Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency

Clinical Immunology

Volumn 136, Issue 3, 2010, Pages 419-425

  Freiberger, T ^a,c   Grodecka L ^a   Ravcukova B ^a   Kurecova B ^b   Postranecka V ^c   Vlcek J ^c   Jarkovsky J ^d   Thon, V ^c   Litzman, J ^c  

^a Centre of Cardiovascular and Transplant Surgery Brno   (Czech Republic)

^b UNIVERSITY HOSPITAL BRNO   (Czech Republic)

^c ST ANNE S UNIVERSITY HOSPITAL   (Czech Republic)

^d MASARYK UNIVERSITY   (Czech Republic)

Author keywords

Common variable immunodeficiency; FcRn; IVIG; Lung disease; Neonatal Fc receptor

Indexed keywords

FC RECEPTOR; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; MESSENGER RNA;

ADOLESCENT; ADULT; AGED; ARTICLE; BRONCHIECTASIS; CATABOLISM; CLINICAL ARTICLE; COMMON VARIABLE IMMUNODEFICIENCY; CONTROLLED STUDY; DIARRHEA; FEMALE; FIBROSIS; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; LUNG DEVELOPMENT; LUNG FUNCTION; LYMPHADENOPATHY; MALE; ONSET AGE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLENOMEGALY;

EID: 77955266751     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2010.05.006     Document Type: Article

References (22)

1. Baker K., Qiao S.W., Kuo T., Kobayashi K., Yoshida M., Lencer W.I., Blumberg R.S. Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn. Semin. Immunopathol. 2009, 31:223-236.
2. Anderson C.L., Chaudhury C., Kim J., Bronson C.L., Wani M.A., Mohanty S. Perspective - FcRn transports albumin: relevance to immunology and medicine. Trends Immunol. 2006, 27:343-348.
3. Kim J., Bronson C.L., Hayton W.L., Radmacher M.D., Roopenian D.C., Robinson J.M., Anderson C.L. Albumin turnover: FcRn-mediated recycling saves as much albumin from degradation as the liver produces. Am. J. Physiol. Gastrointest. Liver Physiol. 2006, 290:G352-G360.
4. Akilesh S., Christianson G.J., Roopenian D.C., Shaw A.S. Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism. J. Immunol. 2007, 179:4580-4588.
5. Yoshida M., Claypool S.M., Wagner J.S., Mizoguchi E., Mizoguchi A., Roopenian D.C., Lencer W.I., Blumberg R.S. Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity 2004, 20:769-783.
6. Qiao S.W., Kobayashi K., Johansen F.E., Sollid L.M., Andersen J.T., Milford E., Roopenian D.C., Lencer W.I., Blumberg R.S. Dependence of antibody-mediated presentation of antigen on FcRn. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:9337-9342.
7. Sachs U.J., Socher I., Braeunlich C.G., Kroll H., Bein G., Santoso S. A variable number of tandem repeats polymorphism influences the transcriptional activity of the neonatal Fc receptor alpha-chain promoter. Immunology 2006, 119:83-89.
8. Park M.A., Li J.T., Hagan J.B., Maddox D.E., Abraham R.S. Common variable immunodeficiency: a new look at an old disease. Lancet 2008, 372:489-502.
9. Mullighan C.G., Fanning G.C., Chapel H.M., Welsh K.I. TNF and lymphotoxin-alpha polymorphisms associated with common variable immunodeficiency: role in the pathogenesis of granulomatous disease. J. Immunol. 1997, 159:6236-6241.
10. Mullighan C.G., Marshall S.E., Bunce M., Welsh K.I. Variation in immunoregulatory genes determines the clinical phenotype of common variable immunodeficiency. Genes Immun. 1999, 1:137-148.
11. Litzman J., Freiberger T., Grimbacher B., Gathmann B., Salzer U., Pavlik T., Vlcek J., Postranecka V., Travnickova Z., Thon V. Mannose-binding lectin gene polymorphic variants predispose to the development of bronchopulmonary complications but have no influence on other clinical and laboratory symptoms or signs of common variable immunodeficiency. Clin. Exp. Immunol. 2008, 153:324-330.
12. Conley M.E., Notarangelo L.D., Etzioni A. Diagnostic criteria for primary immunodeficiencies. Representing PAGID (Pan-American Group for Immunodeficiency) and ESID (European Society for Immunodeficiencies). Clin. Immunol. 1999, 93:190-197.
13. Mankarious S., Lee M., Fischer S., Pyun K.H., Ochs H.D., Oxelius V.A., Wedgwood R.J. The half-lives of IgG subclasses and specific antibodies in patients with primary immunodeficiency who are receiving intravenously administered immunoglobulin. J. Lab. Clin. Med. 1988, 112:634-640.
14. Nolan T., Hands R.E., Bustin S.A. Quantification of mRNA using real-time RT-PCR. Nat. Protoc. 2006, 1:1559-1582.
15. Grimbacher B., Hutloff A., Schlesier M., Glocker E., Warnatz K., Drager R., Eibel H., Fischer B., Schaffer A.A., Mages H.W., Kroczek R.A., Peter H.H. Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. Nat. Immunol. 2003, 4:261-268.
16. van Zelm M.C., Reisli I., van der Burg M., Castano D., van Noesel C.J., van Tol M.J., Woellner C., Grimbacher B., Patino P.J., van Dongen J.J., Franco J.L. An antibody-deficiency syndrome due to mutations in the CD19 gene. N. Engl. J. Med. 2006, 354:1901-1912.
17. Warnatz K., Salzer U., Rizzi M., Fischer B., Gutenberger S., Bohm J., Kienzler A.K., Pan-Hammarstrom Q., Hammarstrom L., Rakhmanov M., Schlesier M., Grimbacher B., Peter H.H., Eibel H. B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:13945-13950.
18. Salzer U., Bacchelli C., Buckridge S., Pan-Hammarstrom Q., Jennings S., Lougaris V., Bergbreiter A., Hagena T., Birmelin J., Plebani A., Webster A.D., Peter H.H., Suez D., Chapel H., McLean-Tooke A., Spickett G.P., Anover-Sombke S., Ochs H.D., Urschel S., Belohradsky B.H., Ugrinovic S., Kumararatne D.S., Lawrence T.C., Holm A.M., Franco J.L., Schulze I., Schneider P., Gertz E.M., Schaffer A.A., Hammarstrom L., Thrasher A.J., Gaspar H.B., Grimbacher B. Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes. Blood 2009, 113:1967-1976.
19. Zhu X., Meng G., Dickinson B.L., Li X., Mizoguchi E., Miao L., Wang Y., Robert C., Wu B., Smith P.D., Lencer W.I., Blumberg R.S. MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells. J. Immunol. 2001, 166:3266-3276.
20. Vidarsson G., Stemerding A.M., Stapleton N.M., Spliethoff S.E., Janssen H., Rebers F.E., de Haas M., van de Winkel J.G. FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis. Blood 2006, 108:3573-3579.
21. Mi W., Wanjie S., Lo S.T., Gan Z., Pickl-Herk B., Ober R.J., Ward E.S. Targeting the neonatal fc receptor for antigen delivery using engineered fc fragments. J. Immunol. 2008, 181:7550-7561.
22. Akilesh S., Petkova S., Sproule T.J., Shaffer D.J., Christianson G.J., Roopenian D. The MHC class I-like Fc receptor promotes humorally mediated autoimmune disease. J. Clin. Invest. 2004, 113:1328-1333.