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Volumn 9, Issue 1, 2014, Pages 34-44

Small Molecules for cell reprogramming and heart repair: Progress and perspective

Author keywords

Cardiac regeneration; Cell reprogramming; Differentiation; PSC; Signaling pathway; Small molecule; TF; Transdifferentiation

Indexed keywords

MOLECULAR THERAPY AGENT;

EID: 84900445950     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb400865w     Document Type: Review
Times cited : (15)

References (107)
  • 1
    • 80052565758 scopus 로고    scopus 로고
    • The cell biology of disease: Cellular mechanisms of cardiomyopathy
    • Harvey, P. A., and Leinwand, L. A. (2011) The cell biology of disease: cellular mechanisms of cardiomyopathy. J. Cell Biol. 194, 355-365.
    • (2011) J. Cell Biol. , vol.194 , pp. 355-365
    • Harvey, P.A.1    Leinwand, L.A.2
  • 2
    • 43749100265 scopus 로고    scopus 로고
    • Stemcell-based therapy and lessons from the heart
    • Passier, R., van Laake, L. W., and Mummery, C. L. (2008) Stemcell-based therapy and lessons from the heart. Nature 453, 322-329.
    • (2008) Nature , vol.453 , pp. 322-329
    • Passier, R.1    Van Laake, L.W.2    Mummery, C.L.3
  • 3
    • 84862907693 scopus 로고    scopus 로고
    • Production of de novo cardiomyocytes: Human pluripotent stem cell differentiation and direct reprogramming
    • Burridge, P. W., Keller, G., Gold, J. D., and Wu, J. C. (2012) Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming. Cell Stem Cell 10, 16-28.
    • (2012) Cell Stem Cell , vol.10 , pp. 16-28
    • Burridge, P.W.1    Keller, G.2    Gold, J.D.3    Wu, J.C.4
  • 5
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K., and Yamanaka, S. (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 6
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., and Yamanaka, S. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 8
    • 34249863603 scopus 로고    scopus 로고
    • Strategies and new developments in the generation of patient specific pluripotent stem cells
    • Yamanaka, S. (2007) Strategies and new developments in the generation of patient specific pluripotent stem cells. Cell Stem Cell 1, 39-49.
    • (2007) Cell Stem Cell , vol.1 , pp. 39-49
    • Yamanaka, S.1
  • 9
    • 84878852415 scopus 로고    scopus 로고
    • Modeling human disease with pluripotent stem cells: From genome association to function
    • Merkle, F. T., and Eggan, K. (2013) Modeling human disease with pluripotent stem cells: from genome association to function. Cell Stem Cell 12, 656-668.
    • (2013) Cell Stem Cell , vol.12 , pp. 656-668
    • Merkle, F.T.1    Eggan, K.2
  • 10
    • 84878878364 scopus 로고    scopus 로고
    • Integrating human pluripotent stem cells into drug development
    • Engle, S. J., and Puppala, D. (2013) Integrating human pluripotent stem cells into drug development. Cell Stem Cell 12, 669-677.
    • (2013) Cell Stem Cell , vol.12 , pp. 669-677
    • Engle, S.J.1    Puppala, D.2
  • 11
    • 84873408831 scopus 로고    scopus 로고
    • Assessing the risks of genotoxicity in the therapeutic development of induced pluripotent stem cells
    • Hong, S. G., and Dunbar., C. E., and Winkler, T. (2013) Assessing the risks of genotoxicity in the therapeutic development of induced pluripotent stem cells. Mol. Ther. 2, 272-281.
    • (2013) Mol. Ther. , vol.2 , pp. 272-281
    • Hong, S.G.1    Dunbar, C.E.2    Winkler, T.3
  • 12
    • 77249142404 scopus 로고    scopus 로고
    • The art of the chemical probe
    • Frye, S. V. (2010) The art of the chemical probe. Nat. Chem. Biol. 6, 159-161.
    • (2010) Nat. Chem. Biol. , vol.6 , pp. 159-161
    • Frye, S.V.1
  • 13
    • 84884152388 scopus 로고    scopus 로고
    • Chemical approaches to stem cell biology and therapeutics
    • Li, W., Li, K., Wei, W., and Ding, S. (2013) Chemical approaches to stem cell biology and therapeutics. Cell Stem Cell 13, 270-283.
