LTBPs, more than just an escort service

Journal of Cellular Biochemistry

Volumn 113, Issue 2, 2012, Pages 410-418

  Todorovic, Vesna ^a   Rifkin, Daniel B ^a,b  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Extracellular matrix; LTBP; TGF beta

Indexed keywords

ACTIVIN; EPIDERMAL GROWTH FACTOR; FIBRILLIN; FIBRONECTIN; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; LATENCY ASSOCIATED PEPTIDE; LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN; MYOSTATIN; SOMATOMEDIN BINDING PROTEIN 3; TRANSFORMING GROWTH FACTOR BETA; TROPOELASTIN;

BINDING AFFINITY; CELL ADHESION; CELL AGGREGATION; CELL MIGRATION; CYTOKINE RELEASE; ECTOPIA LENTIS; ELASTIC FIBER; ENZYME ACTIVATION; EXTRACELLULAR SPACE; FIBER; GENE MUTATION; HUMAN; KYPHOSIS; LUNG EMPHYSEMA; NONHUMAN; OLIGODONTIA; OSTEOARTHRITIS; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REVIEW; SCOLIOSIS; SEA URCHIN; SHORT STATURE; THROMBOCYTE; TRANSCRIPTION REGULATION;

ANIMALS; EXTRACELLULAR MATRIX; GENETIC DISEASES, INBORN; HUMANS; LATENT TGF-BETA BINDING PROTEINS; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 84855525455     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.23385     Document Type: Review

References (61)

