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Volumn 30, Issue 6, 2010, Pages 777-789

Neonatal Fc receptor: From immunity to therapeutics

Author keywords

Albumin; Brambell; Fc; Fcgrt; FcRn; IgG; Recycling; Transcytosis; Transport

Indexed keywords

ALBINTERFERON ALPHA2B; ALBUMIN; ALBUMIN CONJUGATE; ALPHA INTERFERON; BETA INTERFERON; ERYTHROPOIETIN; FC RECEPTOR; FOLLITROPIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; METHOTREXATE; PACLITAXEL; TRASTUZUMAB;

EID: 78651340524     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-010-9468-4     Document Type: Article
Times cited : (209)

References (122)
  • 1
    • 0014489153 scopus 로고
    • The transmission of immune globulins from the mother to the foetal and newborn young
    • Brambell FW. The transmission of immune globulins from the mother to the foetal and newborn young. Proc Nutr Soc. 1969;28(1):35-41.
    • (1969) Proc. Nutr. Soc. , vol.28 , Issue.1 , pp. 35-41
    • Brambell, F.W.1
  • 2
    • 0000146003 scopus 로고
    • A theoretical model of gamma-globulin catabolism
    • Brambell FW, Hemmings WA, Morris IG. A theoretical model of gamma-globulin catabolism. Nature. 1964;203:1352-4.
    • (1964) Nature , vol.203 , pp. 1352-1354
    • Brambell, F.W.1    Hemmings, W.A.2    Morris, I.G.3
  • 3
    • 0017166982 scopus 로고
    • PH-dependent binding of immunoglobulins to intestinal cells of the neonatal rat
    • Rodewald R. pH-dependent binding of immunoglobulins to intestinal cells of the neonatal rat. J Cell Biol. 1976;71(2):666-9.
    • (1976) J. Cell. Biol. , vol.71 , Issue.2 , pp. 666-669
    • Rodewald, R.1
  • 4
    • 0024529856 scopus 로고
    • An Fc receptor structurally related to MHC class I antigens
    • Simister NE, Mostov KE. An Fc receptor structurally related to MHC class I antigens. Nature. 1989;337(6203):184-7.
    • (1989) Nature , vol.337 , Issue.6203 , pp. 184-187
    • Simister, N.E.1    Mostov, K.E.2
  • 5
    • 0027249327 scopus 로고
    • The class I major histocompatibility complex related Fc receptor shows pH-dependent stability differences correlating with immunoglobulin binding and release
    • Raghavan M, Gastinel LN, Bjorkman PJ. The class I major histocompatibility complex related Fc receptor shows pH-dependent stability differences correlating with immunoglobulin binding and release. Biochemistry. 1993;32(33):8654-60.
    • (1993) Biochemistry , vol.32 , Issue.33 , pp. 8654-8660
    • Raghavan, M.1    Gastinel, L.N.2    Bjorkman, P.J.3
  • 6
    • 0027318465 scopus 로고
    • Crystallization and stoichiometry of binding of a complex between a rat intestinal Fc receptor and Fc
    • Huber AH, Kelley RF, Gastinel LN, Bjorkman PJ. Crystallization and stoichiometry of binding of a complex between a rat intestinal Fc receptor and Fc. J Mol Biol. 1993;230(3):1077-83.
    • (1993) J. Mol. Biol. , vol.230 , Issue.3 , pp. 1077-1083
    • Huber, A.H.1    Kelley, R.F.2    Gastinel, L.N.3    Bjorkman, P.J.4
  • 7
    • 0028467948 scopus 로고
    • Investigation of the interaction between the class I MHC-related Fc receptor and its immunoglobulin G ligand
    • Raghavan M, Chen MY, Gastinel LN, Bjorkman PJ. Investigation of the interaction between the class I MHC-related Fc receptor and its immunoglobulin G ligand. Immunity. 1994;1(4):303-15.
    • (1994) Immunity , vol.1 , Issue.4 , pp. 303-315
    • Raghavan, M.1    Chen, M.Y.2    Gastinel, L.N.3    Bjorkman, P.J.4
  • 9
    • 0028808880 scopus 로고
    • Analysis of the pH dependence of the neonatal Fc receptor/immunoglobulin G interaction using antibody and receptor variants
    • Raghavan M, Bonagura VR, Morrison SL, Bjorkman PJ. Analysis of the pH dependence of the neonatal Fc receptor/immunoglobulin G interaction using antibody and receptor variants. Biochemistry. 1995;34(45):14649-57.
    • (1995) Biochemistry , vol.34 , Issue.45 , pp. 14649-14657
    • Raghavan, M.1    Bonagura, V.R.2    Morrison, S.L.3    Bjorkman, P.J.4
  • 10
    • 0031093498 scopus 로고    scopus 로고
    • Delineation of the amino acid residues involved in transcytosis and catabolism of mouse IgG1
    • Medesan C, Matesoi D, Radu C, Ghetie V, Ward ES. Delineation of the amino acid residues involved in transcytosis and catabolism of mouse IgG1. J Immunol. 1997;158(5):2211-7.
    • (1997) J. Immunol. , vol.158 , Issue.5 , pp. 2211-2217
    • Medesan, C.1    Matesoi, D.2    Radu, C.3    Ghetie, V.4    Ward, E.S.5
  • 11
    • 0037415556 scopus 로고    scopus 로고
    • The major histocompatibility complexrelated Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan
    • Chaudhury C, Mehnaz S, Robinson JM, Hayton WL, Pearl DK, Roopenian DC, et al. The major histocompatibility complexrelated Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan. J Exp Med. 2003;197(3):315-22.
    • (2003) J. Exp. Med. , vol.197 , Issue.3 , pp. 315-322
    • Chaudhury, C.1    Mehnaz, S.2    Robinson, J.M.3    Hayton, W.L.4    Pearl, D.K.5    Roopenian, D.C.6
  • 14
    • 33751211517 scopus 로고    scopus 로고
    • The conserved histidine 166 residue of the human neonatal Fc receptor heavy chain is critical for the pH-dependent binding to albumin
    • Andersen JT, Dee Qian J, Sandlie I. The conserved histidine 166 residue of the human neonatal Fc receptor heavy chain is critical for the pH-dependent binding to albumin. Eur J Immunol. 2006;36(11):3044-51.
    • (2006) Eur. J. Immunol. , vol.36 , Issue.11 , pp. 3044-3051
    • Andersen, J.T.1    Qian, J.D.2    Sandlie, I.3
  • 16
    • 0037379288 scopus 로고    scopus 로고
    • The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs
    • Roopenian DC, Christianson GJ, Sproule TJ, et al. The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs. J Immunol. 2003;170(7):3528-33.
    • (2003) J. Immunol. , vol.170 , Issue.7 , pp. 3528-3533
    • Roopenian, D.C.1    Christianson, G.J.2    Sproule, T.J.3
  • 17
    • 0032518373 scopus 로고    scopus 로고
    • Structural basis of pH-dependent antibody binding by the neonatal Fc receptor
    • Vaughn DE, Bjorkman PJ. Structural basis of pH-dependent antibody binding by the neonatal Fc receptor. Structure. 1998;6(1):63-73.
