Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells

Cell Stem Cell

Volumn 11, Issue 2, 2012, Pages 242-252

  Willems, Erik ^a,b   Cabral Teixeira, Joaquim ^a   Schade, Dennis ^a,b,c   Cai, Wenqing ^a   Reeves, Patrick ^d   Bushway, Paul J ^a   Lanier, Marion ^b,c   Walsh, Christopher ^e   Kirchhausen, Tomas ^d   Izpisua Belmonte, Juan Carlos ^e,f   Cashman, John ^b,c   Mercola, Mark ^a,b  

^a BURNHAM INSTITUTE   (United States)

^b ChemRegen Inc   (United States)

^c HUMAN BIOMOLECULAR RESEARCH INSTITUTE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^f CENTER OF REGENERATIVE MEDICINE IN BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDROPYRIDINE DERIVATIVE; CELL SURFACE RECEPTOR; INDUCER OF TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR DEGRADATION 1; PROTEASOME; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DEVELOPMENTAL STAGE; EMBRYO; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; ENDOTHELIUM CELL; HEART DEVELOPMENT; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IC 50; MESODERM; MOLECULAR LIBRARY; MOUSE; MULTIPOTENT STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; DIHYDROPYRIDINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; EMBRYONIC STEM CELLS; EPIDERMAL GROWTH FACTOR; HEK293 CELLS; HUMANS; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MOLECULAR WEIGHT; MYOCYTES, CARDIAC; NEOPLASM PROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTEOLYSIS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84864610045     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2012.04.025     Document Type: Article

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