Transglutaminase 2 and its role in pulmonary fibrosis

American Journal of Respiratory and Critical Care Medicine

Volumn 184, Issue 6, 2011, Pages 699-707

  Olsen, Keith C ^a   Sapinoro, Ramil E ^a,b   Kottmann, R M ^b   Kulkarni, Ajit A ^a,b   Iismaa, Siiri E ^c,d   Johnson, Gail V W ^a   Thatcher, Thomas H ^a,b   Phipps, Richard P ^a,b   Sime, Patricia J ^a,b  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Animal model; Collagen; Fibroblast; Fibronectin; Myofibroblast

Indexed keywords

BLEOMYCIN; CYTOKINE; FIBRONECTIN; FORMALDEHYDE; HYDROXYPROLINE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROSING ALVEOLITIS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; KNOCKOUT MOUSE; LUNG BIOPSY; LUNG FIBROBLAST; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; WILD TYPE;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FIBROBLASTS; FIBRONECTINS; FLOW CYTOMETRY; GTP-BINDING PROTEINS; HUMANS; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOFIBROBLASTS; PULMONARY FIBROSIS; TRANSGLUTAMINASES;

EID: 80052941457     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201101-0013OC     Document Type: Article

References (54)

1. Wynn TA. Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest 2007;117:524-529. (Pubitemid 46348506)
2. Swigris JJ, Kuschner WG, Kelsey JL, Gould MK. Idiopathic pulmonary fibrosis: challenges and opportunities for the clinician and investigator. Chest 2005;127:275-283. (Pubitemid 41724588)
3. Raghu G, Weycker D, Edelsberg J, Bradford WZ, Oster G. Incidence and prevalence of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2006;174:810-816. (Pubitemid 44511663)
4. Sime PJ, O'Reilly KM. Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment. Clin Immunol 2001;99:308-319.
5. Kottmann RM, Hogan CM, Phipps RP, Sime PJ. Determinants of initiation and progression of idiopathic pulmonary fibrosis. Respirology 2009;14:917-933.
6. Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol 2008;214:199-210. (Pubitemid 351160157)
7. White ES, Lazar MH, Thannickal VJ. Pathogenetic mechanisms in usual interstitial pneumonia/idiopathic pulmonary fibrosis. J Pathol 2003;201:343-354. (Pubitemid 37408254)
8. Scotton CJ, Chambers RC. Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest 2007;132:1311-1321.
9. Broekelmann TJ, Limper AH, Colby TV, McDonald JA. Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc Natl Acad Sci USA 1991;88:6642-6646. (Pubitemid 21915005)
10. Lorand L, Graham RM. Transglutaminases: crosslinking enzymes with pleiotropic functions. Nat Rev Mol Cell Biol 2003;4:140-156. (Pubitemid 36172696)
11. Iismaa SE, Mearns BM, Lorand L, Graham RM. Transglutaminases and disease: lessons from genetically engineered mouse models and inherited disorders. Physiol Rev 2009;89:991-1023.
12. Griffin M, Casadio R, Bergamini CM. Transglutaminases: nature's biological glues. Biochem J 2002;368:377-396. (Pubitemid 35454517)
13. Nakaoka H, Perez DM, Baek KJ, Das T, Husain A, Misono K, Im MJ, Graham RM. Gh: A GTP-binding protein with transglutaminase activity and receptor signaling function. Science 1994;264:1593-1596.
14. Shin DM, Jeon JH, Kim CW, Cho SY, Lee HJ, Jang GY, Jeong EM, Lee DS, Kang JH, Melino G, et al. TGFbeta mediates activation of transglutaminase 2 in response to oxidative stress that leads to protein aggregation. FASEB J 2008;22:2498-2507. (Pubitemid 351948667)
15. Verderio E, Nicholas B, Gross S, Griffin M. Regulated expression of tissue transglutaminase in swiss 3T3 fibroblasts: effects on the processing of fibronectin, cell attachment, and cell death. Exp Cell Res 1998;239:119-138. (Pubitemid 28368484)
16. Kawai Y, Wada F, Sugimura Y, Maki M, Hitomi K. Transglutaminase 2 activity promotes membrane resealing after mechanical damage in the lung cancer cell line A549. Cell Biol Int 2008;32:928-934.
