AEG-1/MTDH/LYRIC: Clinical Significance.

Advances in Cancer Research

Volumn 120, Issue , 2013, Pages 39-74

  Sarkar, Devanand ^a,b   Fisher, Paul B ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

AEG 1 MTDH LYRIC; Cancer; Clinicopathological correlation; Metastasis; Prognosis

Indexed keywords

AUTOANTIBODY; BETA CATENIN; CCAAT ENHANCER BINDING PROTEIN; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KI 67 ANTIGEN; LYSINE RICH CEACAM1 COISOLATED PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; METADHERIN; MICRORNA; MICRORNA 136; MICRORNA 26A; MICRORNA 375; PROTEIN; PROTEIN P73; RAD50 PROTEIN; STAPHYLOCOCCAL NUCLEASE DOMAIN CONTAINING PROTEIN 1; TUMOR MARKER; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; ASTROCYTE ELEVATED GENE 1; ATYPICAL DUCTAL HYPERPLASIA; B CELL LYMPHOMA; BLADDER CANCER; BREAST CANCER; CANCER CELL; CANCER GROWTH; CANCER PROGNOSIS; CANCER RESISTANCE; CANCER STAGING; CANCER SURVIVAL; CELL INVASION; CELL PROLIFERATION; CHROMOSOME 8Q; COLORECTAL CANCER; DIAGNOSTIC VALUE; DNA POLYMORPHISM; ENDOMETRIUM CANCER; ESOPHAGUS CANCER; GAIN OF FUNCTION MUTATION; GALLBLADDER CARCINOMA; GENE AMPLIFICATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GLIOBLASTOMA; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; INTRADUCTAL CARCINOMA; KIDNEY CARCINOMA; LARGE CELL LYMPHOMA; LIVER CELL CARCINOMA; LIVER METASTASIS; LOSS OF FUNCTION MUTATION; LUNG NON SMALL CELL CANCER; LYMPH NODE METASTASIS; LYMPHOMA; METASTASIS; METASTASIS POTENTIAL; NEUROBLASTOMA; NONHUMAN; OLIGODENDROGLIOMA; ONCOGENE; OSTEOSARCOMA; OVARY CANCER; POSTTRANSCRIPTIONAL GENE SILENCING; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; PROTEIN EXPRESSION; SALIVARY GLAND CARCINOMA; STOMACH CANCER; T CELL LYMPHOMA; TONGUE CARCINOMA; TRIPLE NEGATIVE BREAST CANCER; TUMOR SUPPRESSOR GENE; TUMOR VASCULARIZATION;

AEG-1/MTDH/LYRIC; CANCER; CLINICOPATHOLOGICAL CORRELATION; METASTASIS; PROGNOSIS;

ANIMALS; CELL ADHESION MOLECULES; GASTROINTESTINAL TRACT; HEAD AND NECK NEOPLASMS; HUMANS; MICE; NEOPLASMS; NERVOUS SYSTEM; NERVOUS SYSTEM PHYSIOLOGICAL PHENOMENA; PROGNOSIS; RESPIRATORY PHYSIOLOGICAL PHENOMENA; UROGENITAL SYSTEM;

EID: 84880927185     PISSN: 0065230X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-401676-7.00002-4     Document Type: Chapter

References (82)

