Efficient mucosal vaccination mediated by the neonatal Fc receptor

Nature Biotechnology

Volumn 29, Issue 2, 2011, Pages 158-165

  Ye, Lilin ^a   Zeng, Rongyu ^a   Bai, Yu ^a   Roopenian, Derry C ^b   Zhu, Xiaoping ^a,c  

^a UNIVERSITY OF MARYLAND   (United States)

^b JACKSON LABORATORY   (United States)

^c Bldg 142   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DELIVERY ROUTES; EPITHELIAL CELLS; HERPES SIMPLEX VIRUS TYPE-2; IMMUNE RESPONSE; IMMUNE SYSTEMS; INFECTIOUS DISEASE; INTRANASAL; MUCOSAL PATHOGENS; MUCOSAL SURFACE; NEONATAL FC RECEPTORS; SUBUNIT VACCINE; TRANSPORT PATHWAYS; WILD TYPES;

ANIMALS; IMMUNIZATION; MACROPHAGES; PEDIATRICS; VIRUSES;

DISEASES;

FC RECEPTOR; GLYCOPROTEIN GD; IMMUNOGLOBULIN FC FRAGMENT; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CPG ISLAND; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; VACCINATION; VIRULENCE;

ADMINISTRATION, MUCOSAL; ANIMALS; CELL LINE; CYTOKINES; FEMALE; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS CLASS I; IMMUNOGLOBULIN G; KAPLAN-MEIER ESTIMATE; MICE; MICE, KNOCKOUT; MOLECULAR TARGETED THERAPY; MUCOUS MEMBRANE; RECEPTORS, FC; RECOMBINANT FUSION PROTEINS; VACCINES; VAGINA; VIRAL ENVELOPE PROTEINS;

ANIMALIA; HUMAN HERPESVIRUS 2; MUS;

EID: 79751497661     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.1742     Document Type: Article

References (40)

