Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling

ACS Chemical Biology

Volumn 6, Issue 2, 2011, Pages 192-197

  Wang, Hanmin ^a,b   Hao, Jijun ^c   Hong, Charles C ^c,d,e  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b Department of Medicine   (United States)

^c Research Medicine   (United States)

^d Division of Cardiovascular Medicine   (United States)

^e VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; WNT PROTEIN; XAV 939;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; ENDOTHELIUM CELL; HEART MUSCLE CELL; HEMATOPOIETIC CELL; IN VITRO STUDY; MESODERM; MOUSE; MUSCLE DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TISSUE REGENERATION;

ANIMALS; BETA CATENIN; CELL DIFFERENTIATION; CELLS, CULTURED; EMBRYONIC STEM CELLS; GROWTH INHIBITORS; MICE; MYOCYTES, CARDIAC; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 79951936909     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb100323z     Document Type: Article

References (22)

1. Fukuda, K. and Yuasa, S. (2006) Stem cells as a source of regenerative cardiomyocytes Circ. Res. 98, 1002-1013
2. Laflamme, M. A., Chen, K. Y., Naumova, A. V., Muskheli, V., Fugate, J. A., Dupras, S. K., Reinecke, H., Xu, C., Hassanipour, M., Police, S., O'Sullivan, C., Collins, L., Chen, Y., Minami, E., Gill, E. A., Ueno, S., Yuan, C., Gold, J., and Murry, C. E. (2007) Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts Nat. Biotechnol. 25, 1015-1024
3. Okita, K., Ichisaka, T., and Yamanaka, S. (2007) Generation of germline-competent induced pluripotent stem cells Nature 448, 313-317
4. Okita, K., Nakagawa, M., Hyenjong, H., Ichisaka, T., and Yamanaka, S. (2008) Generation of mouse induced pluripotent stem cells without viral vectors Science 322, 949-953
5. Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., and Yamanaka, S. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 131, 861-872
6. Takahashi, K. and Yamanaka, S. (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126, 663-676
7. Wernig, M., Meissner, A., Foreman, R., Brambrink, T., Ku, M., Hochedlinger, K., Bernstein, B. E., and Jaenisch, R. (2007) In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state Nature 448, 318-324
8. Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., Slukvin, I. I., and Thomson, J. A. (2007) Induced pluripotent stem cell lines derived from human somatic cells Science 318, 1917-1920
9. Foley, A. C. and Mercola, M. (2005) Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex Genes Dev. 19, 387-396
10. Naito, A. T., Shiojima, I., Akazawa, H., Hidaka, K., Morisaki, T., Kikuchi, A., and Komuro, I. (2006) Developmental stage-specific biphasic roles of Wnt/beta-catenin signaling in cardiomyogenesis and hematopoiesis Proc. Natl. Acad. Sci. U.S.A. 103, 19812-19817
11. Ueno, S., Weidinger, G., Osugi, T., Kohn, A. D., Golob, J. L., Pabon, L., Reinecke, H., Moon, R. T., and Murry, C. E. (2007) Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells Proc. Natl. Acad. Sci. U.S.A. 104, 9685-9690
12. Yuasa, S., Itabashi, Y., Koshimizu, U., Tanaka, T., Sugimura, K., Kinoshita, M., Hattori, F., Fukami, S.-I., Shimazaki, T., Okano, H., Ogawa, S., and Fukuda, K. (2005) Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells Nat. Biotechnol. 23, 607-611
13. Hao, J., Daleo, M. A., Murphy, C. K., Yu, P. B., Ho, J. N., Hu, J., Peterson, R. T., Hatzopoulos, A. K., and Hong, C. C. (2008) Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells PloS One 3, e2904
14. Emre, N., Coleman, R., and Ding, S. (2007) A chemical approach to stem cell biology Curr. Opin. Chem. Biol. 11, 252-258
15. Marvin, M. J., Di Rocco, G., Gardiner, A., Bush, S. M., and Lassar, A. B. (2001) Inhibition of Wnt activity induces heart formation from posterior mesoderm Genes Dev. 15, 316-327
16. Huang, S. M., Mishina, Y. M., Liu, S., Cheung, A., Stegmeier, F., Michaud, G. A., Charlat, O., Wiellette, E., Zhang, Y., Wiessner, S., Hild, M., Shi, X., Wilson, C. J., Mickanin, C., Myer, V., Fazal, A., Tomlinson, R., Serluca, F., Shao, W., Cheng, H., Shultz, M., Rau, C., Schirle, M., Schlegl, J., Ghidelli, S., Fawell, S., Lu, C., Curtis, D., Kirschner, M. W., Lengauer, C., Finan, P. M., Tallarico, J. A., Bouwmeester, T., Porter, J. A., Bauer, A., and Cong, F. (2009) Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling Nature 461, 614-620
17. Chen, B., Dodge, M. E., Tang, W., Lu, J., Ma, Z., Fan, C. W., Wei, S., Hao, W., Kilgore, J., Williams, N. S., Roth, M. G., Amatruda, J. F., Chen, C., and Lum, L. (2009) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer Nat. Chem. Biol. 5, 100-107
18. Friedman, J. R. and Kaestner, K. H. (2006) The Foxa family of transcription factors in development and metabolism Cell. Mol. Life Sci. 63, 2317-2328
19. Wiese, C., Rolletschek, A., Kania, G., Blyszczuk, P., Tarasov, K. V., Tarasova, Y., Wersto, R. P., Boheler, K. R., and Wobus, A. M. (2004) Nestin expression-a property of multi-lineage progenitor cells? Cell. Mol. Life Sci. 61, 2510-2522
20. Shi, Y., Do, J. T., Desponts, C., Hahm, H. S., Scholer, H. R., and Ding, S. (2008) A combined chemical and genetic approach for the generation of induced pluripotent stem cells Cell Stem Cell 2, 525-528
21. Yao, S., Chen, S., Clark, J., Hao, E., Beattie, G. M., Hayek, A., and Ding, S. (2006) Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions Proc. Natl. Acad. Sci. U.S.A. 103, 6907-6912
22. Wada, T., Honda, M., Minami, I., Tooi, N., Amagai, Y., Nakatsuji, N., and Aiba, K. (2009) Highly efficient differentiation and enrichment of spinal motor neurons derived from human and monkey embryonic stem cells PloS One 4, e6722