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Volumn 20, Issue 6, 2012, Pages 1878-1886

Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family

(8) Filippakopoulos, Panagis a Picaud, Sarah a Fedorov, Oleg a Keller, Marco b Wrobel, Matthias b Morgenstern, Olaf c Bracher, Franz b Knapp, Stefan a

a UNIVERSITY OF OXFORD (United Kingdom)

b UNIVERSITY OF MUNICH (Germany)

c UNIVERSITY OF GREIFSWALD (Germany)

Author keywords

Alprazolam; Benzodiazepines; Benzotriazepines; BRD4; Bromodomains

Indexed keywords

1,3,4 BENZOTRIAZEPINE DERIVATIVE; 8 CHLORO 1,6 DIETHYL 4H BENZO[F][1,2,4]TRIAZOLO[4,3 A][1,4]DIAZEPINE; 8 CHLORO 6 ETHYL 1 (3 METHOXYPHENYL) 4H BENZO[F][1,2,4]TRIAZOLO[4,3 A][1,4]DIAZEPINE; 8 CHLORO 6 ETHYL 1 (PYRIDIN 4 YL) 4H BENZO[F][1,2,4]TRIAZOLO[4,3 A][1,4]DIAZEPINE; 8 CHLORO 6 ETHYL 1 METHYL 4H BENZO[F][1,2,4]TRIAZOLO[4,3 A][1,4]DIAZEPINE; 8 CHLORO 6 ETHYL 1 PHENYL 4H BENZO[F][1,2,4]TRIAZOLO[4,3 A][1,4]DIAZEPINE; ALPRAZOLAM; BENZODIAZEPINE DERIVATIVE; BROMODOMAIN AND EXTRATERMINAL PROTEIN; ESTAZOLAM; GW 841819X; JQ 1; L 655708; MIDAZOLAM; TRANSCRIPTION FACTOR; TRIAZOLAM; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; PROTEIN FAMILY; STRUCTURE ACTIVITY RELATION;

ALPRAZOLAM; BENZAZEPINES; BENZODIAZEPINES; GABA MODULATORS; HUMANS; MIDAZOLAM; MODELS, MOLECULAR; NUCLEAR PROTEINS; PROTEIN INTERACTION MAPS; PROTEIN STRUCTURE, TERTIARY; TRANSCRIPTION FACTORS;

EID: 84857913614 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2011.10.080 Document Type: Article

Times cited : (113)

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