-
1
-
-
84901428033
-
Thienotriazolodiazepine compound and a medicinal use thereof
-
K. Adachi, H. Hikawa, M. Hamada, J.-i. Endoh, S. Ishibuchi, N. Fujie, M. Tanaka, K. Sugahara, K. Oshita, and M. Murata Thienotriazolodiazepine compound and a medicinal use thereof Japan patent WO2006JP310709 July 2006
-
(2006)
Japan Patent WO2006JP310709
-
-
Adachi, K.1
Hikawa, H.2
Hamada, M.3
Endoh, J.-I.4
Ishibuchi, S.5
Fujie, N.6
Tanaka, M.7
Sugahara, K.8
Oshita, K.9
Murata, M.10
-
2
-
-
84901455658
-
Bromodomain inhibitors and uses thereof
-
B.K. Albrecht, J.E. Audia, A. Cote, V.S. Gehling, J.-C. Harmange, M.C. Hewitt, Y. LeBlanc, C.G. Naveschuk, A.M. Taylor, and R.G. Vaswani Bromodomain inhibitors and uses thereof U.S. patent 20120157428 A1 June 2012
-
(2012)
U.S. Patent 20120157428 A1
-
-
Albrecht, B.K.1
Audia, J.E.2
Cote, A.3
Gehling, V.S.4
Harmange, J.-C.5
Hewitt, M.C.6
Leblanc, Y.7
Naveschuk, C.G.8
Taylor, A.M.9
Vaswani, R.G.10
-
3
-
-
0030960354
-
Two tyrosine residues on the α subunit are crucial for benzodiazepine binding and allosteric modulation of γ-aminobutyric acid(A) receptors
-
A receptors Mol. Pharmacol. 51 1997 833 841 (Pubitemid 27224689)
-
(1997)
Molecular Pharmacology
, vol.51
, Issue.5
, pp. 833-841
-
-
Amin, J.1
Brooks-Kayal, A.2
Weiss, D.S.3
-
4
-
-
67651100839
-
Benzothiophene inhibitors of MK2. Part 1: Structure-activity relationships, assessments of selectivity and cellular potency
-
D.R. Anderson, M.J. Meyers, R.G. Kurumbail, N. Caspers, G.I. Poda, S.A. Long, B.S. Pierce, M.W. Mahoney, and R.J. Mourey Benzothiophene inhibitors of MK2. Part 1: structure-activity relationships, assessments of selectivity and cellular potency Bioorg. Med. Chem. Lett. 19 2009 4878 4881
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 4878-4881
-
-
Anderson, D.R.1
Meyers, M.J.2
Kurumbail, R.G.3
Caspers, N.4
Poda, G.I.5
Long, S.A.6
Pierce, B.S.7
Mahoney, M.W.8
Mourey, R.J.9
-
5
-
-
0033383112
-
The use of benzodiazepines in anxiety and other disorders
-
S.V. Argyropoulos, and D.J. Nutt The use of benzodiazepines in anxiety and other disorders Eur. Neuropsychopharmacol. 9 Suppl 6 1999 S407 S412
-
(1999)
Eur. Neuropsychopharmacol.
, vol.9
, Issue.SUPPL. 6
-
-
Argyropoulos, S.V.1
Nutt, D.J.2
-
6
-
-
84860371953
-
Epigenetic protein families: A new frontier for drug discovery
-
C.H. Arrowsmith, C. Bountra, P.V. Fish, K. Lee, and M. Schapira Epigenetic protein families: a new frontier for drug discovery Nat. Rev. Drug Discov. 11 2012 384 400
-
(2012)
Nat. Rev. Drug Discov.
, vol.11
, pp. 384-400
-
-
Arrowsmith, C.H.1
Bountra, C.2
Fish, P.V.3
Lee, K.4
Schapira, M.5
-
7
-
-
20344392658
-
A receptors as a target for the development of novel anxiolytics
-
DOI 10.1517/13543784.14.5.601
-
A) receptors as a target for the development of novel anxiolytics Expert Opin. Investig. Drugs 14 2005 601 618 (Pubitemid 40790282)
-
(2005)
Expert Opinion on Investigational Drugs
, vol.14
, Issue.5
, pp. 601-618
-
-
Atack, J.R.1
-
8
-
-
84856399470
-
Fragment-based discovery of bromodomain inhibitors part 2: Optimization of phenylisoxazole sulfonamides
-
P. Bamborough, H. Diallo, J.D. Goodacre, L. Gordon, A. Lewis, J.T. Seal, D.M. Wilson, M.D. Woodrow, and C.W. Chung Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides J. Med. Chem. 55 2012 587 596
-
(2012)
J. Med. Chem.
, vol.55
, pp. 587-596
-
-
Bamborough, P.1
Diallo, H.2
Goodacre, J.D.3
Gordon, L.4
Lewis, A.5
Seal, J.T.6
Wilson, D.M.7
Woodrow, M.D.8
Chung, C.W.9
-
9
-
-
84862738480
-
BET domain co-regulators in obesity, inflammation and cancer
-
A.C. Belkina, and G.V. Denis BET domain co-regulators in obesity, inflammation and cancer Nat. Rev. Cancer 12 2012 465 477
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 465-477
-
-
Belkina, A.C.1
Denis, G.V.2
-
10
-
-
84882873847
-
Benzodiazepines
-
G. Fink, Academic Press Waltham, MA
-
J. Bermak, T. Johnstone, and K. Gee Benzodiazepines G. Fink, Encyclopedia of Stress 2007 Academic Press Waltham, MA 310 316
-
(2007)
Encyclopedia of Stress
, pp. 310-316
-
-
Bermak, J.1
Johnstone, T.2
Gee, K.3
-
11
-
-
0020658848
-
Brain receptor binding and lipophilic character of benzodiazepines
-
DOI 10.1016/0006-2952(83)90482-3
-
P.A. Borea, and A. Bonora Brain receptor binding and lipophilic character of benzodiazepines Biochem. Pharmacol. 32 1983 603 607 (Pubitemid 13148273)
-
(1983)
Biochemical Pharmacology
, vol.32
, Issue.4
, pp. 603-607
-
-
Borea, P.A.1
Bonora, A.2
-
12
-
-
0029998387
-
A) receptor affecting modulation of the channel by ligands of the benzodiazepine binding site
-
A) receptor affecting modulation of the channel by ligands of the benzodiazepine binding site Mol. Pharmacol. 49 1996 1080 1084
-
(1996)
Mol. Pharmacol.
