Biodegradable polymeric scaffolds for musculoskeletal tissue engineering

Journal of Biomedical Materials Research

Volumn 55, Issue 2, 2001, Pages 141-150

  Agrawal, C Mauli ^a   Ray, Robert B ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Biodegradable; Cells; Polymers; Scaffolds; Surface modification

Indexed keywords

BIODEGRADATION; BIOMECHANICS; GROWTH KINETICS; MECHANICAL PERMEABILITY; MUSCULOSKELETAL SYSTEM; POLYMERS; POROUS MATERIALS; TISSUE;

BIODEGRADABLE SCAFFOLDS; TISSUE ENGINEERING;

BIOMATERIALS;

BIOMATERIAL; GROWTH FACTOR; POLY(ORTHO ESTER); POLYANHYDRIDE; POLYCAPROLACTONE; POLYCARBONATE; POLYFUMARATE; POLYGLACTIN; POLYMER; UNCLASSIFIED DRUG;

ARTICLE; BIODEGRADATION; BONE; CARTILAGE; CELL GROWTH; CONTROLLED DRUG RELEASE; MUSCULOSKELETAL SYSTEM; PERMEABILITY; POROSITY; SURFACE PROPERTY; TENSILE STRENGTH;

ANIMALS; BIOCOMPATIBLE MATERIALS; BIOMECHANICS; BIOMEDICAL ENGINEERING; CELL ADHESION; CELL DIVISION; DELAYED-ACTION PREPARATIONS; GROWTH SUBSTANCES; HUMANS; MATERIALS TESTING; MUSCULOSKELETAL DEVELOPMENT; MUSCULOSKELETAL PHYSIOLOGY; MUSCULOSKELETAL SYSTEM; POLYMERS; REGENERATION; SURFACE PROPERTIES; WOUND HEALING;

EID: 0035089551     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4636(200105)55:2<141::AID-JBM1000>3.0.CO;2-J     Document Type: Article

References (100)

