1,3,4-Trisubstituted pyrazole analogues as promising anti-inflammatory agents

Bioorganic Chemistry

Volumn 54, Issue , 2014, Pages 51-59

  Alegaon, S G ^a   Alagawadi, K R ^a   Garg, M K ^a   Dushyant, K ^b   Vinod, D ^c  

^a K L E S S COLLEGE OF PHARMACY   (India)

^b Nehru Nagar   (India)

^c MADRAS MEDICAL COLLEGE   (India)

Author keywords

1,3,4 Thiadiazole; Anti inflammatory activity; COX 1 and COX 2; Molecular docking; Pyrazole; Thiazole; Thiazolidinone

Indexed keywords

1,3 DIPHENYL 1H PYRAZOLE 4 CARBALDEHYDE; 2 [2 [[3 (4 HYDROXYPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE]HYDRAZINYL]THIAZOL 4(5H)ONE; 2 [2 [[3 (4 NITROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE]HYDRAZINYL]THIAZOL 4(5H)ONE; 2 [[3 (4 HYDROXYPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE]HYDRAZINE CARBOAMIDE; 2 [[3 (4 HYDROXYPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE]N PHENYL HYDRAZINECARBOTHIOAMIDE; 2 [[3 (4 NITROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE]HYDRAZINE CARBOTHIOAMIDE; 2 [[3 (4 NITROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE]N PHENYL HYDRAZINECARBOTHIAMIDE; 2 [[[3 (4 HYDROXYPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE]HYDRAZONO] 3 PHENYLTHIAZOLIDIN 4 ONE; 2 [[[3 (4 NITROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE]HYDRAZONO] 3 PHENYLTHIAZOLIDIN 4 ONE; 3 (4 HYDROXYPHENYL) 1 PHENYL 1H PYRAZOLE4 CARBALDEHYDE; 3 (4 NITROPHENYL) 1 PHENYL 1H PYRAZOLE 4 CARBALDEHYDE; 4 (4 BROMOPHENYL) 2 [2 [[3 (4 NITROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE]HYDRAZINYL]THIAZOLE; 4 (4 CHLOROPHENYL) 2 [2 [[3 (4 NITROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE]HYDRAZINYL]THIAZOLE; 4 (4 NITROPHENYL) 2 [2 [[3 (4 NITROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE]HYDRAZINYL]THIAZOLE; 4 [4 [[ 4 (4 NITROPHENYL) 3 PHENYLTHIAZOL 2(3H)YLIDENE]HYDRAZONO]METHYL 1 PHENYL 1H PYRAZOL 3 YL]PHENOL; 4 [4 [[2 [4 (4 BROMOPHENYL)THIAZOL 2 YL]HYDRAZON O]METHYL] 1 PHENYL 1H PYRAZOL 3 YL]PHENOL; 4 [4 [[2 [4 (4 CHLOROPHENYL)THIAZOL 2 YL]HYDRAZON O]METHYL] 1 PHENYL 1H PYRAZOL 3 YL]PHENOL; 4 [4 [[2 [4 (4 NITROPHENYL)THIAZOL 2 YL]HYDRAZON O]METHYL] 1 PHENYL 1H PYRAZOL 3 YL]PHENOL; 4 [4 [[4 (4 BROMOPHENYL) 3 PHENYLTHIAZOL 2(3H)YLIDENE]HYDRAZONO]METHYL 1 PHENYL 1H PYRAZOL 3 YL]PHENOL; 4 [4 [[4 (4 CHLOROPHENYL) 3 PHENYLTHIAZOL 2(3H)YLIDENE]HYDRAZONO]METHYL 1 PHENYL 1H PYRAZOL 3 YL]PHENO; ANTIINFLAMMATORY AGENT; DICLOFENAC; N[4 ACETYL 5 [3 (4 HYDROXYPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 4,5 DIHYDRO 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; N[4 ACETYL 5 [3 (4 HYDROXYPHENYL) 1 PHENYL 1H PYRAZOL 4YL] 4,5 DIHYDRO 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; N[4 ACETYL 5 [3 (4 HYDROXYPHENYL) 1 PHENYL 1H PYRAZOL 4YL] 4,5 DIHYDRO 1,3,4 THIADIAZOL 2 YL]N PHENYLACETAMIDE; N[4 ACETYL 5 [3 (4 NITROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 4,5 DIHYDRO 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; N[4 ACETYL 5 [3 (4 NITROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 4,5 DIHYDRO 1,3,4 THIADIAZOL 2 YL]N PHENYLACETAMIDE; PROSTAGLANDIN SYNTHASE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CARRAGEENAN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE INHIBITOR;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; IN VITRO STUDY; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MCF 7 CELL LINE; MOLECULAR DOCKING; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TOXICITY TESTING; ANIMAL; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMICALLY INDUCED; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; EDEMA; HELA CELL LINE; METABOLISM; SHEEP; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS; CARRAGEENAN; CELL PROLIFERATION; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; HELA CELLS; HUMANS; MCF-7 CELLS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRAZOLES; RATS; SHEEP; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84899804768     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2014.04.001     Document Type: Article

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