Controlled gentamicin release from multi-layered electrospun nanofibrous structures of various thicknesses

International Journal of Nanomedicine

Volumn 7, Issue , 2012, Pages 5315-5325

  Sirc, Jakub ^a   Kubinova, Sarka ^b   Hobzova, Radka ^a   Stranska, Denisa ^c   Kozlik, Petr ^d   Bosakova, Zuzana ^d   Marekova, Dana ^b   Holan, Vladimir ^e   Sykova, Eva ^b   Michalek, Jiri ^a  

^a INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Czech Republic)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Czech Republic)

^c Elmarco Ltd   (Czech Republic)

^d CHARLES UNIVERSITY   (Czech Republic)

^e INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

Author keywords

Drug release; Electrospinning; Gentamicin; Morphology; Multilayered structure; Nanofibers

Indexed keywords

GENTAMICIN; MOLECULAR LAYER; NANOFIBER;

ARTICLE; BACTERIAL GROWTH; BACTERIUM CULTURE; CONTROLLED DRUG RELEASE; CONTROLLED RELEASE FORMULATION; DRUG EFFICACY; DRUG RETENTION; DRUG STABILITY; ELECTROSPINNING; GROWTH INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MASS SPECTROMETRY; NONHUMAN; POROSITY; PSEUDOMONAS AERUGINOSA; QUANTITATIVE ANALYSIS; SCANNING ELECTRON MICROSCOPY; STAPHYLOCOCCUS AUREUS; STRUCTURE ANALYSIS; THICKNESS;

ANTI-BACTERIAL AGENTS; CELL SURVIVAL; DELAYED-ACTION PREPARATIONS; DIFFUSION; ELECTROCHEMISTRY; GENTAMICINS; GRAM-POSITIVE BACTERIA; MATERIALS TESTING; NANOCAPSULES; PARTICLE SIZE; ROTATION;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; POSIBACTERIA; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

EID: 84870383341     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S35781     Document Type: Article

References (36)

