, R.F. Ketting, S.M. Hammond, A.M. Denli, A.M. Bathoorn, and B.B. Tops A micrococcal nuclease homologue in RNAi effector complexes Nature 425 2003 411 414 (Pubitemid 37187271)
8. T.T. Chao, C.C. Chang, and H.M. Shih SUMO modification modulates the transrepression activity of PLZF Biochem Biophys Res Commun 358 2007 475 482
9. W. Chen, Z. Ke, H. Shi, S. Yang, and L. Wang Overexpression of AEG-1 in renal cell carcinoma and its correlation with tumor nuclear grade and progression Neoplasma 57 2010 522 529
10. D.W. Choi Glutamate neurotoxicity and diseases of the nervous system Neuron 1 1988 623 634
11. H. Clevers Wnt/beta-catenin signaling in development and disease Cell 127 2006 469 480
12. A. Doble The role of excitotoxicity in neurodegenerative disease: implications for therapy Pharmacol Ther 81 1999 163 221 (Pubitemid 29094735)
13. L. Emdad, S.-G. Lee, Z.-Z. Su, H.Y. Jeon, H. Boukerche, and D. Sarkar Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis Proc Natl Acad Sci USA 106 2009 21300 21305
14. L. Emdad, D. Sarkar, S.G. Lee, Z.-Z. Su, B.K. Yoo, and R. Dash Astrocyte elevated gene-1: A novel target for human glioma therapy Mol Cancer Ther 9 2010 79 88
15. L. Emdad, D. Sarkar, Z.-Z. Su, A. Randolph, H. Boukerche, and K. Valerie Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: Implications for tumor progression and metastasis Cancer Res 66 2006 1509 1516 (Pubitemid 43259932)
16. P.B. Fisher Enhancement of viral transformation and expression of the transformed phenotype by tumor promoters T.J. Slaga, Tumor promotion and cocarcinogenesis in vitro, mechanisms of tumor promotion 1984 CRC Press, Inc. Florida 57 123
17. F. Fonnum Glutamate: a neurotransmitter in mammalian brain J Neurochem 42 1984 1 11 (Pubitemid 14216942)
18. E. Fossale, V.C. Wheeler, V. Vrbanac, L.A. Lebel, A. Teed, and J.S. Mysore Identification of a presymptomatic molecular phenotype in Hdh CAG knock-in mice Hum Mol Genet 11 2002 2233 2241
19. G. Hu, R.A. Chong, Q. Yang, Y. Wei, M.A. Blanco, and F. Li MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer Cancer Cell 15 2009 9 20
20. A. Jemal, R. Siegel, J. Xu, and E. Ward Cancer statistics, 2010 CA Cancer J Clin 60 2010 277 300
21. H.Y. Jeon, M. Choi, E.L. Howlett, N. Vozhilla, B.K. Yoo, and J.A. Lloyd Expression patterns of astrocyte elevated gene-1 (AEG-1) during development of the mouse embryo Gene Expr Patterns 10 2010 361 367
22. R.C. Kane, P.F. Bross, A.T. Farrell, and R. Pazdur Velcade: U.S. FDA approval for the treatment of multiple myeloma progressing on prior therapy Oncologist 8 2003 508 513 (Pubitemid 37467365)
23. D.-C. Kang, Z.-Z. Su, D. Sarkar, L. Emdad, D.J. Volsky, and P.B. Fisher Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1 Gene 353 2005 8 15 (Pubitemid 40805356)
24. I.I. Khuda, N. Koide, A.S. Noman, J. Dagvadorj, G. Tumurkhuu, and Y. Naiki Astrocyte elevated gene-1 (AEG-1) is induced by lipopolysaccharide as toll-like receptor 4 (TLR4) ligand and regulates TLR4 signalling Immunology 128 2009 e700 e706
25. N. Kikuno, H. Shiina, S. Urakami, K. Kawamoto, H. Hirata, and Y. Tanaka Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity Oncogene 26 2007 7647 7655 (Pubitemid 350224215)
26. S.-G. Lee, H.Y. Jeon, Z.-Z. Su, J.E. Richards, N. Vozhilla, and D. Sarkar Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma Oncogene 28 2009 2476 2484
27. S.-G. Lee, Z.-Z. Su, L. Emdad, D. Sarkar, and P.B. Fisher Astrocyte elevated gene-1 is a target gene of oncogenic Harvey-ras requiring phosphatidylinositol 3-kinase and c-Myc Proc Natl Acad Sci USA 103 2006 17390 17395 (Pubitemid 44788979)
28. S.-G. Lee, Z.-Z. Su, L. Emdad, D. Sarkar, T.F. Franke, and P.B. Fisher Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling Oncogene 27 2008 1114 1121 (Pubitemid 351253177)
29. J. Li, N. Zhang, L.B. Song, W.T. Liao, L.L. Jiang, and L.Y. Gong Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival Clin Cancer Res 14 2008 3319 3326
30. H. Liu, X. Song, C. Liu, L. Xie, L. Wei, and R. Sun Knockdown of astrocyte elevated gene-1 inhibits proliferation and enhancing chemo-sensitivity to cisplatin or doxorubicin in neuroblastoma cells J Exp Clin Cancer Res 28 2009 19
31. L. Liu, J. Wu, Z. Ying, B. Chen, A. Han, and Y. Liang Astrocyte elevated gene-1 upregulates matrix metalloproteinase-9 and induces human glioma invasion Cancer Res 70 2010 3750 3759
32. J. Liu, Y. Yuan, J. Huan, and Z. Shen Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2 Oncogene 20 2001 336 345 (Pubitemid 32142323)
33. D.B. Longley, D.P. Harkin, and P.G. Johnston 5-fluorouracil: Mechanisms of action and clinical strategies Nat Rev Cancer 3 2003 330 338 (Pubitemid 37328853)
34. E.I. Medine, D. Odaci, B.N. Gacal, B. Gacal, S. Sakarya, and P. Unak A new approach for in vitro imaging of breast cancer cells by anti-metadherin targeted PVA-pyrene Macromol Biosci 10 2010 657 663
35. A. Navon, and A. Ciechanover The 26S proteasome: From basic mechanisms to drug targeting J Biol Chem 284 2009 33717 33718
36. T. Ono, H. Kitaura, H. Ugai, T. Murata, K.K. Yokoyama, and S.M. Iguchi-Ariga TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase J Biol Chem 275 2000 31145 31154
37. T.C. Poon, N. Wong, P.B. Lai, M. Rattray, P.J. Johnson, and J.J. Sung A tumor progression model for hepatocellular carcinoma: Bioinformatic analysis of genomic data Gastroenterology 131 2006 1262 1270 (Pubitemid 44515104)
38. C.M. Powell, T.L. Rudge, Q. Zhu, L.F. Johnson, and U. Hansen Inhibition of the mammalian transcription factor LSF induces S-phase-dependent apoptosis by downregulating thymidylate synthase expression EMBO J 19 2000 4665 4675
39. G. Roversi, R. Pfundt, R.F. Moroni, I. Magnani, S. van Reijmersdal, and B. Pollo Identification of novel genomic markers related to progression to glioblastoma through genomic profiling of 25 primary glioma cell lines Oncogene 25 2006 1571 1583 (Pubitemid 43361942)
40. D. Sarkar, L. Emdad, S.-G. Lee, B.K. Yoo, Z.-Z. Su, and P.B. Fisher Astrocyte elevated gene-1: Far more than just a gene regulated in astrocytes Cancer Res 69 2009 8529 8535
41. D. Sarkar, E.S. Park, L. Emdad, S.-G. Lee, Z.-Z. Su, and P.B. Fisher Molecular basis of nuclear factor-κB activation by astrocyte elevated gene-1 Cancer Res 68 2008 1478 1484 (Pubitemid 351346856)
42. H. Song, C. Li, R. Li, and J. Geng Prognostic significance of AEG-1 expression in colorectal carcinoma Int J Colorectal Dis 25 2010 1201 1209
43. L. Song, W. Li, H. Zhang, W. Liao, T. Dai, and C. Yu Over-expression of AEG-1 significantly associates with tumour aggressiveness and poor prognosis in human non-small cell lung cancer J Pathol 219 2009 317 326
