Regulation of immunological responses by the neonatal Fc receptor for IgG, FcRn

Molecular and Cellular Mechanisms of Antibody Activity

Volumn 9781461471073, Issue , 2013, Pages 189-219

  Baker, Kristi ^a   Rath, Timo ^a   Blumberg, Richard S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Antibody dependent cellular cytotoxicity; Fc receptor; FcRn; Humoral immune system; IgG; Immunoglobulins; Immunological responses; Intracellular trafficking; Regulation of IgG

Indexed keywords

EID: 84902121859     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4614-7107-3_8     Document Type: Chapter

References (165)

1. Adams RJ, Heazlewood SP, Gilshenan KS, O'Brien M, McGuckin MA, Florin TH (2008) IgG antibodies against common gut bacteria are more diagnostic for Crohn's disease than IgG against mannan or flagellin. Am J Gastroenterol 103(2):386-396
2. Ahouse JJ, Hagerman CL, Mittal P, Gilbert DJ, Copeland NG, Jenkins NA et al (1993) Mouse MHC class I-like Fc receptor encoded outside the MHC. J Immunol 151(11):6076-6088
3. Akilesh S, Petkova S, Sproule TJ, Shaffer DJ, Christianson GJ, Roopenian D (2004) The MHC class I-like Fc receptor promotes humorally mediated autoimmune disease. J Clin Invest 113(9):1328-1333
4. Akilesh S, Huber TB, Wu H, Wang G, Hartleben B, Kopp JB et al (2008) Podocytes use FcRn to clear IgG from the glomerular basement membrane. Proc Natl Acad Sci USA 105(3):967-972
5. Andersen JT, Daba MB, Berntzen G, Michaelsen TE, Sandlie I (2010) Cross-species binding analyses of mouse and human neonatal Fc receptor (FcRn) show dramatic differences in immuno-globulin G (IgG) and albumin binding. J Biol Chem 285(7):4826-4836
6. Anderson CL, Chaudhury C, Kim J, Bronson CL, Wani MA, Mohanty S (2006) Perspective-FcRn transports albumin: relevance to immunology and medicine. Trends Immunol 27(7):343-348
7. Antohe F, Radulescu L, Gafencu A, Ghetie V, Simionescu M (2001) Expression of functionally active FcRn and the differentiated bidirectional transport of IgG in human placental endothelial cells. Hum Immunol 62(2):93-105
8. Aoyama Y (2010) What's new in i.v. immunoglobulin therapy and pemphigus: high-dose i.v. immunoglobulin therapy and its mode of action for treatment of pemphigus. J Dermatol 37(3):239-245
9. Bai Y, Ye L, Tesar DB, Song H, Zhao D, Bjorkman PJ et al (2011) Intracellular neutralization of viral infection in polarized epithelial cells mediated by neonatal Fc receptor (FcRn)-mediated IgG transport. Proc Natl Acad Sci USA 108(45):18406-18411
10. Baker K, Qiao S-W, Kuo TT, Aveson VG, Platzer B, Andersen J-T et al (2011) Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b + dendritic cells. Proc Natl Acad Sci USA 108(24):9927-9932
11. Ben Suleiman Y, Yoshida M, Nishiumi S, Tanaka H, Mimura T, Nobutani K et al (2012) Neonatal Fc receptor for IgG (FcRn) expressed in the gastric epithelium regulates bacterial infection in mice. Mucosal Immunol 5(1):87-98
12. Bitonti AJ, Dumont JA, Low SC, Peters RT, Kropp KE, Palombella VJ et al (2004) Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immuno-globulin transport pathway. Proc Natl Acad Sci USA 101(26):9763-9768
13. Blumberg RS, Koss T, Story CM, Barisani D, Polischuk J, Lipin A et al (1995) A major histocom-patibility complex class I-related Fc receptor for IgG on rat hepatocytes. J Clin Invest 95(5):2397-2402
14. Borvak J, Richardson J, Medesan C, Antohe F, Radu C, Simionescu M et al (1998) Functional expression of the MHC class I-related receptor, FcRn, in endothelial cells of mice. Int Immunol 10(9):1289-1298
15. Bossuyt X (2006) Serologic markers in inflammatory bowel disease. Clin Chem 52(2):171-181
16. Brambell FWR (1966) The transmission of immunity from mother to young and the catabolism of immunoglobulins. Lancet 288(7473):1087-1093
