Three-dimensional fibrous PLGA/HAp composite scaffold for BMP-2 delivery

Biotechnology and Bioengineering

Volumn 99, Issue 1, 2008, Pages 223-234

  Nie, Hemin ^a   Beng, Wee Soh ^a   Fu, Yin Chih ^b   Wang, Chi Hwa ^a,c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c SINGAPORE MIT ALLIANCE   (Singapore)

Author keywords

Bone morphogenetic protein 2; Electrospinning; Fibrous scaffold; Hydroxylapatite; Poly(D,L lactide co glycolide)

Indexed keywords

ELECTROSPINNING; HYDROXYAPATITE; THREE DIMENSIONAL; TISSUE;

BONE MORPHOGENETIC PROTEIN-2; FIBROUS SCAFFOLD; HYDROXYLAPATITE; POLY(D,L-LACTIDE-CO-GLYCOLIDE);

PROTEINS;

HYDROXYAPATITE; POLYGLACTIN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ARTICLE; CELL ADHESION; CELL CULTURE; CELL STRUCTURE; CELL VIABILITY; COMPOSITE MATERIAL; CONTROLLED STUDY; CYTOTOXICITY; DIFFERENTIAL SCANNING CALORIMETRY; ENCAPSULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; MESENCHYME; PROTEIN SECONDARY STRUCTURE; TISSUE REGENERATION; X RAY DIFFRACTION;

BONE MORPHOGENETIC PROTEINS; CELL ADHESION; CELLS, CULTURED; DRUG CARRIERS; DURAPATITE; HUMANS; LACTIC ACID; MATERIALS TESTING; MESENCHYMAL STEM CELLS; POLYGLYCOLIC ACID; POLYMERS; TRANSFORMING GROWTH FACTOR BETA;

EID: 37549031767     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.21517     Document Type: Article

References (22)

1. Aebli N, Stich H, Schawalder P, Theis JC, Krebs J. 2005. Effects of bone morphogenetic-2 and hyaluronic acid on the osseointegration of hydroxyapatite-coated implants: An experiment study in sheep. J Biomed Mater Res 73A:295-302.
2. Berkland C, Pack DW, Kim K. 2004. Controlling surface nano-structure using flow-limited field injection electrostatic spraying (FFESS) of poly(DL-lactic-co-glycolide). Biomaterials 25:5649-5658.
3. Calis S, Bozdag S, Kas HS, Tuncay M, Hincal AA. 2002. Influence of irradiation sterilization of poly(lactide-co-glycolide) microspheres containing anti-inflammatory drugs. Farmaco 57:55-62.
4. Hedberg EL, Tang A, Crowther RS, Carney DH, Mikos AG. 2002. Controlled release of an osteogenic peptide from injectable biodegradable polymeric composites. J Control Release 84:137-150.
5. Huang YC, Simmons C, Kaigler D, Rice KG, Mooney DJ. 2005. Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4). Gene Ther 12:418-426.
6. Jansen JA, Vehof JWM, Ruhe PQ, Kroeze-Deutman H, Kuboki Y, Takita H, Hedberg EL, Mikos AG. 2005. Growth factor-loaded scaffolds for bone engineering. J Control Release 101:127-136.
7. Kenawy ER, Layman JM, Watkins JR, Bowlin GL, Matthews JA, Simpson DG, Wnek GE. 2003. Electrospining of poly(ethylene-co-vinyl alcohol) fibre. Biomaterials 24:907-913.
8. Kim HW, Song JH, Kim HE. 2005. Nanofiber generation of gelatin-hydroxyapatite biomimetics for guided tissue regeneration. Adv Funct Mater 15:1988-1994.
9. Lazzeri L, Cascone MG, Quiricone S, Morabito L, Giusti P. 2005. Biodegradable hollow microfibres to produce bioactive scaffolds. Polym Int 54:101-107.
10. Luginbuehl V, Wenk E, Koch A, Gander B, Merkle HP, Meinel L. 2005. Insulin-like growth factor I-releasing alginate-tricalciumphosphate composites for bone regeneration. J Pharm Res 22(60):940-950.
11. Mischkowski RA, Selbach I, Neugebauer J, Koebke J, Zoller JE. 2006. Lateral femoral cutaneous nerve and iliac crest bone grafts - anatomical and clinical considerations. Int J Oral Maxillofac Surg 55:366-372.
12. Nahar S, Tajmir-Riahi HA. 1996. Complexation of heavy metal cations Hg, Cd and Pb with proteins of PSII: Evidence for metal-sulfur binding and protein conformational transition by FTIR spectroscopy. J Colloid Interface Sci 178:648-656.
13. Rebecca HL, Wozney JM. 2001. Delivery on the promise of bone morphogenetic proteins. Trends Biotechnol 19(7):255-265.
14. Ruhe PQ, Kroese-Deutman HC, Wolke JGC, Spauwen PHM, Hansen JA. 2004. Bone inductive properties of rhBMP-2 loaded porous calcium phosphate cement implants in cranial defects in rabbits. Biomaterials 25:2123-2132.
15. Saito N, Murakami N, Takahashi J, Horiuchi H, Ota H, Kato H, Okada T, Nozaki K, Takaoka K. 2005. Synthetic biodegradable polymers as drug delivery systems for bone morphogenetic proteins. Adv Drug Deliv Rev 57:1037-1048.
16. Swan MC, Goodarce TEE. 2006. Morbidity at the iliac crest donor site following bone grafting of the cleft alveolus. Br J Oral Maxillofac Surg 44:129-133.
17. Takaoka K, Nakahara H, Yoshikawa H, Masuhara K, Tsuda T, Ono K. 1988. Ectopic bone induction on and in porous hydroxyapatite combined with collagen and bone morphogenetic protein. Clin Orthop Relat Res 234:250-254.
18. Velayudhan S, Ramesh P, Varma HK, Friedrich K. 2004. Dynamic mechanical properties of Hydroxylapatite-ethylene vinyl acetate copolymer composites. Mater Chem Phys 89:454-460.
19. Wei G, Jin Q, Giannobile WV, Ma PX. 2006. Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB. J Control Release 112:103-111.
20. Woo BH, Fink BF, Page R, Schrier JA, Jo YW, Jiang G, Deluca M, Vasconez HC, Deluca PP. 2001. Enhancement of bone growth by sustained delivery of recomninant human bone morphogenetic protein-2 in a polymeric matrix. J Pharm Res 18(12):1747-1753.
21. Xie J, Wang CH. 2005. Self-Assembled biodegradable nanoparticles developed by direct dialysis for the delivery of paclitaxel. Pharm Res 22(12): 2079-2090.
22. Xie J, Marijnissen JCM, Wang CH. 2006. Microparticles developed by electrohydrodynamic atomisation for the local delivery of anticancer drug to treat C6 glioma in vitro. Biomaterials 27:3321-3332.