Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands

Nature Chemical Biology

Volumn 8, Issue 5, 2012, Pages 455-464

  Richter, Lars ^a   De Graaf, Chris ^b   Sieghart, Werner ^c   Varagic, Zdravko ^c   Mörzinger, Martina ^c   De Esch, Iwan J P ^b   Ecker, Gerhard F ^a   Ernst, Margot ^c  

^a UNIVERSITY OF VIENNA   (Austria)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c Medical University of Vienna   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CHLORIDE CHANNEL; DIAZEPAM; FLUMAZENIL; FLUNITRAZEPAM; GLUTAMIC ACID; NITRAZEPAM; TYROSINE; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; ANXIOLYTIC AGENT;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG SCREENING; DRUG STRUCTURE; ELECTROPHYSIOLOGY; MOLECULAR DOCKING; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; RECEPTOR BINDING; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CEREBELLUM; CHEMICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; DRUG DESIGN; DRUG EFFECT; MOLECULAR GENETICS; MOUSE; PHYSIOLOGY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; ANTI-ANXIETY AGENTS; BINDING SITES; CEREBELLUM; COMPUTER SIMULATION; DIAZEPAM; DRUG DESIGN; ELECTROPHYSIOLOGICAL PHENOMENA; GABA-A RECEPTOR AGONISTS; MICE; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84859881146     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.917     Document Type: Article

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