Activation of the antioxidant response element in primary cortical neuronal cultures derived from transgenic reporter mice

Journal of Neurochemistry

Volumn 81, Issue 6, 2002, Pages 1233-1241

  Johnson, D A ^a,b,c,d   Andrews, G K ^d   Xu, W ^b,d   Johnson, J A ^a,b,c,d  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b Environmental Toxicology Center   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

Antioxidant responsive element; NQO1; Oxidative stress; Primary cortical neuronal cultures; tBHQ; Transgenic reporter mice

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ALKALINE PHOSPHATASE; ANTIOXIDANT; GLUTATHIONE ETHYL ESTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CELL PROTECTION; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; EMBRYO; ENZYME ACTIVITY; GENE EXPRESSION; GLIA CELL; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE CELL CULTURE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ALKALINE PHOSPHATASE; ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; CHROMONES; ENZYME ACTIVATION; ENZYME INHIBITORS; GENES, REPORTER; GLUTATHIONE; HISTOCYTOCHEMISTRY; HUMANS; HYDROQUINONES; MICE; MICE, TRANSGENIC; MORPHOLINES; NEURONS; OXIDOREDUCTASES; PLACENTA; QUINONE REDUCTASES; RESPONSE ELEMENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA;

ANIMALIA; EUKARYOTA; MUS MUSCULUS;

EID: 0036319473     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.00913.x     Document Type: Article

References (26)

1. Coordinate regulation of NAD(P)H: Quinone oxidoreductase and glutathione-s-transferases and in primary cultures of rat neurons and glia: Role of the antioxidant/electrophile responsive element
2. Nrf2 is essential for protection against acute pulmonary injury in mice
3. Persuasive evidence that quinone reductase type I (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen
4. Activation of endogenous antioxidant defenses in neuronal cells prevents free radical-mediated damage
5. Regulatory mechanisms of cellular response to oxidative stress
6. Production of reactive oxygen species due to metabolic activation of butylated hydroxyanisole
7. The antioxidant enzyme quinone reductase is up-regulated in vivo following cerebral ischemia
8. Phosphatidylinositol 3 kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant responsive element in IMR-32 human neuroblastoma cells
9. Nrf2 dependent activation of the antioxidant responsive element by tert butylhydroquinone is independent of oxidative stress in IMR-32 human neuroblastoma cells
10. Regulation of human NAD(P)H: Quinone oxidoreductasegene. Role of AP1 binding site contained within human antioxidant response element
11. DT-diaphorase: Purification, properties, and function
12. Activation of antioxidant/electrophile responsive elements in IMR-32 human neuroblastoma cells
13. An electrophile responsive element (EpRE) regulates beta-naphthoflavone induction of the human gamma-glutamylcysteine synthetase regulatory subunit gene. Constitutive expression is mediated by an adjacent AP-1 site
14. Up-regulation of the human γ-glutamylcysteine synthetase subunit gene involves binding of Nrf2 to an electrophile-responsive element
15. Identification of a putative antioxidant response element in the 5′-flanking region of the human gamma-glutamylcysteine synthetase heavy subunit gene
16. Enhanced NAD(P)H: Quinone reductase activity prevents glutamate toxicity produced by oxidative stress
17. Preferential expression of antioxidant response element mediated gene expression in astrocytes
18. Histochemical detection of quinone reductase activity in situ using LY 83583 reduction and oxidation
19. Contribution of oxygen radicals to DNA cleavage by quinone compounds derived from phenolic antioxidants, tert butylhydroquinone and 2,5-di-tert butylhydroquinone
20. Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: Regulation by upstream antioxidant-responsive elements (ARE)
21. Transcriptional regulation of the rat glutathione S transferase Ya subunit gene. Characterization of a xenobiotic responsive element controlling inducible expression by phenolic antioxidants
22. Distribution of DT diaphorase in the rat brain: Biochemical and immunohistochemical studies
23. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues
24. Nrf1 and Nrf2 positively and c-Fos and Fra 1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H: Quinone oxidoreductase 1 gene
25. NAD(P)H: Quinone oxidoreductase activity is increased in hippocampal pyramidal neurons of patients with Alzheimer's disease
26. Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2