1. Altmann CR, Chang C, Munoz-Sanjuan I, Bell E, Heke M, Rifkin DB, Brivanlou AH. 2002. The latent-TGFbeta-binding-protein-1 (LTBP-1) is expressed in the organizer and regulates nodal and activin signaling. Dev Biol 248:118-127.
2. Anderson SB, Goldberg AL, Whitman M. 2008. Identification of a novel pool of extracellular pro-myostatin in skeletal muscle. J Biol Chem 283:7027-7035.
3. Annes JP, Chen Y, Munger JS, Rifkin DB. 2004. Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. J Cell Biol 165:723-734. (Pubitemid 38765773)
4. Annes JP, Munger JS, Rifkin DB. 2003. Making sense of latent TGFbeta activation. J Cell Sci 116:217-224. (Pubitemid 36163863)
5. Brooke JS, Cha JH, Eidels L. 2002. Latent transforming growth factor beta-binding protein-3 and fibulin-1C interact with the extracellular domain of the heparin-binding EGF-like growth factor precursor. BMC Cell Biol 3:2.
6. Carta L, Smaldone S, Zilberberg L, Loch D, Dietz HC, Rifkin DB, Ramirez F. 2009. p38 MAPK is an early determinant of promiscuous Smad2/3 signaling in the aortas of fibrillin-1 (Fbn1)-null mice. J Biol Chem 284:5630-5636.
7. Chandramouli A, Simundza J, Pinderhughes A, Cowin P. 2011. Choreographing metastasis to the tune of LTBP. J Mammary Gland Biol Neoplasia 16:67-80.
8. Chen Q, Sivakumar P, Barley C, Peters DM, Gomes RR, Farach-Carson MC, Dallas SL. 2007. Potential role for heparan sulfate proteoglycans in regulation of transforming growth factor-beta (TGF-beta) by modulating assembly of latent TGF-beta-binding protein-1. J Biol Chem 282:26418-26430. (Pubitemid 47443781)
9. Chen Y, Ali T, Todorovic V, O'Leary JM, Kristina Downing A, Rifkin DB. 2005. Amino acid requirements for formation of the TGF-beta-latent TGF-beta binding protein complexes. J Mol Biol 345:175-186. (Pubitemid 39572834)
10. Chen Y, Dabovic B, Annes JP, Rifkin DB. 2002. Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion. FEBS Lett 517:277-280. (Pubitemid 34327674)
11. Colarossi C, Chen Y, Obata H, Jurukovski V, Fontana L, Dabovic B, Rifkin DB. 2005. Lung alveolar septation defects in Ltbp-3-null mice. Am J Pathol 167:419-428. (Pubitemid 43026098)
12. Dabovic B, Chen Y, Choi J, Vassallo M, Dietz HC, Ramirez F, von Melchner H, Davis EC, Rifkin DB. 2009. Dual functions for LTBP in lung development: LTBP-4 independently modulates elastogenesis and TGF-beta activity. J Cell Physiol 219:14-22.
13. Dabovic B, Chen Y, Colarossi C, Obata H, Zambuto L, Perle MA, Rifkin DB. 2002a. Bone abnormalities in latent TGF-[beta] binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-[beta] bioavailability. J Cell Biol 156:227-232. (Pubitemid 34839904)
14. Dabovic B, Chen Y, Colarossi C, Zambuto L, Obata H, Rifkin DB. 2002b. Bone defects in latent TGF-beta binding protein (Ltbp)-3 null mice; a role for Ltbp in TGF-beta presentation. J Endocrinol 175:129-141. (Pubitemid 35276592)
15. Dallas SL, Chen Q, Sivakumar P. 2006. Dynamics of assembly and reorganization of extracellular matrix proteins. Curr Top Dev Biol 75:1-24. (Pubitemid 44375080)
16. Dallas SL, Rosser JL, Mundy GR, Bonewald LF. 2002. Proteolysis of latent transforming growth factor-beta (TGF-beta)-binding protein-1 by osteoclasts. A cellular mechanism for release of TGF-beta from bone matrix. J Biol Chem 277:21352-21360. (Pubitemid 34952275)
17. Drews F, Knobel S, Moser M, Muhlack KG, Mohren S, Stoll C, Bosio A, Gressner AM, Weiskirchen R. 2008. Disruption of the latent transforming growth factor-beta binding protein-1 gene causes alteration in facial structure and influences TGF-beta bioavailability. Biochim Biophys Acta 1783:34-48.
18. Fontana L, Chen Y, Prijatelj P, Sakai T, Fassler R, Sakai LY, Rifkin DB. 2005. Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1. FASEB J 19:1798-1808. (Pubitemid 41598764)
19. Ge G, Greenspan DS. 2006. BMP1 controls TGFbeta1 activation via cleavage of latent TGFbeta-binding protein. J Cell Biol 175:111-120. (Pubitemid 44537203)
20. Gleizes PE, Beavis RC, Mazzieri R, Shen B, Rifkin DB. 1996. Identification and characterization of an eight-cysteine repeat of the latent transforming growth factor-beta binding protein-1 that mediates bonding to the latent transforming growth factor-beta1. J Biol Chem 271:29891-29896. (Pubitemid 26389623)
