A diazen-1-ium-1,2-diolated nitric oxide donor ester prodrug of 3-(4-hydroxymethylphenyl)-4-(4-methanesulfonylphenyl)-5H-furan-2-one: Synthesis, biological evaluation and nitric oxide release studies

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 13, 2011, Pages 3951-3956

  Abdellatif, Khaled R A ^a   Huang, Zhangjian ^a   Chowdhury, Morshed A ^a   Kaufman, Susan ^a   Knaus, Edward E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Anti inflammatory activity; Cyclooxygenase inhibition; Diazen 1 ium 1 2 diolate; Ester prodrug; Nitric oxide donor; Rofecoxib; Vascular effects

Indexed keywords

3 (4 HYDROXYMETHYLPHENYL) 4 (4 METHYLSULFONYLPHENYL) 5H FURAN 2 ONE; ANTIINFLAMMATORY AGENT; CELECOXIB; FURANONE DERIVATIVE; IBUPROFEN; NITRIC OXIDE; NITRIC OXIDE DONOR; O 2 ACETOXYMETHYL 1 [2 [4 [4 (4 METHANESULFONYLPHENYL) 5H FURAN 2 ON 3 YL]PHENYLMETHOXY CARBONYL]PYRROLIDIN 1 YL]DIAZEN 1 IUM 1,2 DIOLATE; PHENYLEPHRINE; PHOSPHATE BUFFERED SALINE; PRODRUG; ROFECOXIB; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; MESENTERIC ARTERY; NONHUMAN; PH; RAT; VASOCONSTRICTION;

4-BUTYROLACTONE; ANIMALS; CYCLOOXYGENASE 2 INHIBITORS; ESTERS; INHIBITORY CONCENTRATION 50; MESENTERIC ARTERIES; MOLECULAR STRUCTURE; NITRIC OXIDE DONORS; PRODRUGS; RATS; SULFONES; TRIAZENES;

RATTUS;

EID: 79958768095     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.05.017     Document Type: Article

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