Electrospinning for regenerative medicine: A review of the main topics

Drug Discovery Today

Volumn 19, Issue 6, 2014, Pages 743-753

  Braghirolli, Daikelly I ^a   Steffens, Daniela ^a   Pranke, Patricia ^a,b  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b Stem Cell Research Institute   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMATERIAL; NANOFIBER; NANOMATERIAL;

BIOENGINEERING; BONE INJURY; BURN; CARDIOVASCULAR DISEASE; CARTILAGE INJURY; DRUG DELIVERY SYSTEM; ELECTROSPINNING; EXTRACELLULAR MATRIX; NONHUMAN; PERIPHERAL NERVE INJURY; PHYSICAL CHEMISTRY; REGENERATIVE MEDICINE; REVIEW; SCIENTIFIC LITERATURE; SPINAL CORD INJURY; TISSUE ENGINEERING; TISSUE REPAIR; ANIMAL; ELECTROMAGNETIC FIELD; HUMAN; PROCEDURES; TISSUE SCAFFOLD;

ANIMALS; ELECTROMAGNETIC PHENOMENA; HUMANS; REGENERATIVE MEDICINE; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84902116598     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2014.03.024     Document Type: Review

References (138)

1. N. Zhang, and D.H. Kohn Using polymeric materials to control stem cell behavior for tissue regeneration Birth Defects Res. C Embryo Today 96 2012 63 81
2. H. Naderi et al. Review paper: critical issues in tissue engineering: biomaterials, cell sources, angiogenesis, and drug delivery systems J. Biomater. Appl. 26 2011 383 417
3. U. Boudriot et al. Electrospinning approaches toward scaffold engineering - a brief overview Artif. Organs 30 2006 785 792 (Pubitemid 44521370)
4. A. Greiner, and J.H. Wendorff Electrospinning: a fascinating method for the preparation of ultrathin fibers Angew. Chem. Int. Ed. Engl. 46 2007 5670 5703 (Pubitemid 47172190)
5. S.K. Sahoo et al. The present and future of nanotechnology in human health care Nanomedicine 3 2007 20 31 (Pubitemid 46428187)
6. J. Wendorff et al. Electrospinning - Materials, Processing, and Applications 2012 Wiley-VCH
7. J. Doshi, and D. Reneker Electrospinning process and applications of electrospun fibers J. Electrostat. 35 1995 151 160
8. Q.P. Pham et al. Electrospinning of polymeric nanofibers for tissue engineering applications: a review Tissue Eng. 12 2006 1197 1211 (Pubitemid 44024491)
9. T. Subbiah et al. Electrospinning of nanofibers J. Appl. Polym. Sci. 96 2005 557 569 (Pubitemid 40430269)
10. S. Agarwal et al. Use of electrospinning technique for biomedical applications Polymer 49 2008 5603 5621
11. S. Agarwal et al. Progress in the field of electrospinning for tissue engineering applications Adv. Mater. 21 2009 3343 3351
12. A. Tamayol et al. Fiber-based tissue engineering: progress, challenges, and opportunities Biotechnol. Adv. 31 2013 669 687
13. S. Chakraborty et al. Electrohydrodynamics: a facile technique to fabricate drug delivery systems Adv. Drug Deliv. Rev. 61 2009 1043 1054
14. S. Sahoo et al. Growth factor delivery through electrospun nanofibers in scaffolds for tissue engineering applications J. Biomed. Mater. Res. A 93 2010 1539 1550
15. H. Kempski et al. Pilot study to investigate the possibility of cytogenetic and physiological changes in bio-electrosprayed human lymphocyte cells Regen. Med. 3 2008 343 349
16. S. Ramakrishna et al. An Introduction to Electrospinning and Nanofibers 2005 World Scientific
17. Y. Dong et al. Distinctive degradation behaviors of electrospun polyglycolide, poly(dl-lactide-co-glycolide), and poly(l-lactide-co-epsilon- caprolactone) nanofibers cultured with/without porcine smooth muscle cells Tissue Eng. Part A 16 2010 283 298
