Protein mass-modulated effects in the catalytic mechanism of dihydrofolate reductase: Beyond promoting vibrations

Journal of the American Chemical Society

Volumn 136, Issue 23, 2014, Pages 8333-8341

  Wang, Zhen ^a   Singh, Priyanka ^b   Czekster, Clarissa M ^a   Kohen, Amnon ^b   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b E11 SSH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; ENZYMES; ESCHERICHIA COLI; ISOTOPES; LIGANDS; PHYSIOLOGY; QUANTUM CHEMISTRY;

CATALYTIC MECHANISMS; CONFORMATIONAL ENSEMBLE; DIHYDROFOLATE REDUCTASE; ISOTOPIC SUBSTITUTION; PHYSIOLOGICAL TEMPERATURE; PROTEIN-LIGAND INTERACTIONS; TEMPERATURE DEPENDENT; VIBRATIONAL COUPLINGS;

PROTEINS;

BACTERIAL ENZYME; DIHYDROFOLATE REDUCTASE; CARBON; HYDROGEN; LIGAND; NITROGEN; PROTEIN BINDING;

ARTICLE; BINDING KINETICS; CATALYSIS; CIRCULAR DICHROISM; CONTROLLED STUDY; DISSOCIATION; DISSOCIATION CONSTANT; ENERGY TRANSFER; ESCHERICHIA COLI; LIGAND BINDING; MICHAELIS CONSTANT; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; NONHUMAN; PH; PHASE TRANSITION; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN STRUCTURE; STEADY STATE; TEMPERATURE DEPENDENCE; VIBRATION; WILD TYPE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; KINETICS; PROTEIN UNFOLDING; TEMPERATURE;

CARBON ISOTOPES; CATALYSIS; ESCHERICHIA COLI; HYDROGEN; KINETICS; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR WEIGHT; NITROGEN ISOTOPES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN UNFOLDING; TEMPERATURE; TETRAHYDROFOLATE DEHYDROGENASE; VIBRATION;

EID: 84902258731     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja501936d     Document Type: Article

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