17. Siegel M, Strnad P, Watts RE, Choi K, Jabri B, Omary MB, Khosla C. Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury. PLoS ONE 2008;3:e1861.
18. Lee ZW, Kwon SM, Kim SW, Yi SJ, Kim YM, Ha KS. Activation of in situ tissue transglutaminase by intracellular reactive oxygen species. Biochem Biophys Res Commun 2003;305:633-640.
19. Akimov SS, Krylov D, Fleischman LF, Belkin AM. Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin. J Cell Biol 2000;148:825-838.
20. Verderio EA, Johnson T,Griffin M. Tissue transglutaminase in normal and abnormal wound healing: review article. Amino Acids 2004;26:387-404. (Pubitemid 39093142)
21. Mhaouty-Kodja S. Ghalpha/tissue transglutaminase 2: an emerging G protein in signal transduction. Biol Cell 2004;96:363-367. (Pubitemid 38807902)
22. Mehta K, Fok JY, Mangala LS. Tissue transglutaminase: from biological glue to cell survival cues. Front Biosci 2006;11:173-185. (Pubitemid 43253484)
23. Akimov SS, Belkin AM. Cell surface tissue transglutaminase is involved in adhesion and migration of monocytic cells on fibronectin. Blood 2001;98:1567-1576.
24. Stephens P, Grenard P, Aeschlimann P, Langley M, Blain E, Errington R, Kipling D, Thomas D, Aeschlimann D. Crosslinking and g-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responses. J Cell Sci 2004;117:3389-3403. (Pubitemid 39139922)
25. Akimov SS, Belkin AM. Cell-surface transglutaminase promotes fibronectin assembly via interaction with the gelatin-binding domain of fibronectin: a role in TGFbeta-dependent matrix deposition. J Cell Sci 2001;114:2989-3000. (Pubitemid 32821537)
26. Grenard P, Bresson-Hadni S, El Alaoui S, Chevallier M, Vuitton DA, Ricard-Blum S. Transglutaminase-mediated cross-linking is involved in the stabilization of extracellular matrix in human liver fibrosis. J Hepatol 2001;35:367-375. (Pubitemid 32844191)
27. Qiu JF, Zhang ZQ, Chen W, Wu ZY. Cystamine ameliorates liver fibrosis induced by carbon tetrachloride via inhibition of tissue transglutaminase. World J Gastroenterol 2007;13:4328-4332. (Pubitemid 47377137)
28. Johnson TS, Fisher M, Haylor JL, Hau Z, Skill NJ, Jones R, Saint R, Coutts I, Vickers ME, El Nahas AM, et al. Transglutaminase inhibition reduces fibrosis and preserves function in experimental chronic kidney disease. J Am Soc Nephrol 2007;18:3078-3088. (Pubitemid 350223968)
29. Johnson TS, Griffin M, Thomas GL, Skill J, Cox A, Yang B, Nicholas B, Birckbichler PJ, Muchaneta-Kubara C, Meguid El Nahas A. The role of transglutaminase in the rat subtotal nephrectomy model of renal fibrosis. J Clin Invest 1997;99:2950-2960. (Pubitemid 27278672)
30. Huang L, Haylor JL, Hau Z, Jones RA, Vickers ME,Wagner B, GriffinM, Saint RE, Coutts IG, El Nahas AM, et al. Transglutaminase inhibition ameliorates experimental diabetic nephropathy. Kidney Int 2009;76:383-394.
31. Shweke N, Boulos N, Jouanneau C, Vandermeersch S, Melino G, Dussaule JC, Chatziantoniou C, Ronco P, Boffa JJ. Tissue transglutaminase contributes to interstitial renal fibrosis by favoring accumulation of fibrillar collagen through TGF-beta activation and cell infiltration. Am J Pathol 2008;173:631-642.
32. Griffin M, Smith LL, Wynne J. Changes in transglutaminase activity in an experimental model of pulmonary fibrosis induced by paraquat. Br J Exp Pathol 1979;60:653-661. (Pubitemid 10219301)
33. Olsen KC, Sapinoro RA, Filiano AJ, Johnson GV, Phipps RP, Sime PJ. Tissue transglutaminase is a novel regulator of pulmonary fibrogenesis [abstract]. Presented at the American Thoracic Society Meeting. San Diego, California. May 2009. A2699.
34. Olsen KC, Sapinoro RA, Johnson GV, Phipps RP, Sime PJ. Tissue transglutaminase promotes pulmonary fibrosis and represents a novel therapeutic target [abstract]. Presented at the ASCI/AAP Joint Meeting. Chicago, Illinois. April 2010.
