Skin aging and microbiology

Microbiology and Aging: Clinical Manifestations

Volumn , Issue , 2009, Pages 57-94

  Baumann, Leslie ^a   Weisberg, Edmund ^a   Percival, Steven L ^a  

^a UNIVERSITY OF MIAMI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84900260679     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-59745-327-1_4     Document Type: Chapter

References (222)

1. Fenske NA, Lober CW. Structural and functional changes of normal aging skin. J Am Acad Dermatol 1986;15:571-585.
2. Roupe G. Skin of the aging human being. Lakartidningen 2001;98(10):1091-1095.
3. Lovell CR, Smolenski KA, Duance VC, Light ND, Young S, Dyson M. Type I and III collagen content and fibre distribution in normal human skin during ageing. Br J Dermatol 1987;117:419-428.
4. Uitto J. Understanding premature skin aging. N Engl J Med 1997;337:1463-1465.
5. Lavker RM. Structural alterations in exposed and unexposed aged skin. J Invest Dermatol 1979;73:59-66.
6. Yaar M, Gilchrest BA. Aging of Skin in Fitzpatrick's Dermatology in General Medicine. New York: McGraw-Hill, p 1700.
7. Geserick C, Blasco MA. Novel roles for telomerase in aging. Mech Ageing Dev 2006;127(6):579-583.
8. Boukamp P. Ageing mechanisms: the role of telomere loss. Clin Exp Dermatol 2001;26(7):562-565.
9. Bellon M, Nicot C. Regulation of telomerase and telomeres: human tumor viruses take control. J Natl Cancer Inst 2008;100(2):98-108.
10. Pendino F, Tarkanyi I, Dudognon C, Hillion J, Lanotte M, Aradi J, Segal-Bendirdjian E. Telomeres and telomerase: pharmacological targets for new anticancer strategies? Curr Cancer Drug Targets 2006;(2):147-180.
11. Boukamp P. Skin aging: a role for telomerase and telomere dynamics? Curr Mol Med 2005;5(2):71-77.
12. Nakamura K, Izumiyama-Shimomura N, Sawabe M, Arai T, Aoyagi Y, Fujiwara M, Tsuchiya E, Kobayashi Y, Kato M, Oshimura M, Sasajima K, Nakachi K, Takubo K. Comparative analysis of telomere lengths and erosion with age in human epidermis and lingual epithelium. J Invest Dermatol 2002;119(5):1014-1019.
13. Bataille V, Kato BS, Falchi M, Gardner J, Kimura M, Lens M, Perks U, Valdes AM, Bennett DC, Aviv A, Spector TD. Nevus size and number are associated with telomere length and represent potential markers of a decreased senescence in vivo. Cancer Epidemiol Biomarkers Prev 2007;16(7):1499-1502.
14. Kosmadaki MG, Gilchrest BA. The role of telomeres in skin aging/photoaging. Micron 2004;35(3):155-159.
15. Lebel M, Leder P. A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc Natl Acad Sci USA 1998;95(22):13097-13102.
16. Ahn B, Harrigan JA, Indig FE, Wilson DM III, Bohr VA. Regulation of WRN helicase activity in human base excision repair. J Biol Chem 2004;279(51):53465-53474.
17. Poot M, Gollahon KA, Emond MJ, Silber JR, Rabinovitch PS. Werner syndrome diploid fibroblasts are sensitive to 4-nitroquinoline-N-oxide and 8-methoxypsoralen: implications for the disease phenotype. FASEB J 2002;16(7):757-758.
18. Chang S, Multani AS, Cabrera NG, Naylor ML, Laud P, Lombard D, Pathak S, Guarente L, De Pinho RA. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet 2004;36(8):877-882.
19. Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956;11:298-300.
20. Pelle E, Maes D, Padulo GA, Kim EK, Smith WP. An in vitro model to test relative antioxidant potential: ultraviolet-induced lipid peroxidation in liposomes. Arch Biochem Biophys 1990;283:234-240.
21. Werninghaus K. The role of antioxidants in reducing photodamage, in Gilchrest B (ed.) Photodamage. London: Blackwell Science, 1995, p 249.
22. Rikans LE, Hornbrook KR. Lipid peroxidation, antioxidant protection and aging. Biochim Biophys Acta 1997;1362:116-127.
23. Hensley K, Floyd R. Reactive oxygen species and protein oxidation in aging: a look back, a look ahead. Arch Biochem Biophys 2002;397:377-383.
