메뉴 건너뛰기




Volumn 72, Issue 1, 2013, Pages 33-41

Increased xCT expression correlates with tumor invasion and outcome in patients with glioblastomas

Author keywords

Glioblastoma; Glutamate; Magnetic resonance imaging; Prognostic factor; XCT

Indexed keywords

ANTIPORTER; ISOCITRATE DEHYDROGENASE 1; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; TEMOZOLOMIDE; UNCLASSIFIED DRUG; XCT PROTEIN;

EID: 84871962040     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/NEU.0b013e318276b2de     Document Type: Article
Times cited : (81)

References (40)
  • 1
    • 0035843243 scopus 로고    scopus 로고
    • Brain tumors
    • DeAngelis LM. Brain tumors. N Engl J Med. 2001;344(2):114-123.
    • (2001) N Engl J Med. , vol.344 , Issue.2 , pp. 114-123
    • Deangelis, L.M.1
  • 2
    • 35949002429 scopus 로고    scopus 로고
    • Malignant astrocytic glioma: Genetics, biology, and paths to treatment
    • Furnari FB, Fenton T, Bachoo RM, et al. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev. 2007;21(21):2683-2710.
    • (2007) Genes Dev. , vol.21 , Issue.21 , pp. 2683-2710
    • Furnari, F.B.1    Fenton, T.2    Bachoo, R.M.3
  • 3
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • Wen PY, Kesari S. Malignant gliomas in adults. N Engl J Med. 2008;359(5):492-507.
    • (2008) N Engl J Med. , vol.359 , Issue.5 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2
  • 4
    • 0027294649 scopus 로고
    • Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials
    • Curran WJ Jr, Scott CB, Horton J, et al. Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials. J Natl Cancer Inst. 1993;85(9):704-710.
    • (1993) J Natl Cancer Inst. , vol.85 , Issue.9 , pp. 704-710
    • Curran Jr., W.J.1    Scott, C.B.2    Horton, J.3
  • 5
    • 33745010017 scopus 로고    scopus 로고
    • Radiotherapy and temozolomide for newly diagnosed glioblastoma: Recursive partitioning analysis of the EORTC 26981/22981-NCIC CE3 phase III randomized trial
    • Mirimanoff RO, Gorlia T,Mason W, et al. Radiotherapy and temozolomide for newly diagnosed glioblastoma: recursive partitioning analysis of the EORTC 26981/22981-NCIC CE3 phase III randomized trial. J Clin Oncol. 2006;24(16):2563-2569.
    • (2006) J Clin Oncol. , vol.24 , Issue.16 , pp. 2563-2569
    • Mirimanoff, R.O.1    Gorlia Tmason, W.2
  • 6
    • 42449156691 scopus 로고    scopus 로고
    • Identification of noninvasive imaging surrogates for brain tumor geneYexpression modules
    • Diehn M, Nardini C, Wang DS, et al. Identification of noninvasive imaging surrogates for brain tumor geneYexpression modules. Proc Natl Acad Sci U S A. 2008;105(13):5213-5218.
    • (2008) Proc Natl Acad Sci U S A. , vol.105 , Issue.13 , pp. 5213-5218
    • Diehn, M.1    Nardini, C.2    Wang, D.S.3
  • 7
    • 0034871451 scopus 로고    scopus 로고
    • A multivariate analysis of 416 patients with glioblastoma multiforme: Prognosis, extent of resection, and survival
    • Lacroix M, AbiYSaid D, Fourney DR, et al. A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg. 2001;95(2):190-198.
    • (2001) J Neurosurg. , vol.95 , Issue.2 , pp. 190-198
    • Lacroix, M.1    Abiysaid, D.2    Fourney, D.R.3
  • 8
    • 70350314719 scopus 로고    scopus 로고
    • The correlation and prognostic significance of MGMT promoter methylation and MGMT protein in glioblastomas
    • Cao VT, Jung TY, Jung S, et al. The correlation and prognostic significance of MGMT promoter methylation and MGMT protein in glioblastomas. Neurosurgery. 2009;65(5):866-875.
    • (2009) Neurosurgery. , vol.65 , Issue.5 , pp. 866-875
    • Cao, V.T.1    Jung, T.Y.2    Jung, S.3
  • 9
    • 20044372154 scopus 로고    scopus 로고
    • MGMT gene silencing and benefit from temozolomide in glioblastoma
    • Hegi ME, Diserens AC, Gorlia T, et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med. 2005;352(10):997-1003.
    • (2005) N Engl J Med. , vol.352 , Issue.10 , pp. 997-1003
    • Hegi, M.E.1    Diserens, A.C.2    Gorlia, T.3
  • 10
    • 84856098344 scopus 로고    scopus 로고
