Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway

Cell

Volumn 124, Issue 3, 2006, Pages 615-629

  Zhu, Ping ^a   Baek, Sung Hee ^a,c   Bourk, Eliot M ^a   Ohgi, Kenneth A ^a   Garcia Bassets, Ivan ^a   Sanjo, Hideki ^d   Akira, Shizuo ^d   Kotol, Paul F ^d   Glass, Christopher K ^b   Rosenfeld, Michael G ^a   Rose, David W ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Seoul National University   (South Korea)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; CELL NUCLEUS RECEPTOR; INTERLEUKIN 1BETA;

AMINO TERMINAL SEQUENCE; ARTICLE; CANCER CELL; CELL INTERACTION; DEFENSE MECHANISM; HORMONE RESISTANCE; IN VIVO STUDY; MACROPHAGE; PRIORITY JOURNAL;

EID: 32044448683     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2005.12.032     Document Type: Article

References (65)

1. P. Alen, F. Claessens, G. Verhoeven, W. Rombauts, and B. Peeters The androgen receptor amino-terminal domain plays a key role in p160 coactivator-stimulated gene transcription Mol. Cell. Biol. 19 1999 6085 6097
2. L. Alland, R. Muhle, H. Hou Jr., J. Potes, L. Chin, N. Schreiber-Agus, and R.A. DePinho Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression Nature 387 1997 49 55
3. S.H. Baek, K.A. Ohgi, D.W. Rose, E.H. Koo, C.K. Glass, and M.G. Rosenfeld Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-κB and β-amyloid precursor protein Cell 110 2002 55 67
4. C.L. Bevan, S. Hoare, F. Claessens, D.M. Heery, and M.G. Parker The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1 Mol. Cell. Biol. 19 1999 8383 8392
5. C.D. Chen, D.S. Welsbie, C. Tran, S.H. Baek, R. Chen, R. Vessella, M.G. Rosenfeld, and C.L. Sawyers Molecular determinants of resistance to antiandrogen therapy Nat. Med. 10 2004 33 39
6. J.D. Chen, and R.M. Evans A transcriptional co-repressor that interacts with nuclear hormone receptors Nature 377 1995 454 457
7. T.D. Chung, J.J. Yu, M.T. Spiotto, M. Bartkowski, and J.W. Simons Characterization of the role of IL-6 in the progression of prostate cancer Prostate 38 1999 199 207
8. L. Cicatiello, C. Scafoglio, L. Altucci, M. Cancemi, G. Natoli, A. Facchiano, G. Iazzetti, R. Calogero, N. Biglia, and M. De Bortoli A genomic view of estrogen actions in human breast cancer cells by expression profiling of the hormone-responsive transcriptome J. Mol. Endocrinol. 32 2004 719 775
9. K.B. Cleutjens, C.C. van Eekelen, H.A. van der Korput, A.O. Brinkmann, and J. Trapman Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specific antigen promoter J. Biol. Chem. 271 1996 6379 6388
10. P.E. Cohen, K. Nishimura, L. Zhu, and J.W. Pollard Macrophages: important accessory cells for reproductive function J. Leukoc. Biol. 66 1999 765 772
11. J.C. Condon, P. Jevasuria, J.M. Faust, and C.R. Mendelson Surfactant protein secreted by the maturing mouse fetal lung acts as a hormone that signals the initiation of parturition Proc. Natl. Acad. Sci. USA 101 2004 4978 4983
12. L.M. Coussens, and Z. Werb Inflammation and cancer Nature 420 2002 860 867
13. B.D. Darimont, R.L. Wagner, J.W. Apriletti, M.R. Stallcup, P.J. Kushner, J.D. Baxter, R.J. Fletterick, and K.R. Yamamoto Structure and specificity of nuclear receptor-coactivator interactions Genes Dev. 12 1998 3343 3356
14. J.D. Debes, and D.J. Tindall Mechanisms of androgen-refractory prostate cancer N. Engl. J. Med. 351 2004 1488 1490
15. M.J. De los Santos, A. Mercader, A. Frances, E. Portoles, J. Remohi, A. Pellicer, and C. Simon Role of endometrial factors in regulating secretion of components of the immunoreactive human embryonic interleukin-1 system during embryonic development Biol. Reprod. 54 1996 563 574
16. B.J. Feldman, and D. Feldman The development of androgen-independent prostate cancer Nat. Rev. Cancer 1 2001 34 45
17. J. Frasor, J.M. Danes, B. Komm, K.C. Chang, C.R. Lyttle, and B.S. Katzenellenbogen Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype Endocrinology 144 2003 4562 4574
18. C.K. Glass, and M.G. Rosenfeld The coregulator exchange in transcriptional functions of nuclear receptors Genes Dev. 14 2000 121 141
19. V. Gouon-Evans, M.E. Rothenberg, and J.W. Pollard Postnatal mammary gland development requires macrophages and eosinophils Development 127 2000 2269 2282
