Synthesis and antibacterial activity of a novel series of potent DNA gyrase inhibitors. Pyrazole derivatives

Journal of Medicinal Chemistry

Volumn 47, Issue 14, 2004, Pages 3693-3696

  Tanitame, Akihiko ^a   Oyamada, Yoshihiro ^a   Ofuji, Keiko ^a   Fujimoto, Mika ^a   Iwai, Noritaka ^b   Hiyama, Yoichi ^a   Suzuki, Kenji ^a   Ito, Hideaki ^a   Terauchi, Hideo ^a   Kawasaki, Motoji ^a   Nagai, Kazuo ^c   Wachi, Masaaki ^b   Yamagishi, Jun Ichi ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^c CHUBU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 (2,6 DICHLOROPHENYL)VINYL]PYRAZOLE; 5 [2 (2,6 DICHLOROPHENYL)VINYL]PYRAZOLE; 5 [2 (5 CHLOROINDOL 3 YL)VINYL]PYRAZOLE; CLARITHROMYCIN; COUMARIN DERIVATIVE; DNA TOPOISOMERASE IV; GYRASE INHIBITOR; PYRAZOLE DERIVATIVE; QUINOLONE DERIVATIVE; SPARFLOXACIN; UNCLASSIFIED DRUG; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENTEROCOCCUS; ENTEROCOCCUS FAECALIS; ENZYME INHIBITION; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; DNA GYRASE; DNA TOPOISOMERASE IV; DRUG RESISTANCE, BACTERIAL; ENTEROCOCCUS FAECALIS; INDOLES; PYRAZOLES; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 3042552189     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030394f     Document Type: Article

References (9)

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