1. Neutra, M.R. & Kozlowski, P.A. Mucosal vaccines: the promise and the challenge. Nat. Rev. Immunol. 6, 148-158 (2006). (Pubitemid 43361590)
2. Holmgren, J. & Czerkinsky, C. Mucosal immunity and vaccines. Nat. Med. 11 Suppl S45-S53 (2005). (Pubitemid 40562303)
3. McGhee, J.R. et al. The mucosal immune system: from fundamental concepts to vaccine development. Vaccine 10, 75-88 (1992).
4. Gallichan, W.S. & Rosenthal, K.L. Long-term immunity and protection against herpes simplex virus type 2 in the murine female genital tract after mucosal but not systemic immunization. J. Infect. Dis. 177, 1155-1161 (1998). (Pubitemid 28194251)
5. Neutra, M.R., Mantis, N.J. & Kraehenbuhl, J.-P. Collaboration of epithelial cells with organized mucosal lymphoid tissues. Nat. Immunol. 2, 1004-1009 (2001). (Pubitemid 33069494)
6. Nochi, T. et al. A novel M cell-specifc carbohydrate-targeted mucosal vaccine effectively induces antigen-specifc immune responses. J. Exp. Med. 204, 2789-2796 (2007). (Pubitemid 350179549)
7. Ghetie, V. & Ward, E.S. Multiple roles for the major histocompatibility complex class I-related receptor FcRn. Annu. Rev. Immunol. 18, 739-766 (2000). (Pubitemid 30365396)
8. He, W. et al. FcRn-mediated antibody transport across epithelial cells revealed by electron tomography. Nature 455, 542-546 (2008).
9. Dickinson, B.L. et al. Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line. J. Clin. Invest. 104, 903-911 (1999). (Pubitemid 29536340)
10. Roopenian, D.C. & Akilesh, S. FcRn: the neonatal Fc receptor comes of age. Nat. Rev. Immunol. 7, 715-725 (2007). (Pubitemid 47327396)
11. Baker, K. et al. Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn. Semin. Immunopathol. 31, 223-236 (2009).
12. Yoshida, M. et al. Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. J. Clin. Invest. 116, 2142-2151 (2006). (Pubitemid 44162323)
13. Kim, J.K., Tsen, M.F., Ghetie, V. & Ward, E.S. Localization of the site of the murine IgG1 molecule that is involved in binding to the murine intestinal Fc receptor. Eur. J. Immunol. 24, 2429-2434 (1994). (Pubitemid 24303088)
14. Duncan, A.R. & Winter, G. The binding site for C1q on IgG. Nature 332, 738-740 (1988).
15. McCarthy, K.M., Yoong, Y. & Simister, N.E. Bidirectional transcytosis of IgG by the rat neonatal Fc receptor expressed in a rat kidney cell line: a system to study protein transport across epithelia. J. Cell Sci. 113, 1277-1285 (2000). (Pubitemid 30229544)
16. Roopenian, D.C. et al. The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs. J. Immunol. 170, 3528-3533 (2003). (Pubitemid 36359219)
17. Van Duin, D., Medzhitov, R. & Shaw, A.C. Triggering TLR signaling in vaccination. Trends Immunol. 27, 49-55 (2006). (Pubitemid 43083564)
18. Wolf, A.J. et al. Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs. J. Exp. Med. 205, 105-115 (2008). (Pubitemid 351185719)
19. Moyron-Quiroz, J.E. et al. Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity. Nat. Med. 10, 927-934 (2004). (Pubitemid 39273733)
20. Parr, E.L. & Parr, M.B. Immunoglobulin G is the main protective antibody in mouse vaginal secretions after vaginal immunization with attenuated herpes simplex virus type 2. J. Virol. 71, 8109-8115 (1997). (Pubitemid 27446385)
21. Milligan, G.N., Dudley-McClain, K.L., Chu, C.F. & Young, C.G. Effcacy of genital T cell responses to herpes simplex virus type 2 resulting from immunization of the nasal mucosa. Virology 318, 507-515 (2004). (Pubitemid 38224294)
22. Ahmed, R. & Gray, D. Immunological memory and protective immunity: understanding their relation. Science 272, 54-60 (1996). (Pubitemid 26110754)
23. Bernasconi, N.L., Traggiai, E. & Lanzavecchia, A. Maintenance of serological memory by polyclonal activation of human memory B cells. Science 298, 2199-2202 (2002). (Pubitemid 35471246)
24. + T cell memory by promoting the generation of IL-7Rα-expressing cells. J. Exp. Med. 204, 547-557 (2007). (Pubitemid 46457078)
25. Mi, W. et al. Targeting the neonatal Fc receptor for antigen delivery using engineered Fc fragments. J. Immunol. 181, 7550-7561 (2008).
26. Rawool, D.B. et al. Utilization of Fc receptors as a mucosal vaccine strategy against an intracellular bacterium, Francisella tularensis. J. Immunol. 180, 5548-5557 (2008).
27. Gallichan, W.S. et al. Intranasal immunization with CpG oligodeoxynucleotides as an adjuvant dramatically increases IgA and protection against herpes simplex virus-2 in the genital tract. J. Immunol. 166, 3451-3457 (2001). (Pubitemid 33117348)
28. Kwant, A. & Rosenthal, K.L. Intravaginal immunization with viral subunit protein plus CpG oligodeoxynucleotides induces protective immunity against HSV-2. Vaccine 22, 3098-3104 (2004). (Pubitemid 39037213)
29. Tengvall, S., Lundqvist, A., Eisenberg, R.J., Cohen, G.H. & Harandi, A.M. Mucosal administration of CpG oligodeoxynucleotide elicits strong CC and CXC chemokine responses in the vagina and serves as a potent Th1-tilting adjuvant for recombinant gD2 protein vaccination against genital herpes. J. Virol. 80, 5283-5291 (2006).
30. Lindqvist, M., Persson, J., Thörn, K. & Harandi, A.M. The mucosal adjuvant effect of alpha-galactosylceramide for induction of protective immunity to sexually transmitted viral infection. J. Immunol. 182, 6435-6443 (2009).
31. ChangLai, S.P., Hung, W.T. & Liao, K.K. Detecting alveolar epithelial injury following volatile anesthetics by (99m)Tc DTPA radioaerosol inhalation lung scan. Respiration 66, 506-510 (1999).
32. Lin, H. et al. Enhancing effect of surfactants on fexofenadine HCl transport across the human nasal epithelial cell monolayer. Int. J. Pharm. 330, 23-31 (2007). (Pubitemid 46097356)
33. Kodama, S., Abe, N., Hirano, T. & Suzuki, M. Safety and effcacy of nasal application of CpG oligodeoxynucleotide as a mucosal adjuvant. Laryngoscope 116, 331-335 (2006). (Pubitemid 44383948)
34. Kelsall, B.L. & Rescigno, M. Mucosal dendritic cells in immunity and infammation. Nat. Immunol. 5, 1091-1095 (2004). (Pubitemid 39549618)
35. Yoshida, M. et al. Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity 20, 769-783 (2004). (Pubitemid 38757446)
36. Liu, X. et al. Activation of the JAK/STAT-1 signaling pathway by IFN-gamma can down-regulate functional expression of the MHC class I-related neonatal Fc receptor for IgG. J. Immunol. 181, 449-463 (2008).
37. Mestecky, J., Russell, J.N.W. & Elson, C.O. Perspectives on mucosal vaccines: is mucosal tolerance a barrier? J. Immunol. 179, 5633-5638 (2007).
38. Milligan, G.N., Bernstein, D.I. & Bourne, N. T lymphocytes are required for protection of the vaginal mucosae and sensory ganglia of immune mice against reinfection with herpes simplex virus type 2. J. Immunol. 160, 6093-6100 (1998). (Pubitemid 28298073)
39. Van den Broeck, W., Derore, A. & Simoens, P. Anatomy and nomenclature of murine lymph nodes: descriptive study and nomenclatory standardization in BALB/cAnNCrl mice. J. Immunol. Methods 312, 12-19 (2006). (Pubitemid 43795993)
40. Ye, L. et al. The MHC class II-associated invariant chain interacts with the neonatal Fc gamma receptor and modulates its traffcking to endosomal/lysosomal compartments. J. Immunol. 181, 2572-2585 (2008).