Electrohydrodynamics: A facile technique to fabricate drug delivery systems

Advanced Drug Delivery Reviews

Volumn 61, Issue 12, 2009, Pages 1043-1054

  Chakraborty, Syandan ^a   Liao, I Chien ^a   Adler, Andrew ^a   Leong, Kam W ^a  

^a Duke University   (United States)

Author keywords

Coaxial electrospinning; Controlled release; Core shell nanofibers; Drug delivery systems; Electrospinning; Electrospraying; Nanofiber; Nanoparticle; Tissue engineering

Indexed keywords

COAXIAL ELECTROSPINNING; CONTROLLED RELEASE; CORE-SHELL NANOFIBERS; DRUG DELIVERY SYSTEMS; ELECTROSPRAYING;

ELECTROHYDRODYNAMICS; ELECTROSPINNING; FLUID DYNAMICS; NANOFIBERS; NANOPARTICLES; TISSUE ENGINEERING;

CONTROLLED DRUG DELIVERY;

AMPICILLIN; ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; CARMUSTINE; CEFOXITIN; CHITOSAN; COPOLYMER; DRUG CARRIER; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; HYDROXYAPATITE; MACROGOL; NANOFIBER; NANOPARTICLE; NANOTUBE; NERVE GROWTH FACTOR; NUCLEIC ACID; PACLITAXEL; PEPTIDE DERIVATIVE; POLY(METHYL METHACRYLATE); POLYCAPROLACTONE; POLYGLACTIN; POLYGLUTAMIC ACID; POLYLACTIDE; POLYMER; POLYPEPTIDE; POLYSACCHARIDE; PROPYLENE OXIDE; SOLVENT; TETRACYCLINE; UNINDEXED DRUG;

ADSORPTION; BIODEGRADABILITY; CONTROLLED DRUG RELEASE; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; ELECTRIC FIELD; ELECTRIC POTENTIAL; ELECTRICITY; ELECTRONICS; ELECTROSPRAY; ENCAPSULATION; FLOW RATE; GLIOBLASTOMA; HUMAN; HYDRODYNAMICS; HYDROPHILICITY; HYDROPHOBICITY; MEDICAL INSTRUMENTATION; MISCIBILITY; MOLECULAR WEIGHT; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVIEW; SYNTHESIS; TISSUE ENGINEERING; WOUND CARE;

DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; ELECTROCHEMISTRY; MODELS, THEORETICAL; NANOFIBERS; NANOPARTICLES; PHARMACEUTICAL PREPARATIONS; TISSUE ENGINEERING;

EID: 70349840742     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2009.07.013     Document Type: Review

References (106)

1. Moghimi S.M., Hunter A.C., and Murray J.C. Nanomedicine: current status and future prospects. FASEB j. 19 (2005) 311-330
2. Goldberg M., Langer R., and Jia X. Nanostructured materials for applications in drug delivery and tissue engineering. J Biomater Sci Polym Ed 18 (2007) 241-268
3. Sokolsky-Papkov M., Agashi K., Olaye A., Shakesheff K., and Domb A.J. Polymer carriers for drug delivery in tissue engineering. Adv Drug Deliv Rev 59 (2007) 187-206
4. Murugan R., and Ramakrishna S. Design strategies of tissue engineering scaffolds with controlled fiber orientation. Tissue Eng 13 (2007) 1845-1866
5. Quaglia F. Bioinspired tissue engineering: the great promise of protein delivery technologies. Int. J. Pharm. 364 (2008) 281-297
6. Saltzman W.M., and Olbricht W.L. Building drug delivery into tissue engineering. Nat. Rev. Drug. Discov. 1 (2002) 177-186
7. Greiner A., Wendorff J.H., Yarin A.L., and Zussman E. Biohybrid nanosystems with polymer nanofibers and nanotubes. Appl. Microbiol. Biotechnol. 71 (2006) 387-393
8. Vasita R., and Katti D.S. Nanofibers and their applications in tissue engineering. Int. J. Nanomedicine 1 (2006) 15-30
9. Kimizuka N. Self-assembly of supramolecular nanofibers. Adv. Polym. Sci. 219 (2008) 1-26
10. Ma P.X., and Zhang R. Synthetic nano-scale fibrous extracellular matrix. J. Biomed. Mater. Res. 46 (1999) 60-72
11. De Jong W.H., and Borm P.J. Drug delivery and nanoparticles: applications and hazards. Int. J. Nanomedicine 3 (2008) 133-149
12. Kingsley J.D., Dou H., Morehead J., Rabinow B., Gendelman H.E., and Destache C.J. Nanotechnology: a focus on nanoparticles as a drug delivery system. J. Neuroimmune. Pharmacol 1 (2006) 340-350
13. Zambaux M.F., Bonneaux F., Gref R., Maincent P., Dellacherie E., Alonso M.J., Labrude P., and Vigneron C. Influence of experimental parameters on the characteristics of poly(lactic acid) nanoparticles prepared by a double emulsion method. J. Control. Release 50 (1998) 31-40
14. Jain R. The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomaterials 21 (2000) 2475-2490
15. Allemann E., Gurny R., and Doelker E. Preparation of aqueous polymeric nanodispersions by a reversible salting-out process: influence of process parameters on particle size. Int. J. Pharm. 87 (1992) 247-253
16. McCarron P.A., Donnelly R.F., and Marouf W. Celecoxib-loaded poly(d,l-lactide-co-glycolide) nanoparticles prepared using a novel and controllable combination of diffusion and emulsification steps as part of the salting-out procedure. J. Microencapsul 23 (2006) 480-498
17. Bilati U., Allémann E., and Doelker E. Nanoprecipitation versus emulsion-based techniques for the encapsulation of proteins into biodegradable nanoparticles and process-related stability issues. AAPS PharmSciTech 6 (2005) E594-604
18. Bodmeier R., and Wang J. Microencapsulation of drugs with aqueous colloidal polymer dispersions. J. Pharm. Sci. 82 (1993) 191-194
19. Katas H., and Alpar H.O. Development and characterisation of chitosan nanoparticles for siRNA delivery. J. Control. Release 115 (2006) 216-225
20. Mao H.Q., Roy K., Troung-Le V.L., Janes K.A., Lin K.Y., Wang Y., August J.T., and Leong K.W. Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. J. Control. Release 70 (2001) 399-421
21. Vehring R. Pharmaceutical particle engineering via spray drying. Pharm. Res. 25 (2008) 999-1022
22. Soppimath K.S., Aminabhavi T.M., Kulkarni A.R., and Rudzinski W.E. Biodegradable polymeric nanoparticles as drug delivery device. J. Control. Release 70 (2001) 1-20
23. Scholes P., Coombes A.G.A., Illum L., Davis S.S., and Davies M.C. The preparation of sub-200 nm poly(lactide-co-glycolide) microspheres for site-specific drug delivery. J. Control. Release 25 (1993) 145-153