20. F.R. Greten, L. Eckmann, T.F. Greten, J.M. Park, Z.W. Li, L.J. Egan, M.F. Kagnoff, and M. Karin IKKb links inflammation and tumorigenesis in a mouse model of colitis-associated cancer Cell 118 2004 285 296
21. M.G. Guenther, W.S. Lane, W. Fischle, E. Verdin, M.A. Lazar, and R. Shiekhattar A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness Genes Dev. 4 2000 1048 1057
22. T. Heinzel, R.M. Lavinsky, T.M. Mullen, M. Soderstrom, C.D. Laherty, J. Torchia, W.M. Yang, G. Brard, S.D. Ngo, and J.R. Davie A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression Nature 387 1997 43 48
23. A.J. Hörlein, A.M. Naar, T. Heinzel, J. Torchia, B. Gloss, R. Kurokawa, A. Ryan, Y. Kamei, M. Soderstrom, C.K. Glass, and M.G. Rosenfeld Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor Nature 377 1995 397 404
24. X. Hu, and M.A. Lazar The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors Nature 402 1999 93 96
25. T.A. Jackson, J.K. Richer, D.L. Bain, G.S. Takimoto, L. Tung, and K.B. Horwitz The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT Mol. Endocrinol. 11 1997 693 705
26. M. Jakacka, M. Ito, J. Weiss, P.Y. Chien, B.D. Gehm, and J.L. Jameson Estrogen receptor binding to DNA is not required for its activity through the nonclassical AP1 pathway J. Biol. Chem. 276 2001 13615 13621
27. K. Jepsen, and M.G. Rosenfeld Biological roles and mechanistic actions of co-repressor complexes J. Cell Sci. 115 2002 689 698
28. Y. Kamei, L. Xu, T. Heinzel, J. Torchia, R. Kurokawa, B. Gloss, S.C. Lin, R.A. Heyman, D.W. Rose, C.K. Glass, and M.G. Rosenfeld A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors Cell 85 1996 403 414
29. J.H. Kim, B. Kim, L. Cai, H.J. Choi, K.A. Ohgi, C. Tran, C. Chen, C.H. Chung, O. Huber, and D.W. Rose Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes Nature 434 2005 921 926
30. T. Kusumegi, J. Tanaka, M. Kawano, J. Yonemoto, C. Tohyama, and H. Sone BMP7/ActRIIB regulates estrogen-dependent apoptosis: new biomarkers for environmental estrogens J. Biochem. Mol. Toxicol. 18 2004 1 11
31. J. Laganiere, G. Deblois, C. Lefebvre, A.R. Bataille, F. Robert, and V. Giguere Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response Proc. Natl. Acad. Sci. USA 102 2005 11651 11656
32. R.M. Lavinsky, K. Jepsen, T. Heinzel, J. Torchia, T.M. Mullen, R. Schiff, A.L. Del-Rio, M. Ricote, S. Ngo, and J. Gemsch Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes Proc. Natl. Acad. Sci. USA 95 1998 2920 2925
33. R.D. Leek, C.E. Lewis, R. Whitehouse, M. Greenall, J. Clarke, and A.L. Harris Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma Cancer Res. 56 1996 4625 4629
34. A.C. Li, and C.K. Glass The macrophage foam cell as a target for therapeutic intervention Nat. Med. 8 2002 1235 1242
35. J. Li, J. Wang, J. Wang, Z. Nawaz, J.M. Liu, J. Qin, and J. Wong Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3 EMBO J. 19 2000 4342 4350
36. C.Y. Lin, A. Strom, V.B. Vega, S.L. Kong, A.L. Yeo, J.S. Thomsen, W.C. Chan, B. Doray, D.K. Bangarusamy, and A. Ramasamy Discovery of estrogen receptor alpha target genes and response elements in breast tumor cells Genome Biol. 5 2004 R66
37. Z. Lu, S. Xu, C. Joazeiro, M.H. Cobb, and T. Hunter The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2 Mol. Cell 9 2002 945 956
38. N.J. McKenna, and B.W. O'Malley Combinatorial control of gene expression by nuclear receptors and coregulators Cell 108 2002 465 474
39. D.G. Monroe, D.F. Jin, and M.M. Sanders Estrogen opposes the apoptotic effects of bone morphogenetic protein 7 on tissue remodeling Mol. Cell. Biol. 20 2000 4626 4634
40. L. Nagy, H.Y. Kao, D. Chakravarti, R.J. Lin, C.A. Hassig, D.E. Ayer, S.L. Schreiber, and R.M. Evans Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase Cell 89 1997 373 380
41. L. Nagy, H.Y. Kao, J.D. Love, C. Li, E. Banayo, J.T. Gooch, V. Krishna, K. Chatterjee, R.M. Evans, and J.W.R. Schwabe Mechanism of corepressor binding and release from nuclear hormone receptors Genes Dev. 13 1999 3209 3216