1. Vasita R, Katti DS. Nanofibers and their applications in tissue engineering. Int J Nanomedicine. 2006;1(1):15-30.
2. Kubinova S, Sykova E. Nanotechnologies in regenerative medicine. Minim Invasive Ther Allied Technol. 2010;19(3-4):144-156.
3. Khang D, Carpenter J, Chun YW, Pareta R, Webster TJ. Nanotechnology for regenerative medicine. Biomed Microdevices. 2010;12(4):575-587.
4. Kumbar SG, Nair LS, Bhattacharyya S, Laurencin CT. Polymeric nanofibers as novel carriers for the delivery of therapeutic molecules. J Nanosci Nanotechnol. 2006;6(9-10):2591-2607.
5. Chandrasekaran AR, Venugopal J, Sundarrajan S, Ramakrishna S. Fabrication of a nanofibrous scaffold with improved bioactivity for culture of human dermal fibroblasts for skin regeneration. Biomed Mater. 2011;6(1):1-10.
6. Noh HK, Lee SW, Kim JM, etal. Electrospinning of chitin nanofibers: Degradation behavior and cellular response to normal human keratinocytes and fibroblasts. Biomaterials. 2006;27(21):3934-3944.
7. Park CJ, Clark SG, Lichtensteiger CA, Jamison RD, Johnson AJW. Accelerated wound closure of pressure ulcers in aged mice by chitosan scaffolds with and without bFGF. Acta Biomater. 2009;5(6):1926-1936.
8. Rho KS, Jeong L, Lee G, etal. Electrospinning of collagen nanofibers: Effects on the behavior of normal human keratinocytes and early-stage wound healing. Biomaterials. 2006;27(8):1452-1461.
9. Verreck G, Chun I, Rosenblatt J, etal. Incorporation of drugs in an amorphous state into electrospun nanofibers composed of a water-insoluble, nonbiodegradable polymer. J Control Release. 2003;92(3):349-360.
10. Liu X, Lin T, Fang JA, etal. In vivo wound healing and antibacterial performances of electrospun nanofibre membranes. J Biomed Mater Res Part A. 2010;94A(2):499-508.
11. Babaeijandaghi F, Shabani I, Seyedjafari E, etal. Accelerated epidermal regeneration and improved dermal reconstruction achieved by polyethersulfone nanofibers. Tissue Eng Part A. 2010;16(11):3527-3536.
12. Katti DS, Robinson KW, Ko FK, Laurencin CT. Bioresorbable nanofiber-based systems for wound healing and drug delivery: Optimization of fabrication parameters. J Biomed Mater Res Part B. 2004;70B(2):286-296.
13. Thakur RA, Florek CA, Kohn J, Michniak BB. Electrospun nanofibrous polymeric scaffold with targeted drug release profiles for potential application as wound dressing. Int J Phar. 2008;364(1):87-93.
14. Peng HS, Zhou SB, Guo T, etal. In vitro degradation and release profiles for electrospun polymeric fibers containing paracetanol. Colloids Surf B Biointerfaces. 2008;66(2):206-212.
15. Choi JS, Leong KW, Yoo HS. In vivo wound healing of diabetic ulcers using electrospun nanofibers immobilized with human epidermal growth factor (EGF). Biomaterials. 2008;29(5):587-596.
16. Huang Z, Zhang Y, Kotaki M, Ramakrishna S. A review on polymer nanofibers by electrospinning and their applications in nanocomposites. Compos Sci Technol. 2003;63:2223-2253.
17. Martins A, Reis R, Neves N. Electrospinning: processing technique for tissue engineering scaffolding. Int Mater Rev. 2008;53(5):257-274.
18. Bellan L, Craighead H. Applications of controlled electrospinning systems. Polym Adv Technol. 2011;22:304-309.
19. Thompson C, Chase G, Yarin A, Reneker D. Effects of parameters on nanofiber diameter determined from electrospinning model. Polymer. 2007;48(23):6913-6922.
20. Lee GH, Song JC, Yoon KB. Controlled wall thickness and porosity of polymeric hollow nanofibers by coaxial electrospinning. Macromol Res. 2010;18(6):571-576.
21. Wang C, Yan K, Lin Y, Hsieh P. Biodegradable core/shell fibers by coaxial electrospinning: Processing, fiber characterization, and its application in sustained drug release. Macromolecules. 2010;43(15):6389-6397.
22. Jirsak O, Sanetrnik F, Lukas D, Kotek L, Martinova L, Chaloupek J, inventors; Technical University of Liberec, assignee. Method of nanofibers production from polymer solution using electrostatic spinning and a device for carrying out the method. United States patent US 20060290031. December 28, 2006.
23. Lukas D, Sarkar A, Pokorny P. Self-organization of jets in electrospinning from free liquid surface: A generalized approach. J Appl Phys. 2008;103:No 084309.
24. Barnes CP, Sell SA, Boland ED, Simpson DG, Bowlin GL. Nanofiber technology: Designing the next generation of tissue engineering scaffolds. Adv Drug Deliv Rev. 2007;59(14):1413-1433.
25. Taylor G. Electrically driven jets. Proc R Soc Lond A Math Phys Sci. 1969:453-475.
26. Park JC, inventor; Finetex Ene, Inc, assignee. Electric spinning apparatus for mass-production of nano-fiber. United States patent US 7980838. March 26, 2008.
27. Holan V, Chudickova M, Trosan P, etal. Cyclosporine A-loaded and stem cell-seeded electrospun nanofibers for cell-based therapy and local immunosuppression. J Control Release. 2011;156(3):406-412.
28. Srikar R, Yarin AL, Megaridis CM, Bazilevsky AV, Kelley E. Desorption-limited mechanism of release from polymer nanofibers. Langmuir. 2008;24(3):965-974.
29. Gandhi M, Srikar R, Yarin AL, Megaridis CM, Gemeinhart RA. Mechanistic examination of protein release from polymer nanofibers. Mol Phar. 2009;6(2):641-647.
30. Huang ZM, He CL, Yang AZ, etal. Encapsulating drugs in biodegradable ultrafine fibers through co-axial electrospinning. J Biomed Mater Res Part A. 2006;77A(1):169-179.
31. Chen DWC, Liao JY, Liu SJ, Chan EC. Novel biodegradable sandwich-structured nanofibrous drug-eluting membranes for repair of infected wounds: an in vitro and in vivo study. Int J Nanomedicine. 2012;7:763-771.
32. Kim G, Yoon H, Park Y. Drug release from various thicknesses of layered mats consisting of electrospun polycaprolactone and polyethylene oxide micro/nanofibers. Appl Phys A Mater Sci Process. 2010;100(4):1197-1204.
33. Fathi-Azarbayjani A, Chan SY. Single and multi-layered nanofibers for rapid and controlled drug delivery. Chem Pharm Bull. 2010;58(2):143-146.
34. Gibson PW, Schreuder-Gibson HL, Rivin D. Electrospun fiber mats: Transport properties. AIChE J. 1999;45(1):190-195.
35. Dubsky M, Kubinova S, Sirc J, etal. Nanofibers prepared by needleless electrospinning technology as scaffolds for wound healing. J Mater Sci Mater Med. 2012;23(4):931-941.
36. Zajicova A, Pokorna K, Lencova A, etal. Treatment of ocular surface injuries by limbal and mesenchymal stem cells growing on nanofiber scaffolds. Cell Transplant. 2010;19(10):1281-1290.