24. Wu Y., and Clark R.L. Electrohydrodynamic atomization: a versatile process for preparing materials for biomedical applications. J. Biomater. Sci., Polymer. Ed. 19 (2008) 573-601
25. Jaworek A., and Sobczyk A.T. Electrospraying route to nanotechnology: an overview. J. Electrost. 66 (2008) 197-219
26. De la Mora J.F., and Loscartales I. The current emitted by highly conducting Taylor cones. J. Fluid Mech. 260 (1994) 155-184
27. Gañan-Calvo A.M. New microfluidic technologies to generate respirable aerosols for medical applications. J. Aerosol Sci. 30 (1999) 541-542
28. Gañan-Calvo A.M., Davila J., and Barrero A. Current and droplet size in the electrospraying of liquids: scaling laws. J. Aerosol Sci. 28 (1997) 249-275
29. Hartman R.P.A., Brunner D.J., Camelot D.M.A., Marijnissen J.C.M., and Scarlett B. Jet break-up in electrohydrodynamic atomization in the cone-jet mode. J. Aerosol Sci. 31 (2000) 65-95
30. Yao J., Lim L.K., Xie J.W., Hua J.S., and Wang C.H. Characterization of electrospraying process for polymeric particle fabrication. J. Aerosol Sci. 39 (2008) 987-1002
31. Lopez-Herrera J.M., Barrero A., Lopez A., Loscertales I.G., and Marquez M. Coaxial jets generated from electrified Taylor cones. Scaling laws. J. Aerosol Sci. 34 (2003) 535-552
32. Rutledge G.C., and Fridrikh S.V. Formation of fibers by electrospinning. Adv. Drug Deliv. Rev. 59 (2007) 1384-1391
33. Feng J.J. The stretching of an electrified non-Newtonian jet: a model for electrospinning. Phys. Fluids 14 (2002) 3912-3926
34. He J.H., and Liu H.M. Variational approach to nonlinear problems and a review on mathematical model of electrospinning. Nonlinear Anal. 63 (2005) e919-e929
35. Reneker D.H., Yarin A.L., Fong H., and Koombhongse S. Bending instability of electrically charged liquid jets of polymer solutions in electrospinning. J. Appl. Phys. 87 (2000) 4531-4547
36. Shin Y.M., Hohman M.M., Brenner M.P., Rutledge G.C., and Electrospinning G.C. A whipping fluid jet generates submicron polymer fibers. Appl. Phys. Lett. 78 (2001) 1149-1151
37. Moghe A.K., and Gupta B.S. Co-axial electrospinning for nanofiber structures: preparation and applications. Polymer Rev. 48 (2008) 353-377
38. Sill T.J., and von Recum H.A. Electro spinning: applications in drug delivery and tissue engineering. Biomaterials 29 (2008) 1989-2006
39. Chew S.Y., Wen Y., Dzenis Y., and Leong K.W. The role of electrospinning in the emerging field of nanomedicine. Curr. Pharm. Des. 12 (2006) 4751-4770
40. Dror Y., Salalha W., Avrahami R., Zussman E., Yarin A.L., Dersch R., Greiner A., and Wendorff J.H. One-step production of polymeric microtubes by co-electrospinning. Small 3 (2007) 1064-1073
41. Li S., Sun B., Li X.R., and Yuan X.Y. Characterization of electrospun core/shell poly(vinyl pyrrolidone)/poly(l-lactide-co-epsilon-caprolactone) fibrous membranes and their cytocompatibility in vitro. J. Biomater. Sci., Polymer. Ed. 9 (2008) 245-258
42. Zilberman M., and Elsner J.J. Antibiotic-eluting medical devices for various applications. J. Control. Release 130 (2008) 202-215
43. Zilberman M., and Kraitzer A. Paclitaxel-eluting composite fibers: drug release and tensile mechanical properties. J. Biomed. Mater. Res. 84A (2008) 313-323
44. Liao I., Chew S.Y., and Leong K.W. Aligned core-shell nanofibers delivering bioactive proteins. Nanomedicine 1 (2006) 465-471
45. McCann J.T., Li D., and Xia Y.N. Electrospinning of nanofibers with core-sheath, hollow, or porous structures. J. Mater. Chem. 15 (2005) 735-738
46. McCann J.T., Marquez M., and Xia Y.N. Melt coaxial electrospinning: a versatile method for the encapsulation of solid materials and fabrication of phase change nanofibers. Nano Lett. 6 (2006) 2868-2872
