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Volumn 33, Issue 22, 2014, Pages 2815-2825

Androgen receptor functions in castration-resistant prostate cancer and mechanisms of resistance to new agents targeting the androgen axis

Author keywords

androgen; androgen receptor; castration resistant prostate cancer; prostate cancer

Indexed keywords

ABIRATERONE; ANDROGEN; ANDROGEN RECEPTOR; ANDROGEN RECEPTOR ANTAGONIST; ENZALUTAMIDE; NEW DRUG;

EID: 84901827161     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.235     Document Type: Review
Times cited : (297)

References (164)
  • 1
    • 0015489274 scopus 로고
    • Bilateral adrenalectomy for palliative treatment of prostatic cancer
    • Mahoney EM, Harrison JH. Bilateral adrenalectomy for palliative treatment of prostatic cancer. J Urol 1972; 108: 936-938.
    • (1972) J Urol , vol.108 , pp. 936-938
    • Mahoney, E.M.1    Harrison, J.H.2
  • 3
    • 51449124047 scopus 로고    scopus 로고
    • Targeting CYP17: Established and novel approaches in prostate cancer
    • Yap TA, Carden CP, Attard G, de Bono JS. Targeting CYP17: established and novel approaches in prostate cancer. Curr Opin Pharmacol 2008; 8: 449-457.
    • (2008) Curr Opin Pharmacol , vol.8 , pp. 449-457
    • Yap, T.A.1    Carden, C.P.2    Attard, G.3    De Bono, J.S.4
  • 4
    • 72549108829 scopus 로고    scopus 로고
    • Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancer
    • Taplin ME, Regan MM, Ko YJ, Bubley GJ, Duggan SE, Werner L et al. Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancer. Clin Cancer Res 2009; 15: 7099-7105.
    • (2009) Clin Cancer Res , vol.15 , pp. 7099-7105
    • Taplin, M.E.1    Regan, M.M.2    Ko, Y.J.3    Bubley, G.J.4    Duggan, S.E.5    Werner, L.6
  • 6
    • 0037099723 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of monotherapy compared with combined androgen blockade for patients with advanced prostate carcinoma
    • DOI 10.1002/cncr.10647
    • Samson DJ, Seidenfeld J, Schmitt B, Hasselblad V, Albertsen PC, Bennett CL et al. Systematic review and meta-analysis of monotherapy compared with combined androgen blockade for patients with advanced prostate carcinoma. Cancer 2002; 95: 361-376. (Pubitemid 34787603)
    • (2002) Cancer , vol.95 , Issue.2 , pp. 361-376
    • Samson, D.J.1    Seidenfeld, J.2    Schmitt, B.3    Hasselblad, V.4    Albertsen, P.C.5    Bennett, C.L.6    Wilt, T.J.7    Aronson, N.8
  • 10
    • 33645056171 scopus 로고    scopus 로고
    • Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
    • Stanbrough M, Bubley GJ, Ross K, Golub TR, Rubin MA, Penning TM et al. Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. Cancer Res 2006; 66: 2815-2825.
    • (2006) Cancer Res , vol.66 , pp. 2815-2825
    • Stanbrough, M.1    Bubley, G.J.2    Ross, K.3    Golub, T.R.4    Rubin, M.A.5    Penning, T.M.6
  • 11
    • 0028944138 scopus 로고
    • In vivo amplification of the androgen receptor gene and progression of human prostate cancer
    • Visakorpi T, Hyytinen E, Koivisto P, Tanner M, Keinanen R, Palmberg C et al. In vivo amplification of the androgen receptor gene and progression of human prostate cancer. Nat Genet 1995; 9: 401-406.
    • (1995) Nat Genet , vol.9 , pp. 401-406
    • Visakorpi, T.1    Hyytinen, E.2    Koivisto, P.3    Tanner, M.4    Keinanen, R.5    Palmberg, C.6
  • 12
  • 13
    • 0032535307 scopus 로고    scopus 로고
    • Androgen receptor expression in androgen-independent prostate cancer is associated with increased expression of androgen-regulated genes
    • Gregory CW, Hamil KG, Kim D, Hall SH, Pretlow TG, Mohler JL et al. Androgen receptor expression in androgen-independent prostate cancer is associated with increased expression of androgen-regulated genes. Cancer Res 1998; 58: 5718-5724. (Pubitemid 29006412)
    • (1998) Cancer Research , vol.58 , Issue.24 , pp. 5718-5724
    • Gregory, C.W.1    Hamil, K.G.2    Kim, D.3    Hall, S.H.4    Pretlow, T.G.5    Mohler, J.L.6    French, F.S.7
  • 16
    • 0036170838 scopus 로고    scopus 로고
    • Disruption of androgen receptor function inhibits proliferation of androgen-refractory prostate cancer cells
    • Zegarra-Moro OL, Schmidt LJ, Huang H, Tindall DJ. Disruption of androgen receptor function inhibits proliferation of androgen-refractory prostate cancer cells. Cancer Res 2002; 62: 1008-1013. (Pubitemid 34160279)
    • (2002) Cancer Research , vol.62 , Issue.4 , pp. 1008-1013
    • Zegarra-Moro, O.L.1    Schmidt, L.J.2    Huang, H.3    Tindall, D.J.4
  • 19
    • 27644452640 scopus 로고    scopus 로고
    • Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer
    • DOI 10.1158/1078-0432.CCR-05-0525
    • Titus MA, Schell MJ, Lih FB, Tomer KB, Mohler JL. Testosterone and dihy-drotestosterone tissue levels in recurrent prostate cancer. Clin Cancer Res 2005; 11: 4653-4657. (Pubitemid 41557182)
    • (2005) Clinical Cancer Research , vol.11 , Issue.13 , pp. 4653-4657
    • Titus, M.A.1    Schell, M.J.2    Lih, F.B.3    Tomer, K.B.4    Mohler, J.L.5
  • 20
    • 49249119358 scopus 로고    scopus 로고
    • Maintenance of intratumoral androgens in metastatic prostate cancer: A mechanism for castration-resistant tumor growth
    • Montgomery RB, Mostaghel EA, Vessella R, Hess DL, Kalhorn TF, Higano CS et al. Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res 2008; 68: 4447-4454.
    • (2008) Cancer Res , vol.68 , pp. 4447-4454
    • Montgomery, R.B.1    Mostaghel, E.A.2    Vessella, R.3    Hess, D.L.4    Kalhorn, T.F.5    Higano, C.S.6
  • 21
    • 80053940699 scopus 로고    scopus 로고
    • Intratumoral androgen biosynthesis in prostate cancer patho-genesis and response to therapy
    • Cai C, Balk SP. Intratumoral androgen biosynthesis in prostate cancer patho-genesis and response to therapy. Endocr Relat Cancer 2011; 18: R175-R182.
    • (2011) Endocr Relat Cancer , vol.18
    • Cai, C.1    Balk, S.P.2
  • 25
    • 0034714276 scopus 로고    scopus 로고
    • Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations
    • Matias PM, Donner P, Coelho R, Thomaz M, Peixoto C, Macedo S et al. Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations. J Biol Chem 2000; 275: 26164-26171.
    • (2000) J Biol Chem , vol.275 , pp. 26164-26171
    • Matias, P.M.1    Donner, P.2    Coelho, R.3    Thomaz, M.4    Peixoto, C.5    Macedo, S.6
  • 27
    • 8344226282 scopus 로고    scopus 로고
    • Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance
    • DOI 10.1016/j.molcel.2004.09.036, PII S109727650400588X
    • He B, Gampe Jr. RT, Kole AJ, Hnat AT, Stanley TB, An G et al. Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance. Mol Cell 2004; 16: 425-438. (Pubitemid 39504796)
    • (2004) Molecular Cell , vol.16 , Issue.3 , pp. 425-438
    • He, B.1    Gampe Jr., R.T.2    Kole, A.J.3    Hnat, A.T.4    Stanley, T.B.5    An, G.6    Stewart, E.L.7    Kalman, R.I.8    Minges, J.T.9    Wilson, E.M.10
  • 32
    • 33847224474 scopus 로고    scopus 로고
    • Ligand-specific dynamics of the androgen receptor at its response element in living cells
    • Klokk TI, Kurys P, Elbi C, Nagaich AK, Hendarwanto A, Slagsvold T et al. Ligand-specific dynamics of the androgen receptor at its response element in living cells. Mol Cell Biol 2007; 27: 1823-1843.