42. R.T. Nolte, G.B. Wisely, S. Westin, J.E. Cobb, M.H. Lambert, R. Kurokawa, M.G. Rosenfeld, T.M. Willson, C.K. Glass, and M.V. Milburn Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ Nature 395 1998 137 143
43. S.A. Onate, V. Boonyaratanakornkit, T.E. Spencer, S.Y. Tsai, M.J. Tsai, D.P. Edwards, and B.W. O'Malley The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors J. Biol. Chem. 273 1998 12101 12108
44. B.C. Paria, W. Ma, J. Tan, S. Raja, S.K. Das, S.K. Dey, and B.L. Hogan Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors Proc. Natl. Acad. Sci. USA 98 2001 1047 1052
45. V. Perissi, L.M. Staszewski, E.M. McInerney, R. Kurokawa, A. Krones, D.W. Rose, M.H. Lambert, M.V. Milburn, C.K. Glass, and M.G. Rosenfeld Molecular determinants of nuclear receptor-corepressor interaction Genes Dev. 13 1999 3198 3208
46. V. Perissi, A. Aggarwal, C.K. Glass, D.W. Rose, and M.G. Rosenfeld A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors Cell 116 2004 511 526
47. J. Reid, S.M. Kelly, K. Watt, N.C. Price, and I.J. McEwan Conformational analysis of the androgen receptor amino-terminal domain involved in transactivation. Influence of structure-stabilizing solutes and protein-protein interactions J. Biol. Chem. 277 2002 20079 20086
48. S. Sande, and M.L. Privalsky Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors Mol. Endocrinol. 10 1996 813 825
49. H. Sanjo, K. Takeda, T. Tsujimura, J. Ninomiya-Tsuji, K. Matsumoto, and S. Akira TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling Mol. Cell. Biol. 23 2003 1231 1238
50. Y. Shang, X. Hu, J. DiRenzo, M.A. Lazar, and M. Brown Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription Cell 103 2000 843 852
51. Y. Shang, M. Myers, and M. Brown Formation of the androgen receptor transcription complex Mol. Cell 9 2002 601 610
52. A.K. Shiau, D. Barstad, P.M. Loria, L. Cheng, P.J. Kushner, D.A. Agard, and G.L. Greene The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen Cell 95 1998 927 937
53. S. Shimura, G. Yang, S. Ebara, T.M. Wheeler, A. Frolov, and T.C. Thompson Reduced infiltration of tumor-associated macrophages in human prostate cancer: association with cancer progression Cancer Res. 60 2000 5857 5861
54. C.L. Smith, Z. Nawaz, and B.W. O'Malley Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen Mol. Endocrinol. 11 1997 657 666
55. M. Suzuki, H. Suzuki, Y. Sugimoto, and Y. Sugiyama ABCG2 transports sulfated conjugates of steroids and xenobiotics J. Biol. Chem. 278 2003 22644 22649
56. G. Takaesu, S. Kishida, A. Hiyama, K. Yamaguchi, H. Shibuya, K. Irie, J. Ninomiya-Tsuji, and K. Matsumoto TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway Mol. Cell 5 2000 649 658
57. A. Tremblay, G.B. Tremblay, F. Labrie, and V. Giguere Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1 Mol. Cell 3 1999 513 519
58. C. Underhill, M.S. Qutob, S.P. Yee, and J. Torchia A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1 J. Biol. Chem. 275 2000 40463 40470
59. S.P. Weisberg, D. McCann, M. Desai, M. Rosenbaum, R.L. Leibel, and A.W. Ferrante Jr. Obesity is associated with macrophage accumulation in adipose tissue J. Clin. Invest. 112 2003 1796 1808
60. Y.-D. Wen, V. Perissi, L.M. Staszewski, W.-M. Yang, A. Krones, C.K. Glass, M.G. Rosenfeld, and E. Seto The histone deacetylase-3 complex contains nuclear receptor corepressors Proc. Natl. Acad. Sci. USA 97 2000 7202 7207
61. H. Xu, G.T. Barnes, Q. Yang, G. Tan, D. Yang, C.J. Chou, J. Sole, A. Nichols, J.S. Ross, L.A. Tartaglia, and H. Chen Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance J. Clin. Invest. 112 2003 1821 1830
62. H.G. Yoon, D.W. Chan, Z.Q. Huang, J. Li, J.D. Fondell, J. Qin, and J. Wong Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1 EMBO J. 22 2003 1336 1346
63. J. Zhang, M. Kalkum, B.T. Chait, and R.G. Roeder The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2 Mol. Cell 9 2002 611 623
64. Y. Zhang, H.H. Ng, H. Erdjument-Bromage, P. Tempst, A. Bird, and D. Reinberg Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation Genes Dev. 13 1999 1924 1935
65. P. Zhu, E. Martin, J. Mengwasser, P. Schlag, K.P. Janssen, and M. Gottlicher Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis Cancer Cell 5 2004 455 463