47. Dong H., and Jones W. Preparation of submicron polypyrrole/poly(methyl methacrylate) coaxial fibers and conversion to polypyrrole tubes and carbon tubes. Langmuir 26 (2006) 11384-11387
48. Ma M., Krikorian V., Yu J.H., Thomas E.L., and Rutledge G.C. Electrospun polymer nanofibers with internal periodic structure obtained by microphase separation of cylindrically confined block copolymers. Nano Lett. 12 (2006) 2969-2972
49. Jiang H.L., Zhao P.C., and Zhu K.J. Fabrication and characterization of zein-based nanofibrous scaffolds by an electrospinning method. Macromol Biosci 7 4 (2007) 517-525
50. Lagerwall J.P.F., McCann J.T., Formo E., Scalia G., and Xia Y. Coaxial electrospinning of microfibres with liquid crystal in the core. Chem. Commun. (2008) 5420-5422
51. Kraitzer A., Ofek L., Schreiber R., and Zilberman M. Long-term in vitro study of paclitaxel-eluting bioresorbable core/shell fiber structure. J. Control. Release 126 (2008) 139-148
52. Kraitzer A., and Zilberman M. Paclitaxel-loaded composite fibers: microstructure and emulsion stability. J. Biomed. Mater. Res. 81A (2007) 427-436
53. Buschle-Diller G., Cooper J., Xie Z.W., Wu Y., Waldrup J., and Ren X.H. Release of antibiotics from electrospun bicomponent fibers. Cellulose 14 (2007) 553-562
54. Xie J.W., and Wang C.H. Electrospun micro- and nanofibers for sustained delivery of paclitaxel to treat C6 glioma in vitro. Pharm. Res. 23 (2006) 817-1826
55. Xie J., Tan R.S., and Wang C.H. Biodegradable microparticles and fiber fabrics for sustained delivery of cisplatin to treat C6 glioma in invitro. J. Biomed. Mater. Res. 85A (2008) 897-908
56. Katti D.S., Robinson K.W., Ko F.K., and Laurencin C.T. Bioresorbable nanofiber-based systems for wound healing and drug delivery: optimization of fabrication parameters. J. Biomed. Mater. Res. B. Appl. Biomater. 70B (2004) 286-296
57. Kumbar S.G., Nair L.S., Bhattacharyya S., and Laurencin C.T. Polymeric nanofibers as novel carriers for the delivery of therapeutic molecules. J. Nanosci. Nanotechnol 6 (2006) 2591-2607
58. Chew S.Y., Wen J., Yim E.K., and Leong K.W. Sustained release of proteins from electrospun biodegradable fibers. Biomacromolecules 6 (2005) 2017-2024
59. Chew S.Y., Mi R., Hoke A., and Leong K.W. Aligned protein-polymer composite fibers enhance nerve regeneration: a potential tissue-engineering platform. Adv Funct Mater 17 (2007) 1288-1296
60. Jiang H., Hu Y., Zhao P., Li Y., and Zhu K. Modulation of protein release from biodegradable core-shell structured fibers prepared by coaxial electrospinning. J. Biomed. Mater. Res. B. Appl. Biomater. 79B (2006) 50-57
61. Srikar R., Yarin A.L., Megaridis C.M., Bazilevsky A.V., and Kelley E. Desorption-limited mechanism of release from polymer nanofibers. Langmuir 24 (2008) 965-974
62. Taylor G. Electrically driven jets. Proc. R. Soc. Lond., A Math. Phys. Sci. 313 (1969) 453-475
63. Doshi J., and Reneker D.H. Electrospinning process and applications of electrospun fibers. J. Electrost. 35 (1995) 151-160
64. He C.L., Huang Z.M., and Han X.J. Fabrication of drug-loaded electrospun aligned fibrous threads for suture applications. J. Biomed. Mater. Res. (2008) Electronic publication
65. Huang Z., He C., Yang A., Zhang Y., Han X., Yin J., and Wu Q. Encapsulating drugs in biodegradable ultrafine fibers through co-axial electrospinning. J. Biomed. Mater. Res. 39 (2006) 8113-8122
66. Jiang H., Hu Y., Li Y., Zhao P., Zhu K., and Chen W. A facile technique to prepare biodegradable coaxial electrospun nanofibers for controlled release of bioactive agents. J. Control. Release 108 (2005) 237-243