    • (2013) Cell Stem Cell , vol.13 , pp. 270-283
    • Li, W.1    Li, K.2    Wei, W.3    Ding, S.4
  • 14
    • 84871935467 scopus 로고    scopus 로고
    • Cellular reprogramming: A small molecule perspective
    • Nie, B., Wang, H., Laurent, T., and Ding, S. (2012) Cellular reprogramming: a small molecule perspective. Curr. Opin. Cell Biol. 24, 784-792.
    • (2012) Curr. Opin. Cell Biol. , vol.24 , pp. 784-792
    • Nie, B.1    Wang, H.2    Laurent, T.3    Ding, S.4
  • 17
    • 33947301272 scopus 로고    scopus 로고
    • Epigenetic signatures of stem-cell identity
    • Spivakov, M., and Fisher, A. G. (2007) Epigenetic signatures of stem-cell identity. Nat. Rev. Genet. 8, 263-271.
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 263-271
    • Spivakov, M.1    Fisher, A.G.2
  • 20
    • 33745865934 scopus 로고    scopus 로고
    • Chromatin in pluripotent embryonic stem cells and differentiation
    • Meshorer, E., and Misteli, T. (2006) Chromatin in pluripotent embryonic stem cells and differentiation. Nat. Rev. Mol. Cell Biol. 7, 540-546.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 540-546
    • Meshorer, E.1    Misteli, T.2
  • 21
    • 0032030770 scopus 로고    scopus 로고
    • Histone acetylation and transcriptional regulatory mechanisms
    • Struhl, K. (1998) Histone acetylation and transcriptional regulatory mechanisms. Genes Dev. 12, 599-606.
    • (1998) Genes Dev. , vol.12 , pp. 599-606
    • Struhl, K.1
  • 22
    • 84859744612 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in cell pluripotency, differentiation, and reprogramming
    • Kretsovali, A., Hadjimichael, C., and Charmpilas, N. (2012) Histone deacetylase inhibitors in cell pluripotency, differentiation, and reprogramming. Stem Cells Int. 2012, 184154.
    • (2012) Stem Cells Int , vol.2012
    • Kretsovali, A.1    Hadjimichael, C.2    Charmpilas, N.3
  • 23
    • 46949085597 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
    • Huangfu, D., Maehr, R., Guo, W., Eijkelenboom, A., Snitow, M., Chen, A. E., and Melton, D. A. (2008) Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat. Biotechnol. 26, 795-797.
    • (2008) Nat. Biotechnol. , vol.26 , pp. 795-797
    • Huangfu, D.1    Maehr, R.2    Guo, W.3    Eijkelenboom, A.4    Snitow, M.5    Chen, A.E.6    Melton, D.A.7
  • 25
    • 29744447772 scopus 로고    scopus 로고
    • Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells
    • Meshorer, E., Yellajoshula, D., George, E., Scambler, P. J., and Brown., D. T., and Misteli, T. (2006) Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. Dev. Cell 10, 105-116.
    • (2006) Dev. Cell , vol.10 , pp. 105-116
    • Meshorer, E.1    Yellajoshula, D.2    George, E.3    Scambler, P.J.4    Brown, D.T.5    Misteli, T.6
  • 27
    • 37549008674 scopus 로고    scopus 로고
    • C-myc is dispensable for direct reprogramming of mouse fibroblasts
    • Wernig, M., Meissner, A., Cassady, J. P., and Jaenisch, R. (2008) c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Cell Stem Cell 2, 10-12.
    • (2008) Cell Stem Cell , vol.2 , pp. 10-12
    • Wernig, M.1    Meissner, A.2    Cassady, J.P.3    Jaenisch, R.4
  • 30
    • 54949115497 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic fibroblasts by oct4 and klf4 with small-molecule compounds
    • Shi, Y., Desponts, C., Do, J. T., and Hahm., H. S., Scholer, H. R., and Ding, S. (2008) Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 3, 568-574.
    • (2008) Cell Stem Cell , vol.3 , pp. 568-574
    • Shi, Y.1    Desponts, C.2    Do, J.T.3    Hahm, H.S.4    Scholer, H.R.5    Ding, S.6
  • 31
    • 44349103591 scopus 로고    scopus 로고
    • A combined chemical and genetic approach for the generation of induced pluripotent stem cells
    • Shi, Y., and Do., J. T., Desponts, C., Hahm, H. S., and Scholer., H. R., and Ding, S. (2008) A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell 2, 525-528.
