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Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 7, 2008, Pages 2337-2342

Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn

(11) Mezo, Adam R a McDonnell, Kevin A a Tan Hehir, Cristina A a,b Low, Susan C a Palombella, Vito J a,c Stattel, James M a,d Kamphaus, George D a Fraley, Cara a Zhang, Yixia a Dumont, Jennifer A a Bitonti, Alan J a

a Syntonix Pharmaceuticals Inc (United States)

b GE GLOBAL RESEARCH (United States)

c Infinity Pharmaceuticals Inc (United States)

d MEDIMMUNE (United States)

Author keywords

Autoimmune disease; Fcrn antagonist; Phage display; Protein protein interactions

Indexed keywords

ASPARAGINYLSERYLPHENYLALANYLCYSTEINYLARGINYLGLYCYLARGINYLPROLYL GLYCYLHISTIDYLPHENYLALANYLGLYCYLGLYCYLCYSTEINYLTYROSYLLEUCYLPHENYLALANINE; FC RECEPTOR; FC RECEPTOR FCRN; GLUTAMINYLARGINYLPHENYLALANYLCYSTEINYLTHREONYLGLYCYLHISTIDYL PHENYLALANYLGLYCYLGLYCYLLEUCYLTYROSYLPROLYLCYSTEINYLASPARAGINYLGLYCYLPROLINE; GLYCYLGLYCYLGLYCYLCYSTEINYLVALYLTHREONYLGLYCYLHISTIDYLPHENYL ALANYLGLYCYLGLYCYLISOLEUCYLTYROSYLCYSTEINYLASPARAGINYLTYROSYLGLUTAMINE; IMMUNOGLOBULIN G; LYSYLISOLEUCYLISOLEUCYLCYSTEINYLSERYLPROLYLGLYCYLHISTIDYL PHENYLALANYLGLYCYLGLYCYLMETHIONYLTYROSYLCYSTEINYLGLUTAMINYLGLYCYLLYSINE; PEPTIDE DERIVATIVE; PEPTIDE LIBRARY; PROLYLSERYLTYROSYLCYSTEINYLISOLEUCYLGLUTAMYLGLYCYLHISTIDYL ISOLEUCYLASPARTYLGLYCYLISOLEUCYLTYROSYLCYSTEINYLPHENYLALANYLASPARAGINYLALANINE; SERUM ALBUMIN; SYN 1327; SYN 1436; SYN 722; SYN 723; SYN 724; SYN 725; SYN 726; SYN 746; UNCLASSIFIED DRUG; ALBUMINOID; FC RECEPTOR, NEONATAL; HLA A2 ANTIGEN; HLA ANTIGEN CLASS 1; IMMUNOGLOBULIN A; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN M; PEPTIDE;

ALBUMIN BLOOD LEVEL; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MEGADOSE; DRUG POTENCY; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; MONKEY; MOUSE; NONHUMAN; PHAGE DISPLAY; PRIMATE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SINGLE DRUG DOSE; TRANSGENIC MOUSE; ANIMAL; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; IMMUNOLOGY; MACACA; METABOLISM; MOLECULAR GENETICS; SOLUBILITY; SURFACE PLASMON RESONANCE;

ANIMALIA; MACACA FASCICULARIS; MUS; PRIMATES;

ALBUMINS; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA-A2 ANTIGEN; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MACACA FASCICULARIS; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; RECEPTORS, FC; SOLUBILITY; SURFACE PLASMON RESONANCE;

EID: 40649086923 PISSN: 00278424 EISSN: 10916490 Source Type: Journal
DOI: 10.1073/pnas.0708960105 Document Type: Article

Times cited : (95)

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