24. Black HS. Potential involvement of free radical reactions in ultraviolet light-mediated cutaneous damage. Photochem Photobiol 1987;46:213-221.
25. Verdier-Sévrain S, Bonté F, Gilchrest B. Biology of estrogens in skin: implications for skin aging. Exp Dermatol 2006;15:83-94.
26. Creidi P, Faivre B, Agache P, Richard E, Haudiquet V, Sauvanet JP. Effect of a conjugated oestrogen (Premarin) cream on ageing facial skin A.comparative study with a placebo cream. Maturitas 1994;19:211-223.
27. Dunn LB, Damesyn M, Moore AA, Reuben DB, Greendale GA. Does estrogen prevent skin aging? Results from the First National Health and Nutritional Examination Survey. Arch Dermatol 1997;133:339-342.
28. Fisher GJ, Kang S, Varani J, Bata-Csorgo Z, Wan Y, Datta S, Voorhees JJ. Mechanisms of photoaging and chronological skin aging. Arch Dermatol 2002;138:1462-1470.
29. Kligman AM, Kligman LH. Photoaging, in Freedberg IM, Eisen AZ, Wolff K, et al. (eds.) Fitzpatrick's Dermatology in General Medicine, 5th Ed., Vol. 1. New York: McGraw-Hill, 1999, pp 1717-1723.
30. Yao W, Malaviya R, Magliocco M, Gottlieb A. Topical treatment of UVB-irradiated human subjects with EGCG, a green tea polyphenol, increases caspase-3 activity in keratinocytes. J Am Acad Dermatol 2005;52:150.
31. Pinnell S, Lin F-Y, Grichnik J, et al. A topical antioxidant solution containing vitamin C, vitamin E, and ferulic acid prevents ultraviolet radiation induced caspase-3 induction in skin. JAAD 2005;2(52):158.
32. Bosset S, Bonnet-Duquennoy M, Barre P, Chalon A, Kurfurst R, Bonte F, Schnebert S, Le Varlet B, Nicolas JF. Photoageing shows histological features of chronic skin inflammation without clinical and molecular abnormalities. Br J Dermatol 2003;149(4):826-835.
33. Kappes UP, Luo D, Potter M, Schulmeister K, Runger TM. Short- and long-wave UV light (UVB and UVA) induce similar mutations in human skin cells. J Invest Dermatol 2006;126(3):667-675.
34. Marrot L, Belaïdi JP, Meunier JR. Importance of UVA photoprotection as shownby genotoxic related endpoints: DNA damage and p53 status. Mutat Res 2005;571(1-2):175-184.
35. Sugimoto M, Yamashita R, Ueda M. Telomere length of the skin in association with chronological aging and photoaging. J Dermatol Sci 2006;43(1):43-47.
36. Makrantonaki E, Zouboulis CC. Characteristics and pathomechanisms of endogenously aged skin. Dermatology 2007;214:352-360.
37. Moragas A, Castells C, Sans M. Mathematical morphologic analysis of aging-related epidermal changes. Anal Quant Cytol Histol 1993;15:75-82.
38. Lock-Andersen J, Therkildsen P, De Fine Olivarius F, Gniadecka M, Dahlstrom K, Poulsen T, Wulf HC. Epidermal thickness, skin pigmentation and constitutive photosensitivity. Photodermatol Photoimmunol Photomed 1997;13:153-158.
39. Whitton JT, Everall JD. The thickness of the epidermis. Br J Dermatol 1973;89:467-476.
40. Sandby-Møller J, Poulsen T, Wulf HC. Epidermal thickness at different body sites: relationship to age, gender, pigmentation, blood content, skin type and smoking habits. Acta Derm Venereol 2003;83:410-413.
41. El-Domyati M, Attia S, Saleh F, Brown D, Birk DE, Gasparro F, Ahmad H, Uitto J. Intrinsic aging vs. photoaging: a comparative histopathological, immunohistochemical, and ultrastructural study of skin. Exp Dermatol 2002;11(5):398-405.
42. Contet-Audonneau JL, Jeanmaire C, Pauly G. A histological study of human wrinkle structures: comparison between sun-exposed areas of the face, with or without wrinkles, and sun-protected areas. Br J Dermatol 1999;140:1038-1047.