    • (1998) Structure , vol.6 , Issue.1 , pp. 63-73
    • Vaughn, D.E.1    Bjorkman, P.J.2
  • 18
    • 0035210960 scopus 로고    scopus 로고
    • Differences in promiscuity for antibody-FcRn interactions across species: Implications for therapeutic antibodies
    • Ober RJ, Radu CG, Ghetie V, Ward ES. Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies. Int Immunol. 2001;13(12):1551-9.
    • (2001) Int. Immunol. , vol.13 , Issue.12 , pp. 1551-1559
    • Ober, R.J.1    Radu, C.G.2    Ghetie, V.3    Ward, E.S.4
  • 19
    • 0041825386 scopus 로고    scopus 로고
    • Generation of mutated variants of the human form of the MHC class I-related receptor, FcRn, with increased affinity for mouse immunoglobulin G
    • Zhou J, Johnson JE, Ghetie V, Ober RJ, Ward ES. Generation of mutated variants of the human form of the MHC class I-related receptor, FcRn, with increased affinity for mouse immunoglobulin G. J Mol Biol. 2003;332(4):901-13.
    • (2003) J. Mol. Biol. , vol.332 , Issue.4 , pp. 901-913
    • Zhou, J.1    Johnson, J.E.2    Ghetie, V.3    Ober, R.J.4    Ward, E.S.5
  • 20
    • 67649776608 scopus 로고    scopus 로고
    • N-glycan moieties in neonatal Fc receptor determine steady-state membrane distribution and directional transport of IgG
    • Kuo TT, de Muinck EJ, Claypool SM, Yoshida M, Nagaishi T, Aveson VG, et al. N-glycan moieties in neonatal Fc receptor determine steady-state membrane distribution and directional transport of IgG. J Biol Chem. 2009;284(13):8292- 300.
    • (2009) J. Biol. Chem. , vol.284 , Issue.13 , pp. 8292-8300
    • Kuo, T.T.1    De Muinck, E.J.2    Claypool, S.M.3    Yoshida, M.4    Nagaishi, T.5    Aveson, V.G.6
  • 21
    • 77951156788 scopus 로고    scopus 로고
    • Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding
    • Andersen JT, Daba MB, Berntzen G, Michaelsen TE, Sandlie I. Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding. J Biol Chem. 2010;285(7):4826-36.
    • (2010) J. Biol. Chem. , vol.285 , Issue.7 , pp. 4826-4836
    • Andersen, J.T.1    Daba, M.B.2    Berntzen, G.3    Michaelsen, T.E.4    Sandlie, I.5
  • 22
    • 0034803881 scopus 로고    scopus 로고
    • Prolonged in vivo residence times of antibody fragments associated with albumin
    • Smith BJ, Popplewell A, Athwal D, et al. Prolonged in vivo residence times of antibody fragments associated with albumin. Bioconjug Chem. 2001;12(5):750-6.
    • (2001) Bioconjug Chem. , vol.12 , Issue.5 , pp. 750-756
    • Smith, B.J.1    Popplewell, A.2    Athwal, D.3
  • 23
    • 8444222711 scopus 로고    scopus 로고
    • Fc receptors in livestock species
    • Kacskovics I. Fc receptors in livestock species. Vet Immunol Immunopathol. 2004;102(4):351-62.
    • (2004) Vet. Immunol. Immunopathol , vol.102 , Issue.4 , pp. 351-362
    • Kacskovics, I.1
  • 24
    • 35048814454 scopus 로고    scopus 로고
    • Over-expression of the bovine FcRn in the mammary gland results in increased IgG levels in both milk and serum of transgenic mice
    • Lu W, Zhao Z, Zhao Y, et al. Over-expression of the bovine FcRn in the mammary gland results in increased IgG levels in both milk and serum of transgenic mice. Immunology. 2007;122(3):401-8.
    • (2007) Immunology , vol.122 , Issue.3 , pp. 401-408
    • Lu, W.1    Zhao, Z.2    Zhao, Y.3
  • 25
    • 0036846786 scopus 로고    scopus 로고
    • The heavy chain of neonatal Fc receptor for IgG is sequestered in endoplasmic reticulum by forming oligomers in the absence of beta2-microglobulin association
    • Zhu X, Peng J, Raychowdhury R, Nakajima A, Lencer WI, Blumberg RS. The heavy chain of neonatal Fc receptor for IgG is sequestered in endoplasmic reticulum by forming oligomers in the absence of beta2-microglobulin association. Biochem J. 2002;367(Pt 3):703-14.
    • (2002) Biochem. J. , vol.367 , Issue.3 PT , pp. 703-714
    • Zhu, X.1    Peng, J.2    Raychowdhury, R.3    Nakajima, A.4    Lencer, W.I.5    Blumberg, R.S.6
  • 26
    • 0037008670 scopus 로고    scopus 로고
    • Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin
    • Claypool SM, Dickinson BL, Yoshida M, Lencer WI, Blumberg RS. Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin. J Biol Chem. 2002;277(31):28038-50.
    • (2002) J. Biol. Chem. , vol.277 , Issue.31 , pp. 28038-28050
    • Claypool, S.M.1    Dickinson, B.L.2    Yoshida, M.3    Lencer, W.I.4    Blumberg, R.S.5
  • 27
    • 23244432686 scopus 로고    scopus 로고
    • Calnexin and ERp57 facilitate the assembly of the neonatal Fc receptor for IgG with beta 2-microglobulin in the endoplasmic reticulum
    • Zhu X, Peng J, Chen D, et al. Calnexin and ERp57 facilitate the assembly of the neonatal Fc receptor for IgG with beta 2-microglobulin in the endoplasmic reticulum. J Immunol. 2005;175(2):967-76.
    • (2005) J. Immunol. , vol.175 , Issue.2 , pp. 967-976
    • Zhu, X.1    Peng, J.2    Chen, D.3
  • 28
    • 0032741975 scopus 로고    scopus 로고
    • Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line
    • Dickinson BL, Badizadegan K, Wu Z, Ahouse JC, Zhu X, Simister NE, et al. Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line. J Clin Invest. 1999;104(7):903-11.
    • (1999) J. Clin. Invest. , vol.104 , Issue.7 , pp. 903-911
    • Dickinson, B.L.1    Badizadegan, K.2    Wu, Z.3    Ahouse, J.C.4    Zhu, X.5    Simister, N.E.6
  • 29
    • 0035478617 scopus 로고    scopus 로고
    • Apical to basolateral transcytosis and apical recycling of immunoglobulin G in trophoblast-derived BeWo cells: Effects of low temperature, nocodazole, and cytochalasin D
    • Ellinger I, Rothe A, Grill M, Fuchs R. Apical to basolateral transcytosis and apical recycling of immunoglobulin G in trophoblast-derived BeWo cells: effects of low temperature, nocodazole, and cytochalasin D. Exp Cell Res. 2001;269(2):322-31.