1. Baygi M.E., Nikpour P. Deregulation of MTDH gene expression in gastric cancer. Asian Pacific Journal of Cancer Prevention 2012, 13:2833-2836.
2. Bhutia S.K., Kegelman T.P., Das S.K., Azab B., Su Z.Z., Lee S.G., et al. Astrocyte elevated gene-1 induces protective autophagy. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:22243-22248.
3. Blanco M.A., Aleckovic M., Hua Y., Li T., Wei Y., Xu Z., et al. Identification of staphylococcal nuclease domain-containing 1 (SND1) as a Metadherin-interacting protein with metastasis-promoting functions. The Journal of Biological Chemistry 2011, 286:19982-19992.
4. Britt D.E., Yang D.F., Yang D.Q., Flanagan D., Callanan H., Lim Y.P., et al. Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells. Experimental Cell Research 2004, 300:134-148.
5. Brodeur G.M. Neuroblastoma: Biological insights into a clinical enigma. Nature Reviews. Cancer 2003, 3:203-216.
6. Brown D.M., Ruoslahti E. Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell 2004, 5:365-374.
7. Butowski N.A., Sneed P.K., Chang S.M. Diagnosis and treatment of recurrent high-grade astrocytoma. Journal of Clinical Oncology 2006, 24:1273-1280.
8. Caron M., Choquet-Kastylevsky G., Joubert-Caron R. Cancer immunomics using autoantibody signatures for biomarker discovery. Molecular & Cellular Proteomics 2007, 6:1115-1122.
9. Chan A.O., Wong B.C., Lam S.K. Gastric cancer: Past, present and future. Canadian Journal of Gastroenterology 2001, 15:469-474.
10. Chen X., Dong K., Long M., Lin F., Wang X., Wei J., et al. Serum anti-AEG-1 auto-antibody is a potential novel biomarker for malignant tumors. Oncology Letters 2012, 4:319-323.
11. Chen W., Ke Z., Shi H., Yang S., Wang L. Overexpression of AEG-1 in renal cell carcinoma and its correlation with tumor nuclear grade and progression. Neoplasma 2010, 57:522-529.
12. Damron T.A., Ward W.G., Stewart A. Osteosarcoma, chondrosarcoma, and Ewing's sarcoma: National Cancer Data Base Report. Clinical Orthopaedics and Related Research 2007, 459:40-47.
13. El-Serag H.B. Hepatocellular carcinoma. The New England Journal of Medicine 2011, 365:1118-1127.
14. Emdad L., Sarkar D., Lee S.G., Su Z.Z., Yoo B.K., Dash R., et al. Astrocyte elevated gene-1: A novel target for human glioma therapy. Molecular Cancer Therapeutics 2010, 9:79-88.
15. Ferlay J., Shin H.R., Bray F., Forman D., Mathers C., Parkin D.M. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. International Journal of Cancer 2010, 127:2893-2917.
16. Fuller G.N., Scheithauer B.W. The 2007 Revised World Health Organization (WHO) Classification of Tumours of the Central Nervous System: Newly codified entities. Brain Pathology 2007, 17:304-307.
17. Ge X., Lv X., Feng L., Liu X., Gao J., Chen N., et al. Metadherin contributes to the pathogenesis of diffuse large B-cell lymphoma. PLoS One 2012, 7:e39449.
18. Gnosa S., Shen Y.M., Wang C.J., Zhang H., Stratmann J., Arbman G., et al. Expression of AEG-1 mRNA and protein in colorectal cancer patients and colon cancer cell lines. Journal of Translational Medicine 2012, 10:109.
19. Gong Z., Liu W., You N., Wang T., Wang X., Lu P., et al. Prognostic significance of metadherin overexpression in hepatitis B virus-related hepatocellular carcinoma. Oncology Reports 2012, 27:2073-2079.
20. He X.X., Chang Y., Meng F.Y., Wang M.Y., Xie Q.H., Tang F., et al. MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo. Oncogene 2012, 31:3357-3369.
21. Hiyama T., Yoshihara M., Tanaka S., Chayama K. Genetic polymorphisms and esophageal cancer risk. International Journal of Cancer 2007, 121:1643-1658.
22. Hu G., Chong R.A., Yang Q., Wei Y., Blanco M.A., Li F., et al. MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell 2009, 15:9-20.