    • Correlation of IDH1 mutation with clinicopathologic factors and prognosis in primary glioblastoma: A report of 118 patients from China
    • Yan W, Zhang W, You G, et al. Correlation of IDH1 mutation with clinicopathologic factors and prognosis in primary glioblastoma: a report of 118 patients from China. PLoS One. 2012;7(1):e30339.
    • (2012) PLoS One , vol.7 , Issue.1
    • Yan, W.1    Zhang, W.2    You, G.3
  • 11
    • 0031015591 scopus 로고    scopus 로고
    • Recognition and management of gliomas
    • Kaba SE, Kyritsis AP. Recognition and management of gliomas. Drugs. 1997;53 (2):235-244.
    • (1997) Drugs. , vol.53 , Issue.2 , pp. 235-244
    • Kaba, S.E.1    Kyritsis, A.P.2
  • 12
    • 0033198997 scopus 로고    scopus 로고
    • Glioma cells release excitotoxic concentrations of glutamate
    • Ye ZC, Sontheimer H. Glioma cells release excitotoxic concentrations of glutamate. Cancer Res. 1999;59(17):4383-4391.
    • (1999) Cancer Res. , vol.59 , Issue.17 , pp. 4383-4391
    • Ye, Z.C.1    Sontheimer, H.2
  • 13
    • 0033909858 scopus 로고    scopus 로고
    • Extracellular glutamate and other metabolites in and around RG2 rat glioma: An intracerebral microdialysis study
    • Behrens PF, Langemann H, Strohschein R, Draeger J, Hennig J. Extracellular glutamate and other metabolites in and around RG2 rat glioma: an intracerebral microdialysis study. J Neurooncol. 2000;47(1):11-22.
    • (2000) J Neurooncol. , vol.47 , Issue.1 , pp. 11-22
    • Behrens, P.F.1    Langemann, H.2    Strohschein, R.3    Draeger, J.4    Hennig, J.5
  • 15
    • 44949122670 scopus 로고    scopus 로고
    • Small interfering RNAYmediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema
    • Savaskan NE, Heckel A, Hahnen E, et al. Small interfering RNAYmediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema. Nat Med. 2008;14(6):629-632.
    • (2008) Nat Med. , vol.14 , Issue.6 , pp. 629-632
    • Savaskan, N.E.1    Heckel, A.2    Hahnen, E.3
  • 16
    • 77949266026 scopus 로고    scopus 로고
    • In vivo assessment of highgrade glioma biochemistry using microdialysis: A study of energy-related molecules, growth factors and cytokines
    • Marcus HJ, Carpenter KL, Price SJ, Hutchinson PJ. In vivo assessment of highgrade glioma biochemistry using microdialysis: a study of energy-related molecules, growth factors and cytokines. J Neurooncol. 2010;97(1):11-23.
    • (2010) J Neurooncol. , vol.97 , Issue.1 , pp. 11-23
    • Marcus, H.J.1    Carpenter, K.L.2    Price, S.J.3    Hutchinson, P.J.4
  • 18
    • 16444366144 scopus 로고    scopus 로고
    • The excitatory amino acid transporterY2 induces apoptosis and decreases glioma growth in vitro and in vivo
    • de Groot JF, Liu TJ, Fuller G, Yung WK. The excitatory amino acid transporterY2 induces apoptosis and decreases glioma growth in vitro and in vivo. Cancer Res. 2005;65(5):1934-1940.
    • (2005) Cancer Res. , vol.65 , Issue.5 , pp. 1934-1940
    • De Groot, J.F.1    Liu, T.J.2    Fuller, G.3    Yung, W.K.4
  • 19
    • 77956615063 scopus 로고    scopus 로고
    • XCTmodulation in gliomas: Relevance to energy metabolism and tumor microenvironment normalization
    • Savaskan NE, Eyüpoglu IY. xCTmodulation in gliomas: relevance to energy metabolism and tumor microenvironment normalization. Ann Anat. 2010;192(5):309-313.
    • (2010) Ann Anat. , vol.192 , Issue.5 , pp. 309-313
    • Savaskan, N.E.1    Eyüpoglu, I.Y.2
  • 20
    • 23444449591 scopus 로고    scopus 로고
    • Inhibition of cystine uptake disrupts the growth of primary brain tumors
    • Chung WJ, Lyons SA, Nelson GM, et al. Inhibition of cystine uptake disrupts the growth of primary brain tumors. J Neurosci. 2005;25(31):7101-7110.
    • (2005) J Neurosci. , vol.25 , Issue.31 , pp. 7101-7110
    • Chung, W.J.1    Lyons, S.A.2    Nelson, G.M.3
  • 21
    • 42949126711 scopus 로고    scopus 로고
    • The x(c)Y cystine/glutamate antiporter: A potential target for therapy of cancer and other diseases
    • Lo M, Wang YZ, Gout PW. The x(c)Y cystine/glutamate antiporter: a potential target for therapy of cancer and other diseases. J Cell Physiol. 2008;215(3):593-602.