    • (2001) Exp. Cell. Res. , vol.269 , Issue.2 , pp. 322-331
    • Ellinger, I.1    Rothe, A.2    Grill, M.3    Fuchs, R.4
  • 30
    • 3042567229 scopus 로고    scopus 로고
    • Neonatal Fc receptors discriminates and monitors the pathway of native and modified immunoglobulin G in placental endothelial cells
    • Radulescu L, Antohe F, Jinga V, Ghetie V, Simionescu M. Neonatal Fc receptors discriminates and monitors the pathway of native and modified immunoglobulin G in placental endothelial cells. Hum Immunol. 2004;65(6):578-85.
    • (2004) Hum. Immunol. , vol.65 , Issue.6 , pp. 578-585
    • Radulescu, L.1    Antohe, F.2    Jinga, V.3    Ghetie, V.4    Simionescu, M.5
  • 32
    • 66149115113 scopus 로고    scopus 로고
    • The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity
    • Tzaban S, Massol RH, Yen E, et al. The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity. J Cell Biol. 2009;185(4):673-84.
    • (2009) J. Cell. Biol. , vol.185 , Issue.4 , pp. 673-684
    • Tzaban, S.1    Massol, R.H.2    Yen, E.3
  • 33
    • 16344376889 scopus 로고    scopus 로고
    • From sorting endosomes to exocytosis: Association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling
    • Ward ES, Martinez C, Vaccaro C, Zhou J, Tang Q, Ober RJ. From sorting endosomes to exocytosis: association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling. Mol Biol Cell. 2005;16(4):2028-38.
    • (2005) Mol. Biol. Cell. , vol.16 , Issue.4 , pp. 2028-2038
    • Ward, E.S.1    Martinez, C.2    Vaccaro, C.3    Zhou, J.4    Tang, Q.5    Ober, R.J.6
  • 34
    • 52949110519 scopus 로고    scopus 로고
    • FcRn-mediated antibody transport across epithelial cells revealed by electron tomography
    • He W, Ladinsky MS, Huey-Tubman KE, Jensen GJ, McIntosh JR, Bjorkman PJ. FcRn-mediated antibody transport across epithelial cells revealed by electron tomography. Nature. 2008;455(7212):542-6.
    • (2008) Nature , vol.455 , Issue.7212 , pp. 542-546
    • He, W.1    Ladinsky, M.S.2    Huey-Tubman, K.E.3    Jensen, G.J.4    McIntosh, J.R.5    Bjorkman, P.J.6
  • 35
    • 1642546286 scopus 로고    scopus 로고
    • Bidirectional transepithelial IgG transport by a strongly polarized basolateral membrane Fcgamma-receptor
    • Claypool SM, Dickinson BL, Wagner JS, Johansen FE, Venu N, Borawski JA, et al. Bidirectional transepithelial IgG transport by a strongly polarized basolateral membrane Fcgamma-receptor. Mol Biol Cell. 2004;15(4):1746-59.
    • (2004) Mol. Biol. Cell. , vol.15 , Issue.4 , pp. 1746-1759
    • Claypool, S.M.1    Dickinson, B.L.2    Wagner, J.S.3    Johansen, F.E.4    Venu, N.5    Borawski, J.A.6
  • 36
    • 38749097778 scopus 로고    scopus 로고
    • Ca2+-dependent calmodulin binding to FcRn affects immunoglobulin G transport in the transcytotic pathway
    • Dickinson BL, Claypool SM, D'Angelo JA, et al. Ca2+-dependent calmodulin binding to FcRn affects immunoglobulin G transport in the transcytotic pathway. Mol Biol Cell. 2008;19(1):414-23.
    • (2008) Mol. Biol. Cell. , vol.19 , Issue.1 , pp. 414-423
    • Dickinson, B.L.1    Claypool, S.M.2    D'Angelo, J.A.3
  • 37
    • 0035010475 scopus 로고    scopus 로고
    • Effects of mutations in potential phosphorylation sites on transcytosis of FcRn
    • McCarthy KM, Lam M, Subramanian L, Shakya R, Wu Z, Newton EE, et al. Effects of mutations in potential phosphorylation sites on transcytosis of FcRn. J Cell Sci. 2001;114(Pt 8):1591-8.
    • (2001) J. Cell. Sci. , vol.114 , Issue.8 PT , pp. 1591-1598
    • McCarthy, K.M.1    Lam, M.2    Subramanian, L.3    Shakya, R.4    Wu, Z.5    Newton, E.E.6
  • 38
    • 0035895939 scopus 로고    scopus 로고
    • Tryptophan-and dileucine-based endocytosis signals in the neonatal Fc receptor
    • Wu Z, Simister NE. Tryptophan-and dileucine-based endocytosis signals in the neonatal Fc receptor. J Biol Chem. 2001;276(7):5240-7.
    • (2001) J. Biol. Chem. , vol.276 , Issue.7 , pp. 5240-5247
    • Wu, Z.1    Simister, N.E.2
  • 39
    • 0033605685 scopus 로고    scopus 로고
    • Nonvectorial surface transport, endocytosis via a Di-leucine-based motif, and bidirectional transcytosis of chimera encoding the cytosolic tail of rat FcRn expressed in Madin-Darby canine kidney cells
    • Stefaner I, Praetor A, Hunziker W. Nonvectorial surface transport, endocytosis via a Di-leucine-based motif, and bidirectional transcytosis of chimera encoding the cytosolic tail of rat FcRn expressed in Madin-Darby canine kidney cells. J Biol Chem. 1999;274(13):8998-9005.
    • (1999) J. Biol. Chem. , vol.274 , Issue.13 , pp. 8998-9005
    • Stefaner, I.1    Praetor, A.2    Hunziker, W.3
  • 40
    • 48249148222 scopus 로고    scopus 로고
    • Dependence of antibody-mediated presentation of antigen on FcRn
    • Qiao SW, Kobayashi K, Johansen FE, et al. Dependence of antibody-mediated presentation of antigen on FcRn. Proc Natl Acad Sci USA. 2008;105(27):9337-42.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , Issue.27 , pp. 9337-9342
    • Qiao, S.W.1    Kobayashi, K.2    Johansen, F.E.3
  • 41
    • 0035284906 scopus 로고    scopus 로고
    • MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells
    • Zhu X, Meng G, Dickinson BL, et al. MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells. J Immunol. 2001;166(5):3266-76.
    • (2001) J. Immunol. , vol.166 , Issue.5 , pp. 3266-3276
    • Zhu, X.1    Meng, G.2    Dickinson, B.L.3
  • 42
    • 33746976718 scopus 로고    scopus 로고
    • Ligand valency affects transcytosis, recycling and intracellular trafficking mediated by the neonatal Fc receptor
    • Tesar DB, Tiangco NE, Bjorkman PJ. Ligand valency affects transcytosis, recycling and intracellular trafficking mediated by the neonatal Fc receptor. Traffic. 2006;7(9):1127-42.
    • (2006) Traffic , vol.7 , Issue.9 , pp. 1127-1142
    • Tesar, D.B.1    Tiangco, N.E.2    Bjorkman, P.J.3
  • 43
    • 14544280655 scopus 로고    scopus 로고
    • Functional analysis of the mouse Fcgrt 5' proximal promoter
    • Tiwari B, Junghans RP. Functional analysis of the mouse Fcgrt 5' proximal promoter. Biochim Biophys Acta. 2005;1681 (2-3): 88-98.