    • (2007) Mol Cell Biol , vol.27 , pp. 1823-1843
    • Klokk, T.I.1    Kurys, P.2    Elbi, C.3    Nagaich, A.K.4    Hendarwanto, A.5    Slagsvold, T.6
  • 33
    • 40849085514 scopus 로고    scopus 로고
    • FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription
    • DOI 10.1016/j.cell.2008.01.018, PII S0092867408001189
    • Lupien M, Eeckhoute J, Meyer CA, Wang Q, Zhang Y, Li W et al. FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Cell 2008; 132: 958-970. (Pubitemid 351391952)
    • (2008) Cell , vol.132 , Issue.6 , pp. 958-970
    • Lupien, M.1    Eeckhoute, J.2    Meyer, C.A.3    Wang, Q.4    Zhang, Y.5    Li, W.6    Carroll, J.S.7    Liu, X.S.8    Brown, M.9
  • 35
    • 84857360697 scopus 로고    scopus 로고
    • Post-translational modification of the androgen receptor
    • Gioeli D, Paschal BM. Post-translational modification of the androgen receptor. Mol Cell Endocrinol 2012; 352: 70-78.
    • (2012) Mol Cell Endocrinol , vol.352 , pp. 70-78
    • Gioeli, D.1    Paschal, B.M.2
  • 36
    • 0036208492 scopus 로고    scopus 로고
    • Formation of the androgen receptor transcription complex
    • DOI 10.1016/S1097-2765(02)00471-9
    • Shang Y, Myers M, Brown M. Formation of the androgen receptor transcription complex. Mol Cell 2002; 9: 601-610. (Pubitemid 34273790)
    • (2002) Molecular Cell , vol.9 , Issue.3 , pp. 601-610
    • Shang, Y.1    Myers, M.2    Brown, M.3
  • 37
    • 67650758019 scopus 로고    scopus 로고
    • Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer
    • Wang Q, Li W, Zhang Y, Yuan X, Xu K, Yu J et al. Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell 2009; 138: 245-256.
    • (2009) Cell , vol.138 , pp. 245-256
    • Wang, Q.1    Li, W.2    Zhang, Y.3    Yuan, X.4    Xu, K.5    Yu, J.6
  • 38
    • 79960071366 scopus 로고    scopus 로고
    • The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis
    • Massie CE, Lynch A, Ramos-Montoya A, Boren J, Stark R, Fazli L et al. The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis. EMBO J 2011; 30: 2719-2733.
    • (2011) EMBO J , vol.30 , pp. 2719-2733
    • Massie, C.E.1    Lynch, A.2    Ramos-Montoya, A.3    Boren, J.4    Stark, R.5    Fazli, L.6
  • 39
    • 33747880070 scopus 로고    scopus 로고
    • Androgens induce prostate cancer cell proliferation through mammalian target of rapamycin activation and post-transcriptional increases in cyclin D proteins
    • DOI 10.1158/0008-5472.CAN-05-4472
    • Xu Y, Chen SY, Ross KN, Balk SP. Androgens induce prostate cancer cell proliferation through mammalian target of rapamycin activation and post-tran-scriptional increases in cyclin D proteins. Cancer Res 2006; 66: 7783-7792. (Pubitemid 44289239)
    • (2006) Cancer Research , vol.66 , Issue.15 , pp. 7783-7792
    • Xu, Y.1    Chen, S.-Y.2    Ross, K.N.3    Balk, S.P.4
  • 40
    • 0032493489 scopus 로고    scopus 로고
    • 1 regulatory elements control the androgen-dependent proliferation of prostatic carcinoma cells
    • DOI 10.1074/jbc.273.32.20213
    • Knudsen KE, Arden KC, Cavenee WK. Multiple G1 regulatory elements control the androgen-dependent proliferation of prostatic carcinoma cells. J Biol Chem 1998; 273: 20213-20222. (Pubitemid 28377582)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.32 , pp. 20213-20222
    • Knudsen, K.E.1    Arden, K.C.2    Cavenee, W.K.3
  • 42
    • 2342500360 scopus 로고    scopus 로고
    • The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells
    • Lu L, Schulz H, Wolf DA. The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells. BMC Cell Biol 2002; 3: 22.
    • (2002) BMC Cell Biol , vol.3 , pp. 22
    • Lu, L.1    Schulz, H.2    Wolf, D.A.3
  • 43
    • 84862926298 scopus 로고    scopus 로고
    • Androgen receptor enhances p27 degradation in prostate cancer cells through rapid and selective TORC2 activation
    • Fang Z, Zhang T, Dizeyi N, Chen S, Wang H, Swanson KD et al. Androgen receptor enhances p27 degradation in prostate cancer cells through rapid and selective TORC2 activation. J Biol Chem 2012; 287: 2090-2098.
    • (2012) J Biol Chem , vol.287 , pp. 2090-2098
    • Fang, Z.1    Zhang, T.2    Dizeyi, N.3    Chen, S.4    Wang, H.5    Swanson, K.D.6
  • 44
    • 84864256852 scopus 로고    scopus 로고
    • Doxycycline regulated induction of AKT in murine prosate drives proliferation independently of p27 cyclin dependent kinase inhibitor downregulation
    • Wang H, Xu Y, Fang Z, Chen S, Balk SP, Yuan X. Doxycycline regulated induction of AKT in murine prosate drives proliferation independently of p27 cyclin dependent kinase inhibitor downregulation. PLoS ONE 2012; 7: e41330.
    • (2012) PLoS ONE , vol.7
    • Wang, H.1    Xu, Y.2    Fang, Z.3    Chen, S.4    Balk, S.P.5    Yuan, X.6
  • 45
    • 0032913866 scopus 로고    scopus 로고
    • Androgen regulation of the cyclin-dependent kinase inhibitor p21 gene through an androgen response element in the proximal promoter
    • Lu S, Liu M, Epner DE, Tsai SY, Tsai MJ. Androgen regulation of the cyclin-dependent kinase inhibitor p21 gene through an androgen response element in the proximal promoter. Mol Endocrinol 1999; 13: 376-384. (Pubitemid 29113870)
    • (1999) Molecular Endocrinology , vol.13 , Issue.3 , pp. 376-384
    • Lu, S.1    Liu, M.2    Epner, D.E.3    Tsai, S.Y.4    Tsai, M.-J.5
  • 46
    • 0027053785 scopus 로고
    • Heparin-binding keratinocyte growth factor is a candidate stromal to epithelial cell andromedin
    • DOI 10.1210/me.6.12.2123
    • Yan G, Fukabori Y, Nikolaropoulos S, Wang F, McKeehan WL. Heparin-binding keratinocyte growth factor is a candidate stromal-to-epithelial-cell andromedin. Mol Endocrinol 1992; 6: 2123-2128. (Pubitemid 23021561)
    • (1992) Molecular Endocrinology , vol.6 , Issue.12 , pp. 2123-2128
    • Yan, G.1    Fukabori, Y.2    Nikolaropoulos, S.3    Wang, F.4    McKeehan, W.L.5
  • 47
    • 0034749483 scopus 로고    scopus 로고
    • Androgen suppression of GnRH-stimulated rat LHβ gene transcription occurs through Sp1 sites in the distal GnRH-responsive promoter region
    • DOI 10.1210/me.15.11.1906
    • Curtin D, Jenkins S, Farmer N, Anderson AC, Haisenleder DJ, Rissman E et al. Androgen suppression of GnRH-stimulated rat LHbeta gene transcription occurs through Sp1 sites in the distal GnRH-responsive promoter region. Mol Endocrinol 2001; 15: 1906-1917. (Pubitemid 33022531)
    • (2001) Molecular Endocrinology , vol.15 , Issue.11 , pp. 1906-1917
    • Curtin, D.1    Jenkins, S.2    Farmer, N.3    Anderson, A.C.4    Haisenleder, D.J.5    Rissman, E.6    Wilson, E.M.7    Shupnik, M.A.8
  • 48
    • 33847057016 scopus 로고    scopus 로고
    • The androgen receptor negatively regulates the expression of c-Met: Implications for a novel mechanism of prostate cancer progression
    • Verras M, Lee J, Xue H, Li TH, Wang Y, Sun Z. The androgen receptor negatively regulates the expression of c-Met: implications for a novel mechanism of prostate cancer progression. Cancer Res 2007; 67: 967-975.