35. Burgess HA, Daugherty LE, Thatcher TH, Lakatos HF, Ray DM, Redonnet M, Phipps RP, Sime PJ. PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis. Am J Physiol Lung Cell Mol Physiol 2005;288:L1146-L1153. (Pubitemid 40695441)
36. Nanda N, Iismaa SE, Owens WA, Husain A, Mackay F, Graham RM. Targeted inactivation of Gh/tissue transglutaminase II. J Biol Chem 2001;276:20673-20678.
37. Lakatos HF, Burgess HA, Thatcher TH, Redonnet MR, Hernady E, Williams JP, Sime PJ. Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation. Exp Lung Res 2006;32:181-199. (Pubitemid 44266711)
38. Schnabel C, Sawitza I, Tag CG, Lahme B, Gressner AM, Breitkopf K. Expression of cytosolic and membrane associated tissue transglutaminase in rat hepatic stellate cells and its upregulation during transdifferentiation to myofibroblasts in culture. Hepatol Res 2004;28:140-145. (Pubitemid 38220223)
39. Telci D, Collighan RJ, Basaga H, Griffin M. Increased TG2 expression can result in induction of transforming growth factor beta1, causing increased synthesis and deposition of matrix proteins, which can be regulated by nitric oxide. J Biol Chem 2009;284:29547-29558.
40. Akimov SS, Belkin AM. Opposing roles of Ras/Raf oncogenes and the MEK1/ERK signaling module in regulation of expression and adhesive function of surface transglutaminase. J Biol Chem 2003;278:35609-35619. (Pubitemid 37102334)
41. Tucholski J, Lesort M, Johnson GV. Tissue transglutaminase is essential for neurite outgrowth in human neuroblastoma SH-SY5Y cells. Neuroscience 2001;102:481-491. (Pubitemid 32126502)
42. Robitaille K, Daviau A, Lachance G, Couture JP, Blouin R. Calphostin C-induced apoptosis is mediated by a tissue transglutaminase-dependent mechanism involving the DLK/JNK signaling pathway. Cell Death Differ 2008;15:1522-1531.
43. Hocking DC, Sottile J, Langenbach KJ. Stimulation of integrinmediated cell contractility by fibronectin polymerization. J Biol Chem 2000;275:10673-10682. (Pubitemid 30202135)
44. Chen JS, Mehta K. Tissue transglutaminase: an enzyme with a split personality. Int J Biochem Cell Biol 1999;31:817-836. (Pubitemid 29354079)
45. Sime PJ, Xing Z, Graham FL, Csaky KG, Gauldie J. Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J Clin Invest 1997;100:768-776. (Pubitemid 27371693)
46. Wang Z, Collighan RJ, Gross SR, Danen EH, Orend G, Telci D, Griffin M. RGD-independent cell adhesion via a tissue transglutaminasefibronectin matrix promotes fibronectin fibril deposition and requires syndecan-4/2 and {alpha}5{beta}1 integrin co-signaling. J Biol Chem 2010;285:40212-40229.
47. Telci D, Griffin M. Tissue transglutaminase (TG2) - a wound response enzyme. Front Biosci 2006;11:867-882. (Pubitemid 43258187)
48. Moore BB, Hogaboam CM. Murine models of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 2008;294:L152-L160. (Pubitemid 351253350)
49. Phan SH, Kunkel SL. Lung cytokine production in bleomycin-induced pulmonary fibrosis. Exp Lung Res 1992;18:29-43.
50. Annes JP, Munger JS, Rifkin DB. Making sense of latent TGFbeta activation. J Cell Sci 2003;116:217-224. (Pubitemid 36163863)
51. Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR. Cell migration: integrating signals from front to back. Science 2003;302:1704-1709. (Pubitemid 37505725)
52. Telci D, Wang Z, Li X, Verderio EA, Humphries MJ, Baccarini M, Basaga H, Griffin M. Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta1 integrin co-signaling. J Biol Chem 2008;283:20937-20947.
53. Mangala LS, Fok JY, Zorrilla-Calancha IR, Verma A, Mehta K. Tissue transglutaminase expression promotes cell attachment, invasion and survival in breast cancer cells. Oncogene 2007;26:2459-2470. (Pubitemid 46597265)
54. Siegel M, Khosla C. Transglutaminase 2 inhibitors and their therapeutic role in disease states. Pharmacol Ther 2007;115:232-245. (Pubitemid 47042912)