DHEA prevents Aβ25-35-impaired survival of newborn neurons in the dentate gyrus through a modulation of PI3K-Akt-mTOR signaling

Neuropharmacology

Volumn 59, Issue 4-5, 2010, Pages 323-333

  Li, Liang ^a   Xu, Bingzhong ^a   Zhu, Ying ^a   Chen, Lei ^a   Sokabe, Masahiro ^b   Chen, Ling ^a,b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

amyloid (A ); Dehydroepiandrosterone (DHEA); Mammalian target of rapamycin (mTOR); Neurogenesis; Phosphatidylinositol 3 kinase (PI3K)

Indexed keywords

1 PHENYLCYCLOHEXANECARBOXYLIC ACID 2 MORPHOLINOETHYL ESTER; 2 [4 METHOXY 3 (2 PHENYLETHOXY)PHENYL] N,N DIPROPYLETHYLAMINE; 2 MORPHOLINO 8 PHENYLCHROMONE; AMYLOID BETA PROTEIN[25-35]; BROXURIDINE; DOUBLECORTIN; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PRASTERONE; PROTEIN KINASE B; RAPAMYCIN; S6 KINASE; SIGMA 1 OPIATE RECEPTOR;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CELL SURVIVAL; CONCENTRATION LOSS; CONTROLLED STUDY; DENDRITE; DENTATE GYRUS; EMBRYO; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVE FIBER GROWTH; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

AMYLOID BETA-PEPTIDES; ANIMALS; CELL SURVIVAL; DEHYDROEPIANDROSTERONE; DENTATE GYRUS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MICE; MICE, INBRED ICR; NEUROGENESIS; NEURONS; PEPTIDE FRAGMENTS; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 77955926291     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2010.02.009     Document Type: Article

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