Dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) as a new strategy to provide safer non-steroidal anti-inflammatory drugs

European Journal of Medicinal Chemistry

Volumn 38, Issue 7-8, 2003, Pages 645-659

  Charlier, Caroline ^a   Michaux, Catherine ^a  

^a UNIVERSITY OF NAMUR   (Belgium)

Author keywords

5 Lipoxygenase; Cyclooxygenase; Dual; Inflammation; Inhibitor; NSAIDs

Indexed keywords

2 CYCLOPENTYL 2 [4 (2 QUINOLINYLMETHOXY)PHENYL]ACETIC ACID; 3 AMINO 1 (3 TRIFLUOROMETHYLPHENYL) 2 PYRAZOLINE; 3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 (2 QUINOLINYLMETHOXY) 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 4 [5 (4 BROMOPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; 6 [[3 FLUORO 5 (3,4,5,6 TETRAHYDRO 4 METHOXY 2H PYRAN 4 YL)]PHENOXYMETHYL] 1 METHYL 2 QUINOLONE; ACETYLSALICYLIC ACID; ARACHIDONATE 5 LIPOXYGENASE; ATRELEUTON; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DARBULONE; DICLOFENAC; DOCEBENONE; IBUPROFEN; INDOMETACIN; L 697198; LICOFELONE; LIPOXYGENASE INHIBITOR; LONAPALENE; MK 866; N [5 (4 FLUOROPHENOXY) 2 THIENYL]METHANESULFONAMIDE; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PHENIDONE; PHENOL DERIVATIVE; PROSTAGLANDIN; PROSTANOID; PYRAZOLINE DERIVATIVE; S 2474; TEBUFELONE; TEPOXALIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZILEUTON;

CLINICAL TRIAL; DRUG DESIGN; DRUG SAFETY; DRUG STRUCTURE; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME REGULATION; ENZYME STRUCTURE; ENZYME SYNTHESIS; HUMAN; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; REVIEW;

EID: 0042574211     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(03)00115-6     Document Type: Review

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