21. Gui Y, Murphy LJ. 2003. Interaction of insulin-like growth factor binding protein-3 with latent transforming growth factor-beta binding protein-1. Mol Cell Biochem 250:189-195. (Pubitemid 37045737)
22. Hirai M, Horiguchi M, Ohbayashi T, Kita T, Chien KR, Nakamura T. 2007. Latent TGF-beta-binding protein 2 binds to DANCE/fibulin-5 and regulates elastic fiber assembly. EMBO J 26:3283-3295. (Pubitemid 47123533)
23. Hirani R, Hanssen E, Gibson MA. 2007. LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein. Matrix Biol 26:213-223. (Pubitemid 46660588)
24. Holm TM, Habashi JP, Doyle JJ, Bedja D, Chen Y, van Erp C, Lindsay ME, Kim D, Schoenhoff F, Cohn RD, Loeys BL, Thomas CJ, Patnaik S, Marugan JJ, Judge DP, Dietz HC. 2011. Noncanonical TGFbeta signaling contributes to aortic aneurysm progression in Marfan syndrome mice. Science 332:358-361.
25. Horiguchi M, Inoue T, Ohbayashi T, Hirai M, Noda K, Marmorstein LY, Yabe D, Takagi K, Akama TO, Kita T, Kimura T, Nakamura T. 2009. Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidase. Proc Natl Acad Sci USA 106:19029-19034.
26. Hyytiainen M, Keski-Oja J. 2003. Latent TGF-beta binding protein LTBP-2 decreases fibroblast adhesion to fibronectin. J Cell Biol 163:1363-1374. (Pubitemid 38032096)
27. Isogai Z, Ono RN, Ushiro S, Keene DR, Chen Y, Mazzieri R, Charbonneau NL, Reinhardt DP, Rifkin DB, Sakai LY. 2003. Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein. J Biol Chem 278:2750-2757. (Pubitemid 36801356)
28. Kantola AK, Keski-Oja J, Koli K. 2008. Fibronectin and heparin binding domains of latent TGF-beta binding protein (LTBP)-4 mediate matrix targeting and cell adhesion. Exp Cell Res 314:2488-2500.
29. Kantola AK, Ryynanen MJ, Lhota F, Keski-Oja J, Koli K. 2010. Independent regulation of short and long forms of latent TGF-beta binding protein (LTBP)-4 in cultured fibroblasts and human tissues. J Cell Physiol 223:727-736.
30. Koli K, HyytiainenM, Ryynanen MJ, Keski-Oja J. 2005. Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts. Exp Cell Res 310:370-382. (Pubitemid 41457340)
31. Koli K, Saharinen J, Karkkainen M, Keski-Oja J. 2001. Novel non-TGF-beta-binding splice variant of LTBP-4 in human cells and tissues provides means to decrease TGF-beta deposition. J Cell Sci 114:2869-2878. (Pubitemid 32785465)
32. Koski C, Saharinen J, Keski-Oja J. 1999. Independent promoters regulate the expression of two amino terminally distinct forms of latent transforming growth factor-beta binding protein-1 (LTBP-1) in a cell type-specific manner. J Biol Chem 274:32619-32630. (Pubitemid 129535288)
33. Lack J, O'Leary JM, Knott V, Yuan X, Rifkin DB, Handford PA, Downing AK. 2003. Solution structure of the third TB domain from LTBP1 provides insight into assembly of the large latent complex that sequesters latent TGF-beta. J Mol Biol 334:281-291. (Pubitemid 37357267)
34. Le Goff C, Morice-Picard F, Dagoneau N, Wang LW, Perrot C, Crow YJ, Bauer F, Flori E, Prost-Squarcioni C, Krakow D, Ge G, Greenspan DS, Bonnet D, Le Merrer M, Munnich A, Apte SS, Cormier-Daire V. 2008. ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation. Nat Genet 40:1119-1123.
35. Massam-Wu T, Chiu M, Choudhury R, Chaudhry SS, Baldwin AK, McGovern A, Baldock C, Shuttleworth CA, Kielty CM. 2010. Assembly of fibrillin microfibrils governs extracellular deposition of latent TGF beta. J Cell Sci 123:3006-3018.
36. Miyazono K, Hellman U, Wernstedt C, Heldin CH. 1988. Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization. J Biol Chem 263:6407-6415.
37. Moren A, Olofsson A, Stenman G, Sahlin P, Kanzaki T, Claesson-Welsh L, ten Dijke P, Miyazono K, Heldin CH. 1994. Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein. J Biol Chem 269:32469-32478.
38. Noor A, Windpassinger C, Vitcu I, Orlic M, Rafiq MA, Khalid M, Malik MN, Ayub M, Alman B, Vincent JB. 2009. Oligodontia is caused by mutation in LTBP3, the gene encoding latent TGF-beta binding protein 3. Am J Hum Genet 84:519-523.
39. Olivieri J, Smaldone S, Ramirez F. 2010. Fibrillin assemblies: Extracellular determinants of tissue formation and fibrosis. Fibrogenesis Tissue Repair 3:24.
40. Ono RN, Sengle G, Charbonneau NL, Carlberg V, Bachinger HP, Sasaki T, Lee-Arteaga S, Zilberberg L, Rifkin DB, Ramirez F, Chu ML, Sakai LY. 2009. Latent transforming growth factor beta-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sites. J Biol Chem 284:16872-16881.