, vol.49
, pp. 1080-1084
-
-
Buhr, A.1
Baur, R.2
Malherbe, P.3
Sigel, E.4
-
13
-
-
0030801390
-
Residues at positions 206 and 209 of the α1 subunit of γ-aminobutyric acid(A) receptors influence affinities for benzodiazepine binding site ligands
-
A receptors influence affinities for benzodiazepine binding site ligands Mol. Pharmacol. 52 1997 676 682 (Pubitemid 27443990)
-
(1997)
Molecular Pharmacology
, vol.52
, Issue.4
, pp. 676-682
-
-
Buhr, A.1
Schaerer, M.T.2
Baur, R.3
Sigel, E.4
-
14
-
-
0025995750
-
Isosterism and bioisosterism in drug design
-
A. Burger Isosterism and bioisosterism in drug design Prog. Drug Res. 37 1991 287 371
-
(1991)
Prog. Drug Res.
, vol.37
, pp. 287-371
-
-
Burger, A.1
-
15
-
-
77955014467
-
Natural products as chemical probes
-
E.E. Carlson Natural products as chemical probes ACS Chem. Biol. 5 2010 639 653
-
(2010)
ACS Chem. Biol.
, vol.5
, pp. 639-653
-
-
Carlson, E.E.1
-
16
-
-
84877097843
-
Inhibition of BET bromodomain targets genetically diverse glioblastoma
-
Z. Cheng, Y. Gong, Y. Ma, K. Lu, X. Lu, L.A. Pierce, R.C. Thompson, S. Muller, S. Knapp, and J. Wang Inhibition of BET bromodomain targets genetically diverse glioblastoma Clin. Cancer Res. 19 2013 1748 1759
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 1748-1759
-
-
Cheng, Z.1
Gong, Y.2
Ma, Y.3
Lu, K.4
Lu, X.5
Pierce, L.A.6
Thompson, R.C.7
Muller, S.8
Knapp, S.9
Wang, J.10
-
17
-
-
84859926557
-
Small molecule bromodomain inhibitors: Extending the druggable genome
-
C.W. Chung Small molecule bromodomain inhibitors: extending the druggable genome Prog. Med. Chem. 51 2012 1 55
-
(2012)
Prog. Med. Chem.
, vol.51
, pp. 1-55
-
-
Chung, C.W.1
-
18
-
-
79958078949
-
Discovery and characterization of small molecule inhibitors of the BET family bromodomains
-
C.W. Chung, H. Coste, J.H. White, O. Mirguet, J. Wilde, R.L. Gosmini, C. Delves, S.M. Magny, R. Woodward, and S.A. Hughes et al. Discovery and characterization of small molecule inhibitors of the BET family bromodomains J. Med. Chem. 54 2011 3827 3838
-
(2011)
J. Med. Chem.
, vol.54
, pp. 3827-3838
-
-
Chung, C.W.1
Coste, H.2
White, J.H.3
Mirguet, O.4
Wilde, J.5
Gosmini, R.L.6
Delves, C.7
Magny, S.M.8
Woodward, R.9
Hughes, S.A.10
-
19
-
-
84856397832
-
Fragment-based discovery of bromodomain inhibitors part 1: Inhibitor binding modes and implications for lead discovery
-
C.W. Chung, A.W. Dean, J.M. Woolven, and P. Bamborough Fragment-based discovery of bromodomain inhibitors part 1: inhibitor binding modes and implications for lead discovery J. Med. Chem. 55 2012 576 586
-
(2012)
J. Med. Chem.
, vol.55
, pp. 576-586
-
-
Chung, C.W.1
Dean, A.W.2
Woolven, J.M.3
Bamborough, P.4
-
20
-
-
33644872086
-
Privileged structures as leads in medicinal chemistry
-
L. Costantino, and D. Barlocco Privileged structures as leads in medicinal chemistry Curr. Med. Chem. 13 2006 65 85
-
(2006)
Curr. Med. Chem.
, vol.13
, pp. 65-85
-
-
Costantino, L.1
Barlocco, D.2
-
21
-
-
0035122824
-
Molecular targets for the myorelaxant action of diazepam
-
F. Crestani, K. Löw, R. Keist, M.-J. Mandelli, H. Möhler, and U. Rudolph Molecular targets for the myorelaxant action of diazepam Mol. Pharmacol. 59 2001 442 445 (Pubitemid 32179921)
-
(2001)
Molecular Pharmacology
, vol.59
, Issue.3
, pp. 442-445
-
-
Crestani, F.1
Low, K.2
Keist, R.3
Mandelli, M.-J.4
Mohler, H.5
Rudolph, U.6
-
22
-
-
0037173096
-
A receptors
-
DOI 10.1073/pnas.142288699
-
A) receptors Proc. Natl. Acad. Sci. USA 99 2002 8980 8985 (Pubitemid 34693669)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.13
, pp. 8980-8985
-
-
Crestani, F.1
Keist, R.2
Fritschy, J.-M.3
Benke, D.4
Vogt, K.5
Prut, L.6
Bluthmann, H.7
Mohler, H.8
Rudolph, U.9
-
23
-
-
80054984945
-
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
-
M.A. Dawson, R.K. Prinjha, A. Dittmann, G. Giotopoulos, M. Bantscheff, W.-I. Chan, S.C. Robson, C.W. Chung, C. Hopf, and M.M. Savitski et al. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia Nature 478 2011 529 533
-
(2011)
Nature
, vol.478
, pp. 529-533
-
-
Dawson, M.A.1
Prinjha, R.K.2
Dittmann, A.3
Giotopoulos, G.4
Bantscheff, M.5
Chan, W.-I.6
Robson, S.C.7
Chung, C.W.8
Hopf, C.9
Savitski, M.M.10
-
26
-
-
0033519641
-
Structure and ligand of a histone acetyltransferase bromodomain
-
DOI 10.1038/20974
-
C. Dhalluin, J.E. Carlson, L. Zeng, C. He, A.K. Aggarwal, and M.-M. Zhou Structure and ligand of a histone acetyltransferase bromodomain Nature 399 1999 491 496 (Pubitemid 29258857)
-
(1999)
Nature
, vol.399
, Issue.6735
, pp. 491-496
-
-
Dhalluin, C.1
Carlson, J.E.2
Zeng, L.3
He, C.4
Aggarwal, A.K.5
Zhou, M.-M.6
-
27
-
-
0020647123
-
3H-benzodiazepine binding sites in brain and of benzodiazepine pharmacological properties
-
DOI 10.1016/0091-3057(83)90192-2
-
3H-benzodiazepine binding sites in brain and of benzodiazepine pharmacological properties Pharmacol. Biochem. Behav. 18 1983 311 318 (Pubitemid 13137615)
