Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 6, 2011, Pages 2074-2083

  Li, Yue ^a   Chen, Shu Han ^a   Ou, Tian Miao ^a   Tan, Jia Heng ^a   Li, Ding ^a   Gu, Lian Quan ^a   Huang, Zhi Shu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Cyclooxygenase; Dual enzyme inhibitor; Inflammatory; Lipoxygenase; Nimesulide derivatives

Indexed keywords

(3 (4 METHOXYTETRAHYDRO 2H PYRAN 4 YL)PHENYL)METHANESULFONYL CHLORIDE; 2 (2 (BENZYLOXY)PHENYL)ISOINDOLINE 1,3 DIONE; 2 (2 HYDROXYPHENYL)ISOINDOLINE 1,3 DIONE; 2 (BENZYLOXY) 4 CHLOROANILINE; 2 (BENZYLOXY) 5 CHLOROANILINE; 2 (BENZYLOXY) 5 METHYLANILINE; 2 (BENZYLOXY) 5 NITROANILINE; 2 (BENZYLOXY)ANILINE; 4 (3 (BROMOMETHYL)PHENYL) 4 METHOXYTETRAHYDRO 2H PYRAN; 4 3 TOLYLTETRAHYDRO 2H PYRAN 4 OL; 4 METHOXY 4 3 TOLYLTETRAHYDRO 2H PYRAN; 6 [[3 FLUORO 5 (3,4,5,6 TETRAHYDRO 4 METHOXY 2H PYRAN 4 YL)]PHENOXYMETHYL] 1 METHYL 2 QUINOLONE; ARACHIDONATE 5 LIPOXYGENASE; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ETHYL 3 AMINO 4 (BENZYLOXY)BENZOATE; LICOFELONE; N (2 (BENZYLOXY) 4 CHLOROPHENYL) 1 (3 (4 METHOXYTETRAHYDRO 2H PYRAN 4 YL)PHENYL)METHANESULFONAMIDE; N (2 (BENZYLOXY) 4 CHLOROPHENYL)METHANESULFONAMIDE; N (2 (BENZYLOXY) 5 CHLOROPHENYL) 1 (3 (4 METHOXYTETRAHYDRO 2H PYRAN 4 YL)PHENYL)METHANESULFONAMIDE; N (2 (BENZYLOXY) 5 CHLOROPHENYL)METHANESULFONAMIDE; N (2 (BENZYLOXY) 5 METHYLPHENYL) 1 (3 (4 METHOXYTETRAHYDRO 2H PYRAN 4 YL)PHENYL)METHANESULFONAMIDE; N (2 (BENZYLOXY) 5 METHYLPHENYL)METHANESULFONAMIDE; N (2 (BENZYLOXY) 5 NITROPHENYL)METHANESULFONAMIDE; N (2 (BENZYLOXY)PHENYL) 1 (3 (4 METHOXYTETRAHYDRO 2H PYRAN 4 YL)PHENYL)METHANESULFONAMIDE; N (2 (BENZYLOXY)PHENYL)METHANESULFONAMIDE; NIMESULIDE; ROFECOXIB; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HYDROGEN BOND; MOLECULAR DOCKING; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTI-INFLAMMATORY AGENTS; ARACHIDONATE 5-LIPOXYGENASE; BENZOATES; BINDING SITES; COMPUTER SIMULATION; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; LIPOXYGENASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 79952440063     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.01.043     Document Type: Article

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