    • (2008) Cell Stem Cell , vol.2 , pp. 525-528
    • Shi, Y.1    Do, J.T.2    Desponts, C.3    Hahm, H.S.4    Scholer, H.R.5    Ding, S.6
  • 36
    • 70350571742 scopus 로고    scopus 로고
    • Tgfβ signal inhibition cooperates in the induction of iPSCs and replaces sox2 and cMyc
    • Maherali, N., and Hochedlinger, K. (2009) Tgfβ signal inhibition cooperates in the induction of iPSCs and replaces Sox2 and cMyc. Curr. Biol. 19, 1718-1723.
    • (2009) Curr. Biol. , vol.19 , pp. 1718-1723
    • Maherali, N.1    Hochedlinger, K.2
  • 37
    • 79953001876 scopus 로고    scopus 로고
    • Brief report: Combined chemical treatment enables oct4-induced reprogramming from mouse embryonic fibroblasts
    • Yuan, X., Wan, H., Zhao, X., Zhu, S., Zhou, Q., and Ding, S. (2011) Brief report: Combined chemical treatment enables oct4-induced reprogramming from mouse embryonic fibroblasts. Stem Cells 29, 549-553.
    • (2011) Stem Cells , vol.29 , pp. 549-553
    • Yuan, X.1    Wan, H.2    Zhao, X.3    Zhu, S.4    Zhou, Q.5    Ding, S.6
  • 38
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya, T., and Clevers, H. (2005) Wnt signalling in stem cells and cancer. Nature 434, 843-850.
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 44
    • 67649371461 scopus 로고    scopus 로고
    • DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
    • Miranda, T. B., and Cortez., C. C., Yoo, C. B., Liang, G., Abe, M., and Kelly., T. K., Marquez, V. E., and Jones, P. A. (2009) DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. Mol. Cancer. Ther. 8, 1579-1588.
    • (2009) Mol. Cancer. Ther. , vol.8 , pp. 1579-1588
    • Miranda, T.B.1    Cortez, C.C.2    Yoo, C.B.3    Liang, G.4    Abe, M.5    Kelly, T.K.6    Marquez, V.E.7    Jones, P.A.8
  • 45
    • 0034983625 scopus 로고    scopus 로고
    • Multilineage differentiation from human embryonic stem cell lines
    • Odorico, J. S., and Kaufman., D. S., and Thomson, J. A. (2001) Multilineage differentiation from human embryonic stem cell lines. Stem Cells 19, 193-204.
    • (2001) Stem Cells , vol.19 , pp. 193-204
    • Odorico, J.S.1    Kaufman, D.S.2    Thomson, J.A.3
  • 46
    • 84888001410 scopus 로고    scopus 로고
    • Technological progress and challenges towards cGMP manufacturing of human pluripotent stem cells based therapeutic products for allogeneic and autologous cell therapies
    • Abbasalizadeh, S., and Baharvand, H. (2013) Technological progress and challenges towards cGMP manufacturing of human pluripotent stem cells based therapeutic products for allogeneic and autologous cell therapies. Biotechnol. Adv. 31, 1600-1623.
    • (2013) Biotechnol. Adv. , vol.31 , pp. 1600-1623
    • Abbasalizadeh, S.1    Baharvand, H.2
  • 51
    • 55049103881 scopus 로고    scopus 로고
    • Promotion of feeder-independent self-renewal of embryonic stem cells by retinol (Vitamin A)
    • Chen, L., and Khillan, J. S. (2008) Promotion of feeder-independent self-renewal of embryonic stem cells by retinol (vitamin A). Stem Cells 26, 1858-1864.
    • (2008) Stem Cells , vol.26 , pp. 1858-1864
    • Chen, L.1    Khillan, J.S.2
  • 52
    • 77952360137 scopus 로고    scopus 로고
    • Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules
    • Xu, Y., Zhu, X., Hahm, H. S., Wei, W., Hao, E., Hayek, A., and Ding, S. (2010) Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc. Natl. Acad. Sci. U.S.A. 107, 8129-8134.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 8129-8134
    • Xu, Y.1    Zhu, X.2    Hahm, H.S.3    Wei, W.4    Hao, E.5    Hayek, A.6    Ding, S.7
  • 54
    • 84868135412 scopus 로고    scopus 로고
    • Passaging and colony expansion of human pluripotent stem cells by enzyme-free dissociation in chemically defined culture conditions
    • Beers, J., and Gulbranson., D. R., George, N., Siniscalchi, L. I., Jones, J., and Thomson., J. A., and Chen, G. (2012) Passaging and colony expansion of human pluripotent stem cells by enzyme-free dissociation in chemically defined culture conditions. Nat. Protoc. 7, 2029-2040.