    • (2005) Biochim. Biophys. Acta , vol.1681 , Issue.2-3 , pp. 88-98
    • Tiwari, B.1    Junghans, R.P.2
  • 44
    • 38449100939 scopus 로고    scopus 로고
    • NF-kappaB signaling regulates functional expression of the MHC class I-related neonatal Fc receptor for IgG via intronic binding sequences
    • Liu X, Ye L, Christianson GJ, Yang JQ, Roopenian DC, Zhu X. NF-kappaB signaling regulates functional expression of the MHC class I-related neonatal Fc receptor for IgG via intronic binding sequences. J Immunol. 2007;179(5):2999-3011.
    • (2007) J. Immunol. , vol.179 , Issue.5 , pp. 2999-3011
    • Liu, X.1    Ye, L.2    Christianson, G.J.3    Yang, J.Q.4    Roopenian, D.C.5    Zhu, X.6
  • 45
    • 47949112092 scopus 로고    scopus 로고
    • Activation of the JAK/STAT-1 signaling pathway by IFN-gamma can downregulate functional expression of the MHC class I-related neonatal Fc receptor for IgG
    • Liu X, Ye L, Bai Y, Mojidi H, Simister NE, Zhu X. Activation of the JAK/STAT-1 signaling pathway by IFN-gamma can downregulate functional expression of the MHC class I-related neonatal Fc receptor for IgG. J Immunol. 2008;181(1):449-63.
    • (2008) J. Immunol. , vol.181 , Issue.1 , pp. 449-463
    • Liu, X.1    Ye, L.2    Bai, Y.3    Mojidi, H.4    Simister, N.E.5    Zhu, X.6
  • 46
  • 48
    • 70450015733 scopus 로고    scopus 로고
    • Immunization with Cry1Ac from Bacillus thuringiensis increases intestinal IgG response and induces the expression of FcRn in the intestinal epithelium of adult mice
    • Verdin-Teran SL, Vilches-Flores A, Moreno-Fierros L. Immunization with Cry1Ac from Bacillus thuringiensis increases intestinal IgG response and induces the expression of FcRn in the intestinal epithelium of adult mice. Scand J Immunol. 2009;70(6):596-607.
    • (2009) Scand. J. Immunol. , vol.70 , Issue.6 , pp. 596-607
    • Verdin-Teran, S.L.1    Vilches-Flores, A.2    Moreno-Fierros, L.3
  • 50
    • 0030880901 scopus 로고    scopus 로고
    • Expression of the neonatal Fc receptor, FcRn, on human intestinal epithelial cells
    • Israel EJ, Taylor S, Wu Z, Mizoguchi E, Blumberg RS, Bhan A, et al. Expression of the neonatal Fc receptor, FcRn, on human intestinal epithelial cells. Immunology. 1997;92(1):69-74.
    • (1997) Immunology , vol.92 , Issue.1 , pp. 69-74
    • Israel, E.J.1    Taylor, S.2    Wu, Z.3    Mizoguchi, E.4    Blumberg, R.S.5    Bhan, A.6
  • 51
    • 2942516894 scopus 로고    scopus 로고
    • Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells
    • Yoshida M, Claypool SM, Wagner JS, Mizoguchi E, Mizoguchi A, Roopenian DC, et al. Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity. 2004;20(6):769-83.
    • (2004) Immunity , vol.20 , Issue.6 , pp. 769-783
    • Yoshida, M.1    Claypool, S.M.2    Wagner, J.S.3    Mizoguchi, E.4    Mizoguchi, A.5    Roopenian, D.C.6
  • 52
    • 33746684369 scopus 로고    scopus 로고
    • Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria
    • Yoshida M, Kobayashi K, Kuo TT, et al. Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. J Clin Invest. 2006;116(8):2142-51.
    • (2006) J. Clin. Invest. , vol.116 , Issue.8 , pp. 2142-2151
    • Yoshida, M.1    Kobayashi, K.2    Kuo, T.T.3
  • 53
    • 0347364688 scopus 로고    scopus 로고
    • Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen
    • Bry L, Brenner MB. Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol. 2004;172(1):433-41.
    • (2004) J. Immunol. , vol.172 , Issue.1 , pp. 433-441
    • Bry, L.1    Brenner, M.B.2
  • 54
    • 70350093622 scopus 로고    scopus 로고
    • An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice
    • e1-56.e1
    • Kobayashi K, Qiao SW, Yoshida M, Baker K, Lencer WI, Blumberg RS. An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice. Gastroenterology. 2009;137(5):1746. e1-56.e1.
    • (2009) Gastroenterology , vol.137 , Issue.5 , pp. 1746
    • Kobayashi, K.1    Qiao, S.W.2    Yoshida, M.3    Baker, K.4    Lencer, W.I.5    Blumberg, R.S.6
  • 56
    • 0344851751 scopus 로고    scopus 로고
    • The MHC class I related Fc receptor, FcRn, is expressed in the epithelial cells of the human mammary gland
    • Cianga P, Cianga C, Cozma L, Ward ES, Carasevici E. The MHC class I related Fc receptor, FcRn, is expressed in the epithelial cells of the human mammary gland. Hum Immunol. 2003;64(12):1152-9.
    • (2003) Hum. Immunol. , vol.64 , Issue.12 , pp. 1152-1159
    • Cianga, P.1    Cianga, C.2    Cozma, L.3    Ward, E.S.4    Carasevici, E.5
  • 57
    • 33746293842 scopus 로고    scopus 로고
    • Cloning and characterization of the dromedary (Camelus dromedarius) neonatal Fc receptor (drFcRn)
    • Kacskovics I, Mayer B, Kis Z, Frenyo LV, Zhao Y, Muyldermans S, et al. Cloning and characterization of the dromedary (Camelus dromedarius) neonatal Fc receptor (drFcRn). Dev Comp Immunol. 2006;30(12):1203-15.
    • (2006) Dev. Comp. Immunol. , vol.30 , Issue.12 , pp. 1203-1215
    • Kacskovics, I.1    Mayer, B.2    Kis, Z.3    Frenyo, L.V.4    Zhao, Y.5    Muyldermans, S.6
  • 58
    • 77953539409 scopus 로고    scopus 로고
    • Expression and immunohistochemical localization of the neonatal Fc receptor (FcRn) in the mammary glands of the Egyptian water buffalo
    • Sayed-Ahmed A, Kassab M, Abd-Elmaksoud A, Elnasharty M, El-Kirdasy A. Expression and immunohistochemical localization of the neonatal Fc receptor (FcRn) in the mammary glands of the Egyptian water buffalo. Acta Histochem. 2010;112(4):383-91.
    • (2010) Acta Histochem. , vol.112 , Issue.4 , pp. 383-391
    • Sayed-Ahmed, A.1    Kassab, M.2    Abd-Elmaksoud, A.3    Elnasharty, M.4    El-Kirdasy, A.5
  • 59
    • 0028980061 scopus 로고
    • Requirement for a beta 2-microglobulin-associated Fc receptor for acquisition of maternal IgG by fetal and neonatal mice
    • Israel EJ, Patel VK, Taylor SF, Marshak-Rothstein A, Simister NE. Requirement for a beta 2-microglobulin-associated Fc receptor for acquisition of maternal IgG by fetal and neonatal mice. J Immunol. 1995;154(12):6246-51.