43. Katzberg AA. The area of the dermo-epidermal junction in human skin. Anat Rec 1958;131:717-721.
44. Yaar M, Gilchrest BA. Aging of Skin in Fitzpatrick's Dermatology in General Medicine. New York: McGraw-Hill, pp 1697-1706.
45. Kligman AM. Perspectives and problems in cutaneous gerontology. J Invest Dermatol 1979;73:39-46.
46. Orentreich N, Selmanowitz VJ. Levels of biological functions with aging. Trans NY Acad Sci 1969;31:992-998.
47. Grewe M. Chronological ageing and photoageing of dendritic cells. Clin Exp Dermatol 2001;26:608-612.
48. Fisher GJ, Wang ZQ, Datta SC, Varani J, Kang S, Voorhees JJ. Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med 1997;337:1419-1428.
49. Kligman AM, Zheng P, Lavker RM. The anatomy and pathogenesis of wrinkles. Br J Dermatol 1985;113:37-42.
50. Gniadecka M, Nielsen OF, Wessel S, Heidenheim M, Christensen DH, Wulf HC. Water and protein structure in photoaged and chronically aged skin. J Invest Dermatol 1998;111:1129-1133.
51. Oikarinen A. The aging of skin: chronoaging versus photoaging. Photodermatol Photoimmunol Photomed 1990;7:3-4.
52. Shuster S, Black MM, McVitie E. The influence of age and sex on skin thickness, skin collagen and density. Br J Dermatol 1975;93:639-643.
53. Montagna W, Carlisle K. Structural changes in aging human skin. J Invest Dermatol 1979;73:47-53.
54. Griffiths CE, Russman AN, Majmudar G, Singer RS, Hamilton TA, Voorhees JJ. Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid). N Engl J Med 1993;329:530-535.
55. Craven NM, Watson RE, Jones CJ, Shuttleworth CA, Kielty CM, Griffiths CE. Clinical features of photodamaged human skin are associated with a reduction in collagen VII. Br J Dermatol 1997;137:344-350.
56. Rittie L, Fisher GJ. UV-light-induced signal cascades and skin aging. Ageing Res Rev 2002;1(4):705-720.
57. Varani J, Warner RL, Gharaee-Kermani M, Phan SH, Kang S, Chung JH, Wang ZQ, Datta SC, Fisher GJ, Voorhees JJ. Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. J Invest Dermatol 2000;114:480-486.
58. Fisher GJ, Datta SC, Talwar HS, Wang ZQ, Varani J, Kang S, Voorhees JJ. Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature 1996;379:335-339.
59. Mitchel RE. Chronic solar dermatosis: a light and electron microscopic study of the dermis. J Invest Dermatol 1967;48:203-211.
60. Tsuji T, Hamada T. Age-related changes in human dermal elastic fibers. Br J Dermatol 1981;105:57-63.
61. Scharffetter-Kochanek K, Brenneisen P, Wenk J, Herrmann G, Ma W, Kuhr L, Meewes C, Wlaschek M. Photoaging of the skin from phenotype to mechanisms. Exp Gerontol 2000;35:307-316.
62. Matsuoka L, Uitto J. Alterations in the elastic fibers in cutaneous aging and solar elastosis, in Balin A, Kligman AM (eds.) Aging and the Skin. New York: Raven Press, 1989, pp 141-151.
63. Lavker RM. Cutaneous aging: chronologic versus photoaging, in Gilchrest BA (eds.) Photodamage, 1st Ed. Cambridge, MA: Blackwell Science, 1995, p 128.
64. Escoffier C, De Rigal J, Rochefort A, Vasselet R, Lévêque JL, Agache PG. Age-related mechanical properties of human skin: an in vivo study. J Invest Dermatol 1989;93:353-357.
65. Ghersetich I, Lotti T, Campanile G, Grappone C, Dini G. Hyaluronic acid in cutaneous intrinsic aging. Int J Dermatol 1994;33:119-122.
66. Pearce RH, Grimmer BJ. Age and the chemical constitution of normal human dermis. J Invest Dermatol 1972;58:347-361.
67. Elsner P, Maibach HI. Cosmeceuticals and Active Cosmetics: Drugs versus Cosmetics. 2nd Ed. Dekker: New York, 2005.
68. Bernstein EF, Underhill CB, Hahn PJ, Brown DB, Uitto J. Chronic sun exposure alters both the content and distribution of dermal glycosaminoglycans. Br J Dermatol 1996;135:255-262.
