Mechanotransduction and fibrosis

Journal of Biomechanics

Volumn 47, Issue 9, 2014, Pages 1997-2005

  Duscher, Dominik ^a   Maan, Zeshaan N ^a   Wong, Victor W ^b   Rennert, Robert C ^a   Januszyk, Michael ^a   Rodrigues, Melanie ^a   Hu, Michael ^a   Whitmore, Arnetha J ^a   Whittam, Alexander J ^a   Longaker, Michael T ^a   Gurtner, Geoffrey C ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Fibrosis; Mechanical signaling; Mechanotransduction; Scarring

Indexed keywords

BIOMECHANICS; MECHANICS;

BIOCHEMICAL MECHANISMS; BIOCHEMICAL STIMULI; FIBROSIS; MECHANO-TRANSDUCTION PATHWAYS; MECHANOTRANSDUCTION; RECENT RESEARCHES; SCARRING; SIGNALING PATHWAYS;

MECHANICAL ENGINEERING;

ANTIFIBROTIC AGENT; COLLAGEN; IMATINIB; METELIMUMAB; PROTEIN ANTIBODY; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA1 ANTIBODY; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA2 ANTIBODY; TRANSFORMING GROWTH FACTOR BETA3; TRANSFORMING GROWTH FACTOR BETA3 ANTIBODY; UNCLASSIFIED DRUG;

ARTICLE; BIOMECHANICS; CELL PROLIFERATION; COLLAGEN SYNTHESIS; DEVELOPMENTAL STAGE; DISEASE COURSE; EXTRACELLULAR MATRIX; FIBROBLAST; FIBROSIS; HUMAN; IN VIVO STUDY; INFLAMMATION; MECHANICAL STRESS; MECHANOTRANSDUCTION; MOLECULARLY TARGETED THERAPY; MORBIDITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; SCAR FORMATION; SCLERODERMA; SIGNAL TRANSDUCTION; SKIN SCAR; SYSTEMIC SCLEROSIS; UNITED STATES;

FIBROSIS; MECHANICAL SIGNALING; MECHANOTRANSDUCTION; SCARRING;

ANIMALS; CICATRIX; FIBROSIS; HUMANS; MECHANOTRANSDUCTION, CELLULAR;

EID: 84901625332     PISSN: 00219290     EISSN: 18732380     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2014.03.031     Document Type: Article

References (160)

1. Aarabi S., Bhatt K.A., Shi Y., Paterno J., Chang E.I., Loh S.A., Holmes J.W., Longaker M.T., Yee H., Gurtner G.C. Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis. FASEB J. 2007, 21(12):3250-3261.
2. Agha R., Ogawa R., Pietramaggiori G., Orgill D.P. A review of the role of mechanical forces in cutaneous wound healing. J. Surg. Res. 2011, 171(2):700-708.
3. Agrawal C., Ray R.B. Biodegradable polymeric scaffolds for musculoskeletal tissue engineering. J. Biomed. Mater. Res. 2001, 55(2):141-150.
4. Akaishi S., Akimoto M., Hyakusoku H., Ogawa R. The tensile reduction effects of silicone gel sheeting. Plast. Reconstr. Surg. 2010, 126(2):109e-111e.
5. Alenghat F.J., Ingber D.E. Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins. Sci. STKE 2002, 2002(119):pe6.
6. Altman G.H., Lu H.H., Horan R.L., Calabro T., Ryder D., Kaplan D.L., Stark P., Martin I., Richmond J.C., Vunjak-Novakovic G. Advanced bioreactor with controlled application of multi-dimensional strain for tissue engineering. J. Biomech. Eng. 2002, 124(6):742-749.
7. Atkinson J.A., McKenna K.T., Barnett A.G., McGrath D.J., Rudd M. A randomized, controlled trial to determine the efficacy of paper tape in preventing hypertrophic scar formation in surgical incisions that traverse Langer's skin tension lines. Plast. Reconstr. Surg. 2005, 116(6):1648-1656. (discussion 1657-1648).
8. Moore B.B., Lawson W.E., Oury T.D., Sisson T.H., Raghavendran K., Hogaboam C.M. Animal models of fibrotic lung disease. Am. J. Respir. Cell Mol. Biol. 2013, 49(2):167-179.
9. Baneyx G., Baugh L., Vogel V. Fibronectin extension and unfolding within cell matrix fibrils controlled by cytoskeletal tension. Proc. Natl. Acad. Sci. USA 2002, 99(8):5139-5143.
10. Barry S.P., Davidson S.M., Townsend P.A. Molecular regulation of cardiac hypertrophy. Int. J. Biochem. Cell Biol. 2008, 40(10):2023-2039.
