Controlled release of bone morphogenetic protein 2 and dexamethasone loaded in core-shell PLLACL-collagen fibers for use in bone tissue engineering

Acta Biomaterialia

Volumn 8, Issue 2, 2012, Pages 763-771

  Su, Yan ^a,b   Su, Qianqian ^b   Liu, Wei ^a,b   Lim, Marcus ^b   Venugopal, Jayarama Reddy ^b   Mo, Xiumei ^a,c   Ramakrishna, Seeram ^a,b,c   Al Deyab, Salem S ^c   El Newehy, Mohamed ^c,d  

^a DONGHUA UNIVERSITY   (China)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

^d Tanta University   (Egypt)

Author keywords

Bone morphogenetic protein 2; Coaxial electrospinning; Controlled release; Dexamethasone; Nanofibers

Indexed keywords

BIOMECHANICS; BLENDING; BONE; CELL ENGINEERING; CONTROLLED DRUG DELIVERY; DRUG PRODUCTS; ELECTROSPINNING; HYDROPHILICITY; MECHANICAL STABILITY; PROTEINS; SCAFFOLDS (BIOLOGY); SCANNING ELECTRON MICROSCOPY; SHELLS (STRUCTURES); TARGETED DRUG DELIVERY; TISSUE REGENERATION;

BONE MORPHOGENETIC PROTEIN-2; BONE TISSUE ENGINEERING; CAPROLACTONE; COAXIAL ELECTROSPINNING; COLLAGEN NANOFIBERS; CONTROLLED RELEASE; DEXAMETHASONES; MESENCHYMAL STROMAL CELLS; NANO-FIBROUS; POLY (L-LACTIDE);

NANOFIBERS;

BONE MORPHOGENETIC PROTEIN 2; COLLAGEN FIBER; DEXAMETHASONE; LACTONE DERIVATIVE; NANOFIBER; POLY(LACTIDE CO CAPROLACTONE); UNCLASSIFIED DRUG;

ARTICLE; BONE TISSUE; CELL DIFFERENTIATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG STABILITY; DRUG STRUCTURE; ENCAPSULATION; HUMAN; HUMAN CELL; HYDROPHILICITY; MECHANICS; MESENCHYMAL STROMA CELL; OSTEOBLAST; PARAMETERS; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TISSUE ENGINEERING; TISSUE REGENERATION; ULTRAVIOLET SPECTROPHOTOMETRY; WATER CONTACT ANGLE;

EID: 84855454430     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2011.11.002     Document Type: Article

References (37)

1. A.J. Salgado, O.P. Coutinho, and R.L. Reis Bone tissue engineering: state of the art and future trends Macromol Biosci 4 2004 743 765 (Pubitemid 39257140)
2. J.C. Banwart, M.A. Asher, and R.S. Hassanein Iliac crest bone graft harvest donor site morbidity. A statistical evaluation Spine 20 1995 1055 1060
3. J.A. Goulet, L.E. Senunas, G.L. DeSilva, and M.L. Greenfield Autogenous iliac crest bone graft. Complications and functional assessment Clin Orthop Relat Res 1997 76 81 (Pubitemid 27250717)
4. S.N. Parikh Bone graft substitutes: past, present, future J Postgrad Med 48 2002 142 148 (Pubitemid 35012374)
5. Z.Y. Zhang, S.H. Teoh, E.Y. Teo, M. Chong, C.W. Shin, and F.T. Tien A comparison of bioreactors for culture of fetal mesenchymal stem cells for bone tissue engineering Biomaterials 31 2010 8684 8695
6. Y. Su, X.Q. Li, H.S. Wang, C.L. He, and X.M. Mo Fabrication and characterization of biodegradable nanofibrous mats by mix and coaxial electrospinning J Mater Sci: Mater Med 20 2009 2285 2294
7. E.R. Kenawy, G.L. Bowlin, K. Mansfield, J. Layman, D.G. Simpson, and E.H. Sanders Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend J Control Release 81 2002 57 64 (Pubitemid 34454849)
8. Y. Su, X.Q. Li, L.J. Tan, C. Huang, and X.M. Mo Poly(l-lactide-co-3- caprolactone) electrospun nanofibers for encapsulating and sustained releasing proteins Polymer 50 2009 4212 4219
9. S.Y. Chew, J. Wen, K.F. Yim, and K.W. Leong Sustained release of proteins from electrospun biodegradable fibers Biomacromolecules 6 2005 2017 2024 (Pubitemid 41052194)
10. N. Ashammakhi, A. Ndreu, A.M. Piras, L. Nikkola, T. Sindelar, and H. Ylikauppila Biodegradable nanomats produced by electrospinning: expanding multifunctionality and potential for tissue engineering J Nanosci Nanotechnol 7 2007 862 882
11. Z.M. Huang, and A.H. Yang Encapsulation of pure drugs ento the central part of polycaprolactone ultrafine fibers Acta Polymer Sin 1 2006 48 52
12. L.Y. Qiu, and Y.H. Bae Self-assembled polyethylenimine-graft-poly(- caprolactone) micelles as potential dual carriers of genes and anticancer drugs Biomaterials 28 2007 4132 4142 (Pubitemid 47048375)
13. J.S. Lee, J.W. Bae, Y.K. Joung, S.J. Lee, D.K. Han, and K.D. Park Controlled dual release of basic fibroblast growth factor and indomethacin from heparin-conjugated polymeric micelle Int J Pharm 346 2008 57 63 (Pubitemid 350110508)
14. Y. Su, X.Q. Li, S.P. Liu, X.M. Mo, and S. Ramakrishna Controlled release of dual drugs from emulsion electrospun nanofibrous mats Colloid Surf B 73 2009 376 381
15. Y.Z. Zhang, J. Venugopal, A. El-Turki, S. Ramakrishna, B. Su, and C.T. Lim Electrospun biomimetic nanocomposite nanofibers of hydroxyapatite/chitosan for bone tissue engineering Biomaterials 29 2008 4314 4322
16. M. Ngiam, S.S. Liao, A.J. Patil, Z.Y. Cheng, C.K. Chan, and S. Ramakrishna The fabrication of nano-hydroxyapatite on PLGA and PLGA/collagen nanofibrous composite scaffolds and their effects in osteoblastic behavior for bone tissue engineering Bone 45 2009 4 16
17. M. Ngiam, S.S. Liao, A.J. Patil, Z.Y. Cheng, F.Y. Yang, and M.J. Gubler Fabrication of mineralized polymeric nanofibrous composites for bone graft materials Tissue Eng Part A 15 2009 535 546
18. J. Venugopal, P. Vadgama, T.S.S. Kumar, and S. Ramakrishna Biocomposite nanofibers and osteoblasts for bone tissue engineering Nanotechnology 18 2007 1 8
19. J.J. Ben, and J.M. Steven Immunosuppression by mesenchymal stromal cells: from culture to clinic Exp Hematol 36 2008 733 741
20. A. Bartholomew, C. Sturgeon, M. Siatskas, K. Ferrer, K. McIntosh, and S. Patil Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo Exp Hematol 30 2002 42 48 (Pubitemid 34059216)
21. D. Chen, M. Zhao, and G.R. Mundy Bone morphogenetic proteins Growth Factors 22 2004 233 241 (Pubitemid 40136452)
22. Y.N. Zhao, J. Zhang, X. Wang, B. Chen, Z.F. Xiao, and C.Y. Shi The osteogenic effect of bone orphogenetic protein-2 on the collagen scaffold conjugated with antibodies J Control Release 141 2010 30 37
23. N. Jaiswal, S.E. Haynesworth, A.I. Caplan, and S.P. Bruder Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro J Cell Biochem 64 1997 295 312 (Pubitemid 27065443)
24. A.J. Salgado, J.T. Oliveira, A.J. Pedro, and L.R. Reis Adult stem cells in bone and cartilage tissue engineering Curr Stem Cell Res Ther 1 2006 345 364
25. A. Martins, A.R.C. Duarte, S. Faria, A.P. Marques, R.L. Reis, and N.M. Neves Osteogenic induction of hBMSCs by electrospun scaffolds with dexamethasone release functionality Biomaterials 31 2010 5875 5885
26. A.R. Duarte, J.F. Mano, and R.L. Reis Dexamethasone-loaded scaffolds prepared by supercritical-assisted phase inversion Acta Biomater 5 2009 2054 2062
27. M.D. Schofer, S. Fuchs-Winkelmann, C. Gräbedünkel, C. Wack, R. Dersch, and M. Rudisile Influence of poly(l-lactic acid) nanofibers and BMP-2-containing poly(l-lactic acid) nanofibers on growth and osteogenic differentiation of human mesenchymal stem cells The Scientific World J 8 2008 1269 1279
28. Y.N. Zhao, B. Chen, H. Lin, W.J. Sun, W.X. Zhao, and J. Zhang The bone-derived collagen containing mineralized matrix for the loading of collagen-binding bone morphogenetic protein-2 J Biomed Mater Res A 88 2009 725 734
29. O.C.M. Chan, K.F. So, and B.P. Chan Fabrication of nano-fibrous collagen microspheres for protein delivery and effects of photochemical crosslinking on release kinetics J Control Release 129 2008 135 143
30. M. Tezval, H. Tezval, K. Dresing, E.K. Stuermer, M. Blaschke, and K.M. Stuermer Differentiation dependent expression of urocortin's mRNA and peptide in human osteoprogenitor cells: influence of BMP-2, TGF-beta-1 and dexamethasone J Mol Hist 40 2009 331 341
31. K.H. Zhang, H.S. Wang, C. Huang, Y. Su, X.M. Mo, and Y. Ikada Fabrication of silk fibroin blended P(LLA-CL) nanofibrous scaffolds for tissue engineering J Biomed Mater Res A 93 2010 984 993
32. K. Ma, C.K. Chan, S.S. Liao, W.Y.K. Hwang, Q. Feng, and S. Ramakrishna Electrospun nanofiber scaffolds for rapid and rich capture of bone marrow-derived hematopoietic stem cells Biomaterials 29 2008 2096 2103
33. H.T. Zhang, H.L. Nie, S.B. Li, C.B. White, and L.M. Zhu Crosslinking of electrospun polyacrylonitrile/hydroxyethyl cellulose composite nanofibers Mater Lett 63 2009 1199 1202
34. M.P. Prabhakaran, J.R. Venugopal, and S. Ramakrishna Mesenchymal stem cell differentiation to neuronal cells on electrospun nanofibrous substrates for nerve tissue engineering Biomaterials 30 2009 4996 5003
35. Y. Su, X.Q. Li, Y.N. Liu, Q.Q. Su, W.Q.M. Lim, and X.M. Mo Encapsulation and controlled release of heparin from electrospun poly(l-lactide-co - caprolactone) nanofibers J Biomater Sci Polym Ed 22 2011 165 177
36. M. Goldberg, R. Langer, and X.Q. Jia Nanostructured materials for applications in drug delivery and tissue engineering J Biomater Sci Polym Ed 18 2007 241 268 (Pubitemid 46403135)
37. J.N. Beresford, C.J. Joyner, C. Devlin, and J.T. Triffitt The effects of dexamethasone and 1,25-dihydroxyvitamin D3 on osteogenic differentiation of human marrow stromal cells in vitro Arch Oral Biol 39 1994 941 947 (Pubitemid 124034578)