17. Brambell FWR, Halliday R, Morris IG (1958) Interference by human and bovine serum and serum protein fractions with the absorption of antibodies by suckling rats and mice. Proc R Soc Lond B Biol Sci 149(934):1-11
18. Burmeister WP, Gastinel LN, Simister NE, Blum ML, Bjorkman PJ (1994a) Crystal structure at 2.2 A resolution of the MHC-related neonatal Fc receptor. Nature 372(6504):336-343
19. Burmeister WP, Huber AH, Bjorkman PJ (1994b) Crystal structure of the complex of rat neonatal Fc receptor with Fc. Nature 372(6504):379-383
20. Catunda Lemos AP, Cervenak J, Bender B, Hoffmann OI, Baranyi M, Kerekes A et al (2012) Characterization of the rabbit neonatal Fc receptor (FcRn) and analyzing the immunopheno-type of the transgenic rabbits that overexpresses FcRn. PLoS One 7(1):e28869
21. Cervenak J, Bender B, Schneider Z, Magna M, Carstea BV, Liliom K et al (2010) Neonatal FcR overexpression boosts humoral immune response in transgenic mice. J Immunol 186(2):959-968
22. Chaudhury C, Mehnaz S, Robinson JM, Hayton WL, Pearl DK, Roopenian DC et al (2003) The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan. J Exp Med 197(3):315-322
23. Chaudhury C, Brooks CL, Carter DC, Robinson JM, Anderson CL (2006) Albumin binding to FcRn: distinct from the FcRn-IgG interaction. Biochemistry 45(15):4983-4990
24. Cianga P, Cianga C, Cozma L, Ward ES, Carasevici E (2003) The MHC class I related Fc receptor, FcRn, is expressed in the epithelial cells of the human mammary gland. Hum Immunol 64(12):1152-1159
25. Claypool SM, Dickinson BL, Yoshida M, Lencer WI, Blumberg RS (2002) Functional reconstitu-tion of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin. J Biol Chem 277(31):28038-28050
26. Claypool SM, Dickinson BL, Wagner JS, Johansen FE, Venu N, Borawski JA et al (2004) Bidirectional transepithelial IgG transport by a strongly polarized basolateral membrane Fc gamma-receptor. Mol Biol Cell 15(4):1746-1759
27. Conroy ME, Shi HN, Walker WA (2009) The long-term health effects of neonatal microbial flora. Curr Opin Allergy Clin Immunol 9(3):197-201
28. Crow AR, Suppa SJ, Chen X, Mott PJ, Lazarus AH (2011) The neonatal Fc receptor (FcRn) is not required for IVIg or anti-CD44 monoclonal antibody-mediated amelioration of murine immune thrombocytopenia. Blood 118(24):6403-6406
29. Csorba K, Sesarman A, Oswald E, Feldrihan V, Fritsch A, Hashimoto T et al (2010) Cross-reactivity of autoantibodies from patients with epidermolysis bullosa acquisita with murine collagen VII. Cell Mol Life Sci 67(8):1343-1351
30. Deane R, Sagare A, Hamm K, Parisi M, LaRue B, Guo H et al (2005) IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci 25(50):11495-11503
31. Deane R, Bell RD, Sagare A, Zlokovic BV (2009) Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease. CNS Neurol Disord Drug Targets 8(1):16-30
32. Denny MF, Chandaroy P, Killen PD, Caricchio R, Lewis EE, Richardson BC et al (2006) Accelerated macrophage apoptosis induces autoantibody formation and organ damage in systemic lupus erythematosus. J Immunol 176(4):2095-2104
33. Dickinson BL, Badizadegan K, Wu Z, Ahouse JC, Zhu X, Simister NE et al (1999) Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line. J Clin Invest 104(7):903-911
34. Dickinson BL, Claypool SM, D'Angelo JA, Aiken ML, Venu N, Yen EH et al (2008) Ca2 +-dependent calmodulin binding to FcRn affects immunoglobulin G transport in the transcytotic pathway. Mol Biol Cell 19(1):414-423
35. Dumont JA, Bitonti AJ, Clark D, Evans S, Pickford M, Newman SP (2005) Delivery of an eryth-ropoietin-Fc fusion protein by inhalation in humans through an immunoglobulin transport pathway. J Aerosol Med 18(3):294-303
36. Dumont JA, Liu T, Low SC, Zhang X, Kamphaus G, Sakorafas P et al (2012) Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs. Blood 119(13):3024-3030
