Structural basis of the dynamic mechanism of ligand binding to cyclooxygenase

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 19, 1999, Pages 2779-2784

  Llorens, Oriol ^a   Perez, Juan J ^a   Palomer, Albert ^b   Mauleon, David ^b  

^a UNIVERSITAT POLITÈCNICA DE CATALUNYA   (Spain)

^b Laboratorios Menarini   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; FLURBIPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT;

ARTICLE; COMPLEX FORMATION; DRUG BINDING SITE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; LIGAND BINDING; LIPID BILAYER; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BINDING SITES; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; FLURBIPROFEN; HYDROGEN BONDING; ISOENZYMES; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN BINDING; PYRAZOLES; SHEEP;

EID: 0033523610     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00481-3     Document Type: Article

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