    • (2012) Nat. Protoc. , vol.7 , pp. 2029-2040
    • Beers, J.1    Gulbranson, D.R.2    George, N.3    Siniscalchi, L.I.4    Jones, J.5    Thomson, J.A.6    Chen, G.7
  • 55
    • 0034904645 scopus 로고    scopus 로고
    • Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes
    • Kehat, I., Kenyagin-Karsenti, D., Snir, M., Segev, H., Amit, M., and Gepstein, A. (2001) Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J. Clin. Invest. 108, 407-414.
    • (2001) J. Clin. Invest. , vol.108 , pp. 407-414
    • Kehat, I.1    Kenyagin-Karsenti, D.2    Snir, M.3    Segev, H.4    Amit, M.5    Gepstein, A.6
  • 56
  • 57
    • 0037446546 scopus 로고    scopus 로고
    • Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes
    • Takahashi, T., Lord, B., Schulze, P. C., and Fryer., R. M., Sarang, S. S., Gullans, S. R., and Lee, R. T. (2003) Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes. Circulation 107, 1912-1916.
    • (2003) Circulation , vol.107 , pp. 1912-1916
    • Takahashi, T.1    Lord, B.2    Schulze, P.C.3    Fryer, R.M.4    Sarang, S.S.5    Gullans, S.R.6    Lee, R.T.7
  • 58
    • 84855487976 scopus 로고    scopus 로고
    • Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells
    • Cao, N., Liu, Z., Chen, Z., Wang, J., Chen, T., Zhao, X., Ma, Y., Qin, L., Kang, J., Wei, B., Wang, L., Jin, Y., and Yang, H.-T. (2012) Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells. Cell Res. 22, 219-236.
    • (2012) Cell Res. , vol.22 , pp. 219-236
    • Cao, N.1    Liu, Z.2    Chen, Z.3    Wang, J.4    Chen, T.5    Zhao, X.6    Ma, Y.7    Qin, L.8    Kang, J.9    Wei, B.10    Wang, L.11    Jin, Y.12    Yang, H.-T.13
  • 59
    • 1242336840 scopus 로고    scopus 로고
    • Small molecules that induce cardiomyogenesis in embryonic stem cells
    • Wu, X., Ding, S., Ding, Q., Gray, N. S., and Schultz, P. G. (2004) Small molecules that induce cardiomyogenesis in embryonic stem cells. J. Am. Chem. Soc. 126, 590-591.
    • (2004) J. Am. Chem. Soc. , vol.126 , pp. 590-591
    • Wu, X.1    Ding, S.2    Ding, Q.3    Gray, N.S.4    Schultz, P.G.5
  • 60
    • 11244309426 scopus 로고    scopus 로고
    • Isoxazolyl-serine-based agonists of peroxisome proliferator-activated receptor: Design, synthesis, and effects on cardiomyocyte differentiation
    • Wei, Z. L., and Petukhov., P. A., Bizik, F., Teixeira, J. C., Mercola, M., and Volpe., E. A., Glazer, R. I., Willson, T. M., and Kozikowski, A. P. (2004) Isoxazolyl-serine-based agonists of peroxisome proliferator-activated receptor: design, synthesis, and effects on cardiomyocyte differentiation. J. Am. Chem. Soc. 126, 16714-16715.
    • (2004) J. Am. Chem. Soc. , vol.126 , pp. 16714-16715
    • Wei, Z.L.1    Petukhov, P.A.2    Bizik, F.3    Teixeira, J.C.4    Mercola, M.5    Volpe, E.A.6    Glazer, R.I.7    Willson, T.M.8    Kozikowski, A.P.9
  • 65
    • 51449091152 scopus 로고    scopus 로고
    • Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells
    • Hao, J., and Daleo., M. A., Murphy, C. K., Yu, P. B., and Ho., J. N., Hu, J., Peterson, R. T., and Hatzopoulos., A. K., and Hong, C. C. (2008) Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PLoS One 3, e2904.