69. Tammi R, Säämänen AM, Maibach HI, Tammi M. Degradation of newly synthesized high molecular mass hyaluronan in the epidermal and dermal compartments of human skin in organ culture. J Invest Dermatol 1991;97(1):126-130.
70. Sakai S, Yasuda R, Sayo T, Ishikawa O, Inoue S. Hyaluronan exists in the normal stratum corneum. J Invest Dermatol 2000;114(6):1184-1187.
71. Rieger M. Hyaluronic acid in cosmetics. Cosm Toil 1998;113(3):35-42.
72. Ortonne JP. Pigmentary changes of the ageing skin. Br J Dermatol 1990;122:21-28.
73. Gilchrest BA, Stoff JS, Soter NA. Chronologic aging alters the response to ultravioletinduced inflammation in human skin. J Invest Dermatol 1982;79:11-15.
74. Ghadially R, Brown BE, Sequeira-Martin SM, Feingold KR, Elias PM. The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model. J Clin Invest 1995;95:2281-2290.
75. Tezuka T, Qing J, Saheki M, Kusuda S, Takahashi M. Terminal differentiation of facial epidermis of the aged: immunohistochemical studies. Dermatology 1994;188:21-24.
76. Nelson BR, Majmudar G, Griffiths CE, Gillard MO, Dixon AE, Tavakkol A, Hamilton TA, Woodbury RA, Voorhees JJ, Johnson TM. Clinical improvement following dermabrasion of photoaged skin correlates with synthesis of collagen I. Arch Dermatol 1994;130:1136-1142.
77. Ostler EL, Wallis CV, Aboalchamat B, Faragher RG. Telomerase and the cellular lifespan: implications of the aging process. J Pediatr Endocrinol Metab 2000;6:1467-1476.
78. Kang S, Voorhees JJ. Photoaging therapy with topical tretinoin: an evidence-based analysis. J Am Acad Dermatol 1998;39(2 pt 3):S55-S61.
79. Gilchrest BA. Treatment of photodamage with topical tretinoin: an overview. J Am Acad Dermatol 1997;36(3 pt 2):S27-S36.
80. Fisher GJ, Voorhees JJ. Molecular mechanisms of photoaging and its prevention by retinoic acid: ultraviolet irradiation induces MAP kinase signal transduction cascades that induce AP-1-regulated matrix metalloproteinases that degrade human skin in vivo. J Investig Dermatol Symp Proc 1998;3:61-68.
81. Baumann L. How to prevent photoaging? J Invest Dermatol 2005;125(4): xii-xiii.
82. Nusgens BV, Humbert P, Rougier A, Colige AC, Haftek M, Lambert CA, Richard A, Creidi P, Lapiere CM. Topically applied vitamin C enhances the mRNA level of collagens I and III, their processing enzymes and tissue inhibitor of matrix metalloproteinase 1 in the human dermis. J Invest Dermatol 2001;116(6):853-859.
83. Kockaert M, Neumann M. Systemic and topical drugs for aging skin. J Drugs Dermatol 2003;2(4):435-441.
84. Margelin D, Medaisko C, Lombard D, Picard J, Fourtanier A. Hyaluronic acid and dermatan sulfate are selectively stimulated by retinoic acid in irradiated and nonirradiated hairless mouse skin. J Invest Dermatol 1996;106(3):505-509.
85. Tajima S, Hayashi A, Suzuki T. Elastin expression is up-regulated by retinoic acid but not by retinol in chick embryonic skin fibroblasts. J Dermatol Sci 1997;15(3):166-172.
86. Matheson AJ, Perry CM. Glucosamine: a review of its use in the management of osteoarthritis. Drugs Aging 2003;20(14):1041-1060.
87. Fitzpatrick RE. Endogenous growth factors as cosmeceuticals. Dermatol Surg 2005;31(7 pt 2):827-831; discussion 831.
88. Kang S, Chung JH, Lee JH, Fisher GJ, Wan YS, Duell EA, Voorhees JJ. Topical N-acetyl cysteine and genistein prevent ultraviolet-light-induced signaling that leads to photoaging in human skin in vivo. J Invest Dermatol 2003;120(5):835-841.
89. Greul AK, Grundmann JU, Heinrich F, Pfitzner I, Bernhardt J, Ambach A, Biesalski HK, Gollnick H. Photoprotection of UV-irradiated human skin: an antioxidative combination of vitamins E and C, carotenoids, selenium and proanthocyanidins. Skin Pharmacl Appl Skin Physiol 2002;15(5):307-315.