1. Physico-mechanical properties of degradable polymers used in medical applications: A comparative study
2. Sterilization, toxicity, biocompatibility, and clinical applications of polylactic acid/polyglycolic acid copolymers
3. Fabrication and characterization of PLA-PGA orthopaedic implants
4. The use of PLA-PGA polymers in orthopaedics
5. Biodegradable polymers for use in surgery - Polyglycolic/poly(lactic acid) homo- and copolymers: 1
6. Biodegradable materials of poly(L-lactic acid): 1. Melt-spun and solution spun fibres
7. Degradation rates of oral resorbable implants (polylactates and polyglycolates): Rate modification with changes in PLA/PGA copolymer ratios
8. Controlled release of bioactive agents from lactide/glycolide polymers
9. Resorption rate, route of elimination, and ultrastructure of the implant site of polylactic acid in the abdominal wall of the rat
10. Some observations on the role of cellular enzymes in the in vivo degradation of polymers
11. Restoration of bone discontinuities in dogs using a biodegradable implant
12. The use of bone morphogenetic protein in the treatment of non-union in a canine model
13. Protein release kinetics of a biodegradable implant for fracture non-unions
14. Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue-engineering cartilage
15. Cultivation of cell-polymer cartilage implants in bioreactors
16. Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers
17. Biodegradable implants for the treatment of osteochondral defects in a goat model
18. Porous polymer implant for repair of meniscal lesions: A preliminary study in dogs
19. Roles of acid/base nature and molecular weight in drug release from matrices of gel foam and monoisopropyl ester of poly(vinyl methyl ether-maleic anhydride)
20. Degradation of porous poly(anhydride-co-imide) microspheres and implications for controlled macromolecule delivery
21. Controlled protein delivery from biodegradable tyrosine-containing poly(anhydride-co-imide) microspheres
22. Polyanhydrides for controlled drug delivery
23. Preliminary in vivo report on the osteocompatibility of poly(anhydride-co-imides) evaluated in a tibial model
24. Poly(anhydride-co-imides): In vivo biocompatibility in a rat model
25. Preparation of poly(ortho esters) by the reaction of kiketene acetals and polyols
26. Poly(ortho esters)
27. Controlled release of norethindrone from poly(orthoesters)
28. In vitro and in vivo release of levonorgesrel from poly(ortho esters) - 1. Linear polymers
29. Use of poly(ortho esters) for the controlled release of 5-fluorouracil and a LH-RH analog
30. Polycaprolactone-b-poly(ethylene oxide) block copolymer micelles as a novel drug delivery vehicle for neurotrophic agents FK506 and L-685,818
31. Poly-epsilon-caprolactone and its copolymers
32. In vitro evaluation of polymeric matrix and porous biodegradable reservoir devices for slow-release drug delivery
33. In vitro release of trypanocidal drugs from biodegradable implants based on poly(epsilon-caprolactone) and poly(D, L-lactide)
34. Polycaprolactone/glass bioabsorbable implant in a rabbit humerus fracture model
35. Polycarbonate, eine gruppe neuartiger thermoplastischer kunststoffe
36. Polycarbonates
37. Poly(iminocarbonates) as potential biomaterials
38. Synthesis of poly(iminocarbonates): Degradable polymers with potential applications as disposable plastics and as biomaterials
39. Structure-property relationships for the design of polyiminocarbonates
40. Pseudo-poly(amino acids). Biodegradable polymers as drug delivery systems
41. Canine bone response to tyrosine-derived polycarbonates and poly(L-lactic acid)
42. Evaluation of poly(DTH carbonate), a tyrosine-derived degradable polymer, for orthopedic applications
43. Tyrosine-PEG-derived poly(ether carbonate)s as new biomaterials. Part II: Study of inverse temperature transitions
44. Characterization of partially saturated poly(propylene fumarate) for orthopaedic application
45. In vivo degradation of a poly(propylene fumarate)/β-tricalcium phosphate injectable scaffold
46. The ingrowth of new bone tissue and initial mechanical properties of a degradable polymeric composite scaffold
47. Marrow stromal osteoblast function on a poly(propylene fumarate)/β-tricalcium phosphate biodegradable orthopaedic composite
48. Tissue response to resorbable synthetic polymers
49. A preliminary study of the osteogenic potential of a biodegradable alloplastic-osteoinductive alloimplant
50. Salient degradation features of a 50:50 PLA/PGA scaffold for tissue engineering
51. In vitro degradation and release characteristics of biodegradable implants containing trypsin inhibitor
52. Gel casting of resorbable polymers. 1. Processing and applications
53. Gel casting of resorbable polymers. 2. In vitro degradation of bone graft substitutes
54. The effects of ultrasound irradiation on a biodegradable 50-50% copolymer of polylactic and polyglycolic acids
55. Laminated three-dimensional biodegradable foams for use in tissue engineering
56. Novel approach to fabricate porous sponges of poly(D, L-lactic-coglycolic acid) without the use of organic solvents
57. Open pore biodegradable matrices formed with gas foaming
58. Effect of polymer foam morphology and density on kinetics of in vitro controlled release of isoniazid from compressed foam matrices
59. Mechanical properties of dense polylactic acid structures fabricated by three dimensional printing
60. Preparation of poly(glycolic acid) bonded fiber structures for cell attachment and transplantation
61. The use of the vibrating particle technique to fabricate highly permeable biodegradable scaffolds
62. Porous biodegradable polymeric scaffolds prepared by thermally induced phase separation
63. Porous poly(L-lactic acid)/apatite composites created by biomimetic process
64. In vitro analysis of biodegradable polymer blend/hydroxyapatite composites for bone tissue engineering
65. Beyond transplantation. Third annual Samuel Jason Mixter lecture
66. Selective cell transplantation using bioabsorbable artificial polymers as matrices
67. Stabilized polyglycolic acid fibre-based tubes for tissue engineering
68. Development of biocompatible synthetic extracellular matrices for tissue engineering
69. Biodegradable polymer scaffolds for tissue engineering
70. Bone formation by three-dimensional stromal osteoblast culture in biodegradable polymer scaffolds
71. Three-dimensional culture of rat calvarial osteoblasts in porous biodegradable polymers
72. Polymer concepts in tissue engineering
73. Effects of flow on the in vitro degradation kinetics of biodegradable scaffolds for tissue engineering
74. The effects of porosity on degradation of PLA-PGA implants
75. Cartilage engineered in predetermined shapes employing cell transplantation on synthetic biodegradable polymers
76. Tissue-engineered morphogenesis of cartilage and bone by means of cell transplantation using synthetic biodegradable polymer matrices
77. Temporomandibular joint disc replacement made by tissue-engineered growth of cartilage
78. Integrins, versatility, modulation, and signaling in cell adhesion
79. Potent, integrin selective RGD-containing peptides promote cell-specific adhesion on three dimensional collagen matrices
80. Design and function of novel osteoblast-adhesive peptides for chemical modification of biomaterials
81. Cell adhesion strength increases linearly with adsorbed fibronectin surface density
82. New methods of drug delivery
83. Cytokines in context
84. Enhanced induction of engineered bone with basic FGF
85. TGF-β promotes the growth of bovine chondrocytes in monolayer culture and the formation of cartilage tissue on three-dimensional scaffolds
86. Effects of growth-factor-enhanced culture on a chondrocyte-collagen implant for cartilage repair
87. In vitro differentiation of chick embryo bone marrow stromal cells into cartilaginous and bone-like tissues
88. The effects of dynamic compressive loading on biodegradable implants of 50-50% polylactic acid-polyglycolic acid
89. Mechanotransduction in bone cells: Induction of nitric oxide and prostaglandin synthesis by fluid shear stress, but not by mechanical strain
90. Biosynthetic response of cartilage explants to dynamic compression
91. Mechanotransduction in bone: Osteoblasts are more responsive to fluid forces than mechanical strain
92. Influence of intermittent pressure, fluid flow, and mixing on the regenerative properties of articular chondrocytes
93. Tissue engineering of cartilage in space
94. Compression of cartilage results in differential effects on biosynthetic pathways for aggrecan, link protein and hyaluronan
95. Mechanical compression modulates matrix biosynthesis in chondrocyte/agarose culture
96. In vitro bone biocompatibility of poly(anhydride-coimides) containing pyromellitylimidoalanine
97. Fabrication of pliable biodegradable polymer foams to engineer soft tissues