Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: Highly potent against human enzyme within a cellular environment

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 18, 2007, Pages 5115-5120

  Weinstein, David S ^a   Liu, Wen ^a   Ngu, Khehyong ^a   Langevine, Charles ^a   Combs, Donald W ^a   Zhuang, Shaobin ^a   Chen, Cindy ^a   Madsen, Cort S ^a   Harper, Timothy W ^a   Robl, Jeffrey A ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

15 Lipoxygenase; Arachidonic acid; Imidazole; Inhibition; Linoleic acid; Sulfamide; Sulfonamide

Indexed keywords

2,4,5 TRI IMIDAZOLE; ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONIC ACID; IFOSFAMIDE; IMIDAZOLE DERIVATIVE; LINOLEIC ACID; LIPOXYGENASE INHIBITOR; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DISEASE COURSE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; PHYSICAL CHEMISTRY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; ARACHIDONATE 15-LIPOXYGENASE; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; IMIDAZOLES; LIPOXYGENASE INHIBITORS; MALE; RATS; RATS, SPRAGUE-DAWLEY;

MAMMALIA;

EID: 34547860474     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.07.011     Document Type: Article

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