11. Barry-Hamilton V., Spangler R., Marshall D., McCauley S., Rodriguez H.M., Oyasu M., Mikels A., Vaysberg M., Ghermazien H., Wai C., Garcia C.A., Velayo A.C., Jorgensen B., Biermann D., Tsai D., Green J., Zaffryar-Eilot S., Holzer A., Ogg S., Thai D., Neufeld G., Van Vlasselaer P., Smith V. Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment. Nat. Med. 2010, 16(9):1009-1017.
12. Bassett C.A., Herrmann I. Influence of oxygen concentration and mechanical factors on differentiation of connective tissues in vitro. Nature 1961, 190:460-461.
13. Bell E., Ehrlich H.P., Buttle D.J., Nakatsuji T. Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness. Science 1981, 211(4486):1052-1054.
14. Bell E., Ivarsson B., Merrill C. Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro. Proc. Natl. Acad. Sci. USA 1979, 76(3):1274-1278.
15. Beyer C., Reichert H., Akan H., Mallano T., Schramm A., Dees C., Palumbo-Zerr K., Lin N.Y., Distler A., Gelse K., Varga J., Distler O., Schett G., Distler J.H. Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis. Ann. Rheum. Dis. 2013, 72(7):1255-1258.
16. Brown A.C., Fiore V.F., Sulchek T.A., Barker T.H. Physical and chemical microenvironmental cues orthogonally control the degree and duration of fibrosis-associated epithelial-to-mesenchymal transitions. J. Pathol. 2013, 229(1):25-35.
17. Buscemi L., Ramonet D., Klingberg F., Formey A., Smith-Clerc J., Meister J.J., Hinz B. The single-molecule mechanics of the latent TGF-beta1 complex. Curr. Biol. 2011, 21(24):2046-2054.
18. Buxboim A., Ivanovska I.L., Discher D.E. Matrix elasticity, cytoskeletal forces and physics of the nucleus: how deeply do cells 'feel' outside and in?. J. Cell Sci. 2010, 123(Pt 3):297-308.
19. Carver W., Goldsmith E.C. Regulation of tissue fibrosis by the biomechanical environment. Biomed. Res. Int. 2013, 2013:101979.
20. Chang, Z., Y. Kishimoto, A. Hasan and N.V. Welham (2013). TGF-beta3 modulates the inflammatory environment and reduces scar formation following vocal fold mucosal injury. Dis. Models Mech.
21. Chen J.H., Chen W.L., Sider K.L., Yip C.Y., Simmons C.A. beta-catenin mediates mechanically regulated, transforming growth factor-beta1-induced myofibroblast differentiation of aortic valve interstitial cells. Arterioscler. Thromb. Vasc. Biol. 2011, 31(3):590-597.
22. Chen W., Frangogiannis N.G. Fibroblasts in post-infarction inflammation and cardiac repair. Biochim. Biophys. Acta 2013, 1833(4):945-953.
23. Chen Y., Pasapera A.M., Koretsky A.P., Waterman C.M. Orientation-specific responses to sustained uniaxial stretching in focal adhesion growth and turnover. Proc. Natl. Acad. Sci. USA 2013, 110(26):E2352-E2361.
24. Cheon S.S., Cheah A.Y., Turley S., Nadesan P., Poon R., Clevers H., Alman B.A. beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds. Proc. Natl. Acad. Sci. USA 2002, 99(10):6973-6978.
25. Chin M.S., Lancerotto L., Helm D.L., Dastouri P., Prsa M.J., Ottensmeyer M., Akaishi S., Orgill D.P., Ogawa R. Analysis of neuropeptides in stretched skin. Plast. Reconstr. Surg. 2009, 124(1):102-113.
26. Chiquet M., Tunc-Civelek V., Sarasa-Renedo A. Gene regulation by mechanotransduction in fibroblasts. Appl. Physiol. Nutr. Metab. 2007, 32(5):967-973.
27. Cromar G.L., Xiong X., Chautard E., Ricard-Blum S., Parkinson J. Toward a systems level view of the ECM and related proteins: a framework for the systematic definition and analysis of biological systems. Proteins 2012, 80(6):1522-1544.
28. Curtis A.S., Seehar G.M. The control of cell division by tension or diffusion. Nature 1978, 274(5666):52-53.
29. Dallon J.C., Ehrlich H.P. A review of fibroblast-populated collagen lattices. Wound Repair Regen. 2008, 16(4):472-479.
30. Denton C.P., Merkel P.A., Furst D.E., Khanna D., Emery P., Hsu V.M., Silliman N., Streisand J., Powell J., Akesson A., Coppock J., Hoogen F., Herrick A., Mayes M.D., Veale D., Haas J., Ledbetter S., Korn J.H., Black C.M., Seibold J.R. Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192. Arthritis Rheum. 2007, 56(1):323-333.
