Substrate specificity changes for human reticulocyte and epithelial 15-lipoxygenases reveal allosteric product regulation

Biochemistry

Volumn 47, Issue 28, 2008, Pages 7364-7375

  Wecksler, Aaron T ^a   Kenyon, Victor ^a   Deschamps, Joshua D ^a,b   Holman, Theodore R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b KaloBios   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACIDS;

15 LIPOXYGENASE (LOX); HUMAN DISEASES; LINOLEIC ACID (LA); LIPOXYGENASES (LOX); NOVEL METHODS; SUBSTRATE SPECIFICITY;

SUBSTRATES;

12 HYDROPEROXYICOSATETRAENOIC ACID; 12 HYDROXYICOSATETRAENOIC ACID; 13 HYDROPEROXYOCTADIENOIC ACID; ARACHIDONATE 15 LIPOXYGENASE; ICOSANOID; ISOENZYME;

ALLOSTERISM; ARTICLE; ENZYME KINETICS; ENZYME SPECIFICITY; EPITHELIUM CELL; FEEDBACK SYSTEM; HUMAN; MOLECULAR DOCKING; MOLECULAR MODEL; PRIORITY JOURNAL; RETICULOCYTE;

12-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID; ALLOSTERIC REGULATION; ARACHIDONATE 15-LIPOXYGENASE; EPITHELIAL CELLS; HUMANS; KINETICS; LEUKOTRIENES; LINOLEIC ACIDS; LIPID PEROXIDES; MALE; PROSTATE; RETICULOCYTES; SUBSTRATE SPECIFICITY;

EID: 47249091900     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800550n     Document Type: Article

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