Redox inactivation of human 15-lipoxygenase by marine-derived meroditerpenes and synthetic chromanes: Archetypes for a unique class of selective and recyclable inhibitors

Journal of the American Chemical Society

Volumn 126, Issue 45, 2004, Pages 14910-14920

  Cichewicz, Robert H ^a   Kenyon, Victor A ^a   Whitman, Stephanie ^a   Morales, Nancy M ^a   Arguello, Joanne F ^a   Holman, Theodore R ^a   Crews, Phillip ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BIODIVERSITY; DIAGNOSIS; DISEASES; HEALTH CARE; HEALTH RISKS; REDOX REACTIONS;

HUMAN LIPOXYGENASES; MARINE SPONGES; REDOX INACTIVATION; SELECTIVE INHIBITION;

ENZYME INHIBITION;

2 METHYL 2 (4 METHYLPENT 3 ENYL) 6 HYDROXYCHROMANE; 2,2 DIMETHYL 5,7 DIHYDROXYCHROMANE; 2,2 DIMETHYL 6 HYDROXYCHROMANE; 2,2 DIMETHYL 7 HYDROXYCHROMANE; ARACHIDONATE 15 LIPOXYGENASE; ASCORBIC ACID; CHROMAN DERIVATIVE; CHROMAROL A; CHROMAROL B; CHROMAROL C; CHROMAROL D; CHROMAROL E; DITERPENE; ENZYME INHIBITOR; TOCOPHEROL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ATHEROSCLEROSIS; BIOASSAY; DRUG ISOLATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; FRACTIONATION; HUMAN; NONHUMAN; OXIDATION REDUCTION REACTION; PHARMACOPHORE; SPONGE (PORIFERA); STRUCTURE ACTIVITY RELATION;

ANIMALS; ARACHIDONATE 15-LIPOXYGENASE; CHROMANS; DITERPENES; ENZYME ACTIVATION; HUMANS; LIPOXYGENASE INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION-REDUCTION; PORIFERA;

EID: 8844256551     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja046082z     Document Type: Article

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