    • (2007) Cancer Res , vol.67 , pp. 967-975
    • Verras, M.1    Lee, J.2    Xue, H.3    Li, T.H.4    Wang, Y.5    Sun, Z.6
  • 50
    • 0034283030 scopus 로고    scopus 로고
    • Beta-catenin affects androgen receptor tran-scriptional activity and ligand specificity
    • Truica CI, Byers S, Gelmann EP. Beta-catenin affects androgen receptor tran-scriptional activity and ligand specificity. Cancer Res 2000; 60: 4709-4713.
    • (2000) Cancer Res , vol.60 , pp. 4709-4713
    • Truica, C.I.1    Byers, S.2    Gelmann, E.P.3
  • 51
    • 0347481364 scopus 로고    scopus 로고
    • Trans-repression of β-Catenin Activity by Nuclear Receptors
    • DOI 10.1074/jbc.M307154200
    • Shah S, Hecht A, Pestell R, Byers SW. Trans-repression of beta-catenin activity by nuclear receptors. J Biol Chem 2003; 278: 48137-48145. (Pubitemid 37523266)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.48 , pp. 48137-48145
    • Shah, S.1    Hecht, A.2    Pestell, R.3    Byers, S.W.4
  • 53
    • 0037028210 scopus 로고    scopus 로고
    • Ligand-dependent inhibition of β-catenin/TCF signaling by androgen receptor
    • DOI 10.1038/sj.onc.1206049
    • Chesire DR, Isaacs WB. Ligand-dependent inhibition of beta-catenin/TCF signaling by androgen receptor. Oncogene 2002; 21: 8453-8469. (Pubitemid 36054886)
    • (2002) Oncogene , vol.21 , Issue.55 , pp. 8453-8469
    • Chesire, D.R.1    Isaacs, W.B.2
  • 54
    • 0041335563 scopus 로고    scopus 로고
    • Functional localization and competition between the androgen receptor and T-cell factor for nuclear β-catenin: A means for inhibition of the Tcf signaling axis
    • DOI 10.1038/sj.onc.1206802
    • Mulholland DJ, Read JT, Rennie PS, Cox ME, Nelson CC. Functional localization and competition between the androgen receptor and T-cell factor for nuclear beta-catenin: a means for inhibition of the Tcf signaling axis. Oncogene 2003; 22: 5602-5613. (Pubitemid 37102696)
    • (2003) Oncogene , vol.22 , Issue.36 , pp. 5602-5613
    • Mulholland, D.J.1    Read, J.T.2    Rennie, P.S.3    Cox, M.E.4    Nelson, C.C.5
  • 55
    • 31344433667 scopus 로고    scopus 로고
    • Activation of β-catenin signaling in prostate cancer by peptidyl-prolyl isomerase pin1-mediated abrogation of the androgen receptor-β-catenin interaction
    • DOI 10.1128/MCB.26.3.929-939.2006
    • Chen SY, Wulf G, Zhou XZ, Rubin MA, Lu KP, Balk SP. Activation of beta-catenin signaling in prostate cancer by peptidyl-prolyl isomerase Pin1-mediated abrogation of the androgen receptor-beta-catenin interaction. Mol Cell Biol 2006; 26: 929-939. (Pubitemid 43146487)
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.3 , pp. 929-939
    • Chen, S.-Y.1    Wulf, G.2    Zhou, X.Z.3    Rubin, M.A.4    Lu, K.P.5    Balk, S.P.6
  • 56
    • 0035824617 scopus 로고    scopus 로고
    • SRY interacts with and negatively regulates androgen receptor transcriptional activity
    • Yuan X, Lu ML, Li T, Balk SP. SRY interacts with and negatively regulates androgen receptor transcriptional activity. J Biol Chem 2001; 276: 46647-46654.
    • (2001) J Biol Chem , vol.276 , pp. 46647-46654
    • Yuan, X.1    Lu, M.L.2    Li, T.3    Balk, S.P.4
  • 58
    • 34250800192 scopus 로고    scopus 로고
    • Alien interacts with the human androgen receptor and inhibits prostate cancer cell growth
    • DOI 10.1210/me.2006-0468
    • Moehren U, Papaioannou M, Reeb CA, Hong W, Baniahmad A. Alien interacts with the human androgen receptor and inhibits prostate cancer cell growth. Mol Endocrinol 2007; 21: 1039-1048. (Pubitemid 46984757)
    • (2007) Molecular Endocrinology , vol.21 , Issue.5 , pp. 1039-1048
    • Moehren, U.1    Papaioannou, M.2    Reeb, C.A.3    Hong, W.4    Baniahmad, A.5
  • 61
    • 0034948672 scopus 로고    scopus 로고
    • Inhibition of androgen receptor-mediated transcription by amino-terminal enhancer of split
    • DOI 10.1128/MCB.21.14.4614-4625.2001
    • Yu X, Li P, Roeder RG, Wang Z. Inhibition of androgen receptor-mediated transcription by amino-terminal enhancer of split. Mol Cell Biol 2001; 21: 4614-4625. (Pubitemid 32588244)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.14 , pp. 4614-4625
    • Yu, X.1    Li, P.2    Roeder, R.G.3    Wang, Z.4
  • 62
    • 33746507785 scopus 로고    scopus 로고
    • The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist-and antagonist-regulated transcription by androgen receptor
    • Yoon HG, Wong J. The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist-and antagonist-regulated transcription by androgen receptor. Mol Endocrinol 2006; 20: 1048-1060.
    • (2006) Mol Endocrinol , vol.20 , pp. 1048-1060
    • Yoon, H.G.1    Wong, J.2
  • 63
    • 85047683640 scopus 로고    scopus 로고
    • Inhibition of the dihydrotestosterone-activated androgen receptor by nuclear receptor corepressor
    • DOI 10.1210/me.16.7.1492
    • Cheng S, Brzostek S, Lee SR, Hollenberg AN, Balk SP. Inhibition of the dihy-drotestosterone-activated androgen receptor by nuclear receptor corepressor. Mol Endocrinol 2002; 16: 1492-1501. (Pubitemid 34743669)
    • (2002) Molecular Endocrinology , vol.16 , Issue.7 , pp. 1492-1501
    • Cheng, S.1    Brzostek, S.2    Lee, S.R.3    Hollenberg, A.N.4    Balk, S.P.5
  • 64
    • 14844288915 scopus 로고    scopus 로고
    • The androgen receptor recruits nuclear receptor corepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists
    • DOI 10.1074/jbc.M408972200
    • Hodgson MC, Astapova I, Cheng S, Lee LJ, Verhoeven MC, Choi E et al. The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists. J Biol Chem 2005; 280: 6511-6519. (Pubitemid 40341200)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.8 , pp. 6511-6519
    • Hodgson, M.C.1    Astapova, I.2    Cheng, S.3    Lee, L.J.4    Verhoeven, M.C.5    Choi, E.6    Balk, S.P.7    Hollenberg, A.N.8
  • 65
    • 0346025352 scopus 로고    scopus 로고
    • Antiandrogen Effects of Mifepristone on Coactivator and Corepressor Interactions with the Androgen Receptor
    • DOI 10.1210/me.2003-0189
    • Song LN, Coghlan M, Gelmann EP. Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor. Mol Endocrinol 2004; 18: 70-85. (Pubitemid 38073155)
    • (2004) Molecular Endocrinology , vol.18 , Issue.1 , pp. 70-85
    • Song, L.-N.1    Coghlan, M.2    Gelmann, E.P.3
  • 66
    • 84863041971 scopus 로고    scopus 로고
    • Cooperation between Polycomb and androgen receptor during oncogenic transformation
    • Zhao JC, Yu J, Runkle C, Wu L, Hu M, Wu D et al. Cooperation between Polycomb and androgen receptor during oncogenic transformation. Genome Res 2012; 22: 322-331.
