Inhibition of the dihydrotestosterone-activated androgen receptor by nuclear receptor corepressor

Molecular Endocrinology

Volumn 16, Issue 7, 2002, Pages 1492-1501

  Cheng, Shinta ^a   Brzostek, Sabrina ^b   Lee, Suzanne R ^c   Hollenberg, Anthony N ^d   Balk, Steven P ^a,d  

^a Division of Hematology and Oncology   (United States)

^b Diabetes Unit   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; CELL NUCLEUS RECEPTOR; GLUTATHIONE TRANSFERASE; HISTONE DEACETYLASE; HYBRID PROTEIN; THYROID HORMONE RECEPTOR; NUCLEAR PROTEIN; NUCLEAR RECEPTOR CO REPRESSOR 1; NUCLEAR RECEPTOR CO-REPRESSOR 1; REPRESSOR PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; GENE CONTROL; GENE MUTATION; GENE REPRESSION; GENETIC TRANSCRIPTION; IMMUNOPRECIPITATION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CELL CULTURE; DRUG EFFECT; GENETICS; HUMAN; MAMMAL; METABOLISM; MOLECULAR GENETICS; MUTATION; TWO HYBRID SYSTEM;

ANIMALIA; MAMMALIA;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELLS, CULTURED; DIHYDROTESTOSTERONE; HISTONE DEACETYLASES; HUMANS; MAMMALS; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; RECEPTORS, ANDROGEN; REPRESSOR PROTEINS; TRANSCRIPTION, GENETIC; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 85047683640     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.16.7.0870     Document Type: Article

References (63)

1. Androgen receptor defects: Historical, clinical, and molecular perspectives
2. Mechanisms of androgen receptor activation and function
3. Management of cancer of the prostate
4. Treatment of metastatic prostate cancer. Lessons from the androgen receptor
5. A canonical structure for the ligand-binding domain of nuclear receptors
6. Molecular basis of agonism and antagonism in the oestrogen receptor
7. A signature motif in transcriptional co-activators mediates binding to nuclear receptors
8. The transcriptional coactivator p/CIP binds CBP and mediates nuclear-receptor function
9. Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors
10. Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): Multiple motifs with different binding specificities
11. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
12. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily
13. TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors
14. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
15. GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors
16. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer
17. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300
18. TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1
19. Steroid receptor coactivator-1 is a histone acetyltransferase
20. The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors
21. Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization
22. Transcriptional activation and nuclear targeting signals of the human androgen receptor
23. 2-terminal and steroid-binding domains
24. Ligand-dependent, transcriptionally productive association of the amino- and carboxyl-terminal regions of a steroid hormone nuclear receptor
25. Functional in vivo interaction between the amino-terminal, transactivation domain and the ligand binding domain of the androgen receptor
26. Interaction between the amino- and carboxy-terminal regions of the rat androgen receptor modulates transcriptional activity and is influenced by nuclear receptor coactivators
27. Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF2 (transcriptional intermediary factor 2)
28. FXXLF and WXXLF sequences mediate the NH2-terminal interaction with the ligand binding domain of the androgen receptor
29. Estrogen receptor activation function 1 works by binding p160 coactivator proteins
30. The androgen receptor amino-terminal domain plays a key role in p160 coactivator-stimulated gene transcription
31. The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1
32. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
33. A transcriptional co-repressor that interacts with nuclear hormone receptors
34. Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
35. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression
36. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase
37. Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway
38. The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors
39. Molecular determinants of nuclear receptor-corepressor interaction
40. Mechanism of corepressor binding and release from nuclear hormone receptors
41. The nuclear receptor corepressor (N-CoR) contains three isoleucine motifs (I/LXXII) that serve as receptor interaction domains (IDs)
42. The nuclear corepressors recognize distinct nuclear receptor complexes
43. The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains
44. A novel role for helix 12 of retinoid X receptor in regulating repression
45. The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT
46. Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen
47. A nuclear receptor corepressor modulates transcriptional activity of antagonist-occupied steroid hormone receptor
48. Combinatorial roles of the nuclear receptor corepressor in transcription and development
49. The presence of a transcription activation function in the hormone-binding domain of androgen receptor is revealed by studies in yeast cells
50. Function of nuclear co-repressor protein on thyroid hormone response elements is regulated by the receptor A/B domain
51. A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens
52. Two separate NCoR (nuclear receptor corepressor) interaction domains mediate corepressor action on thyroid hormone response elements
53. Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein
54. Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone
55. Specific recognition of androgens by their nuclear receptor. A structure-function study
56. p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation
57. Sharp, an inducible cofactor that integrates nuclear receptor repression and activation
58. Inhibition of androgen receptor-mediated transcription by amino-terminal enhancer of split
59. Effects of ligand activation of peroxisome proliferator-activated receptor γ in human prostate cancer
60. The human androgen receptor: Domain structure, genomic organization and regulation of expression
61. BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation
62. Androgen receptor-associated protein complex binds upstream of the androgen-responsive elements in the promoters of human prostate-specific antigen and kallikrein 2 genes
63. Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation