Cellular mechanisms of cardiomyopathy

Journal of Cell Biology

Volumn 194, Issue 3, 2011, Pages 355-365

  Harvey, Pamela A ^a   Leinwand, Leslie A ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCIUM ION; GUANINE NUCLEOTIDE BINDING PROTEIN; MYOSIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ADAPTATION; APOPTOSIS; CALCIUM METABOLISM; CARDIOMYOPATHY; CELL STRESS; CONGESTIVE CARDIOMYOPATHY; CYTOLOGY; GENE EXPRESSION; HEART; HEART FAILURE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; METABOLIC DISORDER; MUSCULAR DYSTROPHY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SARCOMERE; SIGNAL TRANSDUCTION; GENETICS; HEART MUSCLE; METABOLISM; NECROSIS; PATHOLOGY; PATHOPHYSIOLOGY;

APOPTOSIS; CARDIOMYOPATHIES; HEART; HUMANS; MYOCARDIUM; NECROSIS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 80052565758     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.201101100     Document Type: Review

References (108)

1. Adams, J.W., D.S. Migita, M.K. Yu, R. Young, M.S. Hellickson, F.E. Castro-Vargas, J.D. Domingo, P.H. Lee, J.S. Bui, and S.A. Henderson. 1996. Prostaglandin F2 alpha stimulates hypertrophic growth of cultured neonatal rat ventricular myocytes. J. Biol. Chem. 271:1179-1186.
2. Akyürek, O., N. Akyürek, T. Sayin, I. Dinçer, B. Berkalp, G. Akyol, M. Ozenci, and D. Oral. 2001. Association between the severity of heart failure and the susceptibility of myocytes to apoptosis in patients with idiopathic dilated cardiomyopathy. Int. J. Cardiol. 80:29-36.
3. Ashrafian, H., and M.P. Frenneaux. 2007. Metabolic modulation in heart failure: the coming of age. Cardiovasc. Drugs Ther. 21:5-7.
4. Basso, C., D. Corrado, F.I. Marcus, A. Nava, and G. Thiene. 2009. Arrhythmogenic right ventricular cardiomyopathy. Lancet. 373:1289-1300.
5. Berko, B.A., and M. Swift. 1987. X-linked dilated cardiomyopathy. N. Engl. J. Med. 316:1186-1191.
6. Buvoli, M., M. Hamady, L.A. Leinwand, and R. Knight. 2008. Bioinformatics assessment of beta-myosin mutations reveals myosin's high sensitivity to mutations. Trends Cardiovasc. Med. 18:141-149.
7. Bybee, K.A., T. Kara, A. Prasad, A. Lerman, G.W. Barsness, R.S. Wright, and C.S. Rihal. 2004. Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction. Ann. Intern. Med. 141:858-865.
8. Chin, T.K., J.K. Perloff, R.G. Williams, K. Jue, and R. Mohrmann. 1990. Isolated noncompaction of left ventricular myocardium. A study of eight cases. Circulation. 82:507-513.
9. Communal, C., K. Singh, D.R. Pimentel, and W.S. Colucci. 1998. Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the beta-adrenergic pathway. Circulation. 98:1329-1334.
10. Corrado, D., C. Basso, G. Thiene, W.J. McKenna, M.J. Davies, F. Fontaliran, A. Nava, F. Silvestri, C. Blomstrom-Lundqvist, E.K. Wlodarska, et al. 1997. Spectrum of clinicopathologic manifestations of arrhythmogenic right ventricular cardiomyopathy/dysplasia: a multicenter study. J. Am. Coll. Cardiol. 30:1512-1520.
11. Cregler, L.L. 1989. Progression from hypertrophic cardiomyopathy to dilated cardiomyopathy. J. Natl. Med. Assoc. 81:820: 824-826.
12. D'Angelo, D.D., Y. Sakata, J.N. Lorenz, G.P. Boivin, R.A. Walsh, S.B. Liggett, and G.W. Dorn II. 1997. Transgenic Galphaq overexpression induces cardiac contractile failure in mice. Proc. Natl. Acad. Sci. USA. 94:8121-8126.
13. Dávila-Román, V.G., G. Vedala, P. Herrero, L. de las Fuentes, J.G. Rogers, D.P. Kelly, and R.J. Gropler. 2002. Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy. J. Am. Coll. Cardiol. 40:271-277.
14. Davis, J., H. Wen, T. Edwards, and J.M. Metzger. 2007. Thin filament disinhibition by restrictive cardiomyopathy mutant R193H troponin I induces Ca2+-independent mechanical tone and acute myocyte remodeling. Circ. Res. 100:1494-1502.
15. de Jonge, H.W., D.H. Dekkers, B.C. Tilly, and J.M. Lamers. 2002. Cyclic stretch and endothelin-1 mediated activation of chloride channels in cultured neonatal rat ventricular myocytes. Clin. Sci. 103(Suppl 48):148S-151S.
16. Deinum, J., J.M. van Gool, M.J. Kofflard, F.J. ten Cate, and A.H. Danser. 2001. Angiotensin II type 2 receptors and cardiac hypertrophy in women with hypertrophic cardiomyopathy. Hypertension. 38:1278-1281.
17. Dobrin, J.S., and D. Lebeche. 2010. Diabetic cardiomyopathy: signaling defects and therapeutic approaches. Expert Rev. Cardiovasc. Ther. 8:373-391.
18. Dolci, A., R. Dominici, D. Cardinale, M.T. Sandri, and M. Panteghini. 2008. Biochemical markers for prediction of chemotherapy-induced cardiotoxicity: systematic review of the literature and recommendations for use. Am. J. Clin. Pathol. 130:688-695.
19. Edwards, B.S., R.S. Zimmerman, T.R. Schwab, D.M. Heublein, and J.C. Burnett Jr. 1988. Atrial stretch, not pressure, is the principal determinant controlling the acute release of atrial natriuretic factor. Circ. Res. 62:191-195.
20. Esposito, G., S.V. Prasad, A. Rapacciuolo, L. Mao, W.J. Koch, and H.A. Rockman. 2001. Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload. Circulation. 103:1453-1458.
21. Flavigny, J., M. Souchet, P. Sébillon, I. Berrebi-Bertrand, B. Hainque, A. Mallet, A. Bril, K. Schwartz, and L. Carrier. 1999. COOH-terminal truncated cardiac myosin-binding protein C mutants resulting from familial hypertrophic cardiomyopathy mutations exhibit altered expression and/or incorporation in fetal rat cardiomyocytes. J. Mol. Biol. 294:443-456.
22. Force, T., R. Hajjar, F. Del Monte, A. Rosenzweig, and G. Choukroun. 1999. Signaling pathways mediating the response to hypertrophic stress in the heart. Gene Expr. 7:337-348.
23. Freedom, R.M., S.J. Yoo, D. Perrin, G. Taylor, S. Petersen, and R.H. Anderson. 2005. The morphological spectrum of ventricular noncompaction. Cardiol. Young. 15:345-364.
24. Frey, N., and E.N. Olson. 2003. Cardiac hypertrophy: the good, the bad, and the ugly. Annu. Rev. Physiol. 65:45-79.
25. Geng, Y.J., Y. Ishikawa, D.E. Vatner, T.E. Wagner, S.P. Bishop, S.F. Vatner, and C.J. Homcy. 1999. Apoptosis of cardiac myocytes in Gsalpha transgenic mice. Circ. Res. 84:34-42.
26. Gill, C., R. Mestril, and A. Samali. 2002. Losing heart: the role of apoptosis in heart disease-a novel therapeutic target? FASEB J. 16:135-146.
27. Grogan, M., M.M. Redfield, K.R. Bailey, G.S. Reeder, B.J. Gersh, W.D. Edwards, and R.J. Rodeheffer. 1995. Long-term outcome of patients with biopsyproved myocarditis: comparison with idiopathic dilated cardiomyopathy. J. Am. Coll. Cardiol. 26:80-84.
28. Gupta, A., N.S. Aberle II, J. Ren, and A.C. Sharma. 2005. Endothelin-converting enzyme-1-mediated signaling in adult rat ventricular myocyte contractility and apoptosis during sepsis. J. Mol. Cell. Cardiol. 38:527-537.
29. Haq, S., G. Choukroun, Z.B. Kang, H. Ranu, T. Matsui, A. Rosenzweig, J.D. Molkentin, A. Alessandrini, J. Woodgett, R. Hajjar, et al. 2000. Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy. J. Cell Biol. 151:117-130.
30. Heineke, J., and J.D. Molkentin. 2006. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat. Rev. Mol. Cell Biol. 7:589-600.
31. Herron, T.J., and K.S. McDonald. 2002. Small amounts of alpha-myosin heavy chain isoform expression significantly increase power output of rat cardiac myocyte fragments. Circ. Res. 90:1150-1152.
32. Herron, T.J., R. Vandenboom, E. Fomicheva, L. Mundada, T. Edwards, and J.M. Metzger. 2007. Calcium-independent negative inotropy by beta-myosin heavy chain gene transfer in cardiac myocytes. Circ. Res. 100:1182-1190.
33. Hoogerwaard, E.M., P.A. van der Wouw, A.A. Wilde, E. Bakker, P.F. Ippel, J.C. Oosterwijk, D.F. Majoor-Krakauer, A.J. van Essen, N.J. Leschot, and M. de Visser. 1999. Cardiac involvement in carriers of Duchenne and Becker muscular dystrophy. Neuromuscul. Disord. 9:347-351.
34. Huang, X.P., and J.F. Du. 2004. Troponin I, cardiac diastolic dysfunction and restrictive cardiomyopathy. Acta Pharmacol. Sin. 25:1569-1575.
35. Huang, Y., R.P. Hickey, J.L. Yeh, D. Liu, A. Dadak, L.H. Young, R.S. Johnson, and F.J. Giordano. 2004. Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart. FASEB J. 18:1138-1140.
36. Iacovoni, A., R. De Maria, and A. Gavazzi. 2010. Alcoholic cardiomyopathy. J. Cardiovasc. Med. (Hagerstown). 11:884-892.
37. Ingwall, J.S., and R.G. Weiss. 2004. Is the failing heart energy starved? On using chemical energy to support cardiac function. Circ. Res. 95:135-145.
38. Iwai-Kanai, E., K. Hasegawa, M. Araki, T. Kakita, T. Morimoto, and S. Sasayama. 1999. alpha- and beta-adrenergic pathways differentially regulate cell typespecific apoptosis in rat cardiac myocytes. Circulation. 100:305-311.
39. Kalsi, K.K., R.T. Smolenski, R.D. Pritchard, A. Khaghani, A.M. Seymour, and M.H. Yacoub. 1999. Energetics and function of the failing human heart with dilated or hypertrophic cardiomyopathy. Eur. J. Clin. Invest. 29:469-477.
40. Kamisago, M., S.D. Sharma, S.R. DePalma, S. Solomon, P. Sharma, B. McDonough, L. Smoot, M.P. Mullen, P.K. Woolf, E.D. Wigle, et al. 2000. Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy. N. Engl. J. Med. 343:1688-1696.
41. Kaneda, T., C. Naruse, A. Kawashima, N. Fujino, T. Oshima, M. Namura, S. Nunoda, S. Mori, T. Konno, H. Ino, et al. 2008. A novel beta-myosin heavy chain gene mutation, p.Met531Arg, identified in isolated left ventricular non-compaction in humans, results in left ventricular hypertrophy that progresses to dilation in a mouse model. Clin. Sci. 114:431-440.
42. Kantor, P.F., M.A. Robertson, J.Y. Coe, and G.D. Lopaschuk. 1999. Volume overload hypertrophy of the newborn heart slows the maturation of enzymes involved in the regulation of fatty acid metabolism. J. Am. Coll. Cardiol. 33:1724-1734.
43. Karam, S., M.J. Raboisson, C. Ducreux, L. Chalabreysse, G. Millat, A. Bozio, and P. Bouvagnet. 2008. A de novo mutation of the beta cardiac myosin heavy chain gene in an infantile restrictive cardiomyopathy. Congenit. Heart Dis. 3:138-143.
44. Katritsis, D., P.T. Wilmshurst, J.A. Wendon, M.J. Davies, and M.M. Webb-Peploe. 1991. Primary restrictive cardiomyopathy: clinical and pathologic characteristics. J. Am. Coll. Cardiol. 18:1230-1235.
45. Keeling, P.J., Y. Gang, G. Smith, H. Seo, S.E. Bent, V. Murday, A.L. Caforio, and W.J. McKenna. 1995. Familial dilated cardiomyopathy in the United Kingdom. Br. Heart J. 73:417-421.
46. Kinnunen, P., O. Vuolteenaho, and H. Ruskoaho. 1993. Mechanisms of atrial and brain natriuretic peptide release from rat ventricular myocardium: effect of stretching. Endocrinology. 132:1961-1970.
47. Knowlton, K.U., M.C. Michel, M. Itani, H.E. Shubeita, K. Ishihara, J.H. Brown, and K.R. Chien. 1993. The alpha 1A-adrenergic receptor subtypemediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy. J. Biol. Chem. 268:15374-15380.
48. Kojima, M., I. Shiojima, T. Yamazaki, I. Komuro, Z. Zou, Y. Wang, T. Mizuno, K. Ueki, K. Tobe, T. Kadowaki, et al. 1994. Angiotensin II receptor antagonist TCV-116 induces regression of hypertensive left ventricular hypertrophy in vivo and inhibits the intracellular signaling pathway of stretch-mediated cardiomyocyte hypertrophy in vitro. Circulation. 89:2204-2211.
49. Krown, K.A., M.T. Page, C. Nguyen, D. Zechner, V. Gutierrez, K.L. Comstock, C.C. Glembotski, P.J. Quintana, and R.A. Sabbadini. 1996. Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death. J. Clin. Invest. 98:2854-2865.
50. Kuwahara, K., Y. Saito, M. Takano, Y. Arai, S. Yasuno, Y. Nakagawa, N. Takahashi, Y. Adachi, G. Takemura, M. Horie, et al. 2003. NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function. EMBO J. 22:6310-6321.
51. Le Guennec, J.Y., N. Peineau, J.A. Argibay, K.G. Mongo, and D. Garnier. 1990. A new method of attachment of isolated mammalian ventricular myocytes for tension recording: length dependence of passive and active tension. J. Mol. Cell. Cardiol. 22:1083-1093.
52. Lopaschuk, G.D., M.A. Spafford, and D.R. Marsh. 1991. Glycolysis is predominant source of myocardial ATP production immediately after birth. Am. J. Physiol. 261:H1698-H1705.
53. Lowes, B.D., W. Minobe, W.T. Abraham, M.N. Rizeq, T.J. Bohlmeyer, R.A. Quaife, R.L. Roden, D.L. Dutcher, A.D. Robertson, N.F. Voelkel, et al. 1997. Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium. J. Clin. Invest. 100:2315-2324.
54. Luckey, S.W., L.A. Walker, T. Smyth, J. Mansoori, A. Messmer-Kratzsch, A. Rosenzweig, E.N. Olson, and L.A. Leinwand. 2009. The role of Akt/ GSK-3beta signaling in familial hypertrophic cardiomyopathy. J. Mol. Cell. Cardiol. 46:739-747.
55. Maass, A.H., and M. Buvoli. 2007. Cardiomyocyte preparation, culture, and gene transfer. Methods Mol. Biol. 366:321-330.
56. Marian, A.J. 2000. Pathogenesis of diverse clinical and pathological phenotypes in hypertrophic cardiomyopathy. Lancet. 355:58-60.
57. Maron, B.J., and A. Pelliccia. 2006. The heart of trained athletes: cardiac remodeling and the risks of sports, including sudden death. Circulation. 114:1633-1644.
58. Maron, B.J., P.F. Nichols III, L.W. Pickle, Y.E. Wesley, and J.J. Mulvihill. 1984. Patterns of inheritance in hypertrophic cardiomyopathy: assessment by M-mode and two-dimensional echocardiography. Am. J. Cardiol. 53:1087-1094.
59. Maron, B.J., J.M. Gardin, J.M. Flack, S.S. Gidding, T.T. Kurosaki, and D.E. Bild. 1995. Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) Adults. Circulation. 92:785-789.
60. Matsui, T., L. Li, J.C. Wu, S.A. Cook, T. Nagoshi, M.H. Picard, R. Liao, and A. Rosenzweig. 2002. Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J. Biol. Chem. 277:22896-22901.
61. Menon, S.C., B.W. Eidem, J.A. Dearani, S.R. Ommen, M.J. Ackerman, and D. Miller. 2009. Diastolic dysfunction and its histopathological correlation in obstructive hypertrophic cardiomyopathy in children and adolescents. J. Am. Soc. Echocardiogr. 22:1327-1334.
62. Mestroni, L., C. Rocco, D. Gregori, G. Sinagra, A. Di Lenarda, S. Miocic, M. Vatta, B. Pinamonti, F. Muntoni, A.L. Caforio, et al; Heart Muscle Disease Study Group. 1999. Familial dilated cardiomyopathy: evidence for genetic and phenotypic heterogeneity. J. Am. Coll. Cardiol. 34:181-190.
63. Michael, A., S. Haq, X. Chen, E. Hsich, L. Cui, B. Walters, Z. Shao, K. Bhattacharya, H. Kilter, G. Huggins, et al. 2004. Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart. J. Biol. Chem. 279:21383-21393.
64. Michels, V.V., P.P. Moll, F.A. Miller, A.J. Tajik, J.S. Chu, D.J. Driscoll, J.C. Burnett, R.J. Rodeheffer, J.H. Chesebro, and H.D. Tazelaar. 1992. The frequency of familial dilated cardiomyopathy in a series of patients with idiopathic dilated cardiomyopathy. N. Engl. J. Med. 326:77-82.
65. Minamisawa, S., M. Hoshijima, G. Chu, C.A. Ward, K. Frank, Y. Gu, M.E. Martone, Y. Wang, J. Ross Jr., E.G. Kranias, et al. 1999. Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell. 99:313-322.
66. Miyata, S., W. Minobe, M.R. Bristow, and L.A. Leinwand. 2000. Myosin heavy chain isoform expression in the failing and nonfailing human heart. Circ. Res. 86:386-390.
67. Mogensen, J., T. Kubo, M. Duque, W. Uribe, A. Shaw, R. Murphy, J.R. Gimeno, P. Elliott, and W.J. McKenna. 2003. Idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin I mutations. J. Clin. Invest. 111:209-216.
68. Molkentin, J.D., and G.W. Dorn II. 2001. Cytoplasmic signaling pathways that regulate cardiac hypertrophy. Annu. Rev. Physiol. 63:391-426.
69. Molkentin, J.D., J.R. Lu, C.L. Antos, B. Markham, J. Richardson, J. Robbins, S.R. Grant, and E.N. Olson. 1998. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell. 93:215-228.
70. Nagata, K., R. Liao, F.R. Eberli, N. Satoh, B. Chevalier, C.S. Apstein, and T.M. Suter. 1998. Early changes in excitation-contraction coupling: transition from compensated hypertrophy to failure in Dahl salt-sensitive rat myocytes. Cardiovasc. Res. 37:467-477.
71. Narula, J., N. Haider, R. Virmani, T.G. DiSalvo, F.D. Kolodgie, R.J. Hajjar, U. Schmidt, M.J. Semigran, G.W. Dec, and B.A. Khaw. 1996. Apoptosis in myocytes in end-stage heart failure. N. Engl. J. Med. 335:1182-1189.
72. Narula, J., P. Pandey, E. Arbustini, N. Haider, N. Narula, F.D. Kolodgie, B. Dal Bello, M.J. Semigran, A. Bielsa-Masdeu, G.W. Dec, et al. 1999. Apoptosis in heart failure: release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy. Proc. Natl. Acad. Sci. USA. 96:8144-8149.
73. Neubauer, S. 2007. The failing heart-an engine out of fuel. N. Engl. J. Med. 356:1140-1151.
74. O'Neill, B.T., and E.D. Abel. 2005. Akt1 in the cardiovascular system: friend or foe? J. Clin. Invest. 115:2059-2064.
75. Ohler, A., J. Weisser-Thomas, V. Piacentino, S.R. Houser, G.F. Tomaselli, and B. O'Rourke. 2009. Two-photon laser scanning microscopy of the transverse-axial tubule system in ventricular cardiomyocytes from failing and non-failing human hearts. Cardiol. Res. Pract. 2009:802373.
76. Olivetti, G., R. Abbi, F. Quaini, J. Kajstura, W. Cheng, J.A. Nitahara, E. Quaini, C. Di Loreto, C.A. Beltrami, S. Krajewski, et al. 1997. Apoptosis in the failing human heart. N. Engl. J. Med. 336:1131-1141.
77. Palmiter, K.A., M.J. Tyska, D.E. Dupuis, N.R. Alpert, and D.M. Warshaw. 1999. Kinetic differences at the single molecule level account for the functional diversity of rabbit cardiac myosin isoforms. J. Physiol. 519:669-678.
78. Parvatiyar, M.S., J.R. Pinto, D. Dweck, and J.D. Potter. 2010. Cardiac troponin mutations and restrictive cardiomyopathy. J. Biomed. Biotechnol. 2010:350706.
79. Peddy, S.B., L.A. Vricella, J.E. Crosson, G.L. Oswald, R.D. Cohn, D.E. Cameron, D. Valle, and B.L. Loeys. 2006. Infantile restrictive cardiomyopathy resulting from a mutation in the cardiac troponin T gene. Pediatrics. 117:1830-1833.
80. Ritter, M., E. Oechslin, G. Sütsch, C. Attenhofer, J. Schneider, and R. Jenni. 1997. Isolated noncompaction of the myocardium in adults. Mayo Clin. Proc. 72:26-31.
81. Ro, A., and W.H. Frishman. 2006. Peripartum cardiomyopathy. Cardiol. Rev. 14:35-42.
82. Rodeheffer, R.J., I. Tanaka, T. Imada, A.S. Hollister, D. Robertson, and T. Inagami. 1986. Atrial pressure and secretion of atrial natriuretic factor into the human central circulation. J. Am. Coll. Cardiol. 8:18-26.
83. Rose, E.A., A.C. Gelijns, A.J. Moskowitz, D.F. Heitjan, L.W. Stevenson, W. Dembitsky, J.W. Long, D.D. Ascheim, A.R. Tierney, R.G. Levitan, et al; Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) Study Group. 2001. Long-term use of a left ventricular assist device for end-stage heart failure. N. Engl. J. Med. 345:1435-1443.
84. Sack, M.N., T.A. Rader, S. Park, J. Bastin, S.A. McCune, and D.P. Kelly. 1996. Fatty acid oxidation enzyme gene expression is downregulated in the failing heart. Circulation. 94:2837-2842.
85. Sadoshima, J., and S. Izumo. 1993. Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism. EMBO J. 12:1681-1692.
86. Sakata, Y., B.D. Hoit, S.B. Liggett, R.A. Walsh, and G.W. Dorn II. 1998. Decompensation of pressure-overload hypertrophy in G alpha q-overexpressing mice. Circulation. 97:1488-1495.
87. Sasse-Klaassen, S., B. Gerull, E. Oechslin, R. Jenni, and L. Thierfelder. 2003. Isolated noncompaction of the left ventricular myocardium in the adult is an autosomal dominant disorder in the majority of patients. Am. J. Med. Genet. A. 119A:162-167.
88. Schram, K., S. De Girolamo, S. Madani, D. Munoz, F. Thong, and G. Sweeney. 2010. Leptin regulates MMP-2, TIMP-1 and collagen synthesis via p38 MAPK in HL-1 murine cardiomyocytes. Cell. Mol. Biol. Lett. 15:551-563.
89. Schwartz, K., Y. Lecarpentier, J.L. Martin, A.M. Lompré, J.J. Mercadier, and B. Swynghedauw. 1981. Myosin isoenzymic distribution correlates with speed of myocardial contraction. J. Mol. Cell. Cardiol. 13:1071-1075.
90. Seidman, J.G., and C. Seidman. 2001. The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms. Cell. 104:557-567.
91. Semsarian, C., M.J. Healey, D. Fatkin, M. Giewat, C. Duffy, C.E. Seidman, and J.G. Seidman. 2001. A polymorphic modifier gene alters the hypertrophic response in a murine model of familial hypertrophic cardiomyopathy. J. Mol. Cell. Cardiol. 33:2055-2060.
92. Shen, W.K., W.D. Edwards, S.C. Hammill, K.R. Bailey, D.J. Ballard, and B.J. Gersh. 1995. Sudden unexpected nontraumatic death in 54 young adults: a 30-year population-based study. Am. J. Cardiol. 76:148-152.
93. Shiojima, I., K. Sato, Y. Izumiya, S. Schiekofer, M. Ito, R. Liao, W.S. Colucci, and K. Walsh. 2005. Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J. Clin. Invest. 115:2108-2118.
94. Silberbach, M., T. Gorenc, R.E. Hershberger, P.J. Stork, P.S. Steyger, and C.T. Roberts Jr. 1999. Extracellular signal-regulated protein kinase activation is required for the anti-hypertrophic effect of atrial natriuretic factor in neonatal rat ventricular myocytes. J. Biol. Chem. 274:24858-24864.
95. Simpson, P., A. McGrath, and S. Savion. 1982. Myocyte hypertrophy in neonatal rat heart cultures and its regulation by serum and by catecholamines. Circ. Res. 51:787-801.
96. Smith, C.S., P.A. Bottomley, S.P. Schulman, G. Gerstenblith, and R.G. Weiss. 2006. Altered creatine kinase adenosine triphosphate kinetics in failing hypertrophied human myocardium. Circulation. 114:1151-1158.
97. Stanley, W.C., G.D. Lopaschuk, and J.G. McCormack. 1997. Regulation of energy substrate metabolism in the diabetic heart. Cardiovasc. Res. 34:25-33.
98. Stauffer, B.L., J.P. Konhilas, E.D. Luczak, and L.A. Leinwand. 2006. Soy diet worsens heart disease in mice. J. Clin. Invest. 116:209-216.
99. Taigen, T., L.J. De Windt, H.W. Lim, and J.D. Molkentin. 2000. Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy. Proc. Natl. Acad. Sci. USA. 97:1196-1201.
100. Teekakirikul, P., S. Eminaga, O. Toka, R. Alcalai, L. Wang, H. Wakimoto, M. Nayor, T. Konno, J.M. Gorham, C.M. Wolf, et al. 2010. Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by nonmyocyte proliferation and requires Tgf-β. J. Clin. Invest. 120:3520-3529.
101. Torre-Amione, G., S. Kapadia, J. Lee, J.B. Durand, R.D. Bies, J.B. Young, and D.L. Mann. 1996. Tumor necrosis factor-alpha and tumor necrosis factor receptors in the failing human heart. Circulation. 93:704-711.
102. Vikstrom, K.L., S.M. Factor, and L.A. Leinwand. 1996. Mice expressing mutant myosin heavy chains are a model for familial hypertrophic cardiomyopathy. Mol. Med. 2:556-567.
103. Wang, L., J.G. Seidman, and C.E. Seidman. 2010. Narrative review: harnessing molecular genetics for the diagnosis and management of hypertrophic cardiomyopathy. Ann. Intern. Med. 152:513-520: W181.
104. Weiford, B.C., V.D. Subbarao, and K.M. Mulhern. 2004. Noncompaction of the ventricular myocardium. Circulation. 109:2965-2971.
105. Yamaji, K., S. Fujimoto, Y. Ikeda, K. Masuda, S. Nakamura, Y. Saito, and C. Yutani. 2005. Apoptotic myocardial cell death in the setting of arrhythmogenic right ventricular cardiomyopathy. Acta Cardiol. 60:465-470.
106. Yang, Z., N.E. Bowles, S.E. Scherer, M.D. Taylor, D.L. Kearney, S. Ge, V.V. Nadvoretskiy, G. DeFreitas, B. Carabello, L.I. Brandon, et al. 2006. Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ. Res. 99:646-655.
107. Yousef, Z.R., P.W. Foley, K. Khadjooi, S. Chalil, H. Sandman, N.U. Mohammed, and F. Leyva. 2009. Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging. BMC Cardiovasc. Disord. 9:37.
108. Zhang, Y.H., J.B. Youm, H.K. Sung, S.H. Lee, S.Y. Ryu, W.K. Ho, and Y.E. Earm. 2000. Stretch-activated and background non-selective cation channels in rat atrial myocytes. J. Physiol. 523:607-619.