90. Passi S, De Pita O, Grandinetti M, Simotti C, Littaru GP. The combined use of oral and topical lipophilic antioxidants increases their levels both in sebum and stratum corneum. Biofactors 2003;18(1-4):289-297.
91. Lin FH, Lin JY, Gupta RD, Tournas JA, Burch JA, Selim MA, Monteiro-Riviere NA, Grichnik JM, Zielinski J, Pinnell SR. Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. J Invest Dermatol 2005;125(4):826-832.
92. Conney AH, Lu YP, Lou YR, Huang MT. Inhibitory effects of tea and caffeine on UV-induced carcinogenesis: relationship to enhanced apoptosis and decreased tissue fat. Eur J Cancer Prev 2002;11:S28-S36.
93. Lu YP, Lou YR, Xie JG, Peng QY, Liao J, Yang CS, Huang MT, Conney AH. Topical applications of caffeine or (-)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice. Proc Natl Acad Sci USA 2002;99:12455-12460.
94. Koo SW, Hirakawa S, Fujii S, Kawasumi M, Nghiem P. Protection from photodamage by topical application of caffeine after ultraviolet irradiation. Br J Dermatol 2007;156:957-964.
95. Papucci L, Schiavone N, Witort E, Donnini M, Lapucci A, Tempestini A, Formigli L, Zecchi-Orlandini S, Orlandini G, Carella G, Brancato R, Capaccioli S. Coenzyme q10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radical scavenging property. J Biol Chem 2003;278(30):28220-28228.
96. Beyer RE, Ernster L. The antioxidant role of coenzyme Q, in Lenaz G, et al. (eds.) Highlights in Ubiquinone Research. London: Taylor and Francis, 1990, pp 191-213.
97. Bourne LC, Rice-Evans C. Bioavailability of ferulic acid. Biochem Biophys Res Commun 1998;253:222-227.
98. Svobodova A, Psotova J, Walterova D. Natural phenolics in the prevention of UV-induced skin damage. A review. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2003;147:137-145.
99. Graf E. Antioxidant potential of ferulic acid. Free Radic Biol Med 1992;13:435-448.
100. Bonina F, Puglia C, Ventura D, Aquino R, Tortora S, Sacchi A, Saija A, Tomaino A, Pellegrino ML, De Caprariis P. In vitro antioxidant and in vivo photoprotective effects of a lyophilized extract of Capparis spinosa L buds. J Cosmet Sci 2002;53:321-335.
101. Saija A, Tomaino A, Trombetta D, De Pasquale A, Uccella N, Barbuzzi T, Paolino D, Bonina F. In vitro and in vivo evaluation of caffeic and ferulic acids as topical photoprotective agents. Int J Pharm 2000;199:39-47.
102. Tournas JA, Lin FH, Burch JA, Selim MA, Monteiro-Riviere NA, Zielinski JE, Pinnell SR. Ubiquinone, idebenone, and kinetin provide ineffective photoprotection to skin when compared to a topical antioxidant combination of vitamins C and E with ferulic acid. J Invest Dermatol 2006;126:1185-1187.
103. Mills S, Bone K. Principles and Practice of Phytotherapy: Modern Herbal Medicine. London: Churchill Livingstone, 2000.
104. Won YK, Ong CN, Shi X, Shen HM. Chemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms. Carcinogenesis 2004;25:1449-1458.
105. Herrera F, Martin V, Rodriguez-Blanco J, García-Santos G, Antoĺin I, Rodriguez C. Intracellular redox state regulation by parthenolide. Biochem Biophys Res Commun 2005;332:321-325.
106. Sweeney CJ, Mehrotra S, Sadaria MR, Kumar S, Shortle NH, Roman Y, Sheridan C, Campbell RA, Murry DJ, Badve S, Nakshatri H. The sesquiterpene lactone parthenolide in combination with docetaxel reduces metastasis and improves survival in a xenograft model of breast cancer. Mol Cancer Ther 2005;4:1004-1012.
107. Tanaka K, Hasegawa J, Asamitsu K, Okamoto T. Prevention of the ultraviolet B-mediated skin photoaging by a nuclear factor kappaB inhibitor, parthenolide. J Pharmacol Exp Ther 2005;315:624-630.