23. Hui A.B., Bruce J.P., Alajez N.M., Shi W., Yue S., Perez-Ordonez B., et al. Significance of dysregulated metadherin and microRNA-375 in head and neck cancer. Clinical Cancer Research 2011, 17:7539-7550.
24. Jian-Bo X., Hui W., Yu-Long H., Chang-Hua Z., Long-Juan Z., Shi-Rong C., et al. Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer. Medical Oncology 2011, 28:455-462.
25. Jiang T., Zhu A., Zhu Y., Piao D. Clinical implications of AEG-1 in liver metastasis of colorectal cancer. Medical Oncology 2012, 29:2858-2863.
26. Kamangar F., Dores G.M., Anderson W.F. Patterns of cancer incidence, mortality, and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world. Journal of Clinical Oncology 2006, 24:2137-2150.
27. Kang D.C., Su Z.Z., Sarkar D., Emdad L., Volsky D.J., Fisher P.B. Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene 2005, 353:8-15.
28. Ke Z.F., He S., Li S., Luo D., Feng C., Zhou W. Expression characteristics of astrocyte elevated gene-1 (AEG-1) in tongue carcinoma and its correlation with poor prognosis. Cancer Epidemiology 2012, 37:179-185.
29. Kikkawa F., Kawai M., Mizuno K., Ishikawa H., Kojima M., Maeda O., et al. Recurrence of epithelial ovarian carcinoma after clinical remission. Gynecologic and Obstetric Investigation 1994, 38:65-69.
30. Kiriluk K.J., Prasad S.M., Patel A.R., Steinberg G.D., Smith N.D. Bladder cancer risk from occupational and environmental exposures. Urologic Oncology 2012, 30:199-211.
31. Kochanek D.M., Wells D.G. CPEB1 regulates the expression of MTDH/AEG-1 and glioblastoma cell migration. Molecular Cancer Research 2013, 11(2):149-160.
32. Lee S.G., Su Z.Z., Emdad L., Sarkar D., Fisher P.B. Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc. Proceedings of the National Academy of Sciences of the United States of America 2006, 103:17390-17395.
33. Li C., Li R., Song H., Wang D., Feng T., Yu X., et al. Significance of AEG-1 expression in correlation with VEGF, microvessel density and clinicopathological characteristics in triple-negative breast cancer. Journal of Surgical Oncology 2011, 103:184-192.
34. Li C., Li Y., Wang X., Wang Z., Cai J., Wang L., et al. Elevated expression of astrocyte elevated gene-1 (AEG-1) is correlated with cisplatin-based chemoresistance and shortened outcome in patients with stages III-IV serous ovarian carcinoma. Histopathology 2012, 60:953-963.
35. Li C., Liu J., Lu R., Yu G., Wang X., Zhao Y., et al. AEG-1 overexpression: A novel indicator for peritoneal dissemination and lymph node metastasis in epithelial ovarian cancers. International Journal of Gynecological Cancer 2011, 21:602-608.
36. Li J., Yang L., Song L., Xiong H., Wang L., Yan X., et al. Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1. Oncogene 2009, 28:3188-3196.
37. Li J., Zhang N., Song L.B., Liao W.T., Jiang L.L., Gong L.Y., et al. Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival. Clinical Cancer Research 2008, 14:3319-3326.
38. Liao W.T., Guo L., Zhong Y., Wu Y.H., Li J., Song L.B. Astrocyte elevated gene-1 (AEG-1) is a marker for aggressive salivary gland carcinoma. Journal of Translational Medicine 2011, 9:205.
39. Liu H.Y., Liu C.X., Han B., Zhang X.Y., Sun R.P. AEG-1 is associated with clinical outcome in neuroblastoma patients. Cancer Biomarkers 2012, 11:115-121.
40. Liu L., Wu J., Ying Z., Chen B., Han A., Liang Y., et al. Astrocyte elevated gene-1 upregulates matrix metalloproteinase-9 and induces human glioma invasion. Cancer Research 2010, 70:3750-3759.
41. Liu D.C., Yang Z.L. MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma. Diagnostic Cytopathology 2011, 41(3):199-205.
42. Liu X., Zhang N., Li X., Moran M.S., Yuan C., Yan S., et al. Identification of novel variants of metadherin in breast cancer. PLoS One 2011, 6:e17582.