-
(1983)
Pharmacology Biochemistry and Behavior
, vol.18
, Issue.2
, pp. 311-318
-
-
Dubnick, B.1
Lippa, A.S.2
Klepner, C.A.3
-
28
-
-
0029082485
-
The road to tranquility: The search for selective anti-anxiety agents
-
J.W. Estes The road to tranquility: the search for selective anti-anxiety agents Synapse 21 1995 10 20
-
(1995)
Synapse
, vol.21
, pp. 10-20
-
-
Estes, J.W.1
-
29
-
-
0010401679
-
Design of potent, orally effective, nonpeptidal antagonists of the peptide hormone cholecystokinin
-
B.E. Evans, M.G. Bock, K.E. Rittle, R.M. DiPardo, W.L. Whitter, D.F. Veber, P.S. Anderson, and R.M. Freidinger Design of potent, orally effective, nonpeptidal antagonists of the peptide hormone cholecystokinin Proc. Natl. Acad. Sci. USA 83 1986 4918 4922 (Pubitemid 16075510)
-
(1986)
Proceedings of the National Academy of Sciences of the United States of America
, vol.83
, Issue.13
, pp. 4918-4922
-
-
Evans, B.E.1
Bock, M.G.2
Rittle, K.E.3
-
30
-
-
0024239320
-
Methods for drug discovery: Development of potent, selective, orally effective cholecystokinin antagonists
-
DOI 10.1021/jm00120a002
-
B.E. Evans, K.E. Rittle, M.G. Bock, R.M. DiPardo, R.M. Freidinger, W.L. Whitter, G.F. Lundell, D.F. Veber, P.S. Anderson, and R.S.L. Chang et al. Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists J. Med. Chem. 31 1988 2235 2246 (Pubitemid 19001640)
-
(1988)
Journal of Medicinal Chemistry
, vol.31
, Issue.12
, pp. 2235-2246
-
-
Evans, B.E.1
Rittle, K.E.2
Bock, M.G.3
DiPardo, R.M.4
Freidinger, R.M.5
Whitter, W.L.6
Lundell, G.F.7
Veber, D.F.8
Anderson, P.S.9
Chang, R.S.L.10
Lotti, V.J.11
Cerino, D.J.12
Chen, T.B.13
Kling, P.J.14
Kunkel, K.A.15
Springer, J.P.16
Hirshfield, J.17
-
31
-
-
78650847770
-
Selective inhibition of BET bromodomains
-
P. Filippakopoulos, J. Qi, S. Picaud, Y. Shen, W.B. Smith, O. Fedorov, E.M. Morse, T. Keates, T.T. Hickman, and I. Felletar et al. Selective inhibition of BET bromodomains Nature 468 2010 1067 1073
-
(2010)
Nature
, vol.468
, pp. 1067-1073
-
-
Filippakopoulos, P.1
Qi, J.2
Picaud, S.3
Shen, Y.4
Smith, W.B.5
Fedorov, O.6
Morse, E.M.7
Keates, T.8
Hickman, T.T.9
Felletar, I.10
-
32
-
-
84857913614
-
Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family
-
P. Filippakopoulos, S. Picaud, O. Fedorov, M. Keller, M. Wrobel, O. Morgenstern, F. Bracher, and S. Knapp Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family Bioorg. Med. Chem. 20 2012 1878 1886
-
(2012)
Bioorg. Med. Chem.
, vol.20
, pp. 1878-1886
-
-
Filippakopoulos, P.1
Picaud, S.2
Fedorov, O.3
Keller, M.4
Wrobel, M.5
Morgenstern, O.6
Bracher, F.7
Knapp, S.8
-
33
-
-
84859181036
-
Histone recognition and large-scale structural analysis of the human bromodomain family
-
P. Filippakopoulos, S. Picaud, M. Mangos, T. Keates, J.-P. Lambert, D. Barsyte-Lovejoy, I. Felletar, R. Volkmer, S. Müller, and T. Pawson et al. Histone recognition and large-scale structural analysis of the human bromodomain family Cell 149 2012 214 231
-
(2012)
Cell
, vol.149
, pp. 214-231
-
-
Filippakopoulos, P.1
Picaud, S.2
Mangos, M.3
Keates, T.4
Lambert, J.-P.5
Barsyte-Lovejoy, D.6
Felletar, I.7
Volkmer, R.8
Müller, S.9
Pawson, T.10
-
34
-
-
0035434378
-
You bet-cha: A novel family of transcriptional regulators
-
B. Florence, and D.V. Faller You bet-cha: a novel family of transcriptional regulators Front. Biosci. 6 2001 D1008 D1018
-
(2001)
Front. Biosci.
, vol.6
-
-
Florence, B.1
Faller, D.V.2
-
35
-
-
0035180206
-
BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19)
-
C.A. French, I. Miyoshi, J.C. Aster, I. Kubonishi, T.G. Kroll, P. Dal Cin, S.O. Vargas, A.R. Perez-Atayde, and J.A. Fletcher BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19) Am. J. Pathol. 159 2001 1987 1992 (Pubitemid 33104253)
-
(2001)
American Journal of Pathology
, vol.159
, Issue.6
, pp. 1987-1992
-
-
French, C.A.1
Miyoshi, I.2
Aster, J.C.3
Kubonishi, I.4
Kroll, T.G.5
Ci, P.D.6
Vargas, S.O.7
Perez-Atayde, A.R.8
Fletcher, J.A.9
-
36
-
-
0037439788
-
BRD4-NUT fusion oncogene: A novel mechanism in aggressive carcinoma
-
C.A. French, I. Miyoshi, I. Kubonishi, H.E. Grier, A.R. Perez-Atayde, and J.A. Fletcher BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma Cancer Res. 63 2003 304 307 (Pubitemid 36152484)
-
(2003)
Cancer Research
, vol.63
, Issue.2
, pp. 304-307
-
-
French, C.A.1
Miyoshi, I.2
Kubonishi, I.3
Grier, H.E.4
Perez-Atayde, A.R.5
Fletcher, J.A.6
-
37
-
-
41649120757
-
BRD-NUT oncoproteins: A family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells
-
DOI 10.1038/sj.onc.1210852, PII 1210852
-
C.A. French, C.L. Ramirez, J. Kolmakova, T.T. Hickman, M.J. Cameron, M.E. Thyne, J.L. Kutok, J.A. Toretsky, A.K. Tadavarthy, and U.R. Kees et al. BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells Oncogene 27 2008 2237 2242 (Pubitemid 351483375)
-
(2008)
Oncogene
, vol.27
, Issue.15
, pp. 2237-2242
-
-
French, C.A.1
Ramirez, C.L.2
Kolmakova, J.3
Hickman, T.T.4
Cameron, M.J.5
Thyne, M.E.6
Kutok, J.L.7
Toretsky, J.A.8
Tadavarthy, A.K.9
Kees, U.R.10
Fletcher, J.A.11
Aster, J.C.12
-
38
-
-
0020375148
-
Quinazolines and 1,4-benzodiazepines. 90. Structure-activity relationship between substituted 2-amino-N-(2-benzoyl-4-chlorophenyl)acetamides and 1,4-benzodiazepinones
-
DOI 10.1021/jm00351a009
-
R.I. Fryer, W. Leimgruber, and E.J. Trybulski Quinazolines and 1,4-benzodiazepines. 90. Structure-activity relationship between substituted 2-amino-N-(2-benzoyl-4-chlorophenyl)acetamides and 1,4-benzodiazepinones J. Med. Chem. 25 1982 1050 1055 (Pubitemid 13233576)
-
(1982)
Journal of Medicinal Chemistry
, vol.25
, Issue.9
, pp. 1050-1055
-
-
Fryer, R.I.1
Leimgruber, W.2
Trybulski, E.J.3
-
39
-
-
84857331171
-
Inhibition of bromodomain-mediated protein-protein interactions as a novel therapeutic strategy
-
S.D. Furdas, L. Carlino, W. Sippl, and M. Jung Inhibition of bromodomain-mediated protein-protein interactions as a novel therapeutic strategy Med Chem Commun 3 2012 123 134
-
(2012)
Med Chem Commun
, vol.3
, pp. 123-134
-
-
Furdas, S.D.1
Carlino, L.2
Sippl, W.3
Jung, M.4
-
40
-
-
84867098510
-
Bromodomain-dependent stage-specific male genome programming by Brdt
-
J. Gaucher, F. Boussouar, E. Montellier, S. Curtet, T. Buchou, S. Bertrand, P. Hery, S. Jounier, A. Depaux, and A.-L. Vitte et al. Bromodomain-dependent stage-specific male genome programming by Brdt EMBO J. 31 2012 3809 3820
-
(2012)
EMBO J.
, vol.31
, pp. 3809-3820
-
-
Gaucher, J.1
Boussouar, F.2
Montellier, E.3
Curtet, S.4
Buchou, T.5
Bertrand, S.6
Hery, P.7
Jounier, S.8
Depaux, A.9
Vitte, A.-L.10
-
41
-
-
84884238437
-
Discovery, design, and optimization of isoxazole azepine BET inhibitors
-
V.S. Gehling, M.C. Hewitt, R.G. Vaswani, Y. Leblanc, A. Cote, C.G. Nasveschuk, A.M. Taylor, J.-C. Harmange, J.E. Audia, and E. Pardo et al. Discovery, design, and optimization of isoxazole azepine BET inhibitors ACS Med. Chem. Lett. 4 2013 835 840
-
(2013)
ACS Med. Chem. Lett.
, vol.4
, pp. 835-840
-
-
Gehling, V.S.1
Hewitt, M.C.2
Vaswani, R.G.3
Leblanc, Y.4
Cote, A.5
Nasveschuk, C.G.6
Taylor, A.M.7
Harmange, J.-C.8
Audia, J.E.9
Pardo, E.10
-
42
-
-
13944274061
-
Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells
-
DOI 10.1021/jm049137g
-
B.L. Grasberger, T. Lu, C. Schubert, D.J. Parks, T.E. Carver, H.K. Koblish, M.D. Cummings, L.V. LaFrance, K.L. Milkiewicz, and R.R. Calvo et al. Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells J. Med. Chem. 48 2005 909 912 (Pubitemid 40270436)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.4
, pp. 909-912
-
-
Grasberger, B.L.1
Lu, T.2
Schubert, C.3
Parks, D.J.4
Carver, T.E.5
Koblish, H.K.6
Cummings, M.D.7
LaFrance, L.V.8
Milkiewicz, K.L.9
Calvo, R.R.10
Maguire, D.11
Lattanze, J.12
Franks, C.F.13
Zhao, S.14
Ramachandren, K.15
Bylebyl, G.R.16
Zhang, M.17
Manthey, C.L.18
Petrella, E.C.19
Pantoliano, M.W.20
Deckman, I.C.21
Spurlino, J.C.22
Maroney, A.C.23
Tomczuk, B.E.24
Molloy, C.J.25
Bone, R.F.26
more..
-
43
-
-
84883336698
-
50 years of hurdles and hope in anxiolytic drug discovery
-
G. Griebel, and A. Holmes 50 years of hurdles and hope in anxiolytic drug discovery Nat. Rev. Drug Discov. 12 2013 667 687
-
(2013)
Nat. Rev. Drug Discov.
, vol.12
, pp. 667-687
-
-
Griebel, G.1
Holmes, A.2
-
44
-
-
0032695824
-
Compounds that activate the mouse melanocortin-1 receptor identified by screening a small molecule library based upon the β-turn
-
DOI 10.1021/jm990190s
-
C. Haskell-Luevano, A. Rosenquist, A. Souers, K.C. Khong, J.A. Ellman, and R.D. Cone Compounds that activate the mouse melanocortin-1 receptor identified by screening a small molecule library based upon the β-turn J. Med. Chem. 42 1999 4380 4387 (Pubitemid 29504141)
-
(1999)
Journal of Medicinal Chemistry
, vol.42
, Issue.21
, pp. 4380-4387
-
-
Haskell-Luevano, C.1
Rosenquist, A.2
Souers, A.3
Khong, K.C.4
Ellman, J.A.5
Cone, R.D.6
-
45
-
-
80053924872
-
3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands
-
D.S. Hewings, M. Wang, M. Philpott, O. Fedorov, S. Uttarkar, P. Filippakopoulos, S. Picaud, C. Vuppusetty, B. Marsden, and S. Knapp et al. 3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands J. Med. Chem. 54 2011 6761 6770
-
(2011)
J. Med. Chem.
, vol.54
, pp. 6761-6770
-
-
Hewings, D.S.1
Wang, M.2
Philpott, M.3
Fedorov, O.4
Uttarkar, S.5
Filippakopoulos, P.6
Picaud, S.7
Vuppusetty, C.8
Marsden, B.9
Knapp, S.10
-
46
-
-
0037366605
-
The combinatorial synthesis of bicyclic privileged structures or privileged substructures
-
D.A. Horton, G.T. Bourne, and M.L. Smythe The combinatorial synthesis of bicyclic privileged structures or privileged substructures Chem. Rev. 103 2003 893 930
-
(2003)
Chem. Rev.
, vol.103
, pp. 893-930
-
-
Horton, D.A.1
Bourne, G.T.2
Smythe, M.L.3
-
47
-
-
77954375071
-
1,4-Thienodiazepine-2,5-diones via MCR (II): Scaffold hopping by Gewald and Ugi-deprotection-cyclization strategy
-
Y. Huang, and A. Dömling 1,4-Thienodiazepine-2,5-diones via MCR (II): scaffold hopping by Gewald and Ugi-deprotection-cyclization strategy Chem. Biol. Drug Des. 76 2010 130 141
-
(2010)
Chem. Biol. Drug Des.
, vol.76
, pp. 130-141
-
-
Huang, Y.1
Dömling, A.2
-
48
-
-
77954366814
-
1,4-Thienodiazepine-2,5-diones via MCR (I): Synthesis, virtual space and p53-Mdm2 activity
-
Y. Huang, S. Wolf, M. Bista, L. Meireles, C. Camacho, T.A. Holak, and A. Dömling 1,4-Thienodiazepine-2,5-diones via MCR (I): synthesis, virtual space and p53-Mdm2 activity Chem. Biol. Drug Des. 76 2010 116 129
-
(2010)
Chem. Biol. Drug Des.
, vol.76
, pp. 116-129
-
-
Huang, Y.1
Wolf, S.2
Bista, M.3
Meireles, L.4
Camacho, C.5
Holak, T.A.6
Dömling, A.7
-
49
-
-
41649108801
-
The 1,4-benzodiazepine-2,5-dione small molecule template results in melanocortin receptor agonists with nanomolar potencies
-
DOI 10.1021/jm701303z
-
C.G. Joseph, K.R. Wilson, M.S. Wood, N.B. Sorenson, D.V. Phan, Z. Xiang, R.M. Witek, and C. Haskell-Luevano The 1,4-benzodiazepine-2,5-dione small molecule template results in melanocortin receptor agonists with nanomolar potencies J. Med. Chem. 51 2008 1423 1431 (Pubitemid 351480404)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.5
, pp. 1423-1431
-
-
Joseph, C.G.1
Wilson, K.R.2
Wood, M.S.3
Sorenson, N.B.4
Phan, D.V.5
Xiang, Z.6
Witek, R.M.7
Haskell-Luevano, C.8
-
52
-
-
33746627694
-
Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity
-
DOI 10.1016/j.bmcl.2006.04.009, PII S0960894X06004215
-
K. Leonard, J.J. Marugan, P. Raboisson, R. Calvo, J.M. Gushue, H.K. Koblish, J. Lattanze, S. Zhao, M.D. Cummings, and M.R. Player et al. Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity Bioorg. Med. Chem. Lett. 16 2006 3463 3468 (Pubitemid 44226372)
-
(2006)
Bioorganic and Medicinal Chemistry Letters
, vol.16
, Issue.13
, pp. 3463-3468
-
-
Leonard, K.1
Marugan, J.J.2
Raboisson, P.3
Calvo, R.4
Gushue, J.M.5
Koblish, H.K.6
Lattanze, J.7
Zhao, S.8
Cummings, M.D.9
Player, M.R.10
Maroney, A.C.11
Lu, T.12
-
53
-
-
13244266921
-
Lead- and drug-like compounds: The rule-of-five revolution
-
DOI 10.1016/j.ddtec.2004.11.007, PII S1740674904000551
-
C.A. Lipinski Lead- and drug-like compounds: the rule-of-five revolution Drug Discov. Today. Technol. 1 2004 337 341 (Pubitemid 40186335)
-
(2004)
Drug Discovery Today: Technologies
, vol.1
, Issue.4
, pp. 337-341
-
-
Lipinski, C.A.1
-
54
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
DOI 10.1016/S0169-409X(00)00129-0, PII S0169409X00001290
-
C.A. Lipinski, F. Lombardo, B.W. Dominy, and P.J. Feeney Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Adv. Drug Deliv. Rev. 46 2001 3 26 (Pubitemid 33653411)
-
(2000)
Advanced Drug Delivery Reviews
, vol.46
, Issue.1-3
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
55
-
-
0021186814
-
Theoretical structure-activity studies of benzodiazepine analogues. Requirements for receptor affinity and activity
-
G.H. Loew, J.R. Nienow, and M. Poulsen Theoretical structure-activity studies of benzodiazepine analogues. Requirements for receptor affinity and activity Mol. Pharmacol. 26 1984 19 34 (Pubitemid 14035220)
-
(1984)
Molecular Pharmacology
, vol.26
, Issue.1
, pp. 19-34
-
-
Loew, G.H.1
Nienow, J.R.2
Poulsen, M.3
-
56
-
-
34547509909
-
Design, synthesis and biological evaluation of 1,4-benzodiazepine-2,5- dione-based HDAC inhibitors
-
DOI 10.1016/j.bmcl.2007.06.067, PII S0960894X07007536
-
L. Loudni, J. Roche, V. Potiron, J. Clarhaut, C. Bachmann, J.-P. Gesson, and I. Tranoy-Opalinski Design, synthesis and biological evaluation of 1,4-benzodiazepine-2,5-dione-based HDAC inhibitors Bioorg. Med. Chem. Lett. 17 2007 4819 4823 (Pubitemid 47187707)
-
(2007)
Bioorganic and Medicinal Chemistry Letters
, vol.17
, Issue.17
, pp. 4819-4823
-
-
Loudni, L.1
Roche, J.2
Potiron, V.3
Clarhaut, J.4
Bachmann, C.5
Gesson, J.-P.6
Tranoy-Opalinski, I.7
-
57
-
-
0034613173
-
Molecular and neuronal substrate for the selective attenuation of anxiety
-
K. Löw, F. Crestani, R. Keist, D. Benke, I. Brünig, J.A. Benson, J.-M. Fritschy, T. Rülicke, H. Bluethmann, H. Möhler, and U. Rudolph Molecular and neuronal substrate for the selective attenuation of anxiety Science 290 2000 131 134
-
(2000)
Science
, vol.290
, pp. 131-134
-
-
Löw, K.1
Crestani, F.2
Keist, R.3
Benke, D.4
Brünig, I.5
Benson, J.A.6
Fritschy, J.-M.7
Rülicke, T.8
Bluethmann, H.9
Möhler, H.10
Rudolph, U.11
-
58
-
-
84890680254
-
4-Acyl pyrroles: Mimicking acetylated lysines in histone code reading
-
X. Lucas, D. Wohlwend, M. Hügle, K. Schmidtkunz, S. Gerhardt, R. Schüle, M. Jung, O. Einsle, and S. Günther 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading Angew. Chem. Int. Ed. Engl. 52 2013 14055 14059
-
(2013)
Angew. Chem. Int. Ed. Engl.
, vol.52
, pp. 14055-14059
-
-
Lucas, X.1
Wohlwend, D.2
Hügle, M.3
Schmidtkunz, K.4
Gerhardt, S.5
Schüle, R.6
Jung, M.7
Einsle, O.8
Günther, S.9
-
59
-
-
84865229469
-
Small-molecule inhibition of BRDT for male contraception
-
M.M. Matzuk, M.R. McKeown, P. Filippakopoulos, Q. Li, L. Ma, J.E. Agno, M.E. Lemieux, S. Picaud, R.N. Yu, and J. Qi et al. Small-molecule inhibition of BRDT for male contraception Cell 150 2012 673 684
-
(2012)
Cell
, vol.150
, pp. 673-684
-
-
Matzuk, M.M.1
McKeown, M.R.2
Filippakopoulos, P.3
Li, Q.4
Ma, L.5
Agno, J.E.6
Lemieux, M.E.7
Picaud, S.8
Yu, R.N.9
Qi, J.10
-
60
-
-
64249116614
-
1,5-Benzodiazepine inhibitors of HCV NS5B polymerase
-
D. McGowan, O. Nyanguile, M.D. Cummings, S. Vendeville, K. Vandyck, W. Van den Broeck, C.W. Boutton, H. De Bondt, L. Quirynen, and K. Amssoms et al. 1,5-Benzodiazepine inhibitors of HCV NS5B polymerase Bioorg. Med. Chem. Lett. 19 2009 2492 2496
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 2492-2496
-
-
McGowan, D.1
Nyanguile, O.2
Cummings, M.D.3
Vendeville, S.4
Vandyck, K.5
Van Den Broeck, W.6
Boutton, C.W.7
De Bondt, H.8
Quirynen, L.9
Amssoms, K.10
-
61
-
-
0034108997
-
1 subtype
-
DOI 10.1038/75761
-
1 subtype Nat. Neurosci. 3 2000 587 592 (Pubitemid 30332078)
-
(2000)
Nature Neuroscience
, vol.3
, Issue.6
, pp. 587-592
-
-
McKernan, R.M.1
Rosahl, T.W.2
Reynolds, D.S.3
Sur, C.4
Wafford, K.A.5
Atack, J.R.6
Farrar, S.7
Myers, J.8
Cook, G.9
Ferris, P.10
Garrett, L.11
Bristow, L.12
Marshall, G.13
Macaulay, A.14
Brown, N.15
Howell, O.16
Moore, K.W.17
Carling, R.W.18
Street, L.J.19
Castro, J.L.20
Ragan, C.I.21
Dawson, G.R.22
Whiting, P.J.23
more..
-
62
-
-
80053651202
-
Targeting MYC dependence in cancer by inhibiting BET bromodomains
-
J.A. Mertz, A.R. Conery, B.M. Bryant, P. Sandy, S. Balasubramanian, D.A. Mele, L. Bergeron, and R.J. Sims 3rd Targeting MYC dependence in cancer by inhibiting BET bromodomains Proc. Natl. Acad. Sci. USA 108 2011 16669 16674
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 16669-16674
-
-
Mertz, J.A.1
Conery, A.R.2
Bryant, B.M.3
Sandy, P.4
Balasubramanian, S.5
Mele, D.A.6
Bergeron, L.7
Sims III, R.J.8
-
63
-
-
84859443655
-
From ApoA1 upregulation to BET family bromodomain inhibition: Discovery of I-BET151
-
O. Mirguet, Y. Lamotte, F. Donche, J. Toum, F. Gellibert, A. Bouillot, R. Gosmini, V.-L. Nguyen, D. Delannée, and J. Seal et al. From ApoA1 upregulation to BET family bromodomain inhibition: discovery of I-BET151 Bioorg. Med. Chem. Lett. 22 2012 2963 2967
-
(2012)
Bioorg. Med. Chem. Lett.
, vol.22
, pp. 2963-2967
-
-
Mirguet, O.1
Lamotte, Y.2
Donche, F.3
Toum, J.4
Gellibert, F.5
Bouillot, A.6
Gosmini, R.7
Nguyen, V.-L.8
Delannée, D.9
Seal, J.10
-
64
-
-
84885675970
-
Discovery of epigenetic regulator I-BET762: Lead optimization to afford a clinical candidate inhibitor of the BET bromodomains
-
O. Mirguet, R. Gosmini, J. Toum, C.A. Clément, M. Barnathan, J.-M. Brusq, J.E. Mordaunt, R.M. Grimes, M. Crowe, and O. Pineau et al. Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains J. Med. Chem. 56 2013 7501 7515
-
(2013)
J. Med. Chem.
, vol.56
, pp. 7501-7515
-
-
Mirguet, O.1
Gosmini, R.2
Toum, J.3
Clément, C.A.4
Barnathan, M.5
Brusq, J.-M.6
Mordaunt, J.E.7
Grimes, R.M.8
Crowe, M.9
Pineau, O.10
-
66
-
-
34547858913
-
Structure and acetyl-lysine recognition of the bromodomain
-
DOI 10.1038/sj.onc.1210618, PII 1210618
-
S. Mujtaba, L. Zeng, and M.-M. Zhou Structure and acetyl-lysine recognition of the bromodomain Oncogene 26 2007 5521 5527 (Pubitemid 47255932)
-
(2007)
Oncogene
, vol.26
, Issue.37
, pp. 5521-5527
-
-
Mujtaba, S.1
Zeng, L.2
Zhou, M.-M.3
-
68
-
-
77749232053
-
Pharmacotherapy of anxiety
-
D.R. Sibley, I. Hanin, M. Kuhar, P. Skolnick, John Wiley & Sons, Inc. Hoboken, NJ
-
J.R. Nash, and D.J. Nutt Pharmacotherapy of anxiety D.R. Sibley, I. Hanin, M. Kuhar, P. Skolnick, Handbook of Contemporary Neuropharmacology 2007 John Wiley & Sons, Inc. Hoboken, NJ 59 91
-
(2007)
Handbook of Contemporary Neuropharmacology
, pp. 59-91
-
-
Nash, J.R.1
Nutt, D.J.2
-
69
-
-
78650806593
-
Suppression of inflammation by a synthetic histone mimic
-
E. Nicodeme, K.L. Jeffrey, U. Schaefer, S. Beinke, S. Dewell, C.W. Chung, R. Chandwani, I. Marazzi, P. Wilson, and H. Coste et al. Suppression of inflammation by a synthetic histone mimic Nature 468 2010 1119 1123
-
(2010)
Nature
, vol.468
, pp. 1119-1123
-
-
Nicodeme, E.1
Jeffrey, K.L.2
Schaefer, U.3
Beinke, S.4
Dewell, S.5
Chung, C.W.6
Chandwani, R.7
Marazzi, I.8
Wilson, P.9
Coste, H.10
-
70
-
-
57049126367
-
1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors
-
O. Nyanguile, F. Pauwels, W. Van den Broeck, C.W. Boutton, L. Quirynen, T. Ivens, L. van der Helm, G. Vandercruyssen, W. Mostmans, and F. Delouvroy et al. 1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors Antimicrob. Agents Chemother. 52 2008 4420 4431
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 4420-4431
-
-
Nyanguile, O.1
Pauwels, F.2
Van Den Broeck, W.3
Boutton, C.W.4
Quirynen, L.5
Ivens, T.6
Van Der Helm, L.7
Vandercruyssen, G.8
Mostmans, W.9
Delouvroy, F.10
-
72
-
-
0034669210
-
The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p
-
D.J. Owen, P. Ornaghi, J.-C. Yang, N. Lowe, P.R. Evans, P. Ballario, D. Neuhaus, P. Filetici, and A.A. Travers The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p EMBO J. 19 2000 6141 6149
-
(2000)
EMBO J.