108. Katiyar SK, Ahmad N, Mukhtar H. Green tea and skin. Arch Dermatol 2000;136:989-994.
109. Wright TI, Spencer JM, Flowers FP. Chemoprevention of nonmelanoma skin cancer. J Am Acad Dermatol 2006;54:933-946.
110. Yusuf N, Irby C, Katiyar SK, Elmets CA. Photoprotective effects of green tea polyphenols. Photodermatol Photoimmunol Photomed 2007;23:48-56.
111. Middlekamp-Hup MA, Pathak MA, Parrado C, Garcia-Caballero T, Rius-Diaz F, Fitzpatrick TB, Gonzalez S. Orally administered Polypodium leucotomos extract decreases psoralen-UVA-induced phototoxicity, pigmentation, and damage of human skin. J Am Acad Dermatol 2004;50(1):41-49.
112. Middlekamp-Hup MA, Pathak MA, Parrado C, Goukassian D, Rius-Diaz F, Mihm MC, Fitzpatrick TB, Gonzalez S. Oral Polypodium leucotomos extract decreases ultravioletinduced damage of human skin. J Am Acad Dermatol 2004;51(6):910-918.
113. Philips N, Smith J, Keller T, Gonzalez S. Predominant effects of Polypodium leucotomos on membrane integrity, lipid peroxidation, and expression of elastin and matrixmetalloproteinase-1 in ultraviolet radiation exposed fibroblasts, and keratinocytes. J Dermatol Sci 2003;32(1):1-9.
114. Sime S, Reeve VE. Protection from inflammation, immunosuppression and carcinogenesis induced by UV radiation in mice by topical. Pycnogenol Photochem Photobiol 2004;79(2):193-198.
115. Saliou C, Rimbach G, Moini H, McLaughlin L, Hosseini S, Lee J, Watson RR, Packer L. Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-B-dependent gene expression in keratinocytes are modulated by a French maritime pine bark extract. Free Radic Biol Med 2001;30(2):154-160.
116. Bito T, Roy S, Sen CK, Packer L. Pine bark extract pycnogenol downregulates IFN-gammainduced adhesion of T cells to human keratinocytes by inhibiting inducible ICAM-1 expression. Free Radic Biol Med 2000;28(2):219-227.
117. Chen CY, Jang JH, Li MH, Surh YJ. Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells. Biochem Biophys Res Commun 2005;331:993-1000.
118. She QB, Bode AM, Ma WY, Chen NY, Dong Z. Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase. Cancer Res 2001;61:1604-1610.
119. Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC, Pezzuto JM. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997;275:218-220.
120. Afaq F, Adhami VM, Ahmad N. Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless mice. Toxicol Appl Pharmacol 2003;186:28-37.
121. Chan MM. Antimicrobial effect of resveratrol on dermatophytes and bacterial pathogens of the skin. Biochem Pharmacol 2002;63:99-104.
122. Ding XZ, Adrian TE. Resveratrol inhibits proliferation and induces apoptosis in human pancreatic cancer cells. Pancreas 2002;25:e71-e76.
123. Delmas D, Rébé C, Lacour S, Filomenko R, Athias A, Gambert P, Cherkaoui-Malki M, Jannin B, Dubrez-Daloz L, Latruffe N, Solary E. Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells. J Biol Chem 2003;278:41482-41490.
124. Aziz MH, Afaq F, Ahmad N. Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin. Photochem Photobiol 2005;81:25-31.
125. Aziz MH, Reagan-Shaw S, Wu J, Longley BJ, Ahmad N. Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease? FASEB J 2005;19:1193-1195.
126. Darshan S, Doreswamy R. Patented antiinflammatory plant drug development from traditional medicine. Phytother Res 2004;18:343-357.
127. Aburjai T, Natsheh FM. Plants used in cosmetics. Phytother Res 2003;17:987-1000.
128. Saito Y, Shiga A, Yoshida Y, Furuhashi T, Fujita Y, Niki E. Effects of a novel gaseous antioxidative system containing a rosemary extract on the oxidation induced by nitrogen dioxide and ultraviolet radiation. Biosci Biotechnol Biochem 2004;68:781-786.
129. Ho CT, Wang M, Wei GJ, Huang TC, Huang MT. Chemistry and antioxidative factors in rosemary and sage. Biofactors 2000;13:161-166.
130. Sancheti G, Goyal P. Modulatory influence of Rosemarinus officinalis on DMBA-induced mouse skin tumorigenesis. Asian Pac J Cancer Prev 2006;7:331-335.