31. Derderian C.A., Bastidas N., Lerman O.Z., Bhatt K.A., Lin S.E., Voss J., Holmes J.W., Levine J.P., Gurtner G.C. Mechanical strain alters gene expression in an in vitro model of hypertrophic scarring. Ann. Plast. Surg. 2005, 55(1):69-75. (discussion 75).
32. Diao J.S., Xia W.S., Yi C.G., Yang Y., Zhang X., Xia W., Shu M.G., Wang Y.M., Gui L., Guo S.Z. Histone deacetylase inhibitor reduces hypertrophic scarring in a rabbit ear model. Plast. Reconstr. Surg. 2013, 132(1):61e-69e.
33. Discher D.E., Janmey P., Wang Y.L. Tissue cells feel and respond to the stiffness of their substrate. Science 2005, 310(5751):1139-1143.
34. Doyle J.J., Gerber E.E., Dietz H.C. Matrix-dependent perturbation of TGFbeta signaling and disease. FEBS Lett. 2012, 586(14):2003-2015.
35. Drakos S.G., Kfoury A.G., Selzman C.H., Verma D.R., Nanas J.N., Li D.Y., Stehlik J. Left ventricular assist device unloading effects on myocardial structure and function: current status of the field and call for action. Curr. Opin. Cardiol. 2011, 26(3):245-255.
36. Dumbauld D.W., Lee T.T., Singh A., Scrimgeour J., Gersbach C.A., Zamir E.A., Fu J., Chen C.S., Curtis J.E., Craig S.W., Garcia A.J. How vinculin regulates force transmission. Proc. Natl. Acad. Sci. USA 2013, 110(24):9788-9793.
37. Dupont S., Morsut L., Aragona M., Enzo E., Giulitti S., Cordenonsi M., Zanconato F., Le Digabel J., Forcato M., Bicciato S., Elvassore N., Piccolo S. Role of YAP/TAZ in mechanotransduction. Nature 2011, 474(7350):179-183.
38. Eckes B., Zweers M.C., Zhang Z.G., Hallinger R., Mauch C., Aumailley M., Krieg T. Mechanical tension and integrin alpha 2 beta 1 regulate fibroblast functions. J. Investig. Dermatol. Symp. Proc. 2006, 11(1):66-72.
39. Engrav L.H., Heimbach D.M., Rivara F.P., Moore M.L., Wang J., Carrougher G.J., Costa B., Numhom S., Calderon J., Gibran N.S. 12-Year within-wound study of the effectiveness of custom pressure garment therapy. Burns 2010, 36(7):975-983.
40. Folkman J., Greenspan H.P. Influence of geometry on control of cell growth. Biochim. Biophys. Acta 1975, 417(3-4):211-236.
41. Forster T. Zwischenmolekulare energiewanderung und fluoreszenz. Ann. Phys. 1948, 2(1-2):55-75.
42. Freed L.E., Langer R., Martin I., Pellis N.R., Vunjak-Novakovic G. Tissue engineering of cartilage in space. Proc. Natl. Acad. Sci. 1997, 94(25):13885-13890.
43. Fuller, B., 1961. Tensegrity. Portfolio and Art News Annual no. 4. pp. 112-127, 144, 148.
44. Gieni R.S., Hendzel M.J. Mechanotransduction from the ECM to the genome: are the pieces now in place?. J. Cell. Biochem. 2008, 104(6):1964-1987.
45. Goto M., Ikeyama K., Tsutsumi M., Denda S., Denda M. Calcium ion propagation in cultured keratinocytes and other cells in skin in response to hydraulic pressure stimulation. J. Cell. Physiol. 2010, 224(1):229-233.
46. Grinnell F., Petroll W.M. Cell motility and mechanics in three-dimensional collagen matrices. Annu. Rev. Cell Dev. Biol. 2010, 26:335-361.
47. Gurtner G.C., Dauskardt R.H., Wong V.W., Bhatt K.A., Wu K., Vial I.N., Padois K., Korman J.M., Longaker M.T. Improving cutaneous scar formation by controlling the mechanical environment: large animal and phase I studies. Ann. Surg. 2011, 254(2):217-225.
48. Gurtner G.C., Werner S., Barrandon Y., Longaker M.T. Wound repair and regeneration. Nature 2008, 453(7193):314-321.
49. Guvendiren M., Burdick J.A. Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics. Nat. Commun. 2012, 3:792.
50. Hadjipanayi E., Mudera V., Brown R.A. Close dependence of fibroblast proliferation on collagen scaffold matrix stiffness. J. Tissue Eng. Regen. Med. 2009, 3(2):77-84.
51. Halder G., Dupont S., Piccolo S. Transduction of mechanical and cytoskeletal cues by YAP and TAZ. Nat. Rev. Mol. Cell Biol. 2012, 13(9):591-600.
52. Haudek S.B., Gupta D., Dewald O., Schwartz R.J., Wei L., Trial J., Entman M.L. Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation. Cardiovasc. Res. 2009, 83(3):511-518.
