Synthesis, biological evaluation and molecular modeling study of pyrazole derivatives as selective COX-2 inhibitors and anti-inflammatory agents

Bioorganic Chemistry

Volumn 56, Issue , 2014, Pages 8-15

  Tewari, Ashish Kumar ^a   Singh, Ved Prakash ^a   Yadav, Pratima ^a   Gupta, Garima ^a   Singh, Amit ^a   Goel, Raj Kumar ^a   Shinde, Pravin ^b   Mohan, C Gopi ^b  

^a BANARAS HINDU UNIVERSITY   (India)

^b AMRITA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

COX 2 inhibitors; Drug design; Inflammation; Molecular modeling; Pyrazole

Indexed keywords

(4 METHOXY PHENYL) [4 [2 (5 METHYL 2 PHENYL 2H PYRAZOL 3 YLOXY)ETHOXY]BENZYLIDINE]AMINE; 3 METHYL 1 PHENYL 5 (TOLUENE 4 SULFONYLOXY) 1H PYRAZOLE 4 CARBOXYLIC ACID METHY ESTER; 4 (BIS METHYLSULFANYL METHYLENE) 5 METHYL 2 PHENYL 2,4 DIHYDRO PYRAZOL 3 ONE; 4 [2 (5 METHYL 2 PHENYL 2H PYRAZOL 3 YLOXY)ETHOXY]BENZALDEHYDE; 4 [2 (5 METHYL 2 PHENYL 2H PYRAZOL 3 YLOXY)ETHOXY]BENZALDEHYDE OXIME; ANTIINFLAMMATORY AGENT; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; NIMESULIDE; PYRAZOLE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; [4 [2 (5 METHYL 2 PHENYL 2H PYRAZOL 3 YLOXY)ETHOXY]BENZYLIDINE] 4 TOLYLAMINE; [4 [2 (5 METHYL 2 PHENYL 2H PYRAZOL 3 YLOXY)ETHOXY]BENZYLIDINE]HYDRAZINE; [4 [2 (5 METHYL 2 PHENYL 2H PYRAZOL 3 YLOXY)ETHOXY]PHENYL]METHANOL; [4 [2 (5 METHYL 2 PHENYL 2H PYRAZOL 3 YLOXY)]BENZYLIDINE]PHENYL AMINE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE INHIBITOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DRUG BINDING; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; PAW EDEMA; PHARMACOPHORE; PRIORITY JOURNAL; RAT; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; EDEMA; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; WISTAR RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRAZOLES; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84901847856     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2014.05.004     Document Type: Article

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