    • (2008) PLoS One , vol.3
    • Hao, J.1    Daleo, M.A.2    Murphy, C.K.3    Yu, P.B.4    Ho, J.N.5    Hu, J.6    Peterson, R.T.7    Hatzopoulos, A.K.8    Hong, C.C.9
  • 66
    • 79551597211 scopus 로고    scopus 로고
    • Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines
    • Kattman, S. J., and Witty., A. D., Gagliardi, M., Dubois, N. C., Niapour, M., Hotta, A., Ellis, J., and Keller, G. (2011) Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell 8, 228-240.
    • (2011) Cell Stem Cell , vol.8 , pp. 228-240
    • Kattman, S.J.1    Witty, A.D.2    Gagliardi, M.3    Dubois, N.C.4    Niapour, M.5    Hotta, A.6    Ellis, J.7    Keller, G.8
  • 68
    • 33845928762 scopus 로고    scopus 로고
    • Developmental stage-specific biphasic roles of wnt/beta-catenin signaling in cardiomyogenesis and hematopoiesis
    • Naito, A. T., Shiojima, I., Akazawa, H., Hidaka, K., Morisaki, T., Kikuchi, A., and Komuro, I. (2006) Developmental stage-specific biphasic roles of Wnt/beta-catenin signaling in cardiomyogenesis and hematopoiesis. Proc. Natl. Acad. Sci. U.S.A. 103, 19812-19817.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 19812-19817
    • Naito, A.T.1    Shiojima, I.2    Akazawa, H.3    Hidaka, K.4    Morisaki, T.5    Kikuchi, A.6    Komuro, I.7
  • 69
    • 80051796581 scopus 로고    scopus 로고
    • Small-molecule inhibitors of the wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm
    • Willems, E., Spiering, S., Davidovics, H., Lanier, M., Xia, Z., Dawson, M., Cashman, J., and Mercola, M. (2011) Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm. Circ. Res. 109, 360-364.
    • (2011) Circ. Res. , vol.109 , pp. 360-364
    • Willems, E.1    Spiering, S.2    Davidovics, H.3    Lanier, M.4    Xia, Z.5    Dawson, M.6    Cashman, J.7    Mercola, M.8
  • 70
    • 79951936909 scopus 로고    scopus 로고
    • Cardiac induction of embryonic stem cells by a small molecule inhibitor of wnt/betacatenin signaling
    • Wang, H., Hao, J., and Hong, C. C. (2011) Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/betacatenin signaling. ACS Chem. Biol. 6, 192-197.
    • (2011) ACS Chem. Biol. , vol.6 , pp. 192-197
    • Wang, H.1    Hao, J.2    Hong, C.C.3
  • 71
    • 81255179215 scopus 로고    scopus 로고
    • Stepwise chemically induced cardiomyocyte specification of human embryonic stem cells
    • Gonzalez, R., and Lee., J. W., and Schultz, P. G. (2011) Stepwise chemically induced cardiomyocyte specification of human embryonic stem cells. Angew. Chem., Int. Ed. 50, 11181-11185.
    • (2011) Angew. Chem., Int. Ed. , vol.50 , pp. 11181-11185
    • Gonzalez, R.1    Lee, J.W.2    Schultz, P.G.3
  • 75
    • 77957270888 scopus 로고    scopus 로고
    • Neuregulin/ERBB signaling regulates cardiac subtype specification in differentiating human embryonic stem cells
    • Zhu, W. Z., Xie, Y., Moyes, K. W., and Gold., J. D., Askari, B., and Laflamme, M. A. (2010) Neuregulin/ErbB signaling regulates cardiac subtype specification in differentiating human embryonic stem cells. Circ. Res. 107, 776-786.
    • (2010) Circ. Res. , vol.107 , pp. 776-786
    • Zhu, W.Z.1    Xie, Y.2    Moyes, K.W.3    Gold, J.D.4    Askari, B.5    Laflamme, M.A.6
  • 79
    • 0034971110 scopus 로고    scopus 로고
    • Cardiomyocyte grafting for cardiac repair: Graft cell death and anti-death strategies
    • Zhang, M., Methot, D., Poppa, V., Fujio, Y., Walsh, K., and Murry, C. E. (2001) Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies. J. Mol. Cell Cardiol. 33, 907-921.