43. Malka D., Boige V., Dromain C., Debaere T., Pocard M., Ducreux M. Biliary tract neoplasms: Update 2003. Current Opinion in Oncology 2004, 16:364-371.
44. Meng X., Zhu D., Yang S., Wang X., Xiong Z., Zhang Y., et al. Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein. The Journal of Biological Chemistry 2012, 287:4485-4491.
45. Milano A., Longo F., Basile M., Iaffaioli R.V., Caponigro F. Recent advances in the treatment of salivary gland cancers: Emphasis on molecular targeted therapy. Oral Oncology 2007, 43:729-734.
46. Miller G., Jarnagin W.R. Gallbladder carcinoma. European Journal of Surgical Oncology 2008, 34:306-312.
47. Muris J.J., Cillessen S.A., Vos W., van Houdt I.S., Kummer J.A., van Krieken J.H., et al. Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas. Blood 2005, 105:2916-2923.
48. Nelson E.C., Evans C.P., Lara P.N. Renal cell carcinoma: Current status and emerging therapies. Cancer Treatment Reviews 2007, 33:299-313.
49. Nohata N., Hanazawa T., Kikkawa N., Mutallip M., Sakurai D., Fujimura L., et al. Tumor suppressive microRNA-375 regulates oncogene AEG-1/MTDH in head and neck squamous cell carcinoma (HNSCC). Journal of Human Genetics 2011, 56:595-601.
50. Rusthoven K., Ballonoff A., Raben D., Chen C. Poor prognosis in patients with stage I and II oral tongue squamous cell carcinoma. Cancer 2008, 112:345-351.
51. Sarkar D., Emdad L., Lee S.G., Yoo B.K., Su Z.Z., Fisher P.B. Astrocyte elevated gene-1: Far more than just a gene regulated in astrocytes. Cancer Research 2009, 69:8529-8535.
52. Siegel R., Naishadham D., Jemal A. Cancer statistics, 2012. CA: A Cancer Journal for Clinicians 2012, 62:10-29.
53. Song H., Li C., Li R., Geng J. Prognostic significance of AEG-1 expression in colorectal carcinoma. International Journal of Colorectal Disease 2010, 25:1201-1209.
54. Song H., Li C., Lu R., Zhang Y., Geng J. Expression of astrocyte elevated gene-1: A novel marker of the pathogenesis, progression, and poor prognosis for endometrial cancer. International Journal of Gynecological Cancer 2010, 20:1188-1196.
55. Song L., Li W., Zhang H., Liao W., Dai T., Yu C., et al. Over-expression of AEG-1 significantly associates with tumour aggressiveness and poor prognosis in human non-small cell lung cancer. The Journal of Pathology 2009, 219:317-326.
56. Srivastava J., Siddiq A., Emdad L., Santhekadur P., Chen D., Gredler R., et al. Astrocyte elevated gene-1 (AEG-1) promotes hepatocarcinogenesis: Novel insights from a mouse model. Hepatology 2012, 56(5):1782-1791.
57. Stupp R., Mason W.P., van den Bent M.J., Weller M., Fisher B., Taphoorn M.J., et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. The New England Journal of Medicine 2005, 352:987-996.
58. Su Z.Z., Kang D.C., Chen Y., Pekarskaya O., Chao W., Volsky D.J., et al. Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH. Oncogene 2002, 21:3592-3602.
59. Su P., Zhang Q., Yang Q. Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue. Diagnostic Pathology 2010, 5:38.
60. Sun W., Fan Y.Z., Xi H., Lu X.S., Ye C., Zhang J.T. Astrocyte elevated gene-1 overexpression in human primary gallbladder carcinomas: An unfavorable and independent prognostic factor. Oncology Reports 2011, 26:1133-1142.
61. Sun S., Ke Z., Wang F., Li S., Chen W., Han A., et al. Overexpression of astrocyte-elevated gene-1 is closely correlated with poor prognosis in human non-small cell lung cancer and mediates its metastasis through up-regulation of matrix metalloproteinase-9 expression. Human Pathology 2012, 43:1051-1060.
62. Sutherland H.G., Lam Y.W., Briers S., Lamond A.I., Bickmore W.A. 3D3/lyric: A novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus. Experimental Cell Research 2004, 294:94-105.
