Cross-reactivity of autoantibodies from patients with epidermolysis bullosa acquisita with murine collagen VII

Cellular and Molecular Life Sciences

Volumn 67, Issue 8, 2010, Pages 1343-1351

  Csorba, Kinga ^a   Sesarman, Alina ^a   Oswald, Eva ^a   Feldrihan, Vasile ^a   Fritsch, Anja ^a   Hashimoto, Takashi ^b   Sitaru, Cassian ^a,c  

^a UNIVERSITY OF FREIBURG   (Germany)

^b KURUME UNIVERSITY   (Japan)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Autoantigen; Autoimmunity; Basement membrane zone; Collagen; Extracellular matrix

Indexed keywords

AUTOANTIBODY; COLLAGEN TYPE 7; EPITOPE; IMMUNOGLOBULIN G; MESSENGER RNA; RECOMBINANT PROTEIN;

ADOLESCENT; ADULT; AGED; ANIMAL CELL; ANTIGEN BINDING; ARTICLE; CLINICAL ARTICLE; CROSS REACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDERMOLYSIS BULLOSA ACQUISITA; HUMAN; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; KERATINOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; ANIMAL; CHILD; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN;

ANIMALIA; MURINAE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; AUTOANTIBODIES; CHILD; COLLAGEN TYPE VII; CROSS REACTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPIDERMOLYSIS BULLOSA ACQUISITA; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IMMUNOBLOTTING; IMMUNOGLOBULIN G; KERATINOCYTES; MICE; MIDDLE AGED; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SKIN; YOUNG ADULT;

EID: 77950600514     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-009-0256-3     Document Type: Article

References (33)