53. Heallen T., Zhang M., Wang J., Bonilla-Claudio M., Klysik E., Johnson R.L., Martin J.F. Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science 2011, 332(6028):458-461.
54. Heineke J., Molkentin J.D. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat. Rev. Mol. Cell Biol. 2006, 7(8):589-600.
55. Heise R.L., Stober V., Cheluvaraju C., Hollingsworth J.W., Garantziotis S. Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity. J. Biol. Chem. 2011, 286(20):17435-17444.
56. Hiemer S.E., Varelas X. Stem cell regulation by the Hippo pathway. Biochim. Biophys. Acta 2013, 1830(2):2323-2334.
57. Hinz B. Tissue stiffness, latent TGF-beta1 activation, and mechanical signal transduction: implications for the pathogenesis and treatment of fibrosis. Curr. Rheumatol. Rep. 2009, 11(2):120-126.
58. Hofmann M., Zaper J., Bernd A., Bereiter-Hahn J., Kaufmann R., Kippenberger S. Mechanical pressure-induced phosphorylation of p38 mitogen-activated protein kinase in epithelial cells via Src and protein kinase C. Biochem. Biophys. Res. Commun. 2004, 316(3):673-679.
59. Horn A., Kireva T., Palumbo-Zerr K., Dees C., Tomcik M., Cordazzo C., Zerr P., Akhmetshina A., Ruat M., Distler O., Beyer C., Schett G., Distler J.H. Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis. Ann. Rheum. Dis. 2012, 71(5):785-789.
60. Huang C., Akaishi S., Ogawa R. Mechanosignaling pathways in cutaneous scarring. Arch. Dermatol. Res. 2012, 304(8):589-597.
61. Huang S., Ingber D.E. Cell tension, matrix mechanics, and cancer development. Cancer Cell 2005, 8(3):175-176.
62. Huang X., Yang N., Fiore V.F., Barker T.H., Sun Y., Morris S.W., Ding Q., Thannickal V.J., Zhou Y. Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction. Am. J. Respir. Cell Mol. Biol. 2012, 47(3):340-348.
63. Hubmacher D., Apte S.S. The biology of the extracellular matrix: novel insights. Curr. Opin. Rheumatol. 2013, 25(1):65-70.
64. Huxley-Jones J., Pinney J.W., Archer J., Robertson D.L., Boot-Handford R.P. Back to basics-how the evolution of the extracellular matrix underpinned vertebrate evolution. Int. J. Exp. Pathol. 2009, 90(2):95-100.
65. Hynes R.O. The extracellular matrix: not just pretty fibrils. Science 2009, 326(5957):1216-1219.
66. Ingber D.E. The architecture of life. Sci. Am. 1998, 278(1):48-57.
67. Ingber D.E. Tensegrity-based mechanosensing from macro to micro. Prog. Biophys. Mol. Biol. 2008, 97(2-3):163-179.
68. Jaalouk D.E., Lammerding J. Mechanotransduction gone awry. Nat. Rev. Mol. Cell Biol. 2009, 10(1):63-73.
69. Kadi A., Fawzi-Grancher S., Lakisic G., Stoltz J.F., Muller S. Effect of cyclic stretching and TGF-beta on the SMAD pathway in fibroblasts. Biomed. Mater. Eng. 2008, 18(Suppl 1):S77-S86.
70. Kenny P.A., Bissell M.J. Tumor reversion: correction of malignant behavior by microenvironmental cues. Int. J. Cancer 2003, 107(5):688-695.
71. King T.E., Pardo A., Selman M. Idiopathic pulmonary fibrosis. Lancet 2011, 378(9807):1949-1961.
72. Kinoshita, Aono, Azuma, Kishi, Takezaki, Kishi, Makino, Okazaki, Uehara, Izumi, Sone, Nishioka Antifibrotic effects of focal adhesion kinase inhibitor in bleomycin-induced pulmonary fibrosis in mice. Am. J. Respir. Cell Mol. Biol. 2013, 49(4):536-543.
73. Kook S.H., Jang Y.S., Lee J.C. Involvement of JNK-AP-1 and ERK-NF-kappaB signaling in tension-stimulated expression of type I collagen and MMP-1 in human periodontal ligament fibroblasts. J. Appl. Physiol. (1985) 2011, 111(6):1575-1583.
74. Korossis S., Bolland F., Ingham E., Fisher J., Kearney J., Southgate J. Review: tissue engineering of the urinary bladder: considering structure-function relationships and the role of mechanotransduction. Tissue Eng. 2006, 12(4):635-644.
75. Lagares D., Busnadiego O., Garcia-Fernandez R.A., Kapoor M., Liu S., Carter D.E., Abraham D., Shi-Wen X., Carreira P., Fontaine B.A., Shea B.S., Tager A.M., Leask A., Lamas S., Rodriguez-Pascual F. Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation. Arthritis Rheum. 2012, 64(5):1653-1664.