63. Thirkettle H.J., Girling J., Warren A.Y., Mills I.G., Sahadevan K., Leung H., et al. LYRIC/AEG-1 is targeted to different subcellular compartments by ubiquitinylation and intrinsic nuclear localization signals. Clinical Cancer Research 2009, 15:3003-3013.
64. Thompson L. World Health Organization classification of tumours: Pathology and genetics of head and neck tumours. Ear, Nose, & Throat Journal 2006, 85:74.
65. Unak G., Ozkaya F., Medine E.I., Kozgus O., Sakarya S., Bekis R., et al. Gold nanoparticle probes: Design and in vitro applications in cancer cell culture. Colloids and Surfaces. B, Biointerfaces 2012, 90:217-226.
66. van Wijk F.H., van der Burg M.E., Burger C.W., Vergote I., van Doorn H.C. Management of recurrent endometrioid endometrial carcinoma: An overview. International Journal of Gynecological Cancer 2009, 19:314-320.
67. Wang N., Du X., Zang L., Song N., Yang T., Dong R., et al. Prognostic impact of Metadherin-SND1 interaction in colon cancer. Molecular Biology Reports 2012, 39:10497-10504.
68. Wang F., Ke Z.F., Sun S.J., Chen W.F., Yang S.C., Li S.H., et al. Oncogenic roles of astrocyte elevated gene-1 (AEG-1) in osteosarcoma progression and prognosis. Cancer Biology & Therapy 2011, 12:539-548.
69. Xia Z., Zhang N., Jin H., Yu Z., Xu G., Huang Z. Clinical significance of astrocyte elevated gene-1 expression in human oligodendrogliomas. Clinical Neurology and Neurosurgery 2010, 112:413-419.
70. Yan J., Zhang M., Chen Q., Zhang X. Expression of AEG-1 in human T-cell lymphoma enhances the risk of progression. Oncology Reports 2012, 28:2107-2114.
71. Yang Y., Wu J., Guan H., Cai J., Fang L., Li J., et al. MiR-136 promotes apoptosis of glioma cells by targeting AEG-1 and Bcl-2. FEBS Letters 2012, 586:3608-3612.
72. Yoo B.K., Chen D., Su Z.-Z., Gredler R., Yoo J., Shah K., et al. Molecular mechanism of chemoresistance by Astrocyte Elevated Gene-1 (AEG-1). Cancer Research 2010, 70:3249-3258.
73. Yoo B.K., Emdad L., Lee S.-G., Su Z.-Z., Santhekadur P.K., Chen D., et al. Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology. Pharmacology & Therapeutics 2011, 130:1-8.
74. Yoo B.K., Emdad L., Su Z.Z., Villanueva A., Chiang D.Y., Mukhopadhyay N.D., et al. Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. The Journal of Clinical Investigation 2009, 119:465-477.
75. Yoo B.K., Gredler R., Vozhilla N., Su Z.Z., Chen D., Forcier T., et al. Identification of genes conferring resistance to 5-fluorouracil. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:12938-12943.
76. Yoo B.K., Santhekadur P.K., Gredler R., Chen D., Emdad L., Bhutia S.K., et al. Increased RNA-induced silencing complex (RISC) activity contributes to hepatocelllular carcinoma. Hepatology 2011, 53:1538-1548.
77. Yu C., Chen K., Zheng H., Guo X., Jia W., Li M., et al. Overexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis. Carcinogenesis 2009, 30:894-901.
78. Yuan C., Li X., Yan S., Yang Q., Liu X., Kong B. The MTDH (-470G>A) polymorphism is associated with ovarian cancer susceptibility. PLoS One 2012, 7:e51561.
79. Zhang B., Liu X.X., He J.R., Zhou C.X., Guo M., He M., et al. Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer. Carcinogenesis 2011, 32:2-9.
80. Zhang F., Yang Q., Meng F., Shi H., Li H., Liang Y., Han A. Astrocyte elevated gene-1 interacts with beta-catenin and increases migration and invasion of colorectal carcinoma. Mol Carcinog 2012, in press.
81. Zhou J., Li J., Wang Z., Yin C., Zhang W. Metadherin is a novel prognostic marker for bladder cancer progression and overall patient survival. Asia-Pacific Journal of Clinical Oncology 2012, 8:e42-e48.
82. Zhu K., Dai Z., Pan Q., Wang Z., Yang G.H., Yu L., et al. Metadherin promotes hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. Clinical Cancer Research 2011, 17:7294-7302.