41. Parsi MK, Adams JR, Whitelock J, Gibson MA. 2010. LTBP-2 has multiple heparin/heparan sulfate binding sites. Matrix Biol 29:393-401.
42. Penttinen C, Saharinen J, Weikkolainen K, Hyytiäinen K, Keski-Oja J. 2002. Secretion of human latent TGF-beta binding-protein-3 (LTBP-3) is dependent on co-expression of TGF-beta. J Cell Sci 115:3457-3468. (Pubitemid 34994035)
43. Rifkin DB. 2005. Latent transforming growth factor-beta (TGF-beta) binding proteins: Orchestrators of TGF-beta availability. J Biol Chem 280:7409-7412. (Pubitemid 40349631)
44. Robertson I, Jensen S, Handford P. 2010. TB domain proteins: Evolutionary insights into the multifaceted roles of fibrillins and LTBPs. Biochem J 433:263-276.
45. Saharinen J, Keski-Oja J. 2000. Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta. Mol Biol Cell 11:2691-2704. (Pubitemid 30645036)
46. Saharinen J, Taipale J, Keski-Oja J. 1996. Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1. EMBO J 15:245-253. (Pubitemid 26029204)
47. Shi M, Zhu J, Wang R, Chen X, Mi L, Walz T, Springer TA. 2011. Latent TGF-beta structure and activation. Nature 474:343-349.
48. Shipley JM, Mecham RP, Maus E, Bonadio J, Rosenbloom J, McCarthy RT, Baumann ML, Frankfater C, Segade F, Shapiro SD. 2000. Developmental expression of latent transforming growth factor beta binding protein 2 and its requirement early in mouse development. Mol Cell Biol 20:4879-4887. (Pubitemid 30396134)
49. Sterner-Kock A, Thorey IS, Koli K, Wempe F, Otte J, Bangsow T, Kuhlmeier K, Kirchner T, Jin S, Keski-Oja J, von Melchner H. 2002. Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer. Genes Dev 16:2264-2273. (Pubitemid 35013089)
50. Sun X, Essalmani R, Susan-Resiga D, Prat A, Seidah NG. 2011. Latent transforming growth factor {beta}-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A. J Biol Chem 286:29063-29073.
51. Taipale J, Lohi J, Saarinen J, Kovanen PT, Keski-Oja J. 1995. Human mast cell chymase and leukocyte elastase release latent transforming growth factor-beta 1 from the extracellular matrix of cultured human epithelial and endothelial cells. J Biol Chem 270:4689-4696.
52. Taipale J, Saharinen J, Hedman K, Keski-Oja J. 1996. Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils. J Histochem Cytochem 44:875-889. (Pubitemid 26266744)
53. Todorovic V, Finnegan E, Freyer L, Zilberberg L, Ota M, Rifkin DB. 2011. Long form of latent TGF-beta binding protein 1 (Ltbp1L) regulates cardiac valve development. Dev Dyn 240:176-187.
54. Todorovic V, Frendewey D, Gutstein DE, Chen Y, Freyer L, Finnegan E, Liu F, Murphy A, Valenzuela D, Yancopoulos G, Rifkin DB. 2007. Long form of latent TGF-beta binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling. Development 134:3723-3732. (Pubitemid 350104381)
55. Todorovic V, Jurukovski V, Chen Y, Fontana L, Dabovic B, Rifkin DB. 2005. Latent TGF-beta binding proteins. Int J Biochem Cell Biol 37:38-41.
56. Unsold C, Hyytiainen M, Bruckner-Tuderman L, Keski-Oja J. 2001. Latent TGF-beta binding protein LTBP-1 contains three potential extracellular matrix interacting domains. J Cell Sci 114:187-197. (Pubitemid 32118068)
57. Urban Z, Hucthagowder V, Schurmann N, Todorovic V, Zilberberg L, Choi J, Sens C, Brown CW, Clark RD, Holland KE, Marble M, Sakai LY, Dabovic B, Rifkin DB, Davis EC. 2009. Mutations in LTBP4 cause a syndrome of impaired pulmonary, gastrointestinal, genitourinary, musculoskeletal, and dermal development. Am J Hum Genet 85:593-605.
58. Vehvilainen P, Hyytiainen M, Keski-Oja J. 2009. Matrix association of latent TGF-beta binding protein-2 (LTBP-2) is dependent on fibrillin-1. J Cell Physiol 221:586-593.
59. Walton KL, Makanji Y, Chen J, Wilce MC, Chan KL, Robertson DM, Harrison CA. 2010. Two distinct regions of latency-associated peptide coordinate stability of the latent transforming growth factor-beta1 complex. J Biol Chem 285:17029-17037.
60. Wipff PJ, Rifkin DB, Meister JJ, Hinz B. 2007. Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix. J Cell Biol 179:1311-1323. (Pubitemid 350277747)
61. Yoshinaga K, Obata H, Jurukovski V, Mazzieri R, Chen Y, Zilberberg L, Huso D, Melamed J, Prijatelj P, Todorovic V, Dabovic B, Rifkin DB. 2008. Perturbation of transforming growth factor (TGF)-beta1 association with latent TGF-beta binding protein yields inflammation and tumors. Proc Natl Acad Sci USA 105:18758-18763.