Synthesis and biological evaluation of orally active prodrugs of indomethacin

Journal of Medicinal Chemistry

Volumn 54, Issue 5, 2011, Pages 1191-1201

  Bandgar, Babasaheb P ^a,b   Sarangdhar, Rajendra Janardan ^a   Viswakarma, Santosh ^a   Ahamed, Fakrudeen Ali ^a  

^a SWAMI RAMANAND TEERTH MARATHWADA UNIVERSITY   (India)

^b SOLAPUR UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

(5 METHYL 2 OXO 1,3 DIOXOLENE 4 YL)METHYL 1 (4 CHLOROBENZOYL) 5 METHOXY 2 METHYL 3 INDOLYLACETATE; [(1 METHYL)ETHOXYCARBONYLOXY]METHYL 1 (4 CHLOROBENZOYL) 5 METHOXY 2 METHYL 3 INDOLYLACETATE; ACETYLOXYETHYL 1 (4 CHLOROBENZOYL) 5 METHOXY 2 METHYL 3 INDOLYLACETATE; ANTIINFLAMMATORY AGENT; INDOMETACIN; PIVALOYLOXYMETHYL 1 (4 CHLOROBENZOYL) 5 METHOXY 2 METHYL 3 INDOLYLACETATE; PRODRUG; UNCLASSIFIED DRUG;

ACIDITY; ALKALINITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; DRUG SCREENING; DRUG SYNTHESIS; IN VIVO STUDY; INFLAMMATION; LIPOPHILICITY; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; RAT; ULCER;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; DRUG STABILITY; EDEMA; GASTRIC MUCOSA; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; INDOMETHACIN; MALE; MICROSOMES, LIVER; PLASMA; PRODRUGS; RATS; RATS, WISTAR; STOMACH ULCER; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79952267679     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101085j     Document Type: Article

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