A homolog of Drosophila grainy head is essential for epidermal integrity in mice

Science

Volumn 308, Issue 5720, 2005, Pages 411-413

  Ting, Stephen B ^a   Caddy, Jacinta ^a   Hislop, Nikki ^a   Wilanowski, Tomasz ^a   Auden, Alana ^a   Zhao, Lin Lin ^a   Ellis, Sarah ^b   Kaur, Pritinder ^b   Uchida, Yoshikazu ^c   Holleran, Walter M ^c   Elias, Peter M ^c   Cunningham, John M ^d   Jane, Stephen N ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b PETER MACCALLUM CANCER CENTRE   (Australia)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMEDICAL ENGINEERING; CROSSLINKING; ENZYMES; REPAIR; TISSUE;

COVALENT CROSS-LINKING; DROSSOPHILA GRAINY HEAD; MAMMALIAN HOMOLOGS; SKIN BARRIER FUNCTIONS;

SKIN;

PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GRAINY HEAD; UNCLASSIFIED DRUG;

CELLS AND CELL COMPONENTS;

ARTICLE; CONTROLLED STUDY; CROSS LINKING; DROSOPHILA; EMBRYO; EPIDERMIS; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SEQUENCE HOMOLOGY; SKIN PERMEABILITY; WOUND HEALING;

ANIMALS; BINDING SITES; DNA-BINDING PROTEINS; EMBRYO; EMBRYONIC DEVELOPMENT; EPIDERMIS; EPITHELIUM; EVOLUTION; GENE EXPRESSION; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MUTATION; PERMEABILITY; TRANSCRIPTION FACTORS; TRANSGLUTAMINASES; WOUND HEALING;

MAMMALIA;

EID: 20244389223     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1107511     Document Type: Article

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34. We thank W. McGinnis for sharing of data before publication; members of the Jane lab for helpful discussions; S. Vasudevan, S. Duoangpanya, L. Leypold, and Ozgene Inc. (Perth, Australia) for technical assistance; and B. Mesiti for help with figure preparation. Animal support was provided by staff from the Walter & Eliza Hall Institute. S.M.J. is a Principal Research Fellow of the Australian National Health and Medical Research Council (NHMRC). S.B.T. is a scholar of the Cancer Council of Victoria. J.M.C. is supported by the Cancer Center Support CORE Grant P30 CA 21765, the American Lebanese Syrian Associated Charities, and the Assisi Foundation of Memphis. This work was supported by PO1 HL53749-03 from the National Institutes of Health (USA) and Project Grant 282400 from the NHMRC. Additional support was received from NIH (USA) Grant PO1-AR39448 (W.M.H. and P.M.E.) and from the Department of Veterans Affairs (P.M.E.).