    • (2001) J. Mol. Cell Cardiol. , vol.33 , pp. 907-921
    • Zhang, M.1    Methot, D.2    Poppa, V.3    Fujio, Y.4    Walsh, K.5    Murry, C.E.6
  • 81
    • 33947546577 scopus 로고    scopus 로고
    • Pharmacologically preconditioned skeletal myoblasts are resistant to oxidative stress and promote angiomyogenesis via release of paracrine factors in the infarcted heart
    • Niagara, M. I., Haider, H.-K., Jiang, S., and Ashraf, M. (2007) Pharmacologically preconditioned skeletal myoblasts are resistant to oxidative stress and promote angiomyogenesis via release of paracrine factors in the infarcted heart. Circ. Res. 100, 545-555.
    • (2007) Circ. Res. , vol.100 , pp. 545-555
    • Niagara, M.I.1    Haider, H.-K.2    Jiang, S.3    Ashraf, M.4
  • 82
    • 79952129848 scopus 로고    scopus 로고
    • Pretreatment of human mesenchymal stem cells with pioglitazone improved efficiency of cardiomyogenic transdifferentiation and cardiac function
    • Shinmura, D., Togashi, I., Miyoshi, S., Nishiyama, N., Hida, N., Tsuji, H., Tsuruta, H., Segawa, K., Tsukada, Y., Ogawa, S., and Umezawa, A. (2011) Pretreatment of human mesenchymal stem cells with pioglitazone improved efficiency of cardiomyogenic transdifferentiation and cardiac function. Stem Cells 29, 357-366.
    • (2011) Stem Cells , vol.29 , pp. 357-366
    • Shinmura, D.1    Togashi, I.2    Miyoshi, S.3    Nishiyama, N.4    Hida, N.5    Tsuji, H.6    Tsuruta, H.7    Segawa, K.8    Tsukada, Y.9    Ogawa, S.10    Umezawa, A.11
  • 83
    • 77649100574 scopus 로고    scopus 로고
    • Inhibition of ROCK improves survival of human embryonic stem cell-derived cardiomyocytes after dissociation
    • Braam, S. R., Nauw, R., Ward-van Oostwaard, D., Mummery, C., and Passier, R. (2010) Inhibition of ROCK improves survival of human embryonic stem cell-derived cardiomyocytes after dissociation. Ann. N.Y. Acad. Sci. 1188, 52-67.
    • (2010) Ann. N.Y. Acad. Sci , vol.1188 , pp. 52-67
    • Braam, S.R.1    Nauw, R.2    Oostwaard, W.-V.3    Mummery, D.C.4    Passier, R.5
  • 84
    • 84862909128 scopus 로고    scopus 로고
    • Myocardial improvement with human embryonic stem cell-derived cardiomyo-cytes enriched by p38MAPK inhibition
    • Yeghiazarians, Y., Gaur, M., Zhang, Y., Sievers, R. E., Ritner, C., Prasad, M., Boyle, A., and Bernstein, H. S. (2012) Myocardial improvement with human embryonic stem cell-derived cardiomyo-cytes enriched by p38MAPK inhibition. Cytotherapy 14, 223-231.
    • (2012) Cytotherapy , vol.14 , pp. 223-231
    • Yeghiazarians, Y.1    Gaur, M.2    Zhang, Y.3    Sievers, R.E.4    Ritner, C.5    Prasad, M.6    Boyle, A.7    Bernstein, H.S.8
  • 85
    • 33744501240 scopus 로고    scopus 로고
    • Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction
    • Davis, M. E., and Hsieh., P. C., Takahashi, T., Song, Q., Zhang, S., and Kamm., R. D., Grodzinsky, A. J., Anversa, P., and Lee, R. T. (2006) Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. Proc. Natl. Acad. Sci. U.S.A. 103, 8155-8160.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 8155-8160
    • Davis, M.E.1    Hsieh, P.C.2    Takahashi, T.3    Song, Q.4    Zhang, S.5    Kamm, R.D.6    Grodzinsky, A.J.7    Anversa, P.8    Lee, R.T.9
  • 86
    • 79955060751 scopus 로고    scopus 로고
    • TGF-β2 treatment enhances cytoprotective factors released from embryonic stem cells and inhibits apoptosis in infarcted myocardium
    • Singla, D. K., and Singla., R. D., Lamm, S., and Glass, C. (2011) TGF-β2 treatment enhances cytoprotective factors released from embryonic stem cells and inhibits apoptosis in infarcted myocardium. Am. J. Physiol. Heart Circ. Physiol. 300, H1442-H1450.
