From ApoA1 upregulation to BET family bromodomain inhibition: Discovery of I-BET151

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 8, 2012, Pages 2963-2967

  Mirguet, Olivier ^a   Lamotte, Yann ^a   Donche, Frédéric ^a   Toum, Jérôme ^a   Gellibert, Franoise ^a   Bouillot, Anne ^a   Gosmini, Romain ^a   Nguyen, Van Loc ^a   Delannée, Delphine ^a   Seal, Jonathan ^a   Blandel, Florence ^a   Boullay, Anne Bénédicte ^a   Boursier, Eric ^a   Martin, Sandrine ^a   Brusq, Jean Marie ^a   Krysa, Gael ^a   Riou, Alizon ^a   Tellier, Rémi ^a   Costaz, Agns ^a   Huet, Pascal ^a   Dudit, Yann ^a   Trottet, Lionel ^a   Kirilovsky, Jorge ^a   Nicodeme, Edwige ^a   more..

^a GLAXOSMITHKLINE   (France)

Author keywords

7 Isoxazoloquinolines; ApoA1 upregulators; BET family; Bromodomains inhibitors

Indexed keywords

7 ISOXAZOLOQUINOLINE; APOLIPOPROTEIN A1; CARDIOVASCULAR AGENT; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOLIPOPROTEIN A-I; DRUG DISCOVERY; HEP G2 CELLS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MICE, INBRED BALB C; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; QUINOLINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; UP-REGULATION;

EID: 84859443655     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.125     Document Type: Article

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