메뉴 건너뛰기




Volumn 103, Issue 2, 2008, Pages 386-396

IgG antibodies against common gut bacteria are more diagnostic for Crohn's disease than IgG against mannan or flagellin

Author keywords

[No Author keywords available]

Indexed keywords

FLAGELLIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; MANNAN; MEMBRANE ANTIGEN;

EID: 39049142086     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1111/j.1572-0241.2007.01577.x     Document Type: Article
Times cited : (44)

References (54)
  • 1
    • 0029883566 scopus 로고    scopus 로고
    • Specific antibody response to oligomannosidic epitopes in Crohn's disease
    • Sendid B, Colombel J, Jacquinot P, et al. Specific antibody response to oligomannosidic epitopes in Crohn's disease. Clin Diag Lab Immunol 1996 3 : 219 26.
    • (1996) Clin Diag Lab Immunol , vol.3 , pp. 219-26
    • Sendid, B.1    Colombel, J.2    Jacquinot, P.3
  • 2
    • 23744480856 scopus 로고    scopus 로고
    • Anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic antibodies as predictors of inflammatory bowel disease
    • Israeli E, Grotto I, Gilburd B, et al. Anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic antibodies as predictors of inflammatory bowel disease. Gut 2005 54 : 1232 6.
    • (2005) Gut , vol.54 , pp. 1232-6
    • Israeli, E.1    Grotto, I.2    Gilburd, B.3
  • 3
    • 0023698058 scopus 로고
    • Antibodies to Saccharomyces cerevisiae (bakers' yeast) in Crohn's disease
    • Main J, McKenzie H, Yeaman G, et al. Antibodies to Saccharomyces cerevisiae (bakers' yeast) in Crohn's disease. BMJ 1988 297 : 1105 6.
    • (1988) BMJ , vol.297 , pp. 1105-6
    • Main, J.1    McKenzie, H.2    Yeaman, G.3
  • 4
    • 0025345301 scopus 로고
    • Antibody to selected strains of Saccharomyces cerevisiae (baker's and brewer's yeast) and Candida albicans in Crohn's disease
    • McKenzie H, Main J, Pennington C, et al. Antibody to selected strains of Saccharomyces cerevisiae (baker's and brewer's yeast) and Candida albicans in Crohn's disease. Gut 1990 31 : 536 8.
    • (1990) Gut , vol.31 , pp. 536-8
    • McKenzie, H.1    Main, J.2    Pennington, C.3
  • 5
    • 0036726184 scopus 로고    scopus 로고
    • Selected loss of tolerance evidenced by Crohn's disease associated immune responses to auto- and microbial antigens
    • Landers C, Cohavy O, Misra R, et al. Selected loss of tolerance evidenced by Crohn's disease associated immune responses to auto- and microbial antigens. Gastroenterology 2002 123 : 689 99.
    • (2002) Gastroenterology , vol.123 , pp. 689-99
    • Landers, C.1    Cohavy, O.2    Misra, R.3
  • 6
    • 0031764693 scopus 로고
    • Characterization of oligosaccharides from an antigenic mannan of Saccharomyces cerevisiae
    • Young M, Davies MJ, Bailey D, et al. Characterization of oligosaccharides from an antigenic mannan of Saccharomyces cerevisiae. Glycoconj J 1988 15 : 815 22.
    • (1988) Glycoconj J , vol.15 , pp. 815-22
    • Young, M.1    Davies, M.J.2    Bailey, D.3
  • 7
    • 33644750713 scopus 로고    scopus 로고
    • Correlation between Saccharomyces cerevisiae DNA in intestinal mucosal samples and anti-Saccharomyces cerevisiae antibodies in serum of patients with IBD
    • Mallant-Hent R, Mooij M, Blomberg BV, et al. Correlation between Saccharomyces cerevisiae DNA in intestinal mucosal samples and anti-Saccharomyces cerevisiae antibodies in serum of patients with IBD. World J Gastroenterol 2006 12 : 292 7.
    • (2006) World J Gastroenterol , vol.12 , pp. 292-7
    • Mallant-Hent, R.1    Mooij, M.2    Blomberg, B.V.3
  • 8
    • 2342646956 scopus 로고    scopus 로고
    • Bacterial flagellin is a dominant antigen in Crohn disease
    • Lodes M, Cong Y, Elson C, et al. Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest 2004 113 : 1296 306.
    • (2004) J Clin Invest , vol.113 , pp. 1296-306
    • Lodes, M.1    Cong, Y.2    Elson, C.3
  • 9
    • 0042882421 scopus 로고    scopus 로고
    • Molecular characterisation of the microbial species that colonise normal human ileal and colonic mucosa by using 16S rDNA sequence analysis
    • Wang X, Heazlwood S, Krause D, et al. Molecular characterisation of the microbial species that colonise normal human ileal and colonic mucosa by using 16S rDNA sequence analysis. J Appl Microbiol 2003 95 : 508 21.
    • (2003) J Appl Microbiol , vol.95 , pp. 508-21
    • Wang, X.1    Heazlwood, S.2    Krause, D.3
  • 10
    • 33644908022 scopus 로고    scopus 로고
    • Serum immune responses predict rapid disease progression among children with Crohn's disease: Immune responses predict disease progression
    • Dubinsky M, Lin Y, Dutridge D, et al. Serum immune responses predict rapid disease progression among children with Crohn's disease: Immune responses predict disease progression. Am J Gastroenterol 2006 101 : 360 7.
    • (2006) Am J Gastroenterol , vol.101 , pp. 360-7
    • Dubinsky, M.1    Lin, Y.2    Dutridge, D.3
  • 11
    • 0018394743 scopus 로고
    • Antibodies detectable by counterimmunoelectrophoresis against Bacteroides antigens in serum of patients with inflammatory bowel disease
    • Helphingstine C, Hentges D, Campbell B, et al. Antibodies detectable by counterimmunoelectrophoresis against Bacteroides antigens in serum of patients with inflammatory bowel disease. J Clin Microbiol 1979 9 : 373 8.
    • (1979) J Clin Microbiol , vol.9 , pp. 373-8
    • Helphingstine, C.1    Hentges, D.2    Campbell, B.3
  • 12
    • 0028786710 scopus 로고
    • The pathogenic role of Bacteroides vulgatus in patients with ulcerative colitis
    • Bamba T, Matsuda H, Endo M, et al. The pathogenic role of Bacteroides vulgatus in patients with ulcerative colitis. J Gastroeenterol 1995 30 (Supp 8 45 7.
    • (1995) J Gastroeenterol , vol.30 , Issue.8 , pp. 45-7
    • Bamba, T.1    Matsuda, H.2    Endo, M.3
  • 13
    • 10744228695 scopus 로고    scopus 로고
    • Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease
    • Mow W, Vasiliauskas E, Lin Y, et al. Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease. Gastroenterology 2004 26 : 414 24.
    • (2004) Gastroenterology , vol.26 , pp. 414-24
    • Mow, W.1    Vasiliauskas, E.2    Lin, Y.3
  • 14
    • 31144475758 scopus 로고    scopus 로고
    • The anti-Saccharomyces cerevisiae antibody assay in a province-wide practice: Accurate in identifying cases of Crohn's disease and predicting inflammatory disease
    • Kaila B, Orr K, Bernstein C. The anti-Saccharomyces cerevisiae antibody assay in a province-wide practice: Accurate in identifying cases of Crohn's disease and predicting inflammatory disease. Can J Gastroenterol 2005 19 : 717 21.
    • (2005) Can J Gastroenterol , vol.19 , pp. 717-21
    • Kaila, B.1    Orr, K.2    Bernstein, C.3
  • 15
    • 0033805362 scopus 로고    scopus 로고
    • Marker antibody expression stratifies Crohn's disease into immunologically homogeneous subgroups with distinct clinical characteristics
    • Vasiliauskas E, Kam L, Karp L, et al. Marker antibody expression stratifies Crohn's disease into immunologically homogeneous subgroups with distinct clinical characteristics. Gut 2000 47 : 487 96.
    • (2000) Gut , vol.47 , pp. 487-96
    • Vasiliauskas, E.1    Kam, L.2    Karp, L.3
  • 16
    • 20444441016 scopus 로고    scopus 로고
    • Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease
    • Targan S, Landers C, Yang H, et al. Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease. Gastroenterology 2005 128 : 2020 8.
    • (2005) Gastroenterology , vol.128 , pp. 2020-8
    • Targan, S.1    Landers, C.2    Yang, H.3
  • 17
    • 33750347508 scopus 로고    scopus 로고
    • Anti-outer membrane of porin C and anti-I2 antibodies in indeterminate colitis
    • Jossens S, Colombel J, Landers C, et al. Anti-outer membrane of porin C and anti-I2 antibodies in indeterminate colitis. Gut 2006 55 : 1667 9.
    • (2006) Gut , vol.55 , pp. 1667-9
    • Jossens, S.1    Colombel, J.2    Landers, C.3
  • 18
    • 33746544387 scopus 로고    scopus 로고
    • Serologies in Crohn's disease: Can we change the gray zone to black and white?
    • Abreu M. Serologies in Crohn's disease: Can we change the gray zone to black and white? Gastroenterology 2006 131 : 664 6.
    • (2006) Gastroenterology , vol.131 , pp. 664-6
    • Abreu, M.1
  • 19
    • 33746542174 scopus 로고    scopus 로고
    • Antibodies against laminaribioside and chitobioside are novel serologic markers in Crohn's disease
    • Dotan I, Fishman S, Dgani Y, et al. Antibodies against laminaribioside and chitobioside are novel serologic markers in Crohn's disease. Gastroenterology 2006 131 : 366 78.
    • (2006) Gastroenterology , vol.131 , pp. 366-78
    • Dotan, I.1    Fishman, S.2    Dgani, Y.3
  • 20
    • 33847664069 scopus 로고    scopus 로고
    • Anti-flagellin (CBir1) phenotypic and genetic Crohn's disease associations
    • Papadakis K, Yang H, Ippoliti A, et al. Anti-flagellin (CBir1) phenotypic and genetic Crohn's disease associations. Inflamm Bowel Dis 2007 13 : 524 30.
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 524-30
    • Papadakis, K.1    Yang, H.2    Ippoliti, A.3
  • 21
    • 33847016160 scopus 로고    scopus 로고
    • NOD2 variants and antibody response to microbial antigens in Crohn's disease patients and their unaffected relatives
    • Devlin S, Yang H, Ippoliti A, et al. NOD2 variants and antibody response to microbial antigens in Crohn's disease patients and their unaffected relatives. Gastroenterology 2007 132 : 576 86.
    • (2007) Gastroenterology , vol.132 , pp. 576-86
    • Devlin, S.1    Yang, H.2    Ippoliti, A.3
  • 22
    • 34948854194 scopus 로고    scopus 로고
    • New serological markers in inflammatory bowel disease are associated with complicated disease behaviour
    • 56:1394-403.
    • Ferrante M, Henckaerts L, Joossens M, et al. New serological markers in inflammatory bowel disease are associated with complicated disease behaviour. Gut 2007 56:1394-403.
    • (2007) Gut
    • Ferrante, M.1    Henckaerts, L.2    Joossens, M.3
  • 23
    • 0029866466 scopus 로고    scopus 로고
    • Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria
    • Macpherson A, Khoo UY, Forgacs I, et al. Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria. Gut 1996 38 : 365 75.
    • (1996) Gut , vol.38 , pp. 365-75
    • MacPherson, A.1    Khoo, U.Y.2    Forgacs, I.3
  • 24
    • 39049118186 scopus 로고
    • Cell fractionation. In: Gerhardt, P., ed. WashingtonDC: American Society for microbiology
    • Murray RGE. Cell fractionation. In : Gerhardt P, ed. Methods for general and molecular bacteriology. Washington DC : American Society for microbiology, 1994 : 85 7.
    • (1994) Methods for General and Molecular Bacteriology. , pp. 85-7
    • Murray, R.G.E.1
  • 25
    • 0026750310 scopus 로고
    • Antibody (IgG, IgA, and IgM) to baker's yeast (Saccharomyces cerevisiae), yeast mannan, gliadin, ovalbumin and betalactoglobulin in monozygotic twins with inflammatory bowel disease
    • Lindberg E, Magnusson K, Tysk C, et al. Antibody (IgG, IgA, and IgM) to baker's yeast (Saccharomyces cerevisiae), yeast mannan, gliadin, ovalbumin and betalactoglobulin in monozygotic twins with inflammatory bowel disease. Gut 1992 33 : 909 13.
    • (1992) Gut , vol.33 , pp. 909-13
    • Lindberg, E.1    Magnusson, K.2    Tysk, C.3
  • 26
  • 27
    • 33646381860 scopus 로고    scopus 로고
    • Candida albicans is an immunogen for anti-Saccharomyces cerevisiae antibody markers of Crohn's disease
    • Standaert-Vitse A, Jouault T, Vandewalle P, et al. Candida albicans is an immunogen for anti-Saccharomyces cerevisiae antibody markers of Crohn's disease. Gastroenterology 2006 130 : 1764 75.
    • (2006) Gastroenterology , vol.130 , pp. 1764-75
    • Standaert-Vitse, A.1    Jouault, T.2    Vandewalle, P.3
  • 28
    • 0034798813 scopus 로고    scopus 로고
    • Immune sensitization to food, yeast and bacteria in Crohn's disease
    • Bogaerde JVD, Kamm M, Knight S. Immune sensitization to food, yeast and bacteria in Crohn's disease. Aliment Pharmacol Ther 2001 15 : 1647 53.
    • (2001) Aliment Pharmacol Ther , vol.15 , pp. 1647-53
    • Bogaerde, J.V.D.1    Kamm, M.2    Knight, S.3
  • 29
    • 1542725070 scopus 로고    scopus 로고
    • Immune sensitization to yeast antigens in ASCA-positive patients with Crohn's disease
    • Konrad A, Rutten C, Flogerzi B, et al. Immune sensitization to yeast antigens in ASCA-positive patients with Crohn's disease. Inflamm Bowel Dis 2004 10 : 97 105.
    • (2004) Inflamm Bowel Dis , vol.10 , pp. 97-105
    • Konrad, A.1    Rutten, C.2    Flogerzi, B.3
  • 30
    • 0030823372 scopus 로고    scopus 로고
    • Clustering of increased small intestinal permeability in families with Crohn's disease
    • Peeters M, Geypens B, Claus D, et al. Clustering of increased small intestinal permeability in families with Crohn's disease. Gastroenterology 1997 113 : 802 7.
    • (1997) Gastroenterology , vol.113 , pp. 802-7
    • Peeters, M.1    Geypens, B.2    Claus, D.3
  • 31
    • 0027217379 scopus 로고
    • Intestinal permeability and the prediction of relapse in Crohn's disease
    • Wyatt J, Vogelsang H, Hubi W, et al. Intestinal permeability and the prediction of relapse in Crohn's disease. Lancet 1993 341 : 1437 41.
    • (1993) Lancet , vol.341 , pp. 1437-41
    • Wyatt, J.1    Vogelsang, H.2    Hubi, W.3
  • 32
    • 0032692721 scopus 로고    scopus 로고
    • The intestinal mucus layer from patients with inflammatory bowel disease harbors high numbers of bacteria compared with controls
    • Schultsz C, Berg FVD, Kate F, et al. The intestinal mucus layer from patients with inflammatory bowel disease harbors high numbers of bacteria compared with controls. Gastroenterology 1999 117 : 1089 97.
    • (1999) Gastroenterology , vol.117 , pp. 1089-97
    • Schultsz, C.1    Berg, F.V.D.2    Kate, F.3
  • 33
    • 4143069158 scopus 로고    scopus 로고
    • High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease
    • Darfeuille-Michaud A, Boudeau J, Bulois P, et al. High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease. Gastroenterology 2004 127 : 412 21.
    • (2004) Gastroenterology , vol.127 , pp. 412-21
    • Darfeuille-Michaud, A.1    Boudeau, J.2    Bulois, P.3
  • 34
    • 3242737791 scopus 로고    scopus 로고
    • Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer
    • Martin H, Campbell B, Hart C, et al. Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer. Gastroenterology 2004 127 : 80 93.
    • (2004) Gastroenterology , vol.127 , pp. 80-93
    • Martin, H.1    Campbell, B.2    Hart, C.3
  • 35
    • 4444306100 scopus 로고    scopus 로고
    • Bacterial DNA within granulomas of patients with Crohn's disease - Detection by laser capture microdissection and PCR
    • Ryan P, Kelly R, Lee G, et al. Bacterial DNA within granulomas of patients with Crohn's disease - detection by laser capture microdissection and PCR. Am J Gastroenterol 2004 99 : 1539 43.
    • (2004) Am J Gastroenterol , vol.99 , pp. 1539-43
    • Ryan, P.1    Kelly, R.2    Lee, G.3
  • 36
    • 1542618118 scopus 로고    scopus 로고
    • Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria
    • Macpherson A, Uhr T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 2004 303 : 1662 5.
    • (2004) Science , vol.303 , pp. 1662-5
    • MacPherson, A.1    Uhr, T.2
  • 37
    • 0029586031 scopus 로고
    • Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease
    • Duchmann R, Kaiser I, Hermann E, et al. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease. Clin Exp Immunol 1995 102 : 448 55.
    • (1995) Clin Exp Immunol , vol.102 , pp. 448-55
    • Duchmann, R.1    Kaiser, I.2    Hermann, E.3
  • 38
    • 20544444045 scopus 로고    scopus 로고
    • Diversity of the human intestinal microbial flora
    • Eckburg P, Bik E, Bernstein C, et al. Diversity of the human intestinal microbial flora. Science 2005 308 : 1635 8.
    • (2005) Science , vol.308 , pp. 1635-8
    • Eckburg, P.1    Bik, E.2    Bernstein, C.3
  • 39
    • 0035015975 scopus 로고    scopus 로고
    • Anti-Saccharomyces cerevisiae antibodies (ASCA), phenotypes of IBD, and intestinal permeability: A study in IBD families
    • Vermeire S, Peeters M, Vlietinck R, et al. Anti-Saccharomyces cerevisiae antibodies (ASCA), phenotypes of IBD, and intestinal permeability: A study in IBD families. Inflamm Bowel Dis 2001 7 : 8 15.
    • (2001) Inflamm Bowel Dis , vol.7 , pp. 8-15
    • Vermeire, S.1    Peeters, M.2    Vlietinck, R.3
  • 40
    • 1842430309 scopus 로고    scopus 로고
    • Do high serum levels of anti-Saccharomyces cerevisiae antibodies result from a leakiness of the gut barrier in Crohn's disease?
    • Harrer M, Reinisch W, Dejaco C, et al. Do high serum levels of anti-Saccharomyces cerevisiae antibodies result from a leakiness of the gut barrier in Crohn's disease? Eur J Gastroenterol Hepatol 2003 15 : 1281 5.
    • (2003) Eur J Gastroenterol Hepatol , vol.15 , pp. 1281-5
    • Harrer, M.1    Reinisch, W.2    Dejaco, C.3
  • 42
    • 0004200689 scopus 로고    scopus 로고
    • Anti-Saccharomyces cerevisiae mannan antibodies in familial Crohn's disease
    • Sendid B, Quinton J, Charrier G, et al. Anti-Saccharomyces cerevisiae mannan antibodies in familial Crohn's disease. Am J Gastroenterol 1998 93 : 1306 10.
    • (1998) Am J Gastroenterol , vol.93 , pp. 1306-10
    • Sendid, B.1    Quinton, J.2    Charrier, G.3
  • 43
    • 0034108625 scopus 로고    scopus 로고
    • Familial expression of anti-Saccharomyces cerevisiae mannan antibodies in affected and unaffected relatives of patients with Crohn's disease
    • Sutton C, Yang H, Li Z, et al. Familial expression of anti-Saccharomyces cerevisiae mannan antibodies in affected and unaffected relatives of patients with Crohn's disease. Gut 2000 46 : 58 63.
    • (2000) Gut , vol.46 , pp. 58-63
    • Sutton, C.1    Yang, H.2    Li, Z.3
  • 44
    • 0036747815 scopus 로고    scopus 로고
    • Diagnostic value of anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic antibodies for inflammatory bowel disease: High prevalence in patients with celiac disease
    • Damoiseaux J, Bouten B, Linders A, et al. Diagnostic value of anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic antibodies for inflammatory bowel disease: High prevalence in patients with celiac disease. J Clin Immunol 2002 22 : 281 8.
    • (2002) J Clin Immunol , vol.22 , pp. 281-8
    • Damoiseaux, J.1    Bouten, B.2    Linders, A.3
  • 46
    • 8744240536 scopus 로고    scopus 로고
    • A prospective comparative study of ASCA and pANCA in Chinese and Caucasian IBD patients
    • Lawrance I, Murray K, Hall A, et al. A prospective comparative study of ASCA and pANCA in Chinese and Caucasian IBD patients. Am J Gastroenterol 2004 99 : 2186 94.
    • (2004) Am J Gastroenterol , vol.99 , pp. 2186-94
    • Lawrance, I.1    Murray, K.2    Hall, A.3
  • 47
    • 11144266571 scopus 로고    scopus 로고
    • Sero-reactivity to microbial components in Crohn's disease is associated with disease severity and progression, but not NOD2/CARD15 genotype
    • Arnott I, Landers C, Nimmo E, et al. Sero-reactivity to microbial components in Crohn's disease is associated with disease severity and progression, but not NOD2/CARD15 genotype. Am J Gastroenterol 2004 99 : 2376 84.
    • (2004) Am J Gastroenterol , vol.99 , pp. 2376-84
    • Arnott, I.1    Landers, C.2    Nimmo, E.3
  • 48
    • 33745416072 scopus 로고    scopus 로고
    • Disease outcome of IBD patients: General outline of a Europe-wide population-based 10-year clinical follow-up study
    • Wolters F, Russel M, Sijbrandij J, et al. Disease outcome of IBD patients: General outline of a Europe-wide population-based 10-year clinical follow-up study. Scand J Gastroenterol Suppl 2006 46 54.
    • (2006) Scand J Gastroenterol Suppl , pp. 46-54
    • Wolters, F.1    Russel, M.2    Sijbrandij, J.3
  • 49
    • 0028336890 scopus 로고
    • Diagnostic tests: A statistical review
    • Schulzer M. Diagnostic tests: A statistical review. Muscle Nerve 1994 17 : 815 9.
    • (1994) Muscle Nerve , vol.17 , pp. 815-9
    • Schulzer, M.1
  • 50
    • 26044460461 scopus 로고    scopus 로고
    • The use of receiver operating characteristic curves in biomedical informatics
    • Lasko T, Bhagwat J, Zou K, et al. The use of receiver operating characteristic curves in biomedical informatics. J Biomed Inform 2005 38 : 404 15.
    • (2005) J Biomed Inform , vol.38 , pp. 404-15
    • Lasko, T.1    Bhagwat, J.2    Zou, K.3
  • 51
    • 33644912316 scopus 로고    scopus 로고
    • Measuring diagnostic and predictive accuracy in disease management: An introduction to receiver operating characteristic (ROC) analysis
    • Linden A. Measuring diagnostic and predictive accuracy in disease management: An introduction to receiver operating characteristic (ROC) analysis. J Eval Clin Pract 2006 12 : 132 9.
    • (2006) J Eval Clin Pract , vol.12 , pp. 132-9
    • Linden, A.1
  • 52
    • 33644849605 scopus 로고    scopus 로고
    • NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2
    • Voss E, Wehkamp J, Wehkamp K, et al. NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2. J Biol Chem 2006 281 : 2005 11.
    • (2006) J Biol Chem , vol.281 , pp. 2005-11
    • Voss, E.1    Wehkamp, J.2    Wehkamp, K.3
  • 53
    • 29144483937 scopus 로고    scopus 로고
    • Reduced Paneth cell alpha-defensins in ileal Crohn's disease
    • Wehkamp J, Salzman N, Porter E, et al. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A 2005 102 : 18129 34.
    • (2005) Proc Natl Acad Sci U S a , vol.102 , pp. 18129-34
    • Wehkamp, J.1    Salzman, N.2    Porter, E.3
  • 54
    • 33745556685 scopus 로고    scopus 로고
    • Impaired dendritic cell function in Crohn's disease patients with NOD2 3020insC mutation
    • Guarantor of the article: Timothy H.J. Florin is guarantor of the paper, responsible for the clinical aspects and the overall conduct of the study. Specific author contributions: Rachel J. Adams designed and performed most experiments and analyses, and wrote the first draft of the manuscript. Sharise P. Heazlewood made the flagellin antigen preparation. Kristen S. Gilshenan performed the ROC plot comparisons. Mark O'Brien oversaw the microbiology. Michael A. McGuckin and Timothy H.J. Florin conceived the project, oversaw the experiments, and were responsible for writing the manuscript. Financial support: The authors are most grateful for funding support received from the Australian NHMRC (235608) and the Broad Medical Research Program (0032). T. Florin was supported by an NHMRC Research Practitioner Fellowship, and M. McGuckin by a Queensland Cancer Fund Senior Research Fellowship. Potential competing interests: None.
    • Kramer M, Netea M, Jong DD, et al. Impaired dendritic cell function in Crohn's disease patients with NOD2 3020insC mutation. J Leukoc Biol 2006 79 : 860 6.
    • (2006) J Leukoc Biol , vol.79 , pp. 860-6
    • Kramer, M.1    Netea, M.2    Jong, D.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.