    • (2008) J Cell Physiol. , vol.215 , Issue.3 , pp. 593-602
    • Lo, M.1    Wang, Y.Z.2    Gout, P.W.3
  • 22
    • 67650071137 scopus 로고    scopus 로고
    • Targeting cancer cells by ROSYmediated mechanisms: A radical therapeutic approach?
    • Trachootham D, Alexandre J, Huang P. Targeting cancer cells by ROSYmediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov. 2009;8(7):579-591.
    • (2009) Nat Rev Drug Discov. , vol.8 , Issue.7 , pp. 579-591
    • Trachootham, D.1    Alexandre, J.2    Huang, P.3
  • 23
    • 59149104276 scopus 로고    scopus 로고
    • Disruption of xCT inhibits cancer cell metastasis via the caveolinY1/betaYcatenin pathway
    • Chen RS, Song YM, Zhou ZY, et al. Disruption of xCT inhibits cancer cell metastasis via the caveolinY1/betaYcatenin pathway. Oncogene. 2009;28(4):599-609.
    • (2009) Oncogene. , vol.28 , Issue.4 , pp. 599-609
    • Chen, R.S.1    Song, Y.M.2    Zhou, Z.Y.3
  • 24
    • 27844530663 scopus 로고    scopus 로고
    • Redox imbalance in cystine/glutamate transporterYdeficient mice
    • Sato H, Shiiya A, Kimata M, et al. Redox imbalance in cystine/glutamate transporterYdeficient mice. J Biol Chem. 2005;280(45):37423-37429.
    • (2005) J Biol Chem. , vol.280 , Issue.45 , pp. 37423-37429
    • Sato, H.1    Shiiya, A.2    Kimata, M.3
  • 25
    • 23844486685 scopus 로고    scopus 로고
    • CystineYglutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance
    • Huang Y,Dai Z, Barbacioru C, SadéeW. CystineYglutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance. Cancer Res. 2005;65(16):7446-7454.
    • (2005) Cancer Res. , vol.65 , Issue.16 , pp. 7446-7454
    • Huang, Y.1    Dai, Z.2    Barbacioru, C.3    Sadé, W.4
  • 26
  • 27
    • 38649112593 scopus 로고    scopus 로고
    • In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, eds. WHO Classification of Tumours of the Central Nervous System. Lyon, France: IARC
    • Kleihues P, Burger PC, Aldape KD, et al. Glioblastoma. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, eds. WHO Classification of Tumours of the Central Nervous System. Lyon, France: IARC; 2007:33-49.
    • (2007) Glioblastoma , pp. 33-49
    • Kleihues, P.1    Burger, P.C.2    Aldape, K.D.3
  • 28
    • 34548147443 scopus 로고    scopus 로고
    • Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis
    • Mikeska T, Bock C, ElYMaarri O, et al. Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis. J Mol Diagn. 2007;9(3):368-381.
    • (2007) J Mol Diagn. , vol.9 , Issue.3 , pp. 368-381
    • Mikeska, T.1    Bock, C.2    El-Maarri, O.3
  • 29
    • 0038678777 scopus 로고    scopus 로고
    • Sensitive and quantitative universal pyrosequencing methylation analysis of CpG sites
    • Colella S, Shen L, Baggerly KA, Issa JP, Krahe R. Sensitive and quantitative universal pyrosequencing methylation analysis of CpG sites. Biotechniques. 2003;35(1):146-150.
    • (2003) Biotechniques. , vol.35 , Issue.1 , pp. 146-150
    • Colella, S.1    Shen, L.2    Baggerly, K.A.3    Issa, J.P.4    Krahe, R.5
  • 30
    • 44249112125 scopus 로고    scopus 로고
    • Phase II study of extendedYdose temozolomide in patients with melanoma
    • Rietschel P, Wolchok JD, Krown S, et al. Phase II study of extendedYdose temozolomide in patients with melanoma. J Clin Oncol. 2008;26(14):2299-2304.
    • (2008) J Clin Oncol. , vol.26 , Issue.14 , pp. 2299-2304
    • Rietschel, P.1    Wolchok, J.D.2    Krown, S.3
  • 31
    • 81055127888 scopus 로고    scopus 로고
    • System xc cystine/glutamate antiporter: An update on molecular pharmacology and roles within the CNS
    • Bridges RJ, Natale NR, Patel SA. System xc cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS.Br J Pharmacol. 2012;165(1):20-34.
    • (2012) Br J Pharmacol. , vol.165 , Issue.1 , pp. 20-34
    • Bridges, R.J.1    Natale, N.R.2    Patel, S.A.3
  • 32
    • 84930482848 scopus 로고    scopus 로고
    • Thinking outside the cleft to understand synaptic activity: Contribution of the cystineYglutamate antiporter (System xcY) to normal and pathological glutamatergic signaling