131. Sancheti G, Goyal PK. Effect of Rosmarinus officinalis in modulating 7, 12-dimethylbenz (a) anthracene induced skin tumorigenesis in mice. Phytother Res 2006;20:981-986.
132. Offord EA, Gautier JC, Avanti O, Scaletta C, Runge F, Krämer K, Applegate LA. Photoprotective potential of lycopene, beta-carotene, vitamin E, vitamin C and carnosic acid in UVA-irradiated human skin fibroblasts. Free Radic Biol Med 2002;32:1293-1303.
133. Chiu A, Kimball AB. Topical vitamins, minerals and botanical ingredients as modulators of environmental and chronological skin damage. Br J Dermatol 2003;149:681-691.
134. Calabrese V, Scapagnini G, Catalano C, Dinotta F, Geraci D, Morganti P. Biochemical studies of a natural antioxidant isolated from rosemary and its application in cosmetic dermatology. Int J Tissue React 2000;22:5-13.
135. Calabrese V, Scapagnini G, Catalano C, Bates TE, Dinotta F, Micali G, Giuffrida Stella AM. Induction of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: regulation by a natural antioxidant from rosemary extract. Int J Tissue React 2001;23:51-58.
136. Katiyar SK. Silymarin and skin cancer prevention: anti-inflammatory, antioxidant and immunomodulatory effects (Review). Int J Oncol 2005;26(1):169-176.
137. Zhao J, Agarwal R. Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: implications in cancer chemoprevention. Carcinogenesis 1999;20(11):2101-2108.
138. Dhanalakshmi S, Mallikarjuna GU, Singh RP, Agarwal R. Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis. Carcinogenesis 2004;25(8):1459-1465.
139. Gallagher RP, Rivers JK, Lee TK, Bajdik CD, McLean DI, Coldman AJ. Broad-spectrum sunscreen use and the development of new nevi in white children: a randomized controlled trial. JAMA 2000;283:2955.
140. Schröder JM, Harder J. Innate antimicrobial peptides in the skin. Med Sci Paris 2006;22(2):153-157.
141. Nizet V, Ohtake T, Lauth X, Trowbridge J, Rudisill J, Dorschner RA, Pestonjamasp V, Piraino J, Hutter K, Gallo RL. Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 2001;414:454-457.
142. Elsner P. Antimicrobials and the skin physiological and pathological flora. Curr Probl Dermatol 2006;33:35-41.
143. Harder J, Schröder JM. Antimicrobial peptides in human skin. Chem Immunol Allergy 2005;86:22-41.
144. Ehlers C, Ivens UI, Møller ML, Senderovitz T, Serup J. Females have lower skin surface pH than men: a study on the influence of gender, forearm site variation, right/left difference and time of the day on the skin surface pH. Skin Res Technol 2001;7(2):90-94.
145. Noble WC. Carriage of micro-organisms on the skin, in Newsom SWB, Caldwell ADS (eds.) Problems in the Control of Hospital Infection. London: Royal Society of Medicine, 1980, pp 7-10.
146. Mackowiak PA. The normal microbial flora. N Engl J Med 1982;307:83-93.
147. Price PB. The bacteriology of normal skin; a new quantitative test applied to a study of the bacterial flora and disinfectant action of mechanical cleansing. J Infect Dis 1938;63:301-318.
148. Williamson P, Kligman AM. A new method for the quantitative investigation of cutaneous bacteria. J Invest Dermatol 1965;45(6):498-503.
149. Marples MJ. The Ecology of Human Skin. Springfield, IL: Thomas CC Publisher, 1965.
150. Noble WC, Somerville CA. Microbiology of Human Skin. Philadelphia: Saunders, 1974, pp 50-76, 131, 212.
151. Kligman AM. The bacteriology of normal skin, in Maibach HI, Hildick-Smith G (eds.) Skin Bacteria and Their Role in Infection. New York: McGraw-Hill, 1965, pp 13-31.
152. Hartmann AA. A comparative investigation of methods for sampling skin flora. Arch Dermatol Res 1982;274:381-385.
153. Marples RR. Sex, constancy, and skin bacteria. Arch Dermatol 1982;272:317-320.
154. Wilburg J, Kasprowicz A, Heczko PB. Composition of normal bacterial flora of human skin in relation to the age and sex of examined persons. Przegl Dermatol 1984;71(6):551-557.