67. Zhang Y.Z., Wang X., Feng Y., Li J., Lim C.T., and Ramakrishna S. Coaxial electrospinning of (fluorescein isothiocyanate-conjugated bovine serum albumin)-encapsulated poly(epsilon-caprolactone) nanofibers for sustained release. Biomacromolecules 7 (2006) 1049-1057
68. Zhang Y.Z., Venugopal J., Huang Z.M., Lim C.T., and Ramakrishna S. Characterization of the surface biocompatibility of the electrospun PCL-collagen nanofibers using fibroblasts. Biomacromolecules 6 (2005) 2583-2589
69. Kim T.G., Chung H.J., and Park T.G. Macroporous and nanofibrous hyaluronic acid/collagen hybrid scaffold fabricated by concurrent electrospinning and deposition/leaching of salt particles. Acta Biomater. 4 (2008) 1611-1619
70. Foltran I., Foresti E., Parma B., Sabatino P., and Roveri N. Novel biologically inspired collagen nanofibers reconstituted by electrospinning method. Macromol. Symp. 269 (2008) 111-118
71. Ji Y., Ghosh K., Shu X.Z., Li B., Sokolov J.C., Prestwich G.D., Clark R.A., and Rafailovich M.H. Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds. Biomaterials 27 (2006) 3782-3792
72. Li J., He A., Zheng J., and Han C.C. Gelatin and gelatin-hyaluronic acid nanofibrous membranes produced by electrospinning of their aqueous solutions. Biomacromolecules 7 (2006) 2243-2247
73. Dang J.M., and Leong K.W. Myogenic induction of aligned mesenchymal stem cell sheets by culture on thermally responsive electrospun nanofibers. Adv. Mater. Deerfield 19 (2007) 2775-2779
74. Desai K., Kit K., Li J., and Zivanovic S. Morphological and surface properties of electrospun chitosan nanofibers. Biomacromolecules 9 (2008) 000-1006
75. Chen J.P., Chang G.Y., and Chen J.K. Electrospun collagen/chitosan nanofibrous membrane as wound dressing. Colloides Surf., Physicochem. Eng. Asp. 313 (2008) 183-188
76. Kim G.T., Lee J.S., Shin J.H., Ahn Y.C., Hwang Y.J., Shin H.E., Lee J.K., and Sung C.M. Investigation of pore formation for polystyrene electrospun fiber: effect of relative humidity. Korean J. Chem. Eng. 22 (2005) 783-788
77. Deitzel J.M., Kleinmeyer J., Harris D., and Tan N.C.B. The effect of processing variables on the morphology of electrospun nanofibers and textiles. Polymer 1 (2001) 261-272
78. Li X.H., Shao C.L., and Liu Y.C. A simple method for controllable preparation of polymer nanotubes via a single capillary electrospinning. Langmuir 23 (2007) 10920-10923
79. Megelski S., Stephens J.S., Chase D.B., and Rabolt J.F. Micro- and nanostructured surface morphology on electrospun polymer fibers. Macromolecules 22 (2002) 8456-8466
80. Huang F., Wei Q., Wang J., Cai Y., and Huang Y. Effect of temperature on structure, morphology and crystallinity of PVDF nanofibers via electrospinning. E-Polymers (2008) 152
81. Wang C., Chien H.S., Hsu C.H., Wang Y.C., Wang C.T., and Lu H.A. Electrospinning of polyacrylonitrile solutions at elevated temperatures. Macromolecules 40 (2007) 7973-7983
82. I.C. Liao, S. Chen, J.B. Liu, K.W. Leong, Sustained Viral Gene Delivery Through Core-shell Fibers, Journal of Controlled Release (in press), doi:10.1016/j.jconrel.2009.06.007.
83. Sung K., and Lee C.S. Factors influencing liquid breakup in electrohydrodynamic atomization. J. Appl. Phys. 96 (2004) 3956-3961
84. Chen D.R., Pui D.Y.H., and Kaufman S.L. Electrospraying of conducting liquids for monodisperse aerosol generation in the 4 nm to 1.8 μm diameter range. J. Aerosol Sci. 26 (1995) 963-977
85. Hartman R.P.A., Brunner D.J., Camelot D.M.A., Marijnissen J.C.M., and Scarlett B. Electrohydrodynamic atomization in the cone-jet mode physical modeling of the liquid cone and jet. J. Aerosol Sci. 30 (1999) 823-849
86. Kim G.H., and Park J.H. A PMMA optical diffuser fabricated using an electrospray method. Appl. Phys., Mater. Sci. Process. 86 (2007) 347-351