44. Z.-Z. Su, Y. Chen, D.-C. Kang, W. Chao, M. Simm, and D.J. Volsky Customized rapid subtraction hybridization (RaSH) gene microarrays identify overlapping expression changes in human fetal astrocytes resulting from human immunodeficiency virus-1 infection or tumor necrosis factor-alpha treatment Gene 306 2003 67 78 (Pubitemid 36351396)
45. Z.-Z. Su, D.-C. Kang, Y. Chen, O. Pekarskaya, W. Chao, and D.J. Volsky Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH Oncogene 21 2002 3592 3602 (Pubitemid 34587691)
46. H.G. Sutherland, Y.W. Lam, S. Briers, A.I. Lamond, and W.A. Bickmore 3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus Exp Cell Res 294 2004 94 105 (Pubitemid 38229784)
47. H.J. Thirkettle, J. Girling, A.Y. Warren, I.G. Mills, K. Sahadevan, and H. Leung LYRIC/AEG-1 is targeted to different subcellular compartments by ubiquitinylation and intrinsic nuclear localization signals Clin Cancer Res 15 2009 3003 3013
48. H.J. Thirkettle, I.G. Mills, H.C. Whitaker, and D.E. Neal Nuclear lyric/AEG-1 interacts with PLZF and relives PLZF-mediated repression Oncogene 28 2009 3663 3670
49. B. Vogelstein, and K.W. Kinzler Cancer genes and the pathways they control Nat Med 10 2004 789 799 (Pubitemid 39070849)
50. G. von Heijne Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule J Mol Biol 225 1992 487 494
51. I.B. Weinstein Cancer. Addiction to oncogenes - The Achilles heal of cancer Science 297 2002 102 104
52. I.B. Weinstein, and A.K. Joe Mechanisms of disease: Oncogene addiction - A rationale for molecular targeting in cancer therapy Nat Clin Pract Oncol 3 2006 448 457 (Pubitemid 44203817)
53. P. Workman, P.A. Clarke, F.I. Raynaud, and R.L.M. van Montfort Drugging the PI3 kinome: From chemical tools to drugs in the clinic Cancer Res 70 2010 2146 2157
54. Z. Xia, N. Zhang, H. Jin, Z. Yu, G. Xu, and Z. Huang Clinical significance of astrocyte elevated gene-1 expression in human oligodendrogliomas Clin Neurol Neurosurg 112 2010 413 419
55. Xu J.-B., Wu, H., He, Y.-L., Zhang, C.-H., Zhang, L.-J., Cai, S.-R., et al. (in press). Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer. Med Oncol.
56. J. Yang, T. Välineva, J. Hong, T. Bu, Z. Yao, and O.N. Jensen Transcriptional co-activator protein p100 interacts with snRNP proteins and facilitates the assembly of the spliceosome Nucleic Acids Res 35 2007 4485 4494 (Pubitemid 47244599)
57. B.K. Yoo, D. Chen, Z.-Z. Su, R. Gredler, J. Yoo, and K. Shah Molecular mechanism of chemoresistance by astrocyte elevated gene-1 Cancer Res 70 2010 3249 3258
58. B.K. Yoo, L. Emdad, Z.-Z. Su, A. Villanueva, D.Y. Chiang, and N.D. Mukhopadhyay Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression J Clin Invest 119 2009 465 477
59. B.K. Yoo, R. Gredler, N. Vozhilla, Z.-Z. Su, D. Chen, and T. Forcier Identification of genes conferring resistance to 5-fluorouracil Proc Natl Acad Sci USA 106 2009 12938 12943
60. Yoo, B. K., Santhekadur, P. K., Gredler, R., Chen, D., Emdad, L., Bhutia, S. K., et al. (in press). Increased RNA-induced silencing complex (RISC) activity contributes to hepatocellular carcinoma. Hepatology.
61. C. Yu, K. Chen, H. Zheng, X. Guo, W. Jia, and M. Li Overexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis Carcinogenesis 30 2009 894 901