37. Ellinger I, Schwab M, Stefanescu A, Hunziker W, Fuchs R (1999) IgG transport across trophoblast-derived BeWo cells: a model system to study IgG transport in the placenta. Eur J Immunol 29(3):733-744
38. Firan M, Bawdon R, Radu C, Ober RJ, Eaken D, Antohe F et al (2001) The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humans. Int Immunol 13(8):993-1002
39. Freiberger T, Ravcuková B, Grodecká L, Kurecová B, Jarkovský J, Bartonková D et al (2010a) No association of FCRN promoter VNTR polymorphism with the rate of maternal-fetal IgG transfer. J Reprod Immunol 85(2):193-197
40. Freiberger T, Grodecka L, Ravcukova B, Kurecova B, Postranecka V, Vlcek J et al (2010b) Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency. Clin Immunol 136(3):419-425
41. Furrie E, Macfarlane S, Cummings JH, Macfarlane GT (2004) Systemic antibodies towards muco-sal bacteria in ulcerative colitis and Crohn's disease differentially activate the innate immune response. Gut 53(1):91-98
42. Gafencu A, Heltianu C, Burlacu A, Hunziker W, Simionescu M (2003) Investigation of IgG receptors expressed on the surface of human placental endothelial cells. Placenta 24(6):664-676
43. Hansen RJ, Balthasar JP (2002) Intravenous immunoglobulin mediates an increase in anti-platelet antibody clearance via the FcRn receptor. Thromb Haemost 88(6):898-899
44. Hattori R, Otani H, Moriguchi Y, Matsubara H, Yamamura T, Nakao Y et al (2001) NHE and ICAM-1 expression in hypoxic/reoxygenated coronary microvascular endothelial cells. Am J Physiol Heart Circ Physiol 280(6):H2796-H2803
45. He Y, Bjorkman PJ (2011) Structure of FcRY, an avian immunoglobulin receptor related to mammalian mannose receptors, and its complex with IgY. Proc Natl Acad Sci USA 108(30):12431-12436
46. He W, Ladinsky MS, Huey-Tubman KE, Jensen GJ, McIntosh JR, Bjorkman PJ (2008) FcRn-mediated antibody transport across epithelial cells revealed by electron tomography. Nature 455(7212):542-546
47. Hinton PR, Johlfs MG, Xiong JM, Hanestad K, Ong KC, Bullock C et al (2004) Engineered human IgG antibodies with longer serum half-lives in primates. J Biol Chem 279(8):6213-6216
48. Hinton PR, Xiong JM, Johlfs MG, Tang MT, Keller S, Tsurushita N (2006) An engineered human IgG1 antibody with longer serum half-life. J Immunol 176(1):346-356
49. Ishii-Watabe A, Saito Y, Suzuki T, Tada M, Ukaji M, Maekawa K et al (2010) Genetic polymorphisms of FCGRT encoding FcRn in a Japanese population and their functional analysis. Drug Metab Pharmacokinet 25(6):578-587
50. Israel EJ, Taylor S, Wu Z, Mizoguchi E, Blumberg RS, Bhan A et al (1997) Expression of the neonatal Fc receptor, FcRn, on human intestinal epithelial cells. Immunology 92(1):69-74
51. Jerdeva GV, Tesar DB, Huey-Tubman KE, Ladinsky MS, Fraser SE, Bjorkman PJ (2010) Comparison of FcRn-and pIgR-mediated transport in MDCK cells by fluorescence confocal microscopy. Traffic 11(9):1205-1220
52. Jin-Kyoo K, May-Fang T, Victor G, Ward ES (1994) Localization of the site of the murine IgG1 molecule that is involved in binding to the murine intestinal Fc receptor. Eur J Immunol 24(10):2429-2434
53. Jones EA, Waldmann TA (1972) The mechanism of intestinal uptake and transcellular transport of IgG in the neonatal rat. J Clin Invest 51(11):2916-2927
54. Kacskovics I (2004) Fc receptors in livestock species. Vet Immunol Immunopathol 102(4):351-362
55. Kacskovics I, Wu Z, Simister NE, Frenyo LV, Hammarstrom L (2000) Cloning and characterization of the bovine MHC class I-like Fc receptor. J Immunol 164(4):1889-1897
56. Kacskovics I, Kis Z, Mayer B, West AP Jr, Tiangco NE, Tilahun M et al (2006a) FcRn mediates elongated serum half-life of human IgG in cattle. Int Immunol 18(4):525-536
57. Kacskovics I, Mayer B, Kis Z, Frenyo LV, Zhao Y, Muyldermans S et al (2006b) Cloning and characterization of the dromedary (Camelus dromedarius) neonatal Fc receptor (drFcRn). Dev Comp Immunol 30(12):1203-1215