    • (1995) J. Immunol. , vol.154 , Issue.12 , pp. 6246-6251
    • Israel, E.J.1    Patel, V.K.2    Taylor, S.F.3    Marshak-Rothstein, A.4    Simister, N.E.5
  • 60
    • 0032767535 scopus 로고    scopus 로고
    • Identification and function of neonatal Fc receptor in mammary gland of lactating mice
    • Cianga P, Medesan C, Richardson JA, Ghetie V, Ward ES. Identification and function of neonatal Fc receptor in mammary gland of lactating mice. Eur J Immunol. 1999;29(8):2515-23.
    • (1999) Eur. J. Immunol. , vol.29 , Issue.8 , pp. 2515-2523
    • Cianga, P.1    Medesan, C.2    Richardson, J.A.3    Ghetie, V.4    Ward, E.S.5
  • 61
    • 0033694910 scopus 로고    scopus 로고
    • Expression of the Fc receptor in the mammary gland during lactation in the marsupial Trichosurus vulpecula (brushtail possum)
    • Adamski FM, King AT, Demmer J. Expression of the Fc receptor in the mammary gland during lactation in the marsupial Trichosurus vulpecula (brushtail possum). Mol Immunol. 2000;37(8):435-44.
    • (2000) Mol. Immunol. , vol.37 , Issue.8 , pp. 435-444
    • Adamski, F.M.1    King, A.T.2    Demmer, J.3
  • 64
    • 55449099354 scopus 로고    scopus 로고
    • Allergy prevention starts before conception: Maternofetal transfer of tolerance protects against the development of asthma
    • e5-30.e5
    • Polte T, Hennig C, Hansen G. Allergy prevention starts before conception: maternofetal transfer of tolerance protects against the development of asthma. J Allergy Clin Immunol. 2008;122(5):1022. e5-30.e5.
    • (2008) J. Allergy Clin. Immunol. , vol.122 , Issue.5 , pp. 1022
    • Polte, T.1    Hennig, C.2    Hansen, G.3
  • 65
    • 77951621649 scopus 로고    scopus 로고
    • The transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner
    • Nakata K, Kobayashi K, Ishikawa Y, et al. The transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner. Biochem Biophys Res Commun. 2010;395(2):238-43.
    • (2010) Biochem. Biophys. Res. Commun. , vol.395 , Issue.2 , pp. 238-243
    • Nakata, K.1    Kobayashi, K.2    Ishikawa, Y.3
  • 66
    • 77954413153 scopus 로고    scopus 로고
    • IgG transmitted from allergic mothers decreases allergic sensitization in breastfed offspring
    • doi:10.1186/1476-7961-8-9
    • Matson AP, Thrall RS, Rafti E, Lingenheld EG, Puddington L. IgG transmitted from allergic mothers decreases allergic sensitization in breastfed offspring. Clin Mol Allergy. 2010;8:9. doi:10.1186/1476-7961-8-9.
    • (2010) Clin. Mol. Allergy , vol.8 , pp. 9
    • Matson, A.P.1    Thrall, R.S.2    Rafti, E.3    Lingenheld, E.G.4    Puddington, L.5
  • 67
    • 70049090959 scopus 로고    scopus 로고
    • An interspecies comparison of placental antibody transfer: New insights into developmental toxicity testing of monoclonal antibodies
    • Pentsuk N, van der Laan JW. An interspecies comparison of placental antibody transfer: new insights into developmental toxicity testing of monoclonal antibodies. Birth Defects Res B Dev Reprod Toxicol. 2009;86(4):328-44.
    • (2009) Birth Defects Res. B. Dev. Reprod. Toxicol. , vol.86 , Issue.4 , pp. 328-344
    • Pentsuk, N.1    Van Der Laan, J.W.2
  • 68
    • 0038384134 scopus 로고    scopus 로고
    • Placental transport of immunoglobulin G
    • Simister NE. Placental transport of immunoglobulin G. Vaccine. 2003;21(24):3365-9.
    • (2003) Vaccine , vol.21 , Issue.24 , pp. 3365-3369
    • Simister, N.E.1
  • 69
    • 64849089039 scopus 로고    scopus 로고
    • FcRn in the yolk sac endoderm of mouse is required for IgG transport to fetus
    • Kim J, Mohanty S, Ganesan LP, Hua K, Jarjoura D, Hayton WL, et al. FcRn in the yolk sac endoderm of mouse is required for IgG transport to fetus. J Immunol. 2009;182(5):2583-9.
    • (2009) J. Immunol. , vol.182 , Issue.5 , pp. 2583-2589
    • Kim, J.1    Mohanty, S.2    Ganesan, L.P.3    Hua, K.4    Jarjoura, D.5    Hayton, W.L.6
  • 70
    • 0035113258 scopus 로고    scopus 로고
    • Expression of functionally active FcRn and the differentiated bidirectional transport of IgG in human placental endothelial cells
    • Antohe F, Radulescu L, Gafencu A, Ghetie V, Simionescu M. Expression of functionally active FcRn and the differentiated bidirectional transport of IgG in human placental endothelial cells. Hum Immunol. 2001;62(2):93-105.
    • (2001) Hum. Immunol. , vol.62 , Issue.2 , pp. 93-105
    • Antohe, F.1    Radulescu, L.2    Gafencu, A.3    Ghetie, V.4    Simionescu, M.5
  • 71
    • 76749167520 scopus 로고    scopus 로고
    • IgG is transported across the mouse yolk sac independently of FcgammaRIIb
    • Mohanty S, Kim J, Ganesan LP, et al. IgG is transported across the mouse yolk sac independently of FcgammaRIIb. J Reprod Immunol. 2010;84(2):133-44.
    • (2010) J. Reprod. Immunol. , vol.84 , Issue.2 , pp. 133-144
    • Mohanty, S.1    Kim, J.2    Ganesan, L.P.3
  • 72
    • 46149113010 scopus 로고    scopus 로고
    • Infused Fc-tagged beta-glucuronidase crosses the placenta and produces clearance of storage in utero in mucopolysaccharidosis VII mice
    • Grubb JH, Vogler C, Tan Y, Shah GN, MacRae AF, Sly WS. Infused Fc-tagged beta-glucuronidase crosses the placenta and produces clearance of storage in utero in mucopolysaccharidosis VII mice. Proc Natl Acad Sci USA. 2008;105(24):8375-80.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , Issue.24 , pp. 8375-8380
    • Grubb, J.H.1    Vogler, C.2    Tan, Y.3    Shah, G.N.4    MacRae, A.F.5    Sly, W.S.6
  • 73
    • 78149300934 scopus 로고    scopus 로고
    • Animal model of fetal and neonatal immune thrombocytopenia: Role of neonatal Fc receptor in the pathogenesis and therapy
    • in press
    • Chen P, Li C, Lang S, Zhu G, Reheman A, Spring CM, Freedman J, Ni H. Animal model of fetal and neonatal immune thrombocytopenia: role of neonatal Fc receptor in the pathogenesis and therapy. Blood 2010 (in press)
    • (2010) Blood
    • Chen, P.1    Li, C.2    Lang, S.3    Zhu, G.4    Reheman, A.5    Spring, C.M.6    Freedman, J.7    Ni, H.8
  • 74
    • 0036791018 scopus 로고    scopus 로고
    • Teratogenicity induced by targeting a placental immunoglobulin transporter
    • Kolonin MG, Pasqualini R, Arap W. Teratogenicity induced by targeting a placental immunoglobulin transporter. Proc Natl Acad Sci USA. 2002;99(20):13055-60.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , Issue.20 , pp. 13055-13060
    • Kolonin, M.G.1    Pasqualini, R.2    Arap, W.3
  • 75
    • 0037025895 scopus 로고    scopus 로고
    • Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: Functional expression of FcRn in the mammalian lung
    • Spiekermann GM, Finn PW, Ward ES, Dumont J, Dickinson BL, Blumberg RS, et al. Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung. J Exp Med. 2002;196(3):303-10.