    • (2012) Genome Res , vol.22 , pp. 322-331
    • Zhao, J.C.1    Yu, J.2    Runkle, C.3    Wu, L.4    Hu, M.5    Wu, D.6
  • 67
    • 84862161257 scopus 로고    scopus 로고
    • A transcriptional repressor co-regulatory network governing androgen response in prostate cancers
    • Chng KR, Chang CW, Tan SK, Yang C, Hong SZ, Sng NY et al. A transcriptional repressor co-regulatory network governing androgen response in prostate cancers. EMBO J 2012; 31: 2810-2823.
    • (2012) EMBO J , vol.31 , pp. 2810-2823
    • Chng, K.R.1    Chang, C.W.2    Tan, S.K.3    Yang, C.4    Hong, S.Z.5    Sng, N.Y.6
  • 69
    • 33847392500 scopus 로고    scopus 로고
    • Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression
    • Wissmann M, Yin N, Muller JM, Greschik H, Fodor BD, Jenuwein T et al. Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol 2007; 9: 347-353.
    • (2007) Nat Cell Biol , vol.9 , pp. 347-353
    • Wissmann, M.1    Yin, N.2    Muller, J.M.3    Greschik, H.4    Fodor, B.D.5    Jenuwein, T.6
  • 70
    • 80054761058 scopus 로고    scopus 로고
    • Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase 1
    • Cai C, He HH, Chen S, Coleman I, Wang H, Fang Z et al. Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase 1. Cancer Cell 2011; 20: 457-471.
    • (2011) Cancer Cell , vol.20 , pp. 457-471
    • Cai, C.1    He, H.H.2    Chen, S.3    Coleman, I.4    Wang, H.5    Fang, Z.6
  • 71
    • 11144332565 scopus 로고    scopus 로고
    • Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
    • DOI 10.1016/j.cell.2004.12.012, PII S0092867404011997
    • Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA et al. Histone deme-thylation mediated by the nuclear amine oxidase homolog LSD1. Cell 2004; 119: 941-953. (Pubitemid 40037608)
    • (2004) Cell , vol.119 , Issue.7 , pp. 941-953
    • Shi, Y.1    Lan, F.2    Matson, C.3    Mulligan, P.4    Whetstine, J.R.5    Cole, P.A.6    Casero, R.A.7    Shi, Y.8
  • 73
    • 58049208232 scopus 로고    scopus 로고
    • Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules
    • Hu Q, Kwon YS, Nunez E, Cardamone MD, Hutt KR, Ohgi KA et al. Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules. Proc Natl Acad Sci USA 2008; 105: 19199-19204.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19199-19204
    • Hu, Q.1    Kwon, Y.S.2    Nunez, E.3    Cardamone, M.D.4    Hutt, K.R.5    Ohgi, K.A.6
  • 74
    • 38149045693 scopus 로고    scopus 로고
    • DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression
    • Perillo B, Ombra MN, Bertoni A, Cuozzo C, Sacchetti S, Sasso A et al. DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression. Science 2008; 319: 202-206.
    • (2008) Science , vol.319 , pp. 202-206
    • Perillo, B.1    Ombra, M.N.2    Bertoni, A.3    Cuozzo, C.4    Sacchetti, S.5    Sasso, A.6
  • 76
    • 37749026136 scopus 로고    scopus 로고
    • Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation
    • Metzger E, Yin N, Wissmann M, Kunowska N, Fischer K, Friedrichs N et al. Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation. Nat Cell Biol 2008; 10: 53-60.
    • (2008) Nat Cell Biol , vol.10 , pp. 53-60
    • Metzger, E.1    Yin, N.2    Wissmann, M.3    Kunowska, N.4    Fischer, K.5    Friedrichs, N.6
  • 77
    • 77950460256 scopus 로고    scopus 로고
    • Phosphor-ylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4
    • Metzger E, Imhof A, Patel D, Kahl P, Hoffmeyer K, Friedrichs N et al. Phosphor-ylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. Nature 2010; 464: 792-796.
    • (2010) Nature , vol.464 , pp. 792-796
    • Metzger, E.1    Imhof, A.2    Patel, D.3    Kahl, P.4    Hoffmeyer, K.5    Friedrichs, N.6
  • 78
    • 80054021222 scopus 로고    scopus 로고
    • Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors
    • Cai C, Chen S, Ng P, Bubley GJ, Nelson PS, Mostaghel EA et al. Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors. Cancer Res 2011; 71: 6503-6513.
    • (2011) Cancer Res , vol.71 , pp. 6503-6513
    • Cai, C.1    Chen, S.2    Ng, P.3    Bubley, G.J.4    Nelson, P.S.5    Mostaghel, E.A.6
  • 82
    • 77952103123 scopus 로고    scopus 로고
    • An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression
    • Yu J, Mani RS, Cao Q, Brenner CJ, Cao X, Wang X et al. An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression. Cancer Cell 2010; 17: 443-454.
    • (2010) Cancer Cell , vol.17 , pp. 443-454
    • Yu, J.1    Mani, R.S.2    Cao, Q.3    Brenner, C.J.4    Cao, X.5    Wang, X.6
  • 84
    • 57349137675 scopus 로고    scopus 로고
    • Androgen-induced programs for prostate epithelial growth and invasion arise in embryogenesis and are reactivated in cancer
    • Schaeffer EM, Marchionni L, Huang Z, Simons B, Blackman A, Yu W et al. Androgen-induced programs for prostate epithelial growth and invasion arise in embryogenesis and are reactivated in cancer. Oncogene 2008; 27: 7180-7191.
    • (2008) Oncogene , vol.27 , pp. 7180-7191
    • Schaeffer, E.M.1    Marchionni, L.2    Huang, Z.3    Simons, B.4    Blackman, A.5    Yu, W.6
  • 86
    • 40949145618 scopus 로고    scopus 로고
    • SOX9 is expressed in human fetal prostate epithelium and enhances prostate cancer invasion
    • DOI 10.1158/0008-5472.CAN-07-5915
    • Wang H, Leav I, Ibaragi S, Wegner M, Hu GF, Lu ML et al. SOX9 is expressed in human fetal prostate epithelium and enhances prostate cancer invasion. Cancer Res 2008; 68: 1625-1630. (Pubitemid 351416545)
    • (2008) Cancer Research , vol.68 , Issue.6 , pp. 1625-1630
    • Wang, H.1    Leav, I.2    Ibaragi, S.3    Wegner, M.4    Hu, G.-F.5    Lu, M.L.6    Balk, S.P.7    Yuan, X.8
  • 87
    • 84874598190 scopus 로고    scopus 로고
    • ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer
    • Cai C, Wang H, He HH, Chen S, He L, Ma F et al. ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer. J Clin Invest 2013; 123: 1109-1122.