76. Lambert C.A., Soudant E.P., Nusgens B.V., Lapiere C.M. Pretranslational regulation of extracellular matrix macromolecules and collagenase expression in fibroblasts by mechanical forces. Lab. Invest. 1992, 66(4):444-451.
77. Lancerotto L., Bayer L.R., Orgill D.P. Mechanisms of action of microdeformational wound therapy. Semin. Cell Dev. Biol. 2012, 23(9):987-992.
78. Langer K. Zur Anatomie und Physiologie der Haut. Über die Spaltbarkeit der Cutis. Sitzungsbericht der Mathematisch-naturwissenschaftlichen Classe der Wiener Kaiserlichen Academie der Wissenschaften 1861.
79. Leask A., Abraham D.J. TGF-beta signaling and the fibrotic response. FASEB J. 2004, 18(7):816-827.
80. LeBleu V.S., Taduri G., Oconnell J., Teng Y., Cooke V.G., Woda C., Sugimoto H., Kalluri R. Origin and function of myofibroblasts in kidney fibrosis. Nat. Med. 2013, 19(8):1047-1053.
81. Lee, Ran Byun, Furutani-Seiki, Hong, Jung YAP and TAZ regulate skin wound healing. J. Invest. Dermatol. 2013, 134:518-525.
82. Lele T.P., Sero J.E., Matthews B.D., Kumar S., Xia S., Montoya-Zavala M., Polte T., Overby D., Wang N., Ingber D.E. Tools to study cell mechanics and mechanotransduction. Methods Cell Biol. 2007, 83:443-472.
83. Lemmon C.A., Chen C.S., Romer L.H. Cell traction forces direct fibronectin matrix assembly. Biophys. J. 2009, 96(2):729-738.
84. Li-Tsang C.W., Zheng Y.P., Lau J.C. A randomized clinical trial to study the effect of silicone gel dressing and pressure therapy on posttraumatic hypertrophic scars. J. Burn Care Res. 2010, 31(3):448-457.
85. Lim, Weintraub, Kaplan, Januszyk, Cowley, McLaughlin, Beasley, Gurtner, Longaker The embrace device significantly decreases scarring following scar revision surgery in a randomized control trial. Plast. Reconstr. Surg. 2013, 133(2):398-405.
86. Liu W., Chua C.H., Wu X.L., Wang D.R., Yin D.M., Cui L., Cao Y.L., Longaker M.T. Inhibiting scar formation in rat cutaneous wounds by blocking TGF-beta signaling. Zhonghua Yi Xue Za Zhi 2003, 83(1):31-36.
87. Mammoto A., Mammoto T., Ingber D.E. Mechanosensitive mechanisms in transcriptional regulation. J. Cell Sci. 2012, 125(Pt 13):3061-3073.
88. Mammoto T., Ingber D.E. Mechanical control of tissue and organ development. Development 2010, 137(9):1407-1420.
89. Margadant C., Sonnenberg A. Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing. EMBO Rep. 2010, 11(2):97-105.
90. McCormick L.L., Zhang Y., Tootell E., Gilliam A.C. Anti-TGF-beta treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: a model for human scleroderma. J Immunol 1999, 163(10):5693-5699.
91. Moeller A., Ask K., Warburton D., Gauldie J., Kolb M. The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?. Int. J. Biochem. Cell Biol. 2008, 40(3):362-382.
92. Morris H.L., Reed C.I., Haycock J.W., Reilly G.C. Mechanisms of fluid-flow-induced matrix production in bone tissue engineering. Proc. Inst. Mech. Eng. H 2010, 224(12):1509-1521.
93. Mouratis M.A., Aidinis V. Modeling pulmonary fibrosis with bleomycin. Curr. Opin. Pulm. Med. 2011, 17(5):355-361.
94. Kolb M.R., Gauldie J. Idiopathic pulmonary fibrosis: the matrix is the message. Am. J. Respir. Crit. Care Med. 2011, 184(6):627-629.
95. Mullender M., El Haj A., Yang Y., Van Duin M., Burger E., Klein-Nulend J. Mechanotransduction of bone cellsin vitro: mechanobiology of bone tissue. Med. Biol. Eng. Comput. 2004, 42(1):14-21.
96. Murata H., Zhou L., Ochoa S., Hasan A., Badiavas E., Falanga V. TGF-beta3 stimulates and regulates collagen synthesis through TGF-beta1-dependent and independent mechanisms. J. Invest. Dermatol. 1997, 108(3):258-262.
97. Na S., Wang N. Application of fluorescence resonance energy transfer and magnetic twisting cytometry to quantitate mechano-chemical signaling activities in a living cell. Sci. Signal. 2008, 1(34). (nihpa69932).