, vol.19
, pp. 6141-6149
-
-
Owen, D.J.1
Ornaghi, P.2
Yang, J.-C.3
Lowe, N.4
Evans, P.R.5
Ballario, P.6
Neuhaus, D.7
Filetici, P.8
Travers, A.A.9
-
74
-
-
84878565710
-
PFI-1, a highly selective protein interaction inhibitor, targeting BET bromodomains
-
S. Picaud, D. Da Costa, A. Thanasopoulou, P. Filippakopoulos, P.V. Fish, M. Philpott, O. Fedorov, P. Brennan, M.E. Bunnage, and D.R. Owen et al. PFI-1, a highly selective protein interaction inhibitor, targeting BET bromodomains Cancer Res. 73 2013 3336 3346
-
(2013)
Cancer Res.
, vol.73
, pp. 3336-3346
-
-
Picaud, S.1
Da Costa, D.2
Thanasopoulou, A.3
Filippakopoulos, P.4
Fish, P.V.5
Philpott, M.6
Fedorov, O.7
Brennan, P.8
Bunnage, M.E.9
Owen, D.R.10
-
75
-
-
84889663966
-
RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain
-
S. Picaud, C. Wells, I. Felletar, D. Brotherton, S. Martin, P. Savitsky, B. Diez-Dacal, M. Philpott, C. Bountra, and H. Lingard et al. RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain Proc. Natl. Acad. Sci. 110 2013 19754 19759
-
(2013)
Proc. Natl. Acad. Sci.
, vol.110
, pp. 19754-19759
-
-
Picaud, S.1
Wells, C.2
Felletar, I.3
Brotherton, D.4
Martin, S.5
Savitsky, P.6
Diez-Dacal, B.7
Philpott, M.8
Bountra, C.9
Lingard, H.10
-
76
-
-
84862817809
-
Place your BETs: The therapeutic potential of bromodomains
-
R.K. Prinjha, J. Witherington, and K. Lee Place your BETs: the therapeutic potential of bromodomains Trends Pharmacol. Sci. 33 2012 146 153
-
(2012)
Trends Pharmacol. Sci.
, vol.33
, pp. 146-153
-
-
Prinjha, R.K.1
Witherington, J.2
Lee, K.3
-
78
-
-
2642568535
-
Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity
-
DOI 10.1021/bi049723b
-
T.S. Reid, and L.S. Beese Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity Biochemistry 43 2004 6877 6884 (Pubitemid 38720505)
-
(2004)
Biochemistry
, vol.43
, Issue.22
, pp. 6877-6884
-
-
Reid, T.S.1
Beese, L.S.2
-
79
-
-
77956394108
-
Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains
-
N. Reynoird, B.E. Schwartz, M. Delvecchio, K. Sadoul, D. Meyers, C. Mukherjee, C. Caron, H. Kimura, S. Rousseaux, and P.A. Cole et al. Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains EMBO J. 29 2010 2943 2952
-
(2010)
EMBO J.
, vol.29
, pp. 2943-2952
-
-
Reynoird, N.1
Schwartz, B.E.2
Delvecchio, M.3
Sadoul, K.4
Meyers, D.5
Mukherjee, C.6
Caron, C.7
Kimura, H.8
Rousseaux, S.9
Cole, P.A.10
-
80
-
-
84859881146
-
A receptor models identify new benzodiazepine binding-site ligands
-
A receptor models identify new benzodiazepine binding-site ligands Nat. Chem. Biol. 8 2012 455 464
-
(2012)
Nat. Chem. Biol.
, vol.8
, pp. 455-464
-
-
Richter, L.1
De Graaf, C.2
Sieghart, W.3
Varagic, Z.4
Mörzinger, M.5
De Esch, I.J.6
Ecker, G.F.7
Ernst, M.8
-
81
-
-
33749256952
-
2 receptors
-
DOI 10.1021/jm051222g
-
2 receptors J. Med. Chem. 49 2006 6133 6137 (Pubitemid 44484958)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.20
, pp. 6133-6137
-
-
Rosenstrom, U.1
Skold, C.2
Lindeberg, G.3
Botros, M.4
Nyberg, F.5
Karlen, A.6
Hallberg, A.7
-
82
-
-
80052274158
-
Beyond classical benzodiazepines: Novel therapeutic potential of GABAA receptor subtypes
-
U. Rudolph, and F. Knoflach Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes Nat. Rev. Drug Discov. 10 2011 685 697
-
(2011)
Nat. Rev. Drug Discov.
, vol.10
, pp. 685-697
-
-
Rudolph, U.1
Knoflach, F.2
-
83
-
-
0033592682
-
A) receptor subtypes
-
A) receptor subtypes Nature 401 1999 796 800
-
(1999)
Nature
, vol.401
, pp. 796-800
-
-
Rudolph, U.1
Crestani, F.2
Benke, D.3
Brünig, I.4
Benson, J.A.5
Fritschy, J.-M.6
Martin, J.R.7
Bluethmann, H.8
Möhler, H.9
-
84
-
-
84862809749
-
Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A)
-
J. Seal, Y. Lamotte, F. Donche, A. Bouillot, O. Mirguet, F. Gellibert, E. Nicodeme, G. Krysa, J. Kirilovsky, and S. Beinke et al. Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A) Bioorg. Med. Chem. Lett. 22 2012 2968 2972
-
(2012)
Bioorg. Med. Chem. Lett.