58. Kelly D, King T, Aminov R (2007) Importance of microbial colonization of the gut in early life to the development of immunity. Mutat Res 622(1-2):58-69
59. Kim JK, Firan M, Radu CG, Kim CH, Ghetie V, Ward ES (1999) Mapping the site on human IgG for binding of the MHC class I-related receptor, FcRn. Eur J Immunol 29(9):2819-2825
60. Kim J, Bronson CL, Wani MA, Oberyszyn TM, Mohanty S, Chaudhury C et al (2008) Beta 2-microglobulin deficient mice catabolize IgG more rapidly than FcRn-alpha-chain deficient mice. Exp Biol Med (Maywood) 233(5):603-609
61. Kim J, Mohanty S, Ganesan LP, Hua K, Jarjoura D, Hayton WL et al (2009) FcRn in the yolk sac endoderm of mouse is required for IgG transport to fetus. J Immunol 182(5):2583-2589
62. Kobayashi N, Suzuki Y, Tsuge T, Okumura K, Ra C, Tomino Y (2002) FcRn-mediated transcytosis of immunoglobulin G in human renal proximal tubular epithelial cells. Am J Physiol Renal Physiol 282(2):F358-F365
63. Kobayashi K, Qiao SW, Yoshida M, Baker K, Lencer WI, Blumberg RS (2009) An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice. Gastroenterology 137(5):1746-1756, e1
64. Kozlowski PA, Cu-Uvin S, Neutra MR, Flanigan TP (1997) Comparison of the oral, rectal, and vaginal immunization routes for induction of antibodies in rectal and genital tract secretions of women. Infect Immun 65(4):1387-1394
65. Kuo TT, Aveson VG (2011) Neonatal Fc receptor and IgG-based therapeutics. MAbs 3(5):422-430
66. Kuo TT, de Muinck EJ, Claypool SM, Yoshida M, Nagaishi T, Aveson VG et al (2009) N-glycan moieties in neonatal Fc receptor determine steady-state membrane distribution and directional transport of IgG. J Biol Chem 284(13):8292-8300
67. Kuo T, Baker K, Yoshida M, Qiao S-W, Aveson V, Lencer W et al (2010) Neonatal Fc receptor: from immunity to therapeutics. J Clin Immunol 30(6):777-789
68. Leach JL, Sedmak DD, Osborne JM, Rahill B, Lairmore MD, Anderson CL (1996) Isolation from human placenta of the IgG transporter, FcRn, and localization to the syncytiotrophoblast: implications for maternal-fetal antibody transport. J Immunol 157(8):3317-3322
69. Lencer WI, Blumberg RS (2005) A passionate kiss, then run: exocytosis and recycling of IgG by FcRn. Trends Cell Biol 15(1):5-9
70. Li N, Zhao M, Hilario-Vargas J, Prisayanh P, Warren S, Diaz LA et al (2005) Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases. J Clin Invest 115(12):3440-3450
71. Li Z, Palaniyandi S, Zeng R, Tuo W, Roopenian DC, Zhu X (2011) Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc receptor (FcRn) confers protective immunity to vaginal infection. Proc Natl Acad Sci USA 108(11):4388-4393
72. Liu L, Garcia AM, Santoro H, Zhang Y, McDonnell K, Dumont J et al (2007) Amelioration of experimental autoimmune myasthenia gravis in rats by neonatal FcR blockade. J Immunol 178(8):5390-5398
73. Liu X, Lu L, Yang Z, Palaniyandi S, Zeng R, Gao L-Y et al (2011) The neonatal FcR-mediated presentation of immune-complexed antigen is associated with endosomal and phagosomal pH and antigen stability in macrophages and dendritic cells. J Immunol 186(8):4674-4686
74. Lodes MJ, Cong Y, Elson CO, Mohamath R, Landers CJ, Targan SR et al (2004) Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest 113(9):1296-1306
75. Low SC, Mezo AR (2009) Inhibitors of the FcRn: IgG protein-protein interaction. AAPS J 11(3):432-434
76. Lu W, Zhao Z, Zhao Y, Yu S, Zhao Y, Fan B et al (2007) Over-expression of the bovine FcRn in the mammary gland results in increased IgG levels in both milk and serum of transgenic mice. Immunology 122(3):401-408
77. Lu L, Palaniyandi S, Zeng R, Bai Y, Liu X, Wang Y et al (2011) An FcRn-targeted mucosal vaccine strategy effectively induces HIV-1 antigen-specific immunity to genital infection. J Virol 85(20):10542-10553