    • Bridges R, Lutgen V, Lobner D, Baker DA. Thinking outside the cleft to understand synaptic activity: contribution of the cystineYglutamate antiporter (System xcY) to normal and pathological glutamatergic signaling. Pharmacol Rev. 2012;64(3):780-802.
    • (2012) Pharmacol Rev. , vol.64 , Issue.3 , pp. 780-802
    • Bridges, R.1    Lutgen, V.2    Lobner, D.3    Baker, D.A.4
  • 33
    • 84859031263 scopus 로고    scopus 로고
    • The oxidative stressYinducible cystine/glutamate antiporter, system x (c) (Y) : Cystine supplier and beyond
    • Conrad M, Sato H. The oxidative stressYinducible cystine/glutamate antiporter, system x (c) (Y) : cystine supplier and beyond. Amino Acids. 2012;42(1):231-246.
    • (2012) Amino Acids. , vol.42 , Issue.1 , pp. 231-246
    • Conrad, M.1    Sato, H.2
  • 34
    • 84860262330 scopus 로고    scopus 로고
    • Regulation of xCT expression and system x (c) (Y) function in neuronal cells
    • Lewerenz J, Maher P, Methner A. Regulation of xCT expression and system x (c) (Y) function in neuronal cells. Amino Acids. 2012;42(1):171-179.
    • (2012) Amino Acids. , vol.42 , Issue.1 , pp. 171-179
    • Lewerenz, J.1    Maher, P.2    Methner, A.3
  • 35
    • 33646018919 scopus 로고    scopus 로고
    • Distribution of the cystine/glutamate antiporter system xcY in the brain, kidney, and duodenum
    • Burdo J, Dargusch R, Schubert D. Distribution of the cystine/glutamate antiporter system xcY in the brain, kidney, and duodenum. J Histochem Cytochem. 2006;54 (5):549-557.
    • (2006) J Histochem Cytochem. , vol.54 , Issue.5 , pp. 549-557
    • Burdo, J.1    Dargusch, R.2    Schubert, D.3
  • 36
    • 0025570260 scopus 로고
    • Uptake of glutamate and cysteine in CY6 glioma cells and in cultured astrocytes
    • Cho Y, Bannai S. Uptake of glutamate and cysteine in CY6 glioma cells and in cultured astrocytes. J Neurochem. 1990;55(6):2091-2097.
    • (1990) J Neurochem. , vol.55 , Issue.6 , pp. 2091-2097
    • Cho, Y.1    Bannai, S.2
  • 37
    • 70450228522 scopus 로고    scopus 로고
    • Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of sulfasalazine for the treatment of progressing malignant gliomas in adults
    • Robe PA, Martin DH, NguyenYKhac MT, et al. Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of sulfasalazine for the treatment of progressing malignant gliomas in adults. BMC Cancer. 2009;9:372.
    • (2009) BMC Cancer. , vol.9 , pp. 372
    • Robe, P.A.1    Martin, D.H.2    Nguyenykhac, M.T.3
  • 38
    • 12944305859 scopus 로고    scopus 로고
    • Glutathione synthesis is essential for mouse development but not for cell growth in culture
    • Shi ZZ, OseiYFrimpong J, Kala G, et al. Glutathione synthesis is essential for mouse development but not for cell growth in culture. Proc Natl Acad Sci U S A. 2000;97(10):5101-5106.
    • (2000) Proc Natl Acad Sci U S A. , vol.97 , Issue.10 , pp. 5101-5106
    • Shi, Z.Z.1    Osei, Y.2    Frimpong, J.3    Kala, G.4
  • 39
    • 80052677148 scopus 로고    scopus 로고
    • Prognostic significance of IDHY1 and MGMT in patients with glioblastoma: One step forward, and one step back?
    • Combs SE, Rieken S, Wick W, et al. Prognostic significance of IDHY1 and MGMT in patients with glioblastoma: one step forward, and one step back? Radiat Oncol. 2011;6(1):115.
    • (2011) Radiat Oncol , vol.6 , Issue.1 , pp. 115
    • Combs, S.E.1    Rieken, S.2    Wick, W.3
  • 40
    • 77951748188 scopus 로고    scopus 로고
    • Prognostic value of MGMT promoter methylation in glioblastoma patients treated with temozolomideYbased chemoradiation: A Portuguese multicentre study
    • Costa BM, Caeiro C, Guimarães I, et al. Prognostic value of MGMT promoter methylation in glioblastoma patients treated with temozolomideYbased chemoradiation: a Portuguese multicentre study. Oncol Rep. 2010;23(6):1655-1662.
    • (2010) Oncol Rep. , vol.23 , Issue.6 , pp. 1655-1662
    • Costa, B.M.1    Caeiro, C.2    Guimarães, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.