, vol.22
, pp. 2968-2972
-
-
Seal, J.1
Lamotte, Y.2
Donche, F.3
Bouillot, A.4
Mirguet, O.5
Gellibert, F.6
Nicodeme, E.7
Krysa, G.8
Kirilovsky, J.9
Beinke, S.10
-
85
-
-
84867861360
-
Anxioselective anxiolytics: On a quest for the Holy Grail
-
P. Skolnick Anxioselective anxiolytics: on a quest for the Holy Grail Trends Pharmacol. Sci. 33 2012 611 620
-
(2012)
Trends Pharmacol. Sci.
, vol.33
, pp. 611-620
-
-
Skolnick, P.1
-
86
-
-
0036737026
-
Don't ask, don't tell, but benzodiazepines are still the leading treatments for anxiety disorder
-
S.M. Stahl Don't ask, don't tell, but benzodiazepines are still the leading treatments for anxiety disorder J. Clin. Psychiatry 63 2002 756 757
-
(2002)
J. Clin. Psychiatry
, vol.63
, pp. 756-757
-
-
Stahl, S.M.1
-
88
-
-
3342998425
-
A receptors for the development of tolerance to the sedative action of diazepam in mice
-
DOI 10.1523/JNEUROSCI.1067-04.2004
-
A receptors for the development of tolerance to the sedative action of diazepam in mice J. Neurosci. 24 2004 6785 6790 (Pubitemid 38993900)
-
(2004)
Journal of Neuroscience
, vol.24
, Issue.30
, pp. 6785-6790
-
-
Van Rijnsoever, C.1
Tauber, M.2
Choulli, M.K.3
Keist, R.4
Rudolph, U.5
Mohler, H.6
Fritschy, J.M.7
Crestani, F.8
-
89
-
-
67650763062
-
Structure-based design of a benzodiazepine scaffold yields a potent allosteric inhibitor of hepatitis C NS5B RNA polymerase
-
K. Vandyck, M.D. Cummings, O. Nyanguile, C.W. Boutton, S. Vendeville, D. McGowan, B. Devogelaere, K. Amssoms, S. Last, and K. Rombauts et al. Structure-based design of a benzodiazepine scaffold yields a potent allosteric inhibitor of hepatitis C NS5B RNA polymerase J. Med. Chem. 52 2009 4099 4102
-
(2009)
J. Med. Chem.
, vol.52
, pp. 4099-4102
-
-
Vandyck, K.1
Cummings, M.D.2
Nyanguile, O.3
Boutton, C.W.4
Vendeville, S.5
McGowan, D.6
Devogelaere, B.7
Amssoms, K.8
Last, S.9
Rombauts, K.10
-
90
-
-
1642372087
-
Clinical Pharmacology, Clinical Efficacy, and Behavioral Toxicity of Alprazolam: A Review of the Literature
-
J.C. Verster, and E.R. Volkerts Clinical pharmacology, clinical efficacy, and behavioral toxicity of alprazolam: a review of the literature CNS Drug Rev. 10 2004 45 76 (Pubitemid 38381174)
-
(2004)
CNS Drug Reviews
, vol.10
, Issue.1
, pp. 45-76
-
-
Verster, J.C.1
Volkerts, E.R.2
-
91
-
-
84866338076
-
Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites
-
L.R. Vidler, N. Brown, S. Knapp, and S. Hoelder Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites J. Med. Chem. 55 2012 7346 7359
-
(2012)
J. Med. Chem.
, vol.55
, pp. 7346-7359
-
-
Vidler, L.R.1
Brown, N.2
Knapp, S.3
Hoelder, S.4
-
92
-
-
0025967183
-
Molecular models for recognition and activation at the benzodiazepine receptor: A review
-
H.O. Villar, M.F. Davies, G.H. Loew, and P.A. Maguire Molecular models for recognition and activation at the benzodiazepine receptor: a review Life Sci. 48 1991 593 602
-
(1991)
Life Sci.
, vol.48
, pp. 593-602
-
-
Villar, H.O.1
Davies, M.F.2
Loew, G.H.3
Maguire, P.A.4
-
93
-
-
0021949612
-
Alprazolam: Review of pharmacological, pharmacokinetic, and clinical data
-
P.F. VonVoigtlander, and R.N. Straw Alprazolam: review of pharmacological, pharmacokinetic, and clinical data Drug Dev. Res. 6 1985 1 12
-
(1985)
Drug Dev. Res.
, vol.6
, pp. 1-12
-
-
Vonvoigtlander, P.F.1
Straw, R.N.2
-
94
-
-
0032825862
-
Ligands of the GABA(A) receptor benzodiazepine binding site
-
A receptor benzodiazepine binding site CNS Drug Rev. 5 1999 125 144 (Pubitemid 29451456)
-
(1999)
CNS Drug Reviews
, vol.5
, Issue.2
, pp. 125-144
-
-
Wang, Q.1
Han, Y.2
Xue, H.3
-
98
-
-
34250357662
-
The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation
-
DOI 10.1074/jbc.R700001200
-
S.-Y. Wu, and C.-M. Chiang The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation J. Biol. Chem. 282 2007 13141 13145 (Pubitemid 47100489)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.18
, pp. 13141-13145
-
-
Wu, S.-Y.1
Chiang, C.-M.2
-
99
-
-
84865222098
-
Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition
-
G. Zhang, R. Liu, Y. Zhong, A.N. Plotnikov, W. Zhang, L. Zeng, E. Rusinova, G. Gerona-Nevarro, N. Moshkina, and J. Joshua et al. Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition J. Biol. Chem. 287 2012 28840 28851
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 28840-28851
-
-
Zhang, G.1
Liu, R.2
Zhong, Y.3
Plotnikov, A.N.4
Zhang, W.5
Zeng, L.6
Rusinova, E.7
Gerona-Nevarro, G.8
Moshkina, N.9
Joshua, J.10
-
100
-
-
80055000824
-
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
-
J. Zuber, J. Shi, E. Wang, A.R. Rappaport, H. Herrmann, E.A. Sison, D. Magoon, J. Qi, K. Blatt, and M. Wunderlich et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia Nature 478 2011 524 528
-
(2011)
Nature
, vol.478
, pp. 524-528
-
-
Zuber, J.1
Shi, J.2
Wang, E.3
Rappaport, A.R.4
Herrmann, H.5
Sison, E.A.6
Magoon, D.7
Qi, J.8
Blatt, K.9
Wunderlich, M.10
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