1. Nishie W, Sawamura D, Goto M, Ito K, Shibaki A, McMillan J, Sakai K, Nakamura H, Olasz E, Yancey K, Akiyama M, Shimizu H (2007) Humanization of autoantigen. Nat Med 13:378-383
2. Toyka KV, Brachman DB, Pestronk A, Kao I (1975) Myasthenia gravis: passive transfer from man to mouse. Science 190:397-399
3. Liu Z, Diaz LA, Troy JL, Taylor AF, Emery DJ, Fairley JA, Giudice GJ (1993) A passive transfer model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen, BP180. J Clin Invest 92:2480-2488 (Pubitemid 23333558)
4. Lazarova Z, Yee C, Darling T, Briggaman RA, Yancey KB (1996) Passive transfer of anti-laminin 5 antibodies induces subepidermal blisters in neonatal mice. J Clin Invest 98:1509-1518 (Pubitemid 26327858)
5. Sitaru C, Mihai S, Otto C, Chiriac MT, Hausser I, Dotterweich B, Saito H, Rose C, Ishiko A, Zillikens D (2005) Induction of dermalepidermal separation in mice by passive transfer of antibodies specific to type VII collagen. J Clin Invest 115:870-878 (Pubitemid 40489391)
6. Anhalt GJ, Labib RS, Voorhees JJ, Beals TF, Diaz LA (1982) Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease. N Engl J Med 306:1189-1196
7. Sitaru C (2009) Bullous pemphigoid: a prototypical antibodymediated organ-specific autoimmune disease. J Invest Dermatol 129:822-824
8. Mihai S, Sitaru C (2007) Immunopathology and molecular diagnosis of autoimmune bullous diseases. J Cell Mol Med 11:462-481 (Pubitemid 47160231)
9. Sitaru C, Zillikens D (2005) Mechanisms of blister induction by autoantibodies. Exp Dermatol 14:861-875
10. Lapiere JC, Woodley DT, Parente MG, Iwasaki T, Wynn KC, Christiano AM, Uitto J (1993) Epitope mapping of type VII collagen. Identification of discrete peptide sequences recognized by sera from patients with acquired epidermolysis bullosa. J Clin Invest 92:1831-1839 (Pubitemid 23304550)
11. Ishii N, Yoshida M, Hisamatsu Y, Ishida-Yamamoto A, Nakane H, Iizuka H, Tanaka T, Hashimoto T (2004) Epidermolysis bullosa acquisita sera react with distinct epitopes on the NC1 and NC2 domains of type VII collagen: study using immunoblotting of domain-specific recombinant proteins and postembedding immunoelectron microscopy. Br J Dermatol 150:843-851 (Pubitemid 38903515)
12. Sitaru C, Kromminga A, Hashimoto T, Bröcker EB, Zillikens D (2002) Autoantibodies to type VII collagen mediate Fcgammadependent neutrophil activation and induce dermal-epidermal separation in cryosections of human skin. Am J Pathol 161:301-311 (Pubitemid 34760796)
13. Woodley DT, Ram R, Doostan A, Bandyopadhyay P, Huang Y, Remington J, Hou Y, Keene DR, Liu Z, Chen M (2006) Induction of epidermolysis bullosa acquisita in mice by passive transfer of autoantibodies from patients. J Invest Dermatol 126:1323-1330 (Pubitemid 43997915)
14. Sitaru C, Chiriac MT, Mihai S, Büning J, Gebert A, Ishiko A, Zillikens D (2006) Induction of complement-fixing autoantibodies against type VII collagen results in subepidermal blistering in mice. J Immunol 177:3461-3468 (Pubitemid 44277867)
15. Chen M, Doostan A, Bandyopadhyay P, Remington J, Wang X, Hou Y, Liu Z, Woodley DT (2007) The cartilage matrix protein subdomain of type VII collagen is pathogenic for epidermolysis bullosa acquisita. Am J Pathol 170:2009-2018 (Pubitemid 47339274)
16. Mihai S, Chiriac MT, Takahashi K, Thurman JM, Holers VM, Zillikens D, Botto M, Sitaru C (2007) The alternative pathway of complement activation is critical for blister induction in experimental epidermolysis bullosa acquisita. J Immunol 178:6514-6521 (Pubitemid 46717435)
17. Chiriac MT, Roesler J, Sindrilaru A, Scharffetter-Kochanek K, Zillikens D, Sitaru C (2007) NADPH oxidase is required for neutrophil-dependent autoantibody-induced tissue damage. J Pathol 212:56-65 (Pubitemid 46746290)
18. Sitaru C (2007) Experimental models of epidermolysis bullosa acquisita. Exp Dermatol 16:520-531 (Pubitemid 46845396)
19. Yuspa SH, Hawley-Nelson P, Koehler B, Stanley JR (1980) A survey of transformation markers in differentiating epidermal cell lines in culture. Cancer Res 40:4694-4703 (Pubitemid 11199740)
20. Olaru F, Mihai S, Petrescu I, Zillikens D, Sitaru C (2006) Generation and characterization of monoclonal antibodies against the intracellular domain of human type XVII collagen. Hybridoma 25:158-162 (Pubitemid 43967702)
21. Li K, Tamai K, Tan EM, Uitto J (1993) Cloning of type XVII collagen. Complementary and genomic DNA sequences of mouse 180-kilodalton bullous pemphigoid antigen (BPAG2) predict an interrupted collagenous domain, a transmembrane segment, and unusual features in the 5'-end of the gene and the 3'-untranslated region of the mRNA. J Biol Chem 268:8825-8834 (Pubitemid 23118673)
22. Sitaru C, Schmidt E, Petermann S, Munteanu LS, Bröcker E, Zillikens D (2002) Autoantibodies to bullous pemphigoid antigen 180 induce dermal-epidermal separation in cryosections of human skin. J Invest Dermatol 118:664-671 (Pubitemid 34309987)
23. Sesarman A, Sitaru AG, Olaru F, Zillikens D, Sitaru C (2008) Neonatal Fc receptor deficiency protects from tissue injury in experimental epidermolysis bullosa acquisita. J Mol Med 86:951-959
24. Sitaru C, Powell J, Messer G, Bröcker E, Wojnarowska F, Zillikens D (2004) Immunoblotting and enzyme-linked immunosorbent assay for the diagnosis of pemphigoid gestationis. Obstet Gynecol 103:757-763 (Pubitemid 40459039)
25. Sesarman A, Mihai S, Chiriac MT, Olaru F, Sitaru AG, Thurman JM, Zillikens D, Sitaru C (2008) Binding of avian IgY to type VII collagen does not activate complement and leucocytes and fails to induce subepidermal blistering in mice. Br J Dermatol 158:463-471 (Pubitemid 351239182)
26. Mihai S, Chiriac MT, Herrero-González JE, Goodall M, Jefferis R, Savage COS, Zillikens D, Sitaru C (2007) IgG4 autoantibodies induce dermal-epidermal separation. J Cell Mol Med 11:1117-1128 (Pubitemid 350037053)
27. Smith TF, Waterman MS (1981) Identification of common molecular subsequences. J Mol Biol 147:195-197
28. Kolaskar A, Tongaonkar P (1990) A semi-empirical method for prediction of antigenic determinants on protein antigens. FEBS Lett 276:172-174
29. Shimanovich I, Mihai S, Oostingh GJ, Ilenchuk TT, Bröcker E, Opdenakker G, Zillikens D, Sitaru C (2004) Granulocyte-derived elastase and gelatinase B are required for dermal-epidermal separation induced by autoantibodies from patients with epidermolysis bullosa acquisita and bullous pemphigoid. J Pathol 204:519-527 (Pubitemid 39585950)
30. Woodley DT, Chang C, Saadat P, Ram R, Liu Z, Chen M (2005) Evidence that anti-type VII collagen antibodies are pathogenic and responsible for the clinical, histological, and immunological features of epidermolysis bullosa acquisita. J Invest Dermatol 124:958-964 (Pubitemid 40629096)
31. Li K, Christiano AM, Copeland NG, Gilbert DJ, Chu ML, Jenkins NA, Uitto J (1993) cDNA cloning and chromosomal mapping of the mouse type VII collagen gene (Col7al): evidence for rapid evolutionary divergence of the gene. Genomics 16:733-739 (Pubitemid 23183496)
32. Tanaka T, Furukawa F, Imamura S (1994) Epitope mapping for epidermolysis bullosa acquisita autoantibody by molecularly cloned cDNA for type VII collagen. J Invest Dermatol 102:706-709 (Pubitemid 24144247)
33. Gandhi K, Chen M, Aasi S, Lapiere JC, Woodley DT, Chan LS (2000) Autoantibodies to type VII collagen have heterogeneous subclass and light chain compositions and their complementactivating capacities do not correlate with the inflammatory clinical phenotype. J Clin Immunol 20:416-423 (Pubitemid 32099706)