    • (2013) J Clin Invest , vol.123 , pp. 1109-1122
    • Cai, C.1    Wang, H.2    He, H.H.3    Chen, S.4    He, L.5    Ma, F.6
  • 88
    • 76249098305 scopus 로고    scopus 로고
    • SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation
    • Thomsen MK, Ambroisine L, Wynn S, Cheah KS, Foster CS, Fisher G et al. SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation. Cancer Res 2010; 70: 979-987.
    • (2010) Cancer Res , vol.70 , pp. 979-987
    • Thomsen, M.K.1    Ambroisine, L.2    Wynn, S.3    Cheah, K.S.4    Foster, C.S.5    Fisher, G.6
  • 90
    • 33846673020 scopus 로고    scopus 로고
    • SOX9 is expressed in normal prostate basal cells and regulates androgen receptor expression in prostate cancer cells
    • DOI 10.1158/0008-5472.CAN-06-1672
    • Wang H, McKnight NC, Zhang T, Lu ML, Balk SP, Yuan X. SOX9 is expressed in normal prostate basal cells and regulates androgen receptor expression in prostate cancer cells. Cancer Res 2007; 67: 528-536. (Pubitemid 46192189)
    • (2007) Cancer Research , vol.67 , Issue.2 , pp. 528-536
    • Wang, H.1    McKnight, N.C.2    Zhang, T.3    Lu, M.L.4    Balk, S.P.5    Yuan, X.6
  • 91
    • 79955068168 scopus 로고    scopus 로고
    • Possible risk factors associated with relpase in patients treated with neoadjuvant chemo-hormonal therapy for high risk prostate cancer
    • Bhatt RS, Werner L, Regan MM, Yannucci J, Ko Y-J, Wang H-Y et al. Possible risk factors associated with relpase in patients treated with neoadjuvant chemo-hormonal therapy for high risk prostate cancer. Open Prostate Cancer J 2011; 4: 1-8.
    • (2011) Open Prostate Cancer J , vol.4 , pp. 1-8
    • Bhatt, R.S.1    Werner, L.2    Regan, M.M.3    Yannucci, J.4    Ko, Y.-J.5    Wang, H.-Y.6
  • 93
    • 84871052080 scopus 로고    scopus 로고
    • EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent
    • Xu K, Wu ZJ, Groner AC, He HH, Cai C, Lis RT et al. EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. Science 2012; 338: 1465-1469.
    • (2012) Science , vol.338 , pp. 1465-1469
    • Xu, K.1    Wu, Z.J.2    Groner, A.C.3    He, H.H.4    Cai, C.5    Lis, R.T.6
  • 94
    • 84863979005 scopus 로고    scopus 로고
    • Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer
    • Hu R, Lu C, Mostaghel EA, Yegnasubramanian S, Gurel M, Tannahill C et al. Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer. Cancer Res 2012; 72: 3457-3462.
    • (2012) Cancer Res , vol.72 , pp. 3457-3462
    • Hu, R.1    Lu, C.2    Mostaghel, E.A.3    Yegnasubramanian, S.4    Gurel, M.5    Tannahill, C.6
  • 95
    • 84861728843 scopus 로고    scopus 로고
    • Androgen receptor splice variants activate androgen receptor target genes and support aberrant prostate cancer cell growth independent of canonical androgen receptor nuclear localization signal
    • Chan SC, Li Y, Dehm SM. Androgen receptor splice variants activate androgen receptor target genes and support aberrant prostate cancer cell growth independent of canonical androgen receptor nuclear localization signal. J Biol Chem 2012; 287: 19736-19749.
    • (2012) J Biol Chem , vol.287 , pp. 19736-19749
    • Chan, S.C.1    Li, Y.2    Dehm, S.M.3
  • 96
    • 84872534568 scopus 로고    scopus 로고
    • Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines
    • Li Y, Chan SC, Brand LJ, Hwang TH, Silverstein KA, Dehm SM. Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines. Cancer Res 2013; 73: 483-489.
    • (2013) Cancer Res , vol.73 , pp. 483-489
    • Li, Y.1    Chan, S.C.2    Brand, L.J.3    Hwang, T.H.4    Silverstein, K.A.5    Dehm, S.M.6
  • 97
    • 0023245164 scopus 로고
    • Effects of castration compared with total androgen blockade on tissue dihydrotestosterone (DHT) concentration in benign prostatic hyperplasia (BPH)
    • Geller J, Albert J. Effects of castration compared with total androgen blockade on tissue dihydrotestosterone (DHT) concentration in benign prostatic hyperplasia (BPH). Urol Res 1987; 15: 151-153. (Pubitemid 17116900)
    • (1987) Urological Research , vol.15 , Issue.3 , pp. 151-153
    • Geller, J.1    Albert, J.2
  • 98
    • 0024318399 scopus 로고
    • Comparison of residual C-19 steroids in plasma and prostatic tissue of human, rat and guinea pig after castration: Unique importance of extratesticular androgens in men
    • DOI 10.1016/0022-4731(89)90514-1
    • Belanger B, Belanger A, Labrie F, Dupont A, Cusan L, Monfette G. Comparison of residual C-19 steroids in plasma and prostatic tissue of human, rat and guinea pig after castration: unique importance of extratesticular androgens in men. J Steroid Biochem 1989; 32: 695-698. (Pubitemid 19176012)
    • (1989) Journal of Steroid Biochemistry , vol.32 , Issue.5 , pp. 695-698
    • Belanger, B.1    Belanger, A.2    Labrie, F.3    Dupont, A.4    Cusan, L.5    Monfette, G.6
  • 99
    • 1642475101 scopus 로고    scopus 로고
    • The Adrenal Androgen Androstenediol Is Present in Prostate Cancer Tissue after Androgen Deprivation Therapy and Activates Mutated Androgen Receptor
    • DOI 10.1158/0008-5472.CAN-03-0130
    • Mizokami A, Koh E, Fujita H, Maeda Y, Egawa M, Koshida K et al. The adrenal androgen androstenediol is present in prostate cancer tissue after androgen deprivation therapy and activates mutated androgen receptor. Cancer Res 2004; 64: 765-771. (Pubitemid 38120921)
    • (2004) Cancer Research , vol.64 , Issue.2 , pp. 765-771
    • Mizokami, A.1    Koh, E.2    Fujita, H.3    Maeda, Y.4    Egawa, M.5    Koshida, K.6    Honma, S.7    Keller, E.T.8    Namiki, M.9
  • 100
    • 8444231965 scopus 로고    scopus 로고
    • The influence of androgen deprivation therapy on dihydrotestosterone levels in the prostatic tissue of patients with prostate cancer
    • DOI 10.1158/1078-0432.CCR-04-0913
    • Nishiyama T, Hashimoto Y, Takahashi K. The influence of androgen deprivation therapy on dihydrotestosterone levels in the prostatic tissue of patients with prostate cancer. Clin Cancer Res 2004; 10: 7121-7126. (Pubitemid 39487695)
    • (2004) Clinical Cancer Research , vol.10 , Issue.21 , pp. 7121-7126
    • Nishiyama, T.1    Hashimoto, Y.2    Takahashi, K.3
  • 103
    • 0021220507 scopus 로고
    • Comparison of prostatic cancer tissue dihydrotestosterone levels at the time of relapse following orchiectomy or estrogen therapy
    • Geller J, Albert JD, Nachtsheim DA, Loza D. Comparison of prostatic cancer tissue dihydrotestosterone levels at the time of relapse following orchiectomy or estrogen therapy. J Urol 1984; 132: 693-696. (Pubitemid 14017006)
    • (1984) Journal of Urology , vol.132 , Issue.4 , pp. 693-696
    • Geller, J.1    Albert, J.D.2    Nachtsheim, D.A.3    Loza, D.4
  • 104
    • 0022389768 scopus 로고
    • Rationale for blockade of adrenal as well as testicular androgens in the treatment of advanced prostate cancer
    • Geller J. Rationale for blockade of adrenal as well as testicular androgens in the treatment of advanced prostate cancer. Semin Oncol 1985; 12: 28-35. (Pubitemid 15149394)
    • (1985) Seminars in Oncology , vol.12 , Issue.1 SUPPL. 1 , pp. 28-35
    • Geller, J.1
  • 106
    • 68049131467 scopus 로고    scopus 로고
    • Reactivation of androgen receptor-regulated TMPRSS2:ERG gene expression in castration-resistant prostate cancer
    • Cai C, Wang H, Xu Y, Chen S, Balk SP. Reactivation of androgen receptor-regulated TMPRSS2:ERG gene expression in castration-resistant prostate cancer. Cancer Res 2009; 69: 6027-6032.
    • (2009) Cancer Res , vol.69 , pp. 6027-6032
    • Cai, C.1    Wang, H.2    Xu, Y.3    Chen, S.4    Balk, S.P.5
  • 107
    • 1542615071 scopus 로고    scopus 로고
    • Dysregulation of Sterol Response Element-Binding Proteins and Downstream Effectors in Prostate Cancer during Progression to Androgen Independence
    • DOI 10.1158/0008-5472.CAN-2148-2
    • Ettinger SL, Sobel R, Whitmore TG, Akbari M, Bradley DR, Gleave ME et al. Dys-regulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence. Cancer Res 2004; 64: 2212-2221. (Pubitemid 38339475)
    • (2004) Cancer Research , vol.64 , Issue.6 , pp. 2212-2221
    • Ettinger, S.L.1    Sobel, R.2    Whitmore, T.G.3    Akbari, M.4    Bradley, D.R.5    Gleave, M.E.6    Nelson, C.C.7
  • 108
    • 51049098138 scopus 로고    scopus 로고
    • Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer
    • Locke JA, Guns ES, Lubik AA, Adomat HH, Hendy SC, Wood CA et al. Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer. Cancer Res 2008; 68: 6407-6415.
    • (2008) Cancer Res , vol.68 , pp. 6407-6415
    • Locke, J.A.1    Guns, E.S.2    Lubik, A.A.3    Adomat, H.H.4    Hendy, S.C.5    Wood, C.A.6
  • 109
    • 67349187469 scopus 로고    scopus 로고
    • Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts
    • Locke JA, Nelson CC, Adomat HH, Hendy SC, Gleave ME, Guns ES. Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts. J Steroid Biochem Mol Biol 2009; 115: 126-136.
    • (2009) J Steroid Biochem Mol Biol , vol.115 , pp. 126-136
    • Locke, J.A.1    Nelson, C.C.2    Adomat, H.H.3    Hendy, S.C.4    Gleave, M.E.5    Guns, E.S.6
  • 110
    • 54849435425 scopus 로고    scopus 로고
    • Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol
    • Dillard PR, Lin MF, Khan SA. Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol. Mol Cell Endocrinol 2008; 295: 115-120.
    • (2008) Mol Cell Endocrinol , vol.295 , pp. 115-120
    • Dillard, P.R.1    Lin, M.F.2    Khan, S.A.3
  • 111
    • 80052827038 scopus 로고    scopus 로고
    • Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: Induction of steroidogenesis and androgen receptor splice variants
    • Mostaghel EA, Marck BT, Plymate SR, Vessella RL, Balk S, Matsumoto AM et al. Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variants. Clin Cancer Res 2011; 17: 5913-5925.
    • (2011) Clin Cancer Res , vol.17 , pp. 5913-5925
    • Mostaghel, E.A.1    Marck, B.T.2    Plymate, S.R.3    Vessella, R.L.4    Balk, S.5    Matsumoto, A.M.6
  • 112
    • 78649888666 scopus 로고    scopus 로고
    • The reti-noblastoma tumor suppressor controls androgen signaling and human prostate cancer progression
    • Sharma A, Yeow WS, Ertel A, Coleman I, Clegg N, Thangavel C et al. The reti-noblastoma tumor suppressor controls androgen signaling and human prostate cancer progression. J Clin Invest 2010; 120: 4478-4492.
    • (2010) J Clin Invest , vol.120 , pp. 4478-4492
    • Sharma, A.1    Yeow, W.S.2    Ertel, A.3    Coleman, I.4    Clegg, N.5    Thangavel, C.6
  • 114
    • 0034125195 scopus 로고    scopus 로고
    • Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor
    • DOI 10.1038/76287
    • Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM et al. Gluco-corticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor. Nat Med 2000; 6: 703-706. (Pubitemid 30398797)
    • (2000) Nature Medicine , vol.6 , Issue.6 , pp. 703-706
    • Zhao, X.-Y.1    Malloy, P.J.2    Krishnan, A.V.3    Swami, S.4    Navone, N.M.5    Peehl, D.M.6    Feldman, D.7
  • 115
    • 0025644325 scopus 로고
    • A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-andro-gens
    • Veldscholte J, Ris-Stalpers C, Kuiper GG, Jenster G, Berrevoets C, Claassen E et al. A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-andro-gens. Biochem Biophys Res Commun 1990; 173: 534-540.
    • (1990) Biochem Biophys Res Commun , vol.173 , pp. 534-540
    • Veldscholte, J.1    Ris-Stalpers, C.2    Kuiper, G.G.3    Jenster, G.4    Berrevoets, C.5    Claassen, E.6
  • 117
    • 48549089747 scopus 로고    scopus 로고
    • Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance
    • Dehm SM, Schmidt LJ, Heemers HV, Vessella RL, Tindall DJ. Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance. Cancer Res 2008; 68: 5469-5477.
    • (2008) Cancer Res , vol.68 , pp. 5469-5477
    • Dehm, S.M.1    Schmidt, L.J.2    Heemers, H.V.3    Vessella, R.L.4    Tindall, D.J.5
  • 118
    • 65549168746 scopus 로고    scopus 로고
    • A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth
    • Guo Z, Yang X, Sun F, Jiang R, Linn DE, Chen H et al. A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth. Cancer Res 2009; 69: 2305-2313.
    • (2009) Cancer Res , vol.69 , pp. 2305-2313
    • Guo, Z.1    Yang, X.2    Sun, F.3    Jiang, R.4    Linn, D.E.5    Chen, H.6
  • 119
    • 58249110391 scopus 로고    scopus 로고
    • Ligand-inde-pendent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer
    • Hu R, Dunn TA, Wei S, Isharwal S, Veltri RW, Humphreys E et al. Ligand-inde-pendent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer. Cancer Res 2009; 69: 16-22.
    • (2009) Cancer Res , vol.69 , pp. 16-22
    • Hu, R.1    Dunn, T.A.2    Wei, S.3    Isharwal, S.4    Veltri, R.W.5    Humphreys, E.6
  • 120
    • 78049280194 scopus 로고    scopus 로고
    • Con-stitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor
    • Watson PA, Chen YF, Balbas MD, Wongvipat J, Socci ND, Viale A et al. Con-stitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor. Proc Natl Acad Sci USA 2010; 107: 16759-16765.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 16759-16765
    • Watson, P.A.1    Chen, Y.F.2    Balbas, M.D.3    Wongvipat, J.4    Socci, N.D.5    Viale, A.6
  • 121
    • 80054931284 scopus 로고    scopus 로고
    • Alternatively spliced androgen receptor variants
    • Dehm SM, Tindall DJ. Alternatively spliced androgen receptor variants. Endocr Relat Cancer 2011; 18: R183-R196.
    • (2011) Endocr Relat Cancer , vol.18
    • Dehm, S.M.1    Tindall, D.J.2
  • 122
    • 77955296562 scopus 로고    scopus 로고
    • Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant
    • Sun S, Sprenger CC, Vessella RL, Haugk K, Soriano K, Mostaghel EA et al. Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant. J Clin Invest 2010; 120: 2715-2730.