155. Larson EL, Cronquist AB, Whittier S, Lai L, Lyle CT, Latta PD. Differences in skin flora between inpatients and chronically ill outpatients. Heart Lung 2000;29:298-305.
156. Rebel G, Pillsbury DM, Phalle G, De Saint M, Ginsberg D. Factors affecting the rapid disappearance of bacteria placed on the normal flora. J Invest Dermatol 1950;14:247-263.
157. Aly R, Shirley C, Cunico B, Maibach HI. Effect of prolonged occlusion on the microbial flora, pH, C02 and transepidermal water loss. J Invest Dermatol 1978;71:378-381.
158. Sarkany I, Gaylarde CC. Bacterial colonisation of the skin of the newborn. J Pathol Bacteriol 1968;95:115-122.
159. Thestrup-Pedersen K. Bacteria and the skin: clinical practice and therapy update. Br J Dermatol 1998;13953:1-3.
160. Medves JM, O'Brien B. Does bathing newborns remove potentially harmful pathogens from the skin? Birth 2001;28(3):161-165.
161. Ashbee HR, Leck AK, Puntis JW, Parsons WJ, Evans EG. Skin colonisation by Malassezia in neonates and infants Infect Control Hosp Epidemiol 2002;23:212-216.
162. Juncosa Morros T, González-Cuevas A, Alayeto Ortega J, Muñoz Almagro C, Moreno Hernando J, Gené Giralt A, Latorre Ot́in C. Cutaneous colonization by Malassezia spp. in neonates. An Esp Pediatr 2002;57(5):452-456.
163. Venkatesh MP, Placencia F, Weisman LE. Coagulase-negative staphylococcal infections in the neonate and child: an update. Semin Pediatr Infect Dis 2006;17(3):120-127.
164. Leyden JJ, McGinley KJ, Mills OH, Kligman AM. Age-related changes in the resident bacterial flora of the human face. J Invest Dermatol 1975;65(4):379-381.
165. Sultana B, Cimiotti J, Aiello AE, Sloan D, Larson E. Effects of age and race on skin condition and bacterial counts on hands of neonatal ICU nurses. Heart Lung 2003;32(4):283-289.
166. Foca K, Jakob S, Whittier P, Della-Latta S, Factor D, Rubenstein, Saiman L. Endemic Pseudomonas aeruginosa infection in a neonatal intensive care unit. N Engl J Med 2000;343:695-700.
167. Lindberg E, Ingegerd Adlerberth I, Hesselmar B, Saalman R, Inga-Lisa Strannegård I-L, ̊ Aberg N, Wold AE. High rate of transfer of Staphylococcus aureus from parental skin to infant gut flora. Clin Microbiol 2004;42(2):530-534.
168. Webster GF. Skin microecology: the old and the new. Arch Dermatol 2007;143(1):105-106.
169. Kloos WE, Schleifer KH. Simplified scheme for routine identification of human Staphylococcus species. J Clin Microbiol 1975;1(1):82-88.
170. Frank DN, Spiegelman GB, Davis W, Wagner E, Lyons E, Pace NR. Culture-independent molecular analysis of microbial constituents of the healthy human outer ear. J Clin Microbiol 2003;41:295-303.
171. Dekio I, Hayashi H, Sakamoto M, Kitahara M, Nishikawa T, Suematsu M, Benno Y. Detection of potentially novel bacterial components of the human skin microbiota using culture-independent molecular profiling. J Med Microbiol 2005;54; 1231-1238.
172. Gao Z, Tseng CH, Pei Z et al. Molecular analysis of human forearm superficial skin bacterial biota. Proc Natl Acad Sci USA 2007;104:2927-2932.
173. Vuong C, Otto M. Staphylococcus epidermidis infections. Microbes Infect 2002;4:481-489.
174. Harmory BH, Parisi JT. Staphylococcus epidermidis: a significant nosocomial pathogen. J Infect Control 1987;15:59-74.
175. Fekety FR Jr. The epidemiology and prevention of staphylococcal infection. Medicine 1964;43:593-613.
176. Nagase N, Sasaki A, Yamashita K, Shimizu A, Wakita Y, Kitai S, Kawano J. Isolation and species distribution of staphylococci from animal and human skin. J Vet Med Sci 2002;64(3):245-250.
177. Barth JH. Nasal carriage of staphylococci and streptococci. Int J Dermatol 1987;26:24-26.
178. Solberg CO. Spread of Staphylococcus aureus in hospitals: causes and prevention. Scand J Infