Regulation of the osteogenesis of pre-osteoblasts by spatial arrangement of electrospun nanofibers in two- and three-dimensional environments

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 9, Issue 8, 2013, Pages 1283-1292

  Chen, Xuening ^a   Fu, Xiaoling ^a   Shi, Jian gang ^b   Wang, Hongjun ^a  

^a Stevens Institute of Technology   (United States)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

3D culture; Electrospun nanofibers; Fiber orientation; Osteogenesis; Pre osteoblasts

Indexed keywords

3-D CULTURES; ALKALINE PHOSPHATASE ACTIVITY; CELL-MATERIAL INTERACTION; ELECTROSPUN NANOFIBERS; OSTEOGENESIS; OSTEOGENIC DIFFERENTIATION; PRE-OSTEOBLASTS; THREE-DIMENSIONAL ENVIRONMENT;

BIOMIMETICS; CELLS; COLLAGEN; CYTOLOGY; FIBER REINFORCED MATERIALS; PHOSPHATASES; PHYSIOLOGICAL MODELS; THREE DIMENSIONAL;

NANOFIBERS;

ALKALINE PHOSPHATASE; ALPHA5 INTEGRIN; BETA1 INTEGRIN; BETA3 INTEGRIN; BIOMIMETIC MATERIAL; BONE SIALOPROTEIN; CALCIUM; CD51 ANTIGEN; COLLAGEN TYPE 1; ELECTROSPUN NANOFIBER; F ACTIN; MOLECULAR SCAFFOLD; NANOFIBER; NANOMESH; OSTEOCALCIN; POLYCAPROLACTONE; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; BONE MINERALIZATION; CELL COUNT; CELL CULTURE; CELL DIFFERENTIATION; CELL MIGRATION; CELL POLARITY; CELL STRUCTURE; CONTROLLED STUDY; DNA DETERMINATION; EMBEDDING; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FOURIER TRANSFORMATION; GENE EXPRESSION; MOUSE; NONHUMAN; NUCLEAR SHAPE; OSTEOBLAST; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCANNING ELECTRON MICROSCOPY; SPATIAL ARRANGEMENT; SPATIAL ORIENTATION; THREE DIMENSIONAL CELL CULTURE; TISSUE STRUCTURE; TWO DIMENSIONAL CELL CULTURE;

CELLS; COLLAGEN; THREE DIMENSIONAL DESIGN;

3D CULTURE; ELECTROSPUN NANOFIBERS; FIBER ORIENTATION; OSTEOGENESIS; PRE-OSTEOBLASTS;

3T3 CELLS; ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; COLLAGEN TYPE I; GENE EXPRESSION REGULATION; INTEGRINS; MICE; NANOFIBERS; OSTEOBLASTS; OSTEOGENESIS; POLYESTERS; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84886382164     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2013.04.013     Document Type: Article

References (49)

1. Meijer G.J., de Bruijn J.D., Koole R., van Blitterswijk C.A. Cell-based bone tissue engineering. PLoS Med 2007, 4(2):e9.
2. Kneser U., Schaefer D.J., Polykandriotis E., Horch R.E. Tissue engineering of bone: the reconstructive surgeon's point of view. J Cell Mol Med 2006, 10(1):7-19.
3. Serrao G.W., Turnbull I.C., Ancukiewicz D., Kim D.E., Kao E., Cashman T.J., et al. Myocyte-depleted engineered cardiac tissues support therapeutic potential of mesenchymal stem cells. Tissue Eng Part A 2012, 18(13-14):1322-1333.
4. Nerurkar N.L., Baker B.M., Chen C.Y., Elliott D.M., Mauck R.L. Engineering of fiber-reinforced tissues with anisotropic biodegradable nanofibrous scaffolds. Conf Proc IEEE Eng Med Biol Soc. 2006, 1:787-790.
5. Jones S.J., Boyde A., Pawley J.B. Osteoblasts and collagen orientation. Cell Tissue Res 1975, 159(1):73-80.
6. Shapiro F. Bone development and its relation to fracture repair. The role of mesenchymal osteoblasts and surface osteoblasts. Eur Cell Mater. 2008, 15:53-76.
7. Li W.J., Mauck R.L., Cooper J.A., Yuan X., Tuan R.S. Engineering controllable anisotropy in electrospun biodegradable nanofibrous scaffolds for musculoskeletal tissue engineering. J Biomech 2007, 40(8):1686-1693.
8. Jose M.V., Thomas V., Johnson K.T., Dean D.R., Nyairo E. Aligned PLGA/HA nanofibrous nanocomposite scaffolds for bone tissue engineering. Acta Biomater 2009, 5(1):305-315.
9. Zhu B., Lu Q., Yin J., Hu J., Wang Z. Alignment of osteoblast-like cells and cell-produced collagen matrix induced by nanogrooves. Tissue Eng 2005, 11:825-834.
10. Han D., Gouma P.I. Electrospun bioscaffolds that mimic the topology of extracellular matrix. Nanomedicine 2006, 2(1):37-41.
11. Pham Q.P., Sharma U., Mikos A.G. Electrospinning of polymeric nanofibers for tissue engineering applications: a review. Tissue Eng 2006, 12(5):1197-1211.
12. Yang X., Shah J.D., Wang H. Nanofiber enabled layer-by-layer approach toward three-dimensional tissue formation. Tissue Eng Part A 2009, 15(4):945-956.
13. Khadka D.B., Haynie D.T. Protein- and peptide-based electrospun nanofibers in medical biomaterials. Nanomedicine 2012, 8(8):1-21.
14. Yim E.K., Leong K.W. Significance of synthetic nanostructures in dictating cellular response. Nanomedicine 2005, 1(1):10-21.
15. Yang F., Murugan R., Wang S., Ramakrishna S. Electrospinning of nano/micro scale poly(L-lactic acid) aligned fibers and their potential in neural tissue engineering. Biomaterials 2005, 26(15):2603-2610.
16. Ma J., He X., Jabbari E. Osteogenic differentiation of marrow stromal cells on random and aligned electrospun poly(L-lactide) nanofibers. Ann Biomed Eng 2011, 39(1):14-25.
17. Lee J., Cuddihy M.J., Kotov N.A. Three-dimensional cell culture matrices: state of the art. Tissue Eng Part B Rev 2008, 14(1):61-86.
18. Akhyari P., Fedak P.W., Weisel R.D., Lee T.Y., Verma S., Mickle D.A., et al. Mechanical stretch regimen enhances the formation of bioengineered autologous cardiac muscle grafts. Circulation 2002, 106(12 Suppl 1):137-143.
19. Ng C.P., Hinz B., Swartz M.A. Interstitial fluid flow induces myofibroblast differentiation and collagen alignment in vitro. J Cell Sci 2005, 118(Pt 20):4731-4739.
20. Ito A., Takizawa Y., Honda H., Hata K., Kagami H., Ueda M., et al. Tissue engineering using magnetite nanoparticles and magnetic force: heterotypic layers of cocultured hepatocytes and endothelial cells. Tissue Eng 2004, 10(5-6):833-840.
21. Radisic M., Park H., Shing H., Consi T., Schoen F.J., Langer R., et al. Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds. Proc Nati Acad Sci U S A 2004, 101(52):18129-18134.
22. Xing Q., Zhao F., Chen S., McNamara J., Decoster M.A., Lvov Y.M. Porous biocompatible three-dimensional scaffolds of cellulose microfiber/gelatin composites for cell culture. Acta Biomater 2010, 6:2132-2139.
23. Aubin H., Nichol J.W., Hutson C.B., Bae H., Sieminski A.L., Cropek D.M., et al. Directed 3D cell alignment and elongation in microengineered hydrogels. Biomaterials 2010, 31(27):6941-6951.
24. Norman J.J., Desai T.A. Control of cellular organization in three dimensions. Tissue Eng 2005, 11(3):378-387.
25. Yang X., Chen X., Wang H. Acceleration of osteogenic differentiation of preosteoblastic cells by chitosan containing nanofibrous scaffolds. Biomacromolecules 2009, 10(10):2772-2778.
26. Huang C., Fu X., Liu J., et al. The involvement of integrin β1 signaling in the migration and myofibroblastic differentiation of skin fibroblasts on anisotropic collagen-containing nanofibers. Biomaterials 2012, 33(6):1791-1800.
27. Fu X., Wang H. Spatial arrangement of polycaprolactone/collagen nanofiber scaffolds regulates the wound healing related behaviors of human adipose stromal cells. Tissue Eng Part A 2012, 18(5-6):631-642.
28. Charest J.L., Eliason M.T., García A.J., King W.P. Combined microscale mechanical topography and chemical patterns on polymer cell culture substrates. Biomaterials 2006, 27:2487-2494.
29. Brammer K.S., Oh S., Cobb C.J., Bjursten L.M., van der Heyde H., Jin S. Improved bone-forming functionality on diameter-controlled TiO(2) nanotube surface. Acta Biomater 2009, 5:3215-3223.
30. Decoster M.A. The Nuclear Area Factor (NAF): a measure for cell apoptosis using microscopy and image analysis. Modern research and educational topics in microscopy 2007, 378-384. Formatex, Badajoz. A. Meindez-Vilas, J. Diiaz (Eds.).
31. Daniel B., DeCoster M.A. Quantification of sPLA2-induced early and late apoptosis changes in neuronal cell cultures using combined TUNEL and DAPI staining. Brain Res Brain Res Protoc 2004, 13:144-150.
32. Liu Y., Franco A., Huang L., Gersappe D., Clark R.A.F., Rafailovich M.H. Control of cell migration in two and three dimensions using substrate morphology. Exp Cell Res 2009, 315:2544-2557.
33. Gregory C.A., Gunn W.G., Peister A., Prockop D.J. An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction. Anal Biochem 2004, 329:77-84.
34. Stein G.S., Lian J.B., Owen T.A. Relationship of cell growth to the regulation of tissue-specific gene expression during osteoblast differentiation. FASEB J 1990, 4(13):3111-3123.
35. Çapkin M., Çakmak S., Kurt F.Ö., Gümüşderelioǧlu M., Şen B.H., Türk B.T., et al. Random/aligned electrospun PCL/PCL-collagen nanofibrous membranes: comparison of neural differentiation of rat AdMSCs and BMSCs. Biomed Mater 2012, 7:045013.
36. Boudreau N.J., Jones P.L. Extracellular matrix and integrin signalling: the shape of things to come. Biochem J 1999, 339:481-488.
37. Schmidt S., Friedl P. Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms. Cell Tissue Res 2010, 339(1):83-92.34.
38. García A.J. Get a grip: integrins in cell-biomaterial interactions. Biomaterials 2005, 26:7525-7529.
39. Siebers M.C., ter Brugge P.J., Walboomers X.F., Jansen J.A. Integrins as linker proteins between osteoblasts and bone replacing materials. A critical review. Biomaterials 2005, 26(2):137-146.
40. Parenteau-Bareil R., Gauvin R., Berthod F. Collagen-based biomaterials for tissue engineering applications. Materials 2010, 3:1863-1887.
41. Bashur C.A., Dahlgren L.A., Goldstein A.S. Effect of fiber diameter and orientation on fibroblast morphology and proliferation on electrospun poly(D, L-lactic-co-glycolic acid) meshes. Biomaterials 2006, 27:5681-5688.
42. Wang N., Tytell J.D., Ingber D.E. Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus. Nat Rev Mol Cell Biol 2009, 10(1):75-82.
43. Lauffenburger D.A., Horwitz A.F. Cell migration: a physically integrated molecular process. Cell 1996, 84(3):359-369.
44. Rick A., Thomas J. Cell migration - movin' on. Science 1999, 286:1102-1103.
45. Mogilner A., Oster G. Cell motility driven by actin polymerization. Biophys J 1996, 71:3030-3045.
46. Ridley A.J., Schwartz M.A., Burridge K., Firtel R.A., Ginsberg M.H., Borisy G., et al. Cell migration: integrating signals from front to back. Science 2003, 302:1704-1709.
47. Keselowsky B.G., Collard D.M., García A.J. Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation. Proc Nati Acad Sci U S A 2005, 102(17):5953-5957.
48. Cheng S.L., Lai C.F., Blystone S.D., Avioli L.V. Bone mineralization and osteoblast differentiation are negatively modulated by integrin alpha(v)beta3. J Bone Miner Res 2001, 16(2):277-288.
49. Hamidouche Z., Fromigué O., Ringe J., Häupl T., Vaudin P., Pagès J.C., et al. Priming integrin alpha5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis. Proc Nati Acad Sci U S A 2009, 106(44):18587-18591.