Phosphoinositide 3-kinases upregulate system xc- via eukaryotic initiation factor 2α and activating transcription factor 4-A pathway active in glioblastomas and epilepsy

Antioxidants and Redox Signaling

Volumn 20, Issue 18, 2014, Pages 2907-2922

  Lewerenz, Jan ^a   Baxter, Paul ^b   Kassubek, Rebecca ^a   Albrecht, Philipp ^c   Van Liefferinge, Joeri ^d   Westhoff, Mike Andrew ^e   Halatsch, Marc Eric ^a   Karpel Massler, Georg ^a   Meakin, Paul J ^f   Hayes, John D ^f   Aronica, Eleonora ^g,h   Smolders, Ilse ^d   Ludolph, Albert C ^a   Methner, Axel ⁱ   Conrad, Marcus ^j   Massie, Ann ^d   Hardingham, Giles E ^b   Maher, Pamela ^k  

^a UNIVERSITY OF ULM   (Germany)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^e UNIVERSITY HOSPITAL ULM   (Germany)

^f UNIVERSITY OF DUNDEE   (United Kingdom)

^g UNIVERSITY OF AMSTERDAM   (Netherlands)

^h STICHTING EPILEPSIE INSTELLINGEN NEDERLAND SEIN   (Netherlands)

ⁱ JOHANNES GUTENBERG UNIVERSITY   (Germany)

^j INSTITUTE OF EPIDEMIOLOGY   (Germany)

^k SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ANTIPORTER; CYSTINE GLUTAMATE ANTIPORTER SYSTEM XC; GLYCOGEN SYNTHASE KINASE 3BETA; INITIATION FACTOR 2ALPHA; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; UNCLASSIFIED DRUG; AMINO ACID TRANSPORTER; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; INITIATION FACTOR 2; NEUROPROTECTIVE AGENT; SLC7A11 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; BRAIN CELL; BRAIN CELL CULTURE; CELL PROLIFERATION; CELL STRESS; CONTROLLED STUDY; EMBRYO; ENZYME INHIBITION; FIBROBLAST CULTURE; GLIOBLASTOMA; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; MOUSE; NERVE CELL GROWTH; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIMARY CELL CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; TEMPORAL LOBE EPILEPSY; TRANSCRIPTION INITIATION; TUMOR GROWTH; UPREGULATION; ANTAGONISTS AND INHIBITORS; CANCER STEM CELL; CELL LINE; EPILEPSY; METABOLISM; NERVE CELL; PHOSPHORYLATION; PHYSIOLOGY;

ACTIVATING TRANSCRIPTION FACTOR 4; AMINO ACID TRANSPORT SYSTEM Y+; CELL LINE; EPILEPSY; EUKARYOTIC INITIATION FACTOR-2; GLIOBLASTOMA; GLYCOGEN SYNTHASE KINASE 3; HIPPOCAMPUS; HUMANS; NEOPLASTIC STEM CELLS; NEURONS; NEUROPROTECTIVE AGENTS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84901610814     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2013.5455     Document Type: Article

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