98. Nakagome K., Dohi M., Okunishi K., Tanaka R., Miyazaki J., Yamamoto K. in vivo IL-10 gene delivery attenuates bleomycin induced pulmonary fibrosis by inhibiting the production and activation of TGF-beta in the lung. Thorax 2006, 61(10):886-894.
99. Noguera R., Nieto O.A., Tadeo I., Farinas F., Alvaro T. Extracellular matrix, biotensegrity and tumor microenvironment. An update and overview. Histol. Histopathol. 2012, 27(6):693-705.
100. OKane S., Ferguson M.W. Transforming growth factor beta s and wound healing. Int. J. Biochem. Cell Biol. 1997, 29(1):63-78.
101. Occleston N.L., O'Kane S., Goldspink N., Ferguson M.W. New therapeutics for the prevention and reduction of scarring. Drug Discov. Today 2008, 13(21-22):973-981.
102. Ogawa R., Hsu C.K. Mechanobiological dysregulation of the epidermis and dermis in skin disorders and in degeneration. J. Cell. Mol. Med. 2013, 17(7):817-822.
103. Ohno S., Hirano S., Kanemaru S., Kitani Y., Kojima T., Ishikawa S., Mizuta M., Tateya I., Nakamura T., Ito J. Transforming growth factor beta3 for the prevention of vocal fold scarring. Laryngoscope 2012, 122(3):583-589.
104. Olsen K.C., Sapinoro R.E., Kottmann R.M., Kulkarni A.A., Iismaa S.E., Johnson G.V., Thatcher T.H., Phipps R.P., Sime P.J. Transglutaminase 2 and its role in pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2011, 184(6):699-707.
105. Oschman J.L. Charge transfer in the living matrix. J. Bodyw. Mov. Ther. 2009, 13(3):215-228.
106. Ott H.C., Matthiesen T.S., Goh S.K., Black L.D., Kren S.M., Netoff T.I., Taylor D.A. Perfusion-decellularized matrix: using nature[U+05F3]s platform to engineer a bioartificial heart. Nat. Med. 2008, 14(2):213-221.
107. Parker K.K., Ingber D.E. Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering. Philos. Trans. R. Soc. B: Biol. Sci. 2007, 362(1484):1267-1279.
108. Pathak A., Kumar S. Independent regulation of tumor cell migration by matrix stiffness and confinement. Proc. Natl. Acad. Sci. USA 2012, 109(26):10334-10339.
109. Patten R.D., Hall-Porter M.R. Small animal models of heart failure: development of novel therapies, past and present. Circ. Heart Fail. 2009, 2(2):138-144.
110. Pelosi P., Rocco P.R. Effects of mechanical ventilation on the extracellular matrix. Intensive Care Med. 2008, 34(4):631-639.
111. Prey S., Ezzedine K., Doussau A., Grandoulier A.S., Barcat D., Chatelus E., Diot E., Durant C., Hachulla E., de Korwin-Krokowski J.D., Kostrzewa E., Quemeneur T., Paul C., Schaeverbeke T., Seneschal J., Solanilla A., Sparsa A., Bouchet S., Lepreux S., Mahon F.X., Chene G., Taieb A. Imatinib mesylate in scleroderma-associated diffuse skin fibrosis: a phase II multicentre randomized double-blinded controlled trial. Br. J. Dermatol. 2012, 167(5):1138-1144.
112. Raghunathan V.K., Morgan J.T., Dreier B., Reilly C.M., Thomasy S.M., Wood J.A., Ly I., Tuyen B.C., Hughbanks M., Murphy C.J., Russell P. Role of substratum stiffness in modulating genes associated with extracellular matrix and mechanotransducers YAP and TAZ. Invest. Ophthalmol. Vis. Sci. 2013, 54(1):378-386.
113. Reitamo S., Remitz A., Tamai K., Uitto J. Interleukin-10 modulates type I collagen and matrix metalloprotease gene expression in cultured human skin fibroblasts. J. Clin. Invest. 1994, 94(6):2489-2492.
114. Reno F., Traina V., Cannas M. Mechanical stretching modulates growth direction and MMP-9 release in human keratinocyte monolayer. Cell Adhes. Migr. 2009, 3(3):239-242.
115. Renovo, 2011. Juvista EU Phase 3 Trial Results.
116. Rockman H.A., Ross R.S., Harris A.N., Knowlton K.U., Steinhelper M.E., Field L.J., Ross J., Chien K.R. Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy. Proc. Natl. Acad. Sci. USA 1991, 88(18):8277-8281.
117. Rustad K.C., Wong V.W., Gurtner G.C. The role of focal adhesion complexes in fibroblast mechanotransduction during scar formation. Differentiation 2013, 86(3):87-91.