78. Martin WL, Bjorkman PJ (1999) Characterization of the 2:1 complex between the class I MHC-related Fc receptor and its Fc ligand in solution. Biochemistry 38(39):12639-12647
79. Martin WL, West AP Jr, Gan L, Bjorkman PJ (2001) Crystal structure at 2.8 A of an FcRn/het-erodimeric Fc complex: mechanism of pH-dependent binding. Mol Cell 7(4):867-877
80. Matson AP, Thrall RS, Rafti E, Lingenheld EG, Puddington L (2010) IgG transmitted from allergic mothers decreases allergic sensitization in breastfed offspring. Clin Mol Allergy 8:9
81. Mayer B, Zolnai A, Frenyo LV, Jancsik V, Szentirmay Z, Hammarstrom L et al (2002) Redistribution of the sheep neonatal Fc receptor in the mammary gland around the time of parturition in ewes and its localization in the small intestine of neonatal lambs. Immunology 107(3):288-296
82. Mayer B, Kis Z, Kajan G, Frenyo LV, Hammarstrom L, Kacskovics I (2004) The neonatal Fc receptor (FcRn) is expressed in the bovine lung. Vet Immunol Immunopathol 98(1-2):85-89
83. McCarthy KM, Yoong Y, Simister NE (2000) Bidirectional transcytosis of IgG by the rat neonatal Fc receptor expressed in a rat kidney cell line: a system to study protein transport across epi-thelia. J Cell Sci 113(Pt 7):1277-1285
84. McCarthy KM, Lam M, Subramanian L, Shakya R, Wu Z, Newton EE et al (2001) Effects of mutations in potential phosphorylation sites on transcytosis of FcRn. J Cell Sci 114(Pt 8): 1591-1598
85. Medesan C, Matesoi D, Radu C, Ghetie V, Ward ES (1997) Delineation of the amino acid residues involved in transcytosis and catabolism of mouse IgG1. J Immunol 158(5):2211-2217
86. Mestecky J (1987) The common mucosal immune system and current strategies for induction of immune responses in external secretions. J Clin Immunol 7(4):265-276
87. Mezo AR, McDonnell KA, Hehir CA, Low SC, Palombella VJ, Stattel JM et al (2008a) Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn. Proc Natl Acad Sci USA 105(7):2337-2342
88. Mezo AR, McDonnell KA, Castro A, Fraley C (2008b) Structure-activity relationships of a pep-tide inhibitor of the human FcRn: human IgG interaction. Bioorg Med Chem 16(12):6394-6405
89. Mezo AR, Low SC, Hoehn T, Palmieri H (2011) PEGylation enhances the therapeutic potential of peptide antagonists of the neonatal Fc receptor, FcRn. Bioorg Med Chem Lett 21(21):6332-6335
90. Mi W, Wanjie S, Lo ST, Gan Z, Pickl-Herk B, Ober RJ et al (2008) Targeting the neonatal fc receptor for antigen delivery using engineered fc fragments. J Immunol 181(11):7550-7561
91. Mohanty S, Kim J, Ganesan LP, Phillips GS, Hua K, Jarjoura D et al (2010) IgG is transported across the mouse yolk sac independently of Fc[gamma]RIIb. J Reprod Immunol 84(2):133-144
92. Montoyo HP, Vaccaro C, Hafner M, Ober RJ, Mueller W, Ward ES (2009) Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice. Proc Natl Acad Sci USA 106(8):2788-2793
93. Morell A, Terry WD, Waldmann TA (1970) Metabolic properties of IgG subclasses in man. J Clin Invest 49(4):673-680
94. Mosconi E, Rekima A, Seitz-Polski B, Kanda A, Fleury S, Tissandie E et al (2010) Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development. Mucosal Immunol 3(5):461-474
95. Nimmerjahn F, Ravetch JV (2010) Antibody-mediated modulation of immune responses. Immunol Rev 236(1):265-275
96. Ober RJ, Radu CG, Ghetie V, Ward ES (2001) Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies. Int Immunol 13(12):1551-1559
97. Ober RJ, Martinez C, Vaccaro C, Zhou J, Ward ES (2004a) Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn. J Immunol 172(4):2021-2029
98. Ober RJ, Martinez C, Lai X, Zhou J, Ward ES (2004b) Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level. Proc Natl Acad Sci USA 101(30):11076-11081
99. Patel DA, Puig-Canto A, Challa DK, Montoyo HP, Ober RJ, Ward ES (2011) Neonatal Fc receptor blockade by Fc engineering ameliorates arthritis in a murine model. J Immunol 187(2):1015-1022
100. Peters RT, Low SC, Kamphaus GD, Dumont JA, Amari JV, Lu Q et al (2010) Prolonged activity of factor IX as a monomeric Fc fusion protein. Blood 115(10):2057-2064
101. Petkova SB, Akilesh S, Sproule TJ, Christianson GJ, Al Khabbaz H, Brown AC et al (2006) Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease. Int Immunol 18(12):1759-1769
102. Cianga P, Medesan C, Richardson JA, Ghetie V, Ward ES (1999) Identification and function of neonatal Fc receptor in mammary gland of lactating mice. Eur J Immunol 29(8):2515-2523
103. Popivanova BK, Kitamura K, Yu W, Kondo T, Kagaya T, Kaneko S et al (2008) Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. J Clin Invest 118(2):560-570
104. Porollo A, Meller J (2007) Versatile annotation and publication quality visualization of protein complexes using POLYVIEW-3D. BMC Bioinformatics 8:316
105. Praetor A, Hunziker W (2002) beta(2)-Microglobulin is important for cell surface expression and pH-dependent IgG binding of human FcRn. J Cell Sci 115(Pt 11):2389-2397
106. Qiao SW, Kobayashi K, Johansen FE, Sollid LM, Andersen JT, Milford E et al (2008) Dependence of antibody-mediated presentation of antigen on FcRn. Proc Natl Acad Sci USA 105(27):9337-9342
107. Raghavan M, Gastinel LN, Bjorkman PJ (1993) The class I major histocompatibility complex related Fc receptor shows pH-dependent stability differences correlating with immunoglobulin binding and release. Biochemistry 32(33):8654-8660
108. Raghavan M, Bonagura VR, Morrison SL, Bjorkman PJ (1995) Analysis of the pH dependence of the neonatal Fc receptor/immunoglobulin G interaction using antibody and receptor variants. Biochemistry 34(45):14649-14657
109. Rodewald R (1976) pH-dependent binding of immunoglobulins to intestinal cells of the neonatal rat. J Cell Biol 71(2):666-669
110. Roopenian D, Sun V (2010) Clinical ramifications of the MHC family Fc receptor FcRn. J Clin Immunol 30(6):790-797
111. Roopenian DC, Christianson GJ, Sproule TJ, Brown AC, Akilesh S, Jung N et al (2003) The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs. J Immunol 170(7):3528-3533
112. Roopenian DC, Christianson GJ, Sproule TJ (2010) Human FcRn transgenic mice for pharmaco-kinetic evaluation of therapeutic antibodies. Methods Mol Biol 602:93-104
113. Russell DG (2007) New ways to arrest phagosome maturation. Nat Cell Biol 9(4):357-359
114. Sakagami M, Omidi Y, Campbell L, Kandalaft LE, Morris CJ, Barar J et al (2006) Expression and transport functionality of FcRn within rat alveolar epithelium: a study in primary cell culture and in the isolated perfused lung. Pharm Res 23(2):270-279
115. Sarav M, Wang Y, Hack BK, Chang A, Jensen M, Bao L et al (2009) Renal FcRn reclaims albumin but facilitates elimination of IgG. J Am Soc Nephrol 20(9):1941-1952
116. Savina A, Jancic C, Hugues S, Guermonprez P, Vargas P, Moura IC et al (2006) NOX2 controls phagosomal pH to regulate antigen processing during cross-presentation by dendritic cells. Cell 126(1):205-218
117. Sayed-Ahmed A, Kassab M, Abd-Elmaksoud A, Elnasharty M, El-Kirdasy A (2010) Expression and immunohistochemical localization of the neonatal Fc receptor (FcRn) in the mammary glands of the Egyptian water buffalo. Acta Histochem 112(4):383-391
118. Schlachetzki F, Zhu C, Pardridge WM (2002) Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier. J Neurochem 81(1):203-206
119. Schnulle PM, Hurley WL (2003) Sequence and expression of the FcRn in the porcine mammary gland. Vet Immunol Immunopathol 91(3-4):227-231
120. Schroeder HW Jr, Cavacini L (2010) Structure and function of immunoglobulins. J Allergy Clin Immunol 125(Suppl 2):S41-S52
121. Sesarman A, Sitaru AG, Olaru F, Zillikens D, Sitaru C (2008) Neonatal Fc receptor deficiency protects from tissue injury in experimental epidermolysis bullosa acquisita. J Mol Med 86(8):951-959