    • (2010) J Clin Invest , vol.120 , pp. 2715-2730
    • Sun, S.1    Sprenger, C.C.2    Vessella, R.L.3    Haugk, K.4    Soriano, K.5    Mostaghel, E.A.6
  • 123
    • 81255150464 scopus 로고    scopus 로고
    • Androgen receptor variants occur frequently in castration resistant prostate cancer metastases
    • Zhang X, Morrissey C, Sun S, Ketchandji M, Nelson PS, True LD et al. Androgen receptor variants occur frequently in castration resistant prostate cancer metastases. PLoS ONE 2011; 6: e27970.
    • (2011) PLoS ONE , vol.6
    • Zhang, X.1    Morrissey, C.2    Sun, S.3    Ketchandji, M.4    Nelson, P.S.5    True, L.D.6
  • 124
    • 84869094406 scopus 로고    scopus 로고
    • AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression
    • Li Y, Hwang TH, Oseth LA, Hauge A, Vessella RL, Schmechel SC et al. AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression. Oncogene 2012; 31: 4759-4767.
    • (2012) Oncogene , vol.31 , pp. 4759-4767
    • Li, Y.1    Hwang, T.H.2    Oseth, L.A.3    Hauge, A.4    Vessella, R.L.5    Schmechel, S.C.6
  • 125
    • 77953280591 scopus 로고    scopus 로고
    • Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor
    • Andersen RJ, Mawji NR, Wang J, Wang G, Haile S, Myung JK et al. Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor. Cancer Cell 2010; 17: 535-546.
    • (2010) Cancer Cell , vol.17 , pp. 535-546
    • Andersen, R.J.1    Mawji, N.R.2    Wang, J.3    Wang, G.4    Haile, S.5    Myung, J.K.6
  • 128
    • 33845298019 scopus 로고    scopus 로고
    • Receptor for activated C kinase 1 (RACK1) and Src regulate the tyrosine phosphorylation and function of the androgen receptor
    • DOI 10.1158/0008-5472.CAN-06-0596
    • Kraus S, Gioeli D, Vomastek T, Gordon V, Weber MJ. Receptor for activated C kinase 1 (RACK1) and Src regulate the tyrosine phosphorylation and function of the androgen receptor. Cancer Res 2006; 66: 11047-11054. (Pubitemid 44877005)
    • (2006) Cancer Research , vol.66 , Issue.22 , pp. 11047-11054
    • Kraus, S.1    Gioeli, D.2    Vomastek, T.3    Gordon, V.4    Weber, M.J.5
  • 129
    • 84863245741 scopus 로고    scopus 로고
    • Androgen receptor serine 81 phosphorylation mediates chromatin binding and transcriptional activation
    • Chen S, Gulla S, Cai C, Balk SP. Androgen receptor serine 81 phosphorylation mediates chromatin binding and transcriptional activation. J Biol Chem 2012; 287: 8571-8583.
    • (2012) J Biol Chem , vol.287 , pp. 8571-8583
    • Chen, S.1    Gulla, S.2    Cai, C.3    Balk, S.P.4
  • 131
    • 78649427492 scopus 로고    scopus 로고
    • CDK9 regulates AR promoter selectivity and cell growth through serine 81 phos-phorylation
    • Gordon V, Bhadel S, Wunderlich W, Zhang J, Ficarro SB, Mollah SA et al. CDK9 regulates AR promoter selectivity and cell growth through serine 81 phos-phorylation. Mol Endocrinol 2010; 24: 2267-2280.
    • (2010) Mol Endocrinol , vol.24 , pp. 2267-2280
    • Gordon, V.1    Bhadel, S.2    Wunderlich, W.3    Zhang, J.4    Ficarro, S.B.5    Mollah, S.A.6
  • 132
    • 0347696003 scopus 로고    scopus 로고
    • Suppression Versus Induction of Androgen Receptor Functions by the Phosphatidylinositol 3-Kinase/Akt Pathway in Prostate Cancer LNCaP Cells with Different Passage Numbers
    • DOI 10.1074/jbc.M300676200
    • Lin HK, Hu YC, Yang L, Altuwaijri S, Chen YT, Kang HY et al. Suppression versus induction of androgen receptor functions by the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer LNCaP cells with different passage numbers. J Biol Chem 2003; 278: 50902-50907. (Pubitemid 38020321)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.51 , pp. 50902-50907
    • Lin, H.-K.1    Hu, Y.-C.2    Yang, L.3    Altuwaijri, S.4    Chen, Y.-T.5    Kang, H.-Y.6    Chang, C.7
  • 135
    • 84883199057 scopus 로고    scopus 로고
    • Phosphorylation of the androgen receptor by PIM1 in hormone refractory prostate cancer
    • (e-pub ahead of print 17 September 2012; doi:10.1038/onc.2012.412)
    • Ha S, Iqbal NJ, Mita P, Ruoff R, Gerald WL, Lepor H et al. Phosphorylation of the androgen receptor by PIM1 in hormone refractory prostate cancer. Oncogene (e-pub ahead of print 17 September 2012; doi:10.1038/onc.2012. 412).
    • Oncogene
    • Ha, S.1    Iqbal, N.J.2    Mita, P.3    Ruoff, R.4    Gerald, W.L.5    Lepor, H.6
  • 136
    • 13744257306 scopus 로고    scopus 로고
    • Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation
    • DOI 10.1093/nar/gki141
    • Gaughan L, Logan IR, Neal DE, Robson CN. Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation. Nucleic Acids Res 2005; 33: 13-26. (Pubitemid 40276925)
    • (2005) Nucleic Acids Research , vol.33 , Issue.1 , pp. 13-26
    • Gaughan, L.1    Logan, I.R.2    Neal, D.E.3    Robson, C.N.4
  • 137
  • 138
    • 0036683093 scopus 로고    scopus 로고
    • Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase
    • DOI 10.1093/emboj/cdf406
    • Lin HK, Wang L, Hu YC, Altuwaijri S, Chang C. Phosphorylation-dependent ubi-quitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase. EMBO J 2002; 21: 4037-4048. (Pubitemid 34857436)
    • (2002) EMBO Journal , vol.21 , Issue.15 , pp. 4037-4048
    • Lin, H.-K.1    Wang, L.2    Hu, Y.-C.3    Altuwaijri, S.4    Chang, C.5
  • 139
    • 79955975429 scopus 로고    scopus 로고
    • Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
    • Carver BS, Chapinski C, Wongvipat J, Hieronymus H, Chen Y, Chandarlapaty S et al. Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell 2011; 19: 575-586.
    • (2011) Cancer Cell , vol.19 , pp. 575-586
    • Carver, B.S.1    Chapinski, C.2    Wongvipat, J.3    Hieronymus, H.4    Chen, Y.5    Chandarlapaty, S.6
  • 140
    • 79958764107 scopus 로고    scopus 로고
    • Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth
    • Mulholland DJ, Tran LM, Li Y, Cai H, Morim A, Wang S et al. Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth. Cancer Cell 2011; 19: 792-804.
    • (2011) Cancer Cell , vol.19 , pp. 792-804
    • Mulholland, D.J.1    Tran, L.M.2    Li, Y.3    Cai, H.4    Morim, A.5    Wang, S.6
  • 142
    • 70350036005 scopus 로고    scopus 로고
    • Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1
    • Chen S, Kesler CT, Paschal BM, Balk SP. Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1. J Biol Chem 2009; 284: 25576-25584.
    • (2009) J Biol Chem , vol.284 , pp. 25576-25584
    • Chen, S.1    Kesler, C.T.2    Paschal, B.M.3    Balk, S.P.4
  • 143
    • 63249104202 scopus 로고    scopus 로고
    • Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination
    • Xu K, Shimelis H, Linn DE, Jiang R, Yang X, Sun F et al. Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination. Cancer Cell 2009; 15: 270-282.