118. Samuel M.S., Lopez J.I., McGhee E.J., Croft D.R., Strachan D., Timpson P., Munro J., Schroder E., Zhou J., Brunton V.G., Barker N., Clevers H., Sansom O.J., Anderson K.I., Weaver V.M., Olson M.F. Actomyosin-mediated cellular tension drives increased tissue stiffness and beta-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell 2011, 19(6):776-791.
119. Schwarz U.S., Gardel M.L. United we stand: integrating the actin cytoskeleton and cell-matrix adhesions in cellular mechanotransduction. J. Cell Sci. 2012, 125(Pt 13):3051-3060.
120. Sen S., Kumar S. Combining mechanical and optical approaches to dissect cellular mechanobiology. J. Biomech. 2010, 43(1):45-54.
121. Shah M., Foreman D.M., Ferguson M.W. Control of scarring in adult wounds by neutralising antibody to transforming growth factor beta. Lancet 1992, 339(8787):213-214.
122. Shah M., Foreman D.M., Ferguson M.W. Neutralising antibody to TGF-beta 1,2 reduces cutaneous scarring in adult rodents. J. Cell Sci. 1994, 107(Pt 5):1137-1157.
123. Shah M., Foreman D.M., Ferguson M.W. Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring. J. Cell Sci. 1995, 108(Pt 3):985-1002.
124. Shi J., Votruba A.R., Farokhzad O.C., Langer R. Nanotechnology in drug delivery and tissue engineering: from discovery to applications. Nano Lett. 2010, 10(9):3223-3230.
125. Shi J.H., Guan H., Shi S., Cai W.X., Bai X.Z., Hu X.L., Fang X.B., Liu J.Q., Tao K., Zhu X.X., Tang C.W., Hu D.H. Protection against TGF-beta1-induced fibrosis effects of IL-10 on dermal fibroblasts and its potential therapeutics for the reduction of skin scarring. Arch. Dermatol. Res. 2013, 305(4):341-352.
126. Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer T.A. Latent TGF-beta structure and activation. Nature 2011, 474(7351):343-349.
127. Singer A.J., Clark R.A. Cutaneous wound healing. N. Engl. J. Med. 1999, 341(10):738-746.
128. Solon J., Levental I., Sengupta K., Georges P.C., Janmey P.A. Fibroblast adaptation and stiffness matching to soft elastic substrates. Biophys. J. 2007, 93(12):4453-4461.
129. Steinstraesser L., Flak E., Witte B., Ring A., Tilkorn D., Hauser J., Langer S., Steinau H.U., Al-Benna S. Pressure garment therapy alone and in combination with silicone for the prevention of hypertrophic scarring: randomized controlled trial with intraindividual comparison. Plast. Reconstr. Surg. 2011, 128(4):306e-313e.
130. Subramony S.D., Dargis B.R., Castillo M., Azeloglu E.U., Tracey M.S., Su A., Lu H.H. The guidance of stem cell differentiation by substrate alignment and mechanical stimulation. Biomaterials 2013, 34(8):1942-1953.
131. Throm Quinlan A.M., Sierad L.N., Capulli A.K., Firstenberg L.E., Billiar K.L. Combining dynamic stretch and tunable stiffness to probe cell mechanobiology in vitro. PLoS One 2011, 6(8):e23272.
132. Ting S.B., Caddy J., Hislop N., Wilanowski T., Auden A., Zhao L.L., Ellis S., Kaur P., Uchida Y., Holleran W.M., Elias P.M., Cunningham J.M., Jane S.M. A homolog of Drosophila grainy head is essential for epidermal integrity in mice. Science 2005, 308(5720):411-413.
133. Todorovic V., Rifkin D.B. LTBPs, more than just an escort service. J. Cell. Biochem. 2012, 113(2):410-418.
134. Tomcik M., Zerr P., Pitkowski J., Palumbo-Zerr K., Avouac J., Distler O., Becvar R., Senolt L., Schett G., Distler J.H. Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-beta signalling to prevent fibrosis. Ann. Rheum. Dis. 2013.
135. Tremblay A.M., Camargo F.D. Hippo signaling in mammalian stem cells. Semin. Cell Dev. Biol. 2012, 23(7):818-826.
136. Varelas X., Samavarchi-Tehrani P., Narimatsu M., Weiss A., Cockburn K., Larsen B.G., Rossant J., Wrana J.L. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway. Dev. Cell 2010, 19(6):831-844.
137. Vunjak-Novakovic G., Altman G., Horan R., Kaplan D.L. Tissue engineering of ligaments. Annu. Rev. Biomed. Eng. 2004, 6:131-156.
138. Wang J.G., Miyazu M., Xiang P., Li S.N., Sokabe M., Naruse K. Stretch-induced cell proliferation is mediated by FAK-MAPK pathway. Life Sci. 2005, 76(24):2817-2825.
139. Wang N., Tytell J.D., Ingber D.E. Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus. Nat. Rev. Mol. Cell Biol. 2009, 10(1):75-82.