122. Sesarman A, Vidarsson G, Sitaru C (2010) The neonatal Fc receptor as therapeutic target in IgG-mediated autoimmune diseases. Cell Mol Life Sci 67(15):2533-2550
123. Shah U, Dickinson BL, Blumberg RS, Simister NE, Lencer WI, Walker WA (2003) Distribution of the IgG Fc receptor, FcRn, in the human fetal intestine. Pediatr Res 53(2):295-301
124. Shiomi H, Masuda A, Nishiumi S, Nishida M, Takagawa T, Shiomi Y et al (2010) Gamma inter-feron produced by antigen-specific CD4+ T cells regulates the mucosal immune responses to Citrobacter rodentium infection. Infect Immun 78(6):2653-2666
125. Simister NE (2003) Placental transport of immunoglobulin G. Vaccine 21(24):3365-3369
126. Simister NE, Ahouse JC (1996) The structure and evolution of FcRn. Res Immunol 147(5):333-337
127. Simister NE, Mostov KE (1989a) An Fc receptor structurally related to MHC class I antigens. Nature 337(6203):184-187
128. Simister NE, Mostov KE (1989b) Cloning and expression of the neonatal rat intestinal Fc receptor, a major histocompatibility complex class I antigen homolog. Cold Spring Harb Symp Quant Biol 54(Pt 1):571-580
129. Simister NE, Rees AR (1985) Isolation and characterization of an Fc receptor from neonatal rat small intestine. Eur J Immunol 15(7):733-738
130. Spiegelberg HL (1989) Biological role of different antibody classes. Int Arch Allergy Appl Immunol 90(Suppl 1):22-27
131. Spiegelberg HL, Weigle WO (1965) Studies on the catabolism of gamma-G subunits and chains. J Immunol 95(6):1034-1040
132. Spiegelberg HL, Fishkin BG, Grey HM (1968) Catabolism of human gammaG-immunoglobulins of different heavy chain subclasses. I. Catabolism of gammaG-myeloma proteins in man. J Clin Invest 47(10):2323-2330
133. Spiekermann GM, Finn PW, Ward ES, Dumont J, Dickinson BL, Blumberg RS et al (2002) Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung. J Exp Med 196(3):303-310
134. Stirling CM, Charleston B, Takamatsu H, Claypool S, Lencer W, Blumberg RS et al (2005) Characterization of the porcine neonatal Fc receptor-potential use for trans-epithelial protein delivery. Immunology 114(4):542-553
135. Story CM, Mikulska JE, Simister NE (1994) A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus. J Exp Med 180(6):2377-2381
136. Suzuki T, Ishii-Watabe A, Tada M, Kobayashi T, Kanayasu-Toyoda T, Kawanishi T et al (2010) Importance of neonatal FcR in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1: a comparative study of the affinity of monoclonal antibodies and Fc-fusion proteins to human neonatal FcR. J Immunol 184(4):1968-1976
137. Szlauer R, Ellinger I, Haider S, Saleh L, Busch BL, Knofler M et al (2009) Functional expression of the human neonatal Fc-receptor, hFcRn, in isolated cultured human syncytiotrophoblasts. Placenta 30(6):507-515
138. Tesar DB, Björkman PJ (2010) An intracellular traffic jam: Fc receptor-mediated transport of immunoglobulin G. Curr Opin Struct Biol 20(2):226-233
139. Tesar DB, Cheung EJ, Bjorkman PJ (2008) The chicken yolk sac IgY receptor, a mammalian man-nose receptor family member, transcytoses IgY across polarized epithelial cells. Mol Biol Cell 19(4):1587-1593
140. Tiwari B, Junghans RP (2005) Functional analysis of the mouse Fcgrt 5′ proximal promoter. Biochim Biophys Acta 1681(2-3):88-98
141. Tzaban S, Massol RH, Yen E, Hamman W, Frank SR, Lapierre LA et al (2009) The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity. J Cell Biol 185(4):673-684
142. Vaccaro C, Zhou J, Ober RJ, Ward ES (2005) Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels. Nat Biotechnol 23(10):1283-1288
143. Vaccaro C, Bawdon R, Wanjie S, Ober RJ, Ward ES (2006) Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies. Proc Natl Acad Sci USA 103(49):18709-18714
144. Vaughn DE, Bjorkman PJ (1998) Structural basis of pH-dependent antibody binding by the neonatal Fc receptor. Structure 6(1):63-73