    • (2002) J. Exp. Med. , vol.196 , Issue.3 , pp. 303-310
    • Spiekermann, G.M.1    Finn, P.W.2    Ward, E.S.3    Dumont, J.4    Dickinson, B.L.5    Blumberg, R.S.6
  • 76
    • 0015966366 scopus 로고
    • Antibacterial mechanisms of the lower respiratory tract. I. Immunoglobulin synthesis and secretion
    • Hand WL, Cantey JR. Antibacterial mechanisms of the lower respiratory tract. I. Immunoglobulin synthesis and secretion. J Clin Invest. 1974;53(2):354-62.
    • (1974) J. Clin. Invest. , vol.53 , Issue.2 , pp. 354-362
    • Hand, W.L.1    Cantey, J.R.2
  • 77
    • 32544438613 scopus 로고    scopus 로고
    • Expression and transport functionality of FcRn within rat alveolar epithelium: A study in primary cell culture and in the isolated perfused lung
    • Sakagami M, Omidi Y, Campbell L, Kandalaft LE, Morris CJ, Barar J, et al. Expression and transport functionality of FcRn within rat alveolar epithelium: a study in primary cell culture and in the isolated perfused lung. Pharm Res. 2006;23(2):270-9.
    • (2006) Pharm. Res. , vol.23 , Issue.2 , pp. 270-279
    • Sakagami, M.1    Omidi, Y.2    Campbell, L.3    Kandalaft, L.E.4    Morris, C.J.5    Barar, J.6
  • 79
    • 33750699277 scopus 로고    scopus 로고
    • Pulmonary administration of therapeutic proteins using an immunoglobulin transport pathway
    • Bitonti AJ, Dumont JA. Pulmonary administration of therapeutic proteins using an immunoglobulin transport pathway. Adv Drug Deliv Rev. 2006;58 (9-10): 1106-18.
    • (2006) Adv. Drug Deliv. Rev. , vol.58 , Issue.9-10 , pp. 1106-1118
    • Bitonti, A.J.1    Dumont, J.A.2
  • 80
    • 25844528107 scopus 로고    scopus 로고
    • Delivery of an erythropoietin-Fc fusion protein by inhalation in humans through an immunoglobulin transport pathway
    • Dumont JA, Bitonti AJ, Clark D, Evans S, Pickford M, Newman SP. Delivery of an erythropoietin-Fc fusion protein by inhalation in humans through an immunoglobulin transport pathway. J Aerosol Med. 2005;18(3):294-303.
    • (2005) J. Aerosol Med. , vol.18 , Issue.3 , pp. 294-303
    • Dumont, J.A.1    Bitonti, A.J.2    Clark, D.3    Evans, S.4    Pickford, M.5    Newman, S.P.6
  • 81
    • 33744937065 scopus 로고    scopus 로고
    • Monomeric Fc fusions: Impact on pharmacokinetic and biological activity of protein therapeutics
    • Dumont JA, Low SC, Peters RT, Bitonti AJ. Monomeric Fc fusions: impact on pharmacokinetic and biological activity of protein therapeutics. BioDrugs. 2006;20(3):151-60.
    • (2006) BioDrugs , vol.20 , Issue.3 , pp. 151-160
    • Dumont, J.A.1    Low, S.C.2    Peters, R.T.3    Bitonti, A.J.4
  • 82
    • 62449200475 scopus 로고    scopus 로고
    • Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice
    • Montoyo HP, Vaccaro C, Hafner M, Ober RJ, Mueller W, Ward ES. Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice. Proc Natl Acad Sci USA. 2009;106(8):2788-93.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , Issue.8 , pp. 2788-2793
    • Montoyo, H.P.1    Vaccaro, C.2    Hafner, M.3    Ober, R.J.4    Mueller, W.5    Ward, E.S.6
  • 83
    • 39549088649 scopus 로고    scopus 로고
    • Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism
    • Akilesh S, Christianson GJ, Roopenian DC, Shaw AS. Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism. J Immunol. 2007;179(7):4580-8.
    • (2007) J. Immunol. , vol.179 , Issue.7 , pp. 4580-4588
    • Akilesh, S.1    Christianson, G.J.2    Roopenian, D.C.3    Shaw, A.S.4
  • 85
    • 53049110126 scopus 로고    scopus 로고
    • New immunosuppressive approaches: Oral administration of CD3-specific antibody to treat autoimmunity
    • Ochi H, Abraham M, Ishikawa H, et al. New immunosuppressive approaches: oral administration of CD3-specific antibody to treat autoimmunity. J Neurol Sci. 2008;274 (1-2): 9-12.
    • (2008) J. Neurol. Sci. , vol.274 , Issue.1-2 , pp. 9-12
    • Ochi, H.1    Abraham, M.2    Ishikawa, H.3
  • 88
    • 38949210805 scopus 로고    scopus 로고
    • Podocytes use FcRn to clear IgG from the glomerular basement membrane
    • Akilesh S, Huber TB, Wu H, et al. Podocytes use FcRn to clear IgG from the glomerular basement membrane. Proc Natl Acad Sci USA. 2008;105(3):967-72.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , Issue.3 , pp. 967-972
    • Akilesh, S.1    Huber, T.B.2    Wu, H.3
  • 89
    • 0034023794 scopus 로고    scopus 로고
    • Characterization and localization of the neonatal Fc receptor in adult human kidney
    • Haymann JP, Levraud JP, Bouet S, et al. Characterization and localization of the neonatal Fc receptor in adult human kidney. J Am Soc Nephrol. 2000;11(4):632-9.
    • (2000) J. Am. Soc. Nephrol. , vol.11 , Issue.4 , pp. 632-639
    • Haymann, J.P.1    Levraud, J.P.2    Bouet, S.3
  • 91
    • 31544451031 scopus 로고    scopus 로고
    • Renal albumin absorption in physiology and pathology
    • Birn H, Christensen EI. Renal albumin absorption in physiology and pathology. Kidney Int. 2006;69(3):440-9.