140. Wang Y., Wang N. FRET and mechanobiology. Integr. Biol. (Camb) 2009, 1(10):565-573.
141. Ward R.S. Pressure therapy for the control of hypertrophic scar formation after burn injury. A history and review. J. Burn Care Rehabil. 1991, 12(3):257-262.
142. Wehrle-Haller B. Structure and function of focal adhesions. Curr. Opin. Cell Biol. 2012, 24(1):116-124.
143. Wipff P.J., Hinz B. Integrins and the activation of latent transforming growth factor beta1-an intimate relationship. Eur. J. Cell Biol. 2008, 87(8-9):601-615.
144. Wong V.W., Akaishi S., Longaker M.T., Gurtner G.C. Pushing back: wound mechanotransduction in repair and regeneration. J. Invest. Dermatol. 2011, 131(11):2186-2196.
145. Wong V.W., Levi K., Akaishi S., Schultz G., Dauskardt R.H. Scar zones: region-specific differences in skin tension may determine incisional scar formation. Plast. Reconstr. Surg. 2012, 129(6):1272-1276.
146. Wong V.W., Longaker M.T., Gurtner G.C. Soft tissue mechanotransduction in wound healing and fibrosis. Semin. Cell Dev. Biol. 2012, 23(9):981-986.
147. Wong V.W., Paterno J., Sorkin M., Glotzbach J.P., Levi K., Januszyk M., Rustad K.C., Longaker M.T., Gurtner G.C. Mechanical force prolongs acute inflammation via T-cell-dependent pathways during scar formation. FASEB J. 2011, 25(12):4498-4510.
148. Wong V.W., Rustad K.C., Akaishi S., Sorkin M., Glotzbach J.P., Januszyk M., Nelson E.R., Levi K., Paterno J., Vial I.N., Kuang A.A., Longaker M.T., Gurtner G.C. Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling. Nat. Med. 2012, 18(1):148-152.
149. Wong V.W., Sorkin M., Glotzbach J.P., Longaker M.T., Gurtner G.C. Surgical approaches to create murine models of human wound healing. J. Biomed. Biotechnol. 2011, 2011:969618.
150. Wynn T.A. Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J. Clin. Invest. 2007, 117(3):524-529.
151. Yamaguchi Y., Takihara T., Chambers R.A., Veraldi K.L., Larregina A.T., Feghali-Bostwick C.A. A peptide derived from endostatin ameliorates organ fibrosis. Sci. Transl. Med. 2012, 4(136). (p. 136ra71).
152. Yamamoto T., Eckes B., Krieg T. Effect of interleukin-10 on the gene expression of type I collagen, fibronectin, and decorin in human skin fibroblasts: differential regulation by transforming growth factor-beta and monocyte chemoattractant protein-1. Biochem. Biophys. Res. Commun. 2001, 281(1):200-205.
153. Yamazaki T., Komuro I., Yazaki Y. Molecular aspects of mechanical stress-induced cardiac hypertrophy. Mol. Cell. Biochem. 1996, 163-164:197-201.
154. Yano S., Komine M., Fujimoto M., Okochi H., Tamaki K. Mechanical stretching in vitro regulates signal transduction pathways and cellular proliferation in human epidermal keratinocytes. J. Invest. Dermatol. 2004, 122(3):783-790.
155. Yarbrough W.M., Mukherjee R., Stroud R.E., Rivers W.T., Oelsen J.M., Dixon J.A., Eckhouse S.R., Ikonomidis J.S., Zile M.R., Spinale F.G. Progressive induction of left ventricular pressure overload in a large animal model elicits myocardial remodeling and a unique matrix signature. J. Thorac. Cardiovasc. Surg. 2012, 143(1):215-223.
156. Yu F.X., Zhao B., Panupinthu N., Jewell J.L., Lian I., Wang L.H., Zhao J., Yuan H., Tumaneng K., Li H., Fu X.D., Mills G.B., Guan K.L. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell 2012, 150(4):780-791.
157. Yuan W., Varga J. Transforming growth factor-beta repression of matrix metalloproteinase-1 in dermal fibroblasts involves Smad3. J. Biol. Chem. 2001, 276(42):38502-38510.
158. Zaidel-Bar R., Itzkovitz S., Maayan A., Iyengar R., Geiger B. Functional atlas of the integrin adhesome. Nat. Cell Biol. 2007, 9(8):858-867.
159. Zhao B., Tumaneng K., Guan K.L. The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nat. Cell Biol. 2011, 13(8):877-883.
160. Zhou S.B., Wang J., Chiang C.A., Sheng L.L., Li Q.F. Mechanical stretch upregulates Sdf-1alpha in skin tissue and induces migration of circulating bone marrow-derived stem cells into the expanded skin. Stem Cells 2013, 31(12):2703-2713.