145. Verhasselt V, Milcent V, Cazareth J, Kanda A, Fleury S, Dombrowicz D et al (2008) Breast milk-mediated transfer of an antigen induces tolerance and protection from allergic asthma. Nat Med 14(2):170-175
146. Waldmann TA, Terry WD (1990) Familial hypercatabolic hypoproteinemia. A disorder of endogenous catabolism of albumin and immunoglobulin. J Clin Invest 86(6):2093-2098
147. Wang Y, Geer LY, Chappey C, Kans JA, Bryant SH (2000) Cn3D: sequence and structure views for Entrez. Trends Biochem Sci 25(6):300-302
148. Wani MA, Haynes LD, Kim J, Bronson CL, Chaudhury C, Mohanty S et al (2006) Familial hyper-catabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene. Proc Natl Acad Sci USA 103(13):5084-5089
149. Ward ES, Ober RJ, Frederick WA (2009) Chapter 4 Multitasking by exploitation of intracellular transport functions: the many faces of FcRn. Adv Immunol 103:77-115, Academic Press
150. Wernick NL, Haucke V, Simister NE (2005) Recognition of the tryptophan-based endocytosis signal in the neonatal Fc receptor by the mu subunit of adaptor protein-2. J Biol Chem 280(8):7309-7316
151. West AP Jr, Bjorkman PJ (2000) Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor. Biochemistry 39(32):9698-9708
152. West AP Jr, Herr AB, Bjorkman PJ (2004) The chicken yolk sac IgY receptor, a functional equivalent of the mammalian MHC-related Fc receptor, is a phospholipase A2 receptor homolog. Immunity 20(5):601-610
153. Wu Z, Simister NE (2001) Tryptophan-and dileucine-based endocytosis signals in the neonatal Fc receptor. J Biol Chem 276(7):5240-5247
154. Ye L, Liu X, Rout SN, Li Z, Yan Y, Lu L et al (2008) The MHC class II-associated invariant chain interacts with the neonatal Fc gamma receptor and modulates its trafficking to endosomal/lysosomal compartments. J Immunol 181(4):2572-2585
155. Ye L, Zeng R, Bai Y, Roopenian DC, Zhu X (2011) Efficient mucosal vaccination mediated by the neonatal Fc receptor. Nat Biotech 29(2):158-163
156. Yeung YA, Leabman MK, Marvin JS, Qiu J, Adams CW, Lien S et al (2009) Engineering human IgG1 affinity to human neonatal Fc receptor: impact of affinity improvement on pharmacoki-netics in primates. J Immunol 182(12):7663-7671
157. Yeung YA, Wu X, Reyes AE 2nd, Vernes JM, Lien S, Lowe J et al (2010) A therapeutic anti-VEGF antibody with increased potency independent of pharmacokinetic half-life. Cancer Res 70(8):3269-3277
158. Yoshida M, Claypool SM, Wagner JS, Mizoguchi E, Mizoguchi A, Roopenian DC et al (2004) Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity 20(6):769-783
159. Yoshida M, Kobayashi K, Kuo TT, Bry L, Glickman JN, Claypool SM et al (2006) Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. J Clin Invest 116(8):2142-2151
160. Zalevsky J, Chamberlain AK, Horton HM, Karki S, Leung IWL, Sproule TJ et al (2010) Enhanced antibody half-life improves in vivo activity. Nat Biotech 28(2):157-159
161. Zheng Y, Scheerens H, Davis JC Jr, Deng R, Fischer SK, Woods C et al (2011) Translational phar-macokinetics and pharmacodynamics of an FcRn-variant anti-CD4 monoclonal antibody from preclinical model to phase I study. Clin Pharmacol Ther 89(2):283-290
162. Zhou J, Mateos F, Ober RJ, Ward ES (2005a) Conferring the binding properties of the mouse MHC class I-related receptor, FcRn, onto the human ortholog by sequential rounds of site-directed mutagenesis. J Mol Biol 345(5):1071-1081
163. Zhou J, Pop LM, Ghetie V (2005b) Hypercatabolism of IgG in mice with lupus-like syndrome. Lupus 14(6):458-466
164. Zhou XJ, Yu L, Zhu L, Hou P, Lv JC, Yu F et al (2009) Association between polymorphisms in the FCGRT gene and lupus nephritis in Chinese patients. Clin Exp Rheumatol 27(4):609-614
165. Zhu X, Meng G, Dickinson BL, Li X, Mizoguchi E, Miao L et al (2001) MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells. J Immunol 166(5):3266-3276