18. X. Chen et al. Regulation of the osteogenesis of pre-osteoblasts by spatial arrangement of electrospun nanofibers in two- and three-dimensional environments Nanomedicine 9 2013 1283 1292
19. K.J. Shields et al. Mechanical properties and cellular proliferation of electrospun collagen type II Tissue Eng. 10 2004 1510 1517 (Pubitemid 39557854)
20. A.J. Meinel et al. Electrospun matrices for localized drug delivery: current technologies and selected biomedical applications Eur. J. Pharm. Biopharm. 81 2012 1 13
21. R. Ravichandran et al. Expression of cardiac proteins in neonatal cardiomyocytes on PGS/fibrinogen core/shell substrate for cardiac tissue engineering Int. J. Cardiol. 167 2012 1461 1468
22. W.W. Hu, and H.N. Yu Coelectrospinning of chitosan/alginate fibers by dual-jet system for modulating material surfaces Carbohydr. Polym. 95 2013 716 727
23. T.G. Kim et al. Macroporous and nanofibrous hyaluronic acid/collagen hybrid scaffold fabricated by concurrent electrospinning and deposition/leaching of salt particles Acta Biomater. 4 2008 1611 1619
24. X. Fang, and D.H. Reneker DNA fibers by electrospinning J. Macromol. Sci. Part B: Phys. 36 1997 169 173 (Pubitemid 127561189)
25. D. Li, and Y. Xia Electrospinning of nanofibers: reinventing the wheel? Adv. Mater. 16 2004 1151 1170
26. Z.M. Huang et al. A review on polymer nanofibers by electrospinning and their applications in nanocomposites Compos. Sci. Technol. 63 2003 2223 2253
27. L. Ye et al. The in vitro and in vivo biocompatibility evaluation of heparin-poly(epsilon-caprolactone) conjugate for vascular tissue engineering scaffolds J. Biomed. Mater. Res. A 100 2012 3251 3258
28. J-E. Kim et al. A fibronectin peptide-coupled biopolymer nanofibrous matrix to speed up initial cellular events Adv. Biomater. 12 2010 94 100
29. F. Boccafoschi et al. The biological response of poly(l-lactide) films modified by different biomolecules: role of the coating strategy J. Biomed. Mater. Res. A 100 2012 2373 2381
30. N. Bölgen et al. In vivo performance of antibiotic embedded electrospun PCL membranes for prevention of abdominal adhesions J. Biomed. Mater. Res. B: Appl. Biomater. 81 2007 530 543 (Pubitemid 46685124)
31. T. Briggs, and T.L. Arinzeh Examining the formulation of emulsion electrospinning for improving the release of bioactive proteins from electrospun fibers J. Biomed. Mater. Res. A 102 2013 674 684
32. K. Wei et al. Emulsion electrospinning of a collagen-like protein/PLGA fibrous scaffold: empirical modeling and preliminary release assessment of encapsulated protein Macromol. Biosci. 11 2011 1526 1536
33. D. Brahatheeswaran et al. Hybrid fluorescent curcumin loaded zein electrospun nanofibrous scaffold for biomedical applications Biomed. Mater. 7 2012 045001
34. D.W. Chen et al. Sustainable release of vancomycin, gentamicin and lidocaine from novel electrospun sandwich-structured PLGA/collagen nanofibrous membranes Int. J. Pharm. 430 2012 335 341
35. W. Ji et al. Incorporation of stromal cell-derived factor-1alpha in PCL/gelatin electrospun membranes for guided bone regeneration Biomaterials 34 2013 735 745
36. W. Xu et al. Controllable dual protein delivery through electrospun fibrous scaffolds with different hydrophilicities Biomed. Mater. 8 2013 1 8
37. H. Zhu et al. Biological activity of a nanofibrous barrier membrane containing bone morphogenetic protein formed by core-shell electrospinning as a sustained delivery vehicle J. Biomed. Mater. Res. B: Appl. Biomater. 101 2013 541 552
38. X. Guo et al. Creating 3D angiogenic growth factor gradients in fibrous constructs to guide fast angiogenesis Biomacromolecules 13 2012 3262 3271
39. K.D. Andrews et al. Effects of sterilisation method on surface topography and in-vitro cell behaviour of electrostatically spun scaffolds Biomaterials 28 2007 1014 1026 (Pubitemid 44809414)
40. F. Gentile et al. Cells preferentially grow on rough substrates Biomaterials 31 2010 7205 7212
41. S. Sahoo et al. Characterization of a novel polymeric scaffold for potential application in tendon/ligament tissue engineering Tissue Eng. 12 2006 91 99
42. G. Jin et al. Stem cell differentiation to epidermal lineages on electrospun nanofibrous substrates for skin tissue engineering Acta Biomater. 7 2011 3113 3122
43. J.D. Wei et al. Characterizations of chondrocyte attachment and proliferation on electrospun biodegradable scaffolds of PLLA and PBSA for use in cartilage tissue engineering J. Biomater. Appl. 26 2012 963 985
44. S.H. Ku, and C.B. Park Human endothelial cell growth on mussel-inspired nanofiber scaffold for vascular tissue engineering Biomaterials 31 2010 9431 9437
45. D. Steffens et al. A new biomaterial of nanofibers with the microalga Spirulina as scaffolds to cultivate with stem cells for use in tissue engineering J. Biomed. Nanotechnol. 9 2013 710 718
46. P. Kuppan et al. Development of poly(3-hydroxybutyrate-co-3- hydroxyvalerate) fibers for skin tissue engineering: effects of topography, mechanical, and chemical stimuli Biomacromolecules 12 2011 3156 3165
47. C. Bao et al. Effects of electrospun submicron fibers in calcium phosphate cement scaffold on mechanical properties and osteogenic differentiation of umbilical cord stem cells Acta Biomater. 7 2011 4037 4044
48. Y. Ji et al. Electrospinning and characterization of chitin nanofibril/polycaprolactone nanocomposite fiber mats Carbohydr. Polym. 101 2014 68 74
49. I. Kwon et al. Electrospun nano- to microfiber fabrics made of biodegradable copolyesters: structural characteristics, mechanical properties and cell adhesion potential Biomaterials 26 2005 3929 3939 (Pubitemid 40038784)
50. G. Kim et al. Hybrid process for fabricating 3D hierarchical scaffolds combining rapid prototyping and electrospinning Macromol. J. 29 2008 1577 1581
51. J. Sirc et al. Controlled gentamicin release from multi-layered electrospun nanofibrous structures of various thicknesses Int. J. Nanomed. 7 2012 5315 5325
52. Q.P. Pham et al. Electrospun poly(epsilon-caprolactone) microfiber and multilayer nanofiber/microfiber scaffolds: characterization of scaffolds and measurement of cellular infiltration Biomacromolecules 7 2006 2796 2805 (Pubitemid 44615263)
53. J.L. Lowery et al. Effect of fiber diameter, pore size and seeding method on growth of human dermal fibroblasts in electrospun poly(epsilon-caprolactone) fibrous mats Biomaterials 31 2010 491 504
54. D.I. Braghirolli et al. The effect of sterilization methods on electrospun poly(lactide-co-glycolide) and subsequent adhesion efficiency of mesenchymal stem cells J. Biomed. Mater. Res. B: Appl. Biomater. 2013 10.1002/jbm.b.33049
55. A. Mittal et al. Integration of porosity and bio-functionalization to form a 3D scaffold: cell culture studies and in vitro degradation Biomed. Mater. 5 2010 045001
56. M. Navarro et al. Development of a biodegradable composite scaffold for bone tissue engineering: physicochemical, topographical, mechanical, degradation, and biological properties Adv. Polym. Sci. 200 2006 209 231
57. Q. Yu et al. Structure-property relationship of regenerated spider silk protein nano/microfibrous scaffold fabricated by electrospinning J. Biomed. Mater. Res. A 2013 10.1002/jbm.a.35051
58. X. Li et al. Encapsulation of proteins in poly(l-lactide-co-caprolactone) fibers by emulsion electrospinning Colloids Surf. B: Biointerfaces 75 2010 418 424
59. N.E. Zander et al. Quantification of protein incorporated into electrospun polycaprolactone tissue engineering scaffolds ACS Appl. Mater. Interfaces 4 2012 2074 2081
60. W.B. Tsai et al. Poly(dopamine) coating of scaffolds for articular cartilage tissue engineering Acta Biomater. 7 2011 4187 4194
61. A. Rainer et al. A biomimetic three-layered compartmented scaffold for vascular tissue engineering Conf. Proc. IEEE Eng. Med. Biol. Soc. 2010 2010 839 842
62. L.C. Cheng et al. Nano-bio effects: interaction of nanomaterials with cells Nanoscale 5 2013 3547 3569
63. E. Masaeli et al. Does the tissue engineering architecture of poly(3-hydroxybutyrate) scaffold affects cell-material interactions? J. Biomed. Mater. Res. A 100 2012 1907 1918
64. A.R. Chandrasekaran et al. Fabrication of a nanofibrous scaffold with improved bioactivity for culture of human dermal fibroblasts for skin regeneration Biomed. Mater. 6 2011 015001
65. C.R. Wittmer et al. Multifunctionalized electrospun silk fibers promote axon regeneration in central nervous system Adv. Funct. Mater. 21 2011 4232 4242
66. D. Kai et al. Mechanical properties and in vitro behavior of nanofiber-hydrogel composites for tissue engineering applications Nanotechnology 23 2012 095705
67. U.A. Stock, and J.P. Vacanti Tissue engineering: current state and prospects Annu. Rev. Med. 52 2001 443 451 (Pubitemid 32195334)
68. H.B. Wang et al. Varying the diameter of aligned electrospun fibers alters neurite outgrowth and Schwann cell migration Acta Biomater. 6 2010 2970 2978
69. M. Kempf et al. A denatured collagen microfiber scaffold seeded with human fibroblasts and keratinocytes for skin grafting Biomaterials 32 2011 4782 4792
70. A. Thorvaldsson et al. Electrospinning of highly porous scaffolds for cartilage regeneration Biomacromolecules 9 2008 1044 1049 (Pubitemid 351560500)
71. A. Shafiee et al. Electrospun nanofiber-based regeneration of cartilage enhanced by mesenchymal stem cells J. Biomed. Mater. Res. A 99 2011 467 478
72. L. da Silva Meirelles et al. Mesenchymal stem cells reside in virtually all post-natal organs and tissues J. Cell Sci. 119 2006 2204 2213
73. Y.H. Zheng et al. Multilineage differentiation of human bone marrow mesenchymal stem cells and Exp. Ther. Med. 5 2013 1576 1580
74. A.I. Caplan Adult mesenchymal stem cells for tissue engineering versus regenerative medicine J. Cell. Physiol. 213 2007 341 347 (Pubitemid 47509711)
75. S. Soliman et al. Controlling the porosity of fibrous scaffolds by modulating the fiber diameter and packing density J. Biomed. Mater. Res. A 96 2011 566 574
76. B.M. Whited, and M.N. Rylander The influence of electrospun scaffold topography on endothelial cell morphology, alignment, and adhesion in response to fluid flow Biotechnol. Bioeng. 111 2014 184 195
77. H.C. Hsia et al. The fiber diameter of synthetic bioresorbable extracellular matrix influences human fibroblast morphology and fibronectin matrix assembly Plast. Reconstr. Surg. 127 2011 2312 2320
78. W.J. Li et al. Fabrication and characterization of six electrospun poly(alpha-hydroxy ester)-based fibrous scaffolds for tissue engineering applications Acta Biomater. 2 2006 377 385
79. G. Zanatta et al. Mesenchymal stem cell adherence on poly(d,l-lactide-co- glycolide) nanofibers scaffold is integrin-beta 1 receptor dependent J. Biomed. Nanotechnol. 8 2012 211 218
80. A. Zonari et al. Endothelial differentiation of human stem cells seeded onto electrospun polyhydroxybutyrate/polyhydroxybutyrate-co-hydroxyvalerate fiber mesh PLoS ONE 7 2012 e35422
81. M. Ghaedi et al. Hepatic differentiation from human mesenchymal stem cells on a novel nanofiber scaffold Cell. Mol. Biol. Lett. 17 2012 89 106
82. R. Ravichandran et al. Cardiogenic differentiation of mesenchymal stem cells on elastomeric poly (glycerol sebacate)/collagen core/shell fibers World J. Cardiol. 5 2013 28 41
83. H. Peng et al. Electrospun biomimetic scaffold of hydroxyapatite/chitosan supports enhanced osteogenic differentiation of mMSCs Nanotechnology 23 2012 485102
84. F. Du et al. Gradient nanofibrous chitosan/poly varepsilon-caprolactone scaffolds as extracellular microenvironments for vascular tissue engineering Biomaterials 33 2012 762 770
85. R. Laurenti et al. Ischemic heart disease, hospitalization, length of stay and expenses in Brazil from 1993 to 1997 Arq. Bras. Cardiol. 74 2000 488 492
86. W. He et al. The preparation and performance of a new polyurethane vascular prosthesis Cell. Biochem. Biophys. 66 2013 855 866
87. R.Y. Kannan et al. Current status of prosthetic bypass grafts: a review J. Biomed. Mater. Res. B: Appl. Biomater. 74 2005 570 581 (Pubitemid 40917728)
88. W. Mrowczynski et al. Porcine carotid artery replacement with biodegradable electrospun poly-e-caprolactone vascular prosthesis J. Vasc. Surg. 59 2013 210 219
89. L. Ye et al. Heparin-conjugated PCL scaffolds fabricated by electrospinning and loaded with fibroblast growth factor 2 J. Biomater. Sci. Polym. Ed. 2010 (Epub ahead of print)
90. H. Bergmeister et al. Electrospun small-diameter polyurethane vascular grafts: ingrowth and differentiation of vascular-specific host cells Artif. Organs 36 2012 54 61
91. H. Liu et al. Electrospun sulfated silk fibroin nanofibrous scaffolds for vascular tissue engineering Biomaterials 32 2011 3784 3793
92. B.L. Dargaville et al. Electrospinning and crosslinking of low-molecular-weight poly(trimethylene carbonate-co-(l)-lactide) as an elastomeric scaffold for vascular engineering Acta Biomater. 9 2013 6885 6897
93. N. Nseir et al. Biodegradable scaffold fabricated of electrospun albumin fibers: mechanical and biological characterization Tissue Eng. Part C: Methods 19 2013 257 264
94. B.W. Tillman et al. The in vivo stability of electrospun polycaprolactone-collagen scaffolds in vascular reconstruction Biomaterials 30 2009 583 588
95. Y.M. Ju et al. Bilayered scaffold for engineering cellularized blood vessels Biomaterials 31 2010 4313 4321
96. S. Wang et al. Fabrication of small-diameter vascular scaffolds by heparin-bonded P(LLA-CL) composite nanofibers to improve graft patency Int. J. Nanomed. 8 2013 2131 2139
97. S. Singh et al. The enhancement of VEGF-mediated angiogenesis by polycaprolactone scaffolds with surface cross-linked heparin Biomaterials 32 2011 2059 2069
98. M. Kim et al. Composite system of PLCL scaffold and heparin-based hydrogel for regeneration of partial-thickness cartilage defects Biomacromolecules 13 2012 2287 2298
99. N. Toyokawa et al. Electrospun synthetic polymer scaffold for cartilage repair without cultured cells in an animal model Arthroscopy 26 2010 375 383
100. S.D. McCullen et al. Anisotropic fibrous scaffolds for articular cartilage regeneration Tissue Eng. Part A 18 2012 2073 2083
101. A.R. Esposito et al. PLDLA/PCL-T scaffold for meniscus tissue engineering Bioresour. Open Access 2 2013 138 147
102. Y. Gu et al. Repair of meniscal defect using an induced myoblast-loaded polyglycolic acid mesh in a canine model Exp. Ther. Med. 3 2012 293 298
103. M.B. Fisher et al. Organized nanofibrous scaffolds that mimic the macroscopic and microscopic architecture of the knee meniscus Acta Biomater. 9 2013 4496 4504
104. E.K. Ko et al. In vitro osteogenic differentiation of human mesenchymal stem cells and in vivo bone formation in composite nanofiber meshes Tissue Eng. Part A 14 2008 2105 2119
105. J.H. Lee et al. Control of osteogenic differentiation and mineralization of human mesenchymal stem cells on composite nanofibers containing poly[lactic-co-(glycolic acid)] and hydroxyapatite Macromol. Biosci. 10 2010 173 182
106. M.V. Jose et al. Aligned bioactive multi-component nanofibrous nanocomposite scaffolds for bone tissue engineering Macromol. Biosci. 10 2010 433 444
107. T. Chae et al. Novel biomimetic hydroxyapatite/alginate nanocomposite fibrous scaffolds for bone tissue regeneration J. Mater. Sci. Mater. Med. 24 2013 1885 1894
108. H. Liu et al. The promotion of bone regeneration by nanofibrous hydroxyapatite/chitosan scaffolds by effects on integrin-BMP/Smad signaling pathway in BMSCs Biomaterials 34 2013 4404 4417
109. R. Fang et al. Electrospun PCL/PLA/HA based nanofibers as scaffold for osteoblast-like cells J. Nanosci. Nanotechnol. 10 2010 7747 7751
110. L.X. Lu et al. Effects of hydroxyapatite-containing composite nanofibers on osteogenesis of mesenchymal stem cells in vitro and bone regeneration in vivo ACS Appl. Mater. Interfaces 5 2013 319 330
111. H. Nie et al. Three-dimensional fibrous PLGA/HAp composite scaffold for BMP-2 delivery Biotechnol. Bioeng. 99 2008 223 234
112. Y. Su et al. Controlled release of bone morphogenetic protein 2 and dexamethasone loaded in core-shell PLLACL-collagen fibers for use in bone tissue engineering Acta Biomater. 8 2012 763 771
113. B.H. Park et al. Enhancement of tibial regeneration in a rat model by adipose-derived stromal cells in a PLGA scaffold Bone 51 2012 313 323
114. E. Biazar et al. Types of neural guides and using nanotechnology for peripheral nerve reconstruction Int. J. Nanomed. 5 2010 839 852
115. M.P. Prabhakaran et al. Mesenchymal stem cell differentiation to neuronal cells on electrospun nanofibrous substrates for nerve tissue engineering Biomaterials 30 2009 4996 5003
116. D. Gupta et al. Aligned and random nanofibrous substrate for the in vitro culture of Schwann cells for neural tissue engineering Acta Biomater. 5 2009 2560 2569
117. M.K. Leach et al. The culture of primary motor and sensory neurons in defined media on electrospun poly-l-lactide nanofiber scaffolds J. Vis. Exp. 2011 10.3791/2389
118. E. Masaeli et al. Fabrication, characterization and cellular compatibility of poly(hydroxy alkanoate) composite nanofibrous scaffolds for nerve tissue engineering PLoS ONE 8 2013 e57157
119. J. Xie et al. The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages Biomaterials 30 2009 354 362
120. J. Xie et al. Conductive core-sheath nanofibers and their potential application in neural tissue engineering Adv. Funct. Mater. 19 2009 2312 2318
121. S.Y. Chew et al. Aligned protein-polymer composite fibers enhance nerve regeneration: a potential tissue-engineering platform Adv. Funct. Mater. 17 2007 1288 1296 (Pubitemid 46847643)
122. J-J. Liu et al. Peripheral nerve regeneration using composite poly(lactic acid-caprolactone)/nerve growth factor conduits prepared by coaxial electrospinning J. Biomed. Mater. Res. A 96 2010 13 20
123. C.Y. Wang et al. The effect of aligned core-shell nanofibres delivering NGF on the promotion of sciatic nerve regeneration J. Biomater. Sci. Polym. Ed. 23 2012 167 184
124. J. Liu et al. Fibrin scaffolds containing ectomesenchymal stem cells enhance behavioral and histological improvement in a rat model of spinal cord injury Cells Tissues Organs 198 2013 35 46
125. B.L. Du et al. A comparative study of gelatin sponge scaffolds and PLGA scaffolds transplanted to completely transected spinal cord of rat J. Biomed. Mater. Res. A 2013 10.1002/jbm.a.34835
126. F. Zamani et al. Promotion of spinal cord axon regeneration by 3D nanofibrous core-sheath scaffolds J. Biomed. Mater. Res. A 102 2014 506 513
127. J. Andrychowski et al. Nanofiber nets in prevention of cicatrisation in spinal procedures. Experimental study Folia Neuropathol. 51 2013 147 157
128. V.C. van der Veen et al. New dermal substitutes Wound Repair Regen. 19 Suppl 1 2011 59 65
129. B.M. Min et al. Electrospinning of silk fibroin nanofibers and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro Biomaterials 25 2004 1289 1297
130. E. Vatankhah et al. Development of nanofibrous cellulose acetate/gelatin skin substitutes for variety wound treatment applications J. Biomater. Appl. 28 2013 909 921
131. G. Jin et al. Controlled release of multiple epidermal induction factors through core-shell nanofibers for skin regeneration Eur. J. Pharm. Biopharm. 85 2013 689 698
132. K.M. Guthrie et al. Antibacterial efficacy of silver-impregnated polyelectrolyte multilayers immobilized on a biological dressing in a murine wound infection model Ann. Surg. 256 2012 371 377
133. A. Yari et al. Synthesis and evaluation of novel absorptive and antibacterial polyurethane membranes as wound dressing J. Mater. Sci. Mater. Med. 23 2012 2187 2202
134. P. Losi et al. Fibrin-based scaffold incorporating VEGF- and bFGF-loaded nanoparticles stimulates wound healing in diabetic mice Acta Biomater. 9 2013 7814 7821
135. C. Spadaccio et al. A G-CSF functionalized PLLA scaffold for wound repair: an in vitro preliminary study Conf. Proc. IEEE Eng. Med. Biol. Soc. 2010 2010 843 846
136. P. Lopez-Jaramillo et al. A controlled, randomized-blinded clinical trial to assess the efficacy of a nitric oxide releasing patch in the treatment of cutaneous leishmaniasis by Leishmania (V.) panamensis Am. J. Trop. Med. Hyg. 83 2010 97 101
137. M. Arenbergerova et al. Light-activated nanofibre textiles exert antibacterial effects in the setting of chronic wound healing Exp. Dermatol. 21 2012 619 624
138. J. Lademann et al. Decontamination of the skin with absorbing materials Skin Pharmacol. Physiol. 24 2011 87 92