87. Tang K.Q., and Gomez A. Monodisperse electrosprays of low electric conductivity liquids in the cone-jet mode. J. Colloid Interface Sci. 184 (1996) 500-511
88. Langer G., and Yamate G. Encapsulation of liquid and solid aerosol particles to form dry powders. J. Colloid Interface Sci. 29 (1969) 450-455
89. Wu Y., MacKay J.A., McDaniel J.R., Chilkoti A., and Clark R.L. Fabrication of elastin-like polypeptide nanoparticles for drug delivery by electrospraying. Biomacromolecules 10 1 (2009) 19-24
90. Xu Y., and Hanna M.A. Electrosprayed bovine serum albumin-loaded tripolyphosphate cross-linked chitosan capsules: synthesis and characterization. J. Microencapsul 24 (2007) 143-151
91. Hwang Y.K., Jeong U., and Cho E.C. Production of uniform-sized polymer core-shell microcapsules by coaxial electrospraying. Langmuir 24 (2008) 2446-2451
92. Casper C.L., Yamaguchi N., Kiick K.L., and Rabolt J.F. Functionalizing electrospun fibers with biologically relevant macromolecules. Biomacromolecules 6 (2005) 1998-2007
93. Li C., Vepari C., Jin H.J., Kim H.J., and Kaplan D.L. Electrospun silk-BMP-2 scaffolds for bone tissue engineering. Biomaterials 27 (2006) 3115-3125
94. Luu Y.K., Kim K., Hsiao B.S., Chu B., and Hadjiargyrou M. Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA-PEG block copolymers. J. Control. Release 89 (2003) 341-353
95. Liang D., Luu Y.K., Kim K., Hsiao B.S., Hadjiargyrou M., and Chu B. In vitro non-viral gene delivery with nanofibrous scaffolds. Nucleic Acids Res 33 (2005) e170
96. Xu Y., Skotak M., and Hanna M. Electrospray encapsulation of water-soluble protein with polylactide. I. Effects of formulations and process on morphology and particle size. J. Microencapsul 23 (2006) 69-78
97. Xu X., Chen X., Xu X., Lu T., Wang X., Yang L., and Jing X. BCNU-loaded PEG-PLLA ultrafine fibers and their in vitro antitumor activity against glioma C6 cells. J. Control. Release 114 (2006) 307-316
98. Xu X., Yang L., Xu X., Wang X., Chen X., Liang Q., Zeng J., and Jing X. Ultrafine medicated fibers electrospun from W/O emulsions. J. Control. Release 108 (2005) 33-42
99. Khil M.S., Cha D.I., Kim H.Y., Kim I., and Bhattarai N. Electrospun nanofibrous polyurethane membrane as wound dressing. J. Biomed. Mater. Res. B. Appl. Biomater. 67b (2003) 675-679
100. Choi J.S., Leong K.W., and Yoo H.S. In vivo wound healing of diabetic ulcers using electrospun nanofibers immobilized with human epidermal growth factor (EGF). Biomaterials 29 (2008) 587-596
101. Bölgen N., Vargel I., Korkusuz P., Menceloǧlu Y.Z., and Pişkin E. In vivo performance of antibiotic embedded electrospun PCL membranes for prevention of abdominal adhesions. J. Biomed. Mater. Res. B. Appl. Biomater. 81B (2007) 530-543
102. Kim K., Luu Y.K., Chang C., Fang D., Hsiao B.S., Chu B., and Hadjiargyrou M. Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide-co-glycolide)-based electrospun nanofibrous scaffolds. J. Control. Release 98 (2004) 47-56
103. Huang Z.M., He C.L., Yang A., Zhang Y., Han X.J., Yin J., and Wu Q. Encapsulating drugs in biodegradable ultrafine fibers through co-axial electrospinning. J. Biomed. Mater. Res., A. 77A (2006) 169-179
104. Arya N., Chakraborty S., Dube N., and Katti D.S. Electrospraying: a facile technique for synthesis of chitosan-based micro/nanospheres for drug delivery applications. J. Biomed. Mater. Res. B Appl. Biomater. 88 (2009) 17-31
105. Clarke J.D., and Jayasinghe S.N. Bio-electrosprayed multicellular zebrafish embryos are viable and develop normally. Biomed. Mater. 3 (2008) 011001
106. Yeo L.Y., Gagnon Z., and Chang H.C. AC electrospray biomaterials synthesis. Biomaterials 26 (2005) 6122-6128