    • (2011) Am. J. Physiol. Heart Circ. Physiol , vol.300 , pp. H1442-H1450
    • Singla, D.K.1    Singla, R.D.2    Lamm, S.3    Glass, C.4
  • 87
    • 53549131225 scopus 로고    scopus 로고
    • Systems approaches to preventing transplanted cell death in cardiac repair
    • Robey, T. E., and Saiget., M. K., Reinecke, H., and Murry, C. E. (2008) Systems approaches to preventing transplanted cell death in cardiac repair. J. Mol. Cell Cardiol. 45, 567-581.
    • (2008) J. Mol. Cell Cardiol. , vol.45 , pp. 567-581
    • Robey, T.E.1    Saiget, M.K.2    Reinecke, H.3    Murry, C.E.4
  • 88
    • 34248593790 scopus 로고    scopus 로고
    • Cardiac myocyte cell cycle control in development, disease, and regeneration
    • Ahuja, P., Sdek, P., and MacLellan, W. R. (2007) Cardiac myocyte cell cycle control in development, disease, and regeneration. Physiol. Rev. 87, 521-544.
    • (2007) Physiol. Rev. , vol.87 , pp. 521-544
    • Ahuja, P.1    Sdek, P.2    MacLellan, W.R.3
  • 89
    • 84880839534 scopus 로고    scopus 로고
    • Mending broken hearts: Cardiac development as a basis for adult heart regeneration and repair
    • Xin, M., and Olson., E. N., and Bassel-Duby, R. (2013) Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair. Nat. Rev. Mol. Cell Biol. 14, 529-541.
    • (2013) Nat. Rev. Mol. Cell Biol. , vol.14 , pp. 529-541
    • Xin, M.1    Olson, E.N.2    Bassel-Duby, R.3
  • 93
    • 11844292733 scopus 로고    scopus 로고
    • Targeted expression of cyclin D2 results in cardiomyocyte DNA synthesis and infarct regression in transgenic mice
    • Pasumarthi, K. B., Nakajima, H., Nakajima, H. O., and Soonpaa., M. H., and Field, L. J. (2005) Targeted expression of cyclin D2 results in cardiomyocyte DNA synthesis and infarct regression in transgenic mice. Circ. Res. 96, 110-118.
    • (2005) Circ. Res. , vol.96 , pp. 110-118
    • Pasumarthi, K.B.1    Nakajima, H.2    Nakajima, H.O.3    Soonpaa, M.H.4    Field, L.J.5
  • 95
    • 33750298315 scopus 로고    scopus 로고
    • FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction
    • Engel, F. B., and Hsieh., P. C., Lee, R. T., and Keating, M. T. (2006) FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction. Proc. Natl. Acad. Sci. U.S.A. 103, 15546-15551.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 15546-15551
    • Engel, F.B.1    Hsieh, P.C.2    Lee, R.T.3    Keating, M.T.4
  • 99
    • 79952273710 scopus 로고    scopus 로고
    • Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy
    • Efe, J. A., Hilcove, S., Kim, J., Zhou, H., Ouyang, K., Wang, G., Chen, J., and Ding, S. (2011) Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat. Cell Biol. 13, 215-222.
    • (2011) Nat. Cell Biol. , vol.13 , pp. 215-222
    • Efe, J.A.1    Hilcove, S.2    Kim, J.3    Zhou, H.4    Ouyang, K.5    Wang, G.6    Chen, J.7    Ding, S.8
  • 103
    • 79751521773 scopus 로고    scopus 로고
    • Developmental and regenerative biology of multipotent cardiovascular progenitor cells
    • Sturzu, A. C., and Wu, S. M. (2011) Developmental and regenerative biology of multipotent cardiovascular progenitor cells. Circ. Res. 108, 353-364.
    • (2011) Circ. Res. , vol.108 , pp. 353-364
    • Sturzu, A.C.1    Wu, S.M.2
  • 104
    • 79953903083 scopus 로고    scopus 로고
    • Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair
    • Loffredo, F. S., and Steinhauser., M. L., Gannon, J., and Lee, R. T. (2011) Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair. Cell Stem Cell 8, 389-398.
    • (2011) Cell Stem Cell , vol.8 , pp. 389-398
    • Loffredo, F.S.1    Steinhauser, M.L.2    Gannon, J.3    Lee, R.T.4
  • 107


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