    • (2006) Kidney Int. , vol.69 , Issue.3 , pp. 440-449
    • Birn, H.1    Christensen, E.I.2
  • 92
    • 0028960488 scopus 로고
    • A major histocompatibility complex class I-related Fc receptor for IgG on rat hepatocytes
    • Blumberg RS, Koss T, Story CM, et al. A major histocompatibility complex class I-related Fc receptor for IgG on rat hepatocytes. J Clin Invest. 1995;95(5):2397-402.
    • (1995) J. Clin. Invest. , vol.95 , Issue.5 , pp. 2397-2402
    • Blumberg, R.S.1    Koss, T.2    Story, C.M.3
  • 93
    • 0031685365 scopus 로고    scopus 로고
    • Functional expression of the MHC class I-related receptor, FcRn, in endothelial cells of mice
    • Borvak J, Richardson J, Medesan C, Antohe F, Radu C, Simionescu M, et al. Functional expression of the MHC class I-related receptor, FcRn, in endothelial cells of mice. Int Immunol. 1998;10(9):1289-98.
    • (1998) Int. Immunol. , vol.10 , Issue.9 , pp. 1289-1298
    • Borvak, J.1    Richardson, J.2    Medesan, C.3    Antohe, F.4    Radu, C.5    Simionescu, M.6
  • 94
    • 0034129672 scopus 로고    scopus 로고
    • The role of the Brambell receptor (FcRB) in liver: Protection of endocytosed immunoglobulin G (IgG) from catabolism in hepatocytes rather than transport of IgG to bile
    • Telleman P, Junghans RP. The role of the Brambell receptor (FcRB) in liver: protection of endocytosed immunoglobulin G (IgG) from catabolism in hepatocytes rather than transport of IgG to bile. Immunology. 2000;100(2):245-51.
    • (2000) Immunology , vol.100 , Issue.2 , pp. 245-251
    • Telleman, P.1    Junghans, R.P.2
  • 95
    • 0036079202 scopus 로고    scopus 로고
    • Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier
    • DOI 10.1046/j.1471-4159.2002.00840.x
    • Schlachetzki F, Zhu C, Pardridge WM. Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier. J Neurochem. 2002;81(1):203-6. (Pubitemid 34808868)
    • (2002) Journal of Neurochemistry , vol.81 , Issue.1 , pp. 203-206
    • Schlachetzki, F.1    Zhu, C.2    Pardridge, W.M.3
  • 97
    • 30844472909 scopus 로고    scopus 로고
    • IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor
    • Deane R, Sagare A, Hamm K, et al. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci. 2005;25(50):11495-503.
    • (2005) J. Neurosci. , vol.25 , Issue.50 , pp. 11495-11503
    • Deane, R.1    Sagare, A.2    Hamm, K.3
  • 98
    • 73349086530 scopus 로고    scopus 로고
    • Investigation of the influence of FcRn on the distribution of IgG to the brain
    • Garg A, Balthasar JP. Investigation of the influence of FcRn on the distribution of IgG to the brain. AAPS J. 2009;11(3):553-7.
    • (2009) AAPS J. , vol.11 , Issue.3 , pp. 553-557
    • Garg, A.1    Balthasar, J.P.2
  • 100
    • 77649253359 scopus 로고    scopus 로고
    • FcRn receptor-mediated pharmacokinetics of therapeutic IgG in the eye
    • Kim H, Robinson SB, Csaky KG. FcRn receptor-mediated pharmacokinetics of therapeutic IgG in the eye. Mol Vis. 2009;15:2803-12.
    • (2009) Mol. Vis. , vol.15 , pp. 2803-2812
    • Kim, H.1    Robinson, S.B.2    Csaky, K.G.3
  • 103
    • 31044440897 scopus 로고    scopus 로고
    • Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases
    • Li N, Zhao M, Hilario-Vargas J, Prisayanh P, Warren S, Diaz LA, et al. Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases. J Clin Invest. 2005;115(12):3440-50.
    • (2005) J. Clin. Invest. , vol.115 , Issue.12 , pp. 3440-3450
    • Li, N.1    Zhao, M.2    Hilario-Vargas, J.3    Prisayanh, P.4    Warren, S.5    Diaz, L.A.6
  • 104
    • 33645531322 scopus 로고    scopus 로고
    • Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene
    • Wani MA, Haynes LD, Kim J, et al. Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene. Proc Natl Acad Sci USA. 2006;103(13):5084-9.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , Issue.13 , pp. 5084-5089
    • Wani, M.A.1    Haynes, L.D.2    Kim, J.3
  • 105
    • 70350163828 scopus 로고    scopus 로고
    • Association between polymorphisms in the FCGRT gene and lupus nephritis in Chinese patients
    • Zhou XJ, Yu L, Zhu L, Hou P, Lv JC, Yu F, et al. Association between polymorphisms in the FCGRT gene and lupus nephritis in Chinese patients. Clin Exp Rheumatol. 2009;27(4):609-14.
    • (2009) Clin. Exp. Rheumatol. , vol.27 , Issue.4 , pp. 609-614
    • Zhou, X.J.1    Yu, L.2    Zhu, L.3    Hou, P.4    Lv, J.C.5    Yu, F.6
  • 106
    • 34548229364 scopus 로고    scopus 로고
    • FcRn: The neonatal Fc receptor comes of age
    • Roopenian DC, Akilesh S. FcRn: the neonatal Fc receptor comes of age. Nat Rev Immunol. 2007;7(9):715-25.
    • (2007) Nat. Rev. Immunol. , vol.7 , Issue.9 , pp. 715-725
    • Roopenian, D.C.1    Akilesh, S.2
  • 107
    • 33845364560 scopus 로고    scopus 로고
    • Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: Potential application in humorally mediated autoimmune disease
    • Petkova SB, Akilesh S, Sproule TJ, et al. Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease. Int Immunol. 2006;18(12):1759-69.
    • (2006) Int. Immunol. , vol.18 , Issue.12 , pp. 1759-1769
    • Petkova, S.B.1    Akilesh, S.2    Sproule, T.J.3
  • 108
    • 15244351004 scopus 로고    scopus 로고
    • Overview of monoclonal antibodies in cancer therapy: Present and promise
    • Stern M, Herrmann R. Overview of monoclonal antibodies in cancer therapy: present and promise. Crit Rev Oncol Hematol. 2005;54(1):11-29.
    • (2005) Crit. Rev. Oncol. Hematol , vol.54 , Issue.1 , pp. 11-29
    • Stern, M.1    Herrmann, R.2
  • 109
    • 19944430279 scopus 로고    scopus 로고
    • Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments
    • Kenanova V, Olafsen T, Crow DM, et al. Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments. Cancer Res. 2005;65(2):622-31.