    • (2009) Cancer Cell , vol.15 , pp. 270-282
    • Xu, K.1    Shimelis, H.2    Linn, D.E.3    Jiang, R.4    Yang, X.5    Sun, F.6
  • 145
    • 79952155998 scopus 로고    scopus 로고
    • Lysine methylation and functional modulation of androgen receptor by Set9 methyltransferase
    • Ko S, Ahn J, Song CS, Kim S, Knapczyk-Stwora K, Chatterjee B. Lysine methylation and functional modulation of androgen receptor by Set9 methyltransferase. Mol Endocrinol 2011; 25: 433-444.
    • (2011) Mol Endocrinol , vol.25 , pp. 433-444
    • Ko, S.1    Ahn, J.2    Song, C.S.3    Kim, S.4    Knapczyk-Stwora, K.5    Chatterjee, B.6
  • 146
    • 0035361340 scopus 로고    scopus 로고
    • A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy
    • Gregory CW, He B, Johnson RT, Ford OH, Mohler JL, French FS et al. A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy. Cancer Res 2001; 61: 4315-4319. (Pubitemid 32685750)
    • (2001) Cancer Research , vol.61 , Issue.11 , pp. 4315-4319
    • Gregory, C.W.1    He, B.2    Johnson, R.T.3    Ford, O.H.4    Mohler, J.L.5    French, F.S.6    Wilson, E.M.7
  • 149
    • 33751304953 scopus 로고    scopus 로고
    • Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer
    • DOI 10.1158/0008-5472.CAN-06-1023
    • Agoulnik IU, Vaid A, Nakka M, Alvarado M, Bingman 3rd WE, Erdem H et al. Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer. Cancer Res 2006; 66: 10594-10602. (Pubitemid 44799783)
    • (2006) Cancer Research , vol.66 , Issue.21 , pp. 10594-10602
    • Agoulnik, I.U.1    Vaid, A.2    Nakka, M.3    Alvarado, M.4    Bingman III, W.E.5    Erdem, H.6    Frolov, A.7    Smith, C.L.8    Ayala, G.E.9    Ittmann, M.M.10    Weigel, N.L.11
  • 151
    • 33646138230 scopus 로고    scopus 로고
    • JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor
    • Yamane K, Toumazou C, Tsukada Y, Erdjument-Bromage H, Tempst P, Wong J et al. JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell 2006; 125: 483-495.
    • (2006) Cell , vol.125 , pp. 483-495
    • Yamane, K.1    Toumazou, C.2    Tsukada, Y.3    Erdjument-Bromage, H.4    Tempst, P.5    Wong, J.6
  • 153
    • 80054751998 scopus 로고    scopus 로고
    • Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers
    • Kumar A, White TA, MacKenzie AP, Clegg N, Lee C, Dumpit RF et al. Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers. Proc Natl Acad Sci USA 2011; 108: 17087-17092.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 17087-17092
    • Kumar, A.1    White, T.A.2    Mackenzie, A.P.3    Clegg, N.4    Lee, C.5    Dumpit, R.F.6
  • 155
    • 34250365377 scopus 로고    scopus 로고
    • Crystal structure of the T877A human androgen receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational changes and structure-based drug design
    • DOI 10.1074/jbc.M611711200
    • Bohl CE, Wu Z, Miller DD, Bell CE, Dalton JT. Crystal structure of the T877A human androgen receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational changes and structure-based drug design. J Biol Chem 2007; 282: 13648-13655. (Pubitemid 47100516)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.18 , pp. 13648-13655
    • Bohl, C.E.1    Wu, Z.2    Miller, D.D.3    Bell, C.E.4    Dalton, J.T.5
  • 156
    • 0037135630 scopus 로고    scopus 로고
    • Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptor
    • DOI 10.1074/jbc.M203310200
    • Masiello D, Cheng S, Bubley GJ, Lu ML, Balk SP. Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptor. J Biol Chem 2002; 277: 26321-26326. (Pubitemid 34967123)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.29 , pp. 26321-26326
    • Masiello, D.1    Cheng, S.2    Bubley, G.J.3    Lu, M.L.4    Balk, S.P.5
  • 157
    • 27144466425 scopus 로고    scopus 로고
    • Antiandrogens prevent stable DNA-binding of the androgen receptor
    • DOI 10.1242/jcs.02546
    • Farla P, Hersmus R, Trapman J, Houtsmuller AB. Antiandrogens prevent stable DNA-binding of the androgen receptor. J Cell Sci 2005; 118: 4187-4198. (Pubitemid 41488956)
    • (2005) Journal of Cell Science , vol.118 , Issue.18 , pp. 4187-4198
    • Farla, P.1    Hersmus, R.2    Trapman, J.3    Houtsmuller, A.B.4
  • 158
    • 65649090203 scopus 로고    scopus 로고
    • Development of a second-generation antiandrogen for treatment of advanced prostate cancer
    • Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, Arora V et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 2009; 324: 787-790.
    • (2009) Science , vol.324 , pp. 787-790
    • Tran, C.1    Ouk, S.2    Clegg, N.J.3    Chen, Y.4    Watson, P.A.5    Arora, V.6
  • 160
    • 84868089097 scopus 로고    scopus 로고
    • In silico discovery of androgen receptor antagonists with activity in castration resistant prostate cancer
    • Shen HC, Shanmugasundaram K, Simon NI, Cai C, Wang H, Chen S et al. In silico discovery of androgen receptor antagonists with activity in castration resistant prostate cancer. Mol Endocrinol 2012; 26: 1836-1846.
    • (2012) Mol Endocrinol , vol.26 , pp. 1836-1846
    • Shen, H.C.1    Shanmugasundaram, K.2    Simon, N.I.3    Cai, C.4    Wang, H.5    Chen, S.6
  • 161
    • 8344272750 scopus 로고    scopus 로고
    • Coregulator recruitment and histone modifications in transcriptional regulation by the androgen receptor
    • DOI 10.1210/me.2004-0245
    • Kang Z, Janne OA, Palvimo JJ. Coregulator recruitment and histone modifications in transcriptional regulation by the androgen receptor. Mol Endocrinol 2004; 18: 2633-2648. (Pubitemid 39482054)
    • (2004) Molecular Endocrinology , vol.18 , Issue.11 , pp. 2633-2648
    • Kang, Z.1    Janne, O.A.2    Palvimo, J.J.3
  • 162
    • 55749094858 scopus 로고    scopus 로고
    • Structural basis for nuclear receptor corepressor recruitment by antagonist-liganded androgen receptor
    • Hodgson MC, Shen HC, Hollenberg AN, Balk SP. Structural basis for nuclear receptor corepressor recruitment by antagonist-liganded androgen receptor. Mol Cancer Ther 2008; 7: 3187-3194.
    • (2008) Mol Cancer Ther , vol.7 , pp. 3187-3194
    • Hodgson, M.C.1    Shen, H.C.2    Hollenberg, A.N.3    Balk, S.P.4
  • 163
    • 34548595236 scopus 로고    scopus 로고
    • Activity of androgen receptor antagonist bicalutamide in prostate cancer cells is independent of NCoR and SMRT corepressors
    • DOI 10.1158/0008-5472.CAN-07-0617
    • Hodgson MC, Astapova I, Hollenberg AN, Balk SP. Activity of androgen receptor antagonist bicalutamide in prostate cancer cells is independent of NCoR and SMRT corepressors. Cancer Res 2007; 67: 8388-8395. (Pubitemid 47395178)
    • (2007) Cancer Research , vol.67 , Issue.17 , pp. 8388-8395
    • Hodgson, M.C.1    Astapova, I.2    Hollenberg, A.N.3    Balk, S.P.4


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