    • (2005) Cancer Res. , vol.65 , Issue.2 , pp. 622-631
    • Kenanova, V.1    Olafsen, T.2    Crow, D.M.3
  • 110
    • 40649086923 scopus 로고    scopus 로고
    • Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn
    • Mezo AR, McDonnell KA, Hehir CA, et al. Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn. Proc Natl Acad Sci USA. 2008;105(7):2337-42.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , Issue.7 , pp. 2337-2342
    • Mezo, A.R.1    McDonnell, K.A.2    Hehir, C.A.3
  • 111
    • 77649196896 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationships of dimeric peptide antagonists of the human immunoglobulin G-human neonatal Fc receptor (IgG-FcRn) interaction
    • McDonnell KA, Low SC, Hoehn T, Donnelly R, Palmieri H, Fraley C, et al. Synthesis and structure-activity relationships of dimeric peptide antagonists of the human immunoglobulin G-human neonatal Fc receptor (IgG-FcRn) interaction. J Med Chem. 2010;53(4):1587-96.
    • (2010) J. Med. Chem. , vol.53 , Issue.4 , pp. 1587-1596
    • McDonnell, K.A.1    Low, S.C.2    Hoehn, T.3    Donnelly, R.4    Palmieri, H.5    Fraley, C.6
  • 112
    • 77956242476 scopus 로고    scopus 로고
    • X-ray crystal structures of monomeric and dimeric peptide inhibitors in complex with the human neonatal Fc receptor, FcRn
    • Mezo AR, Sridhar V, Badger J, Sakorafas P, Nienaber V. X-ray crystal structures of monomeric and dimeric peptide inhibitors in complex with the human neonatal Fc receptor, FcRn. J Biol Chem. 2010;285(36):27694-701.
    • (2010) J. Biol. Chem. , vol.285 , Issue.36 , pp. 27694-27701
    • Mezo, A.R.1    Sridhar, V.2    Badger, J.3    Sakorafas, P.4    Nienaber, V.5
  • 113
    • 17744366208 scopus 로고    scopus 로고
    • Pharmacokinetic effects of 4C9, an anti-FcRn antibody, in rats: Implications for the use of FcRn inhibitors for the treatment of humoral autoimmune and alloimmune conditions
    • Getman KE, Balthasar JP. Pharmacokinetic effects of 4C9, an anti-FcRn antibody, in rats: implications for the use of FcRn inhibitors for the treatment of humoral autoimmune and alloimmune conditions. J Pharm Sci. 2005;94(4):718-29.
    • (2005) J. Pharm. Sci. , vol.94 , Issue.4 , pp. 718-729
    • Getman, K.E.1    Balthasar, J.P.2
  • 114
    • 21644443969 scopus 로고    scopus 로고
    • Oral and pulmonary delivery of FSH-Fc fusion proteins via neonatal Fc receptor-mediated transcytosis
    • Low SC, Nunes SL, Bitonti AJ, Dumont JA. Oral and pulmonary delivery of FSH-Fc fusion proteins via neonatal Fc receptor-mediated transcytosis. Hum Reprod. 2005;20(7):1805-13.
    • (2005) Hum. Reprod. , vol.20 , Issue.7 , pp. 1805-1813
    • Low, S.C.1    Nunes, S.L.2    Bitonti, A.J.3    Dumont, J.A.4
  • 115
    • 0017336288 scopus 로고
    • High molecular weight derivatives of methotrexate as chemotherapeutic agents
    • Chu BC, Whiteley JM. High molecular weight derivatives of methotrexate as chemotherapeutic agents. Mol Pharmacol. 1977;13(1):80-8.
    • (1977) Mol. Pharmacol. , vol.13 , Issue.1 , pp. 80-88
    • Chu, B.C.1    Whiteley, J.M.2
  • 116
    • 0036201980 scopus 로고    scopus 로고
    • A phase II trial of methotrexate-human serum albumin (MTX-HSA) in patients with metastatic renal cell carcinoma who progressed under immunotherapy
    • Vis AN, van der Gaast A, van Rhijn BW, Catsburg TK, Schmidt C, Mickisch GH. A phase II trial of methotrexate-human serum albumin (MTX-HSA) in patients with metastatic renal cell carcinoma who progressed under immunotherapy. Cancer Chemother Pharmacol. 2002;49(4):342-5.
    • (2002) Cancer Chemother. Pharmacol. , vol.49 , Issue.4 , pp. 342-345
    • Vis, A.N.1    Van Der Gaast, A.2    Van Rhijn, B.W.3    Catsburg, T.K.4    Schmidt, C.5    Mickisch, G.H.6
  • 117
    • 0242416983 scopus 로고    scopus 로고
    • Albumin-based drug delivery as novel therapeutic approach for rheumatoid arthritis
    • Wunder A, Muller-Ladner U, Stelzer EH, et al. Albumin-based drug delivery as novel therapeutic approach for rheumatoid arthritis. J Immunol. 2003;170(9):4793-801.
    • (2003) J. Immunol. , vol.170 , Issue.9 , pp. 4793-4801
    • Wunder, A.1    Muller-Ladner, U.2    Stelzer, E.H.3
  • 118
    • 70350438004 scopus 로고    scopus 로고
    • The versatile MHC class I-related FcRn protects IgG and albumin from degradation: Implications for development of new diagnostics and therapeutics
    • Andersen JT, Sandlie I. The versatile MHC class I-related FcRn protects IgG and albumin from degradation: implications for development of new diagnostics and therapeutics. Drug Metab Pharmacokinet. 2009;24(4):318-32.
    • (2009) Drug Metab. Pharmacokinet , vol.24 , Issue.4 , pp. 318-332
    • Andersen, J.T.1    Sandlie, I.2
  • 119
    • 49649089488 scopus 로고    scopus 로고
    • Albinterferon alfa-2b dosed every two or four weeks in interferon-naive patients with genotype 1 chronic hepatitis C
    • Zeuzem S, Yoshida EM, Benhamou Y, et al. Albinterferon alfa-2b dosed every two or four weeks in interferon-naive patients with genotype 1 chronic hepatitis C. Hepatology. 2008;48(2):407-17.
    • (2008) Hepatology , vol.48 , Issue.2 , pp. 407-417
    • Zeuzem, S.1    Yoshida, E.M.2    Benhamou, Y.3
  • 121
    • 33947672248 scopus 로고    scopus 로고
    • Radionuclide therapy of HER2-positive microxenografts using a 177Lu-labeled HER2-specific affibody molecule
    • Tolmachev V, Orlova A, Pehrson R, et al. Radionuclide therapy of HER2-positive microxenografts using a 177Lu-labeled HER2-specific affibody molecule. Cancer Res. 2007;67(6):2773-82.
    • (2007) Cancer Res. , vol.67 , Issue.6 , pp. 2773-2782
    • Tolmachev, V.1    Orlova, A.2    Pehrson, R.3
  • 122
    • 36549022608 scopus 로고    scopus 로고
    • A novel tri-functional antibody fusion protein with improved pharmacokinetic properties generated by fusing a bispecific single-chain diabody with an albumin-binding domain from streptococcal protein G
    • Stork R, Muller D, Kontermann RE. A novel tri-functional antibody fusion protein with improved pharmacokinetic properties generated by fusing a bispecific single-chain diabody with an albumin-binding domain from streptococcal protein G. Protein Eng Des Sel. 2007;20(11):569-76.
    • (2007) Protein Eng. Des. Sel , vol.20 , Issue.11 , pp. 569-576
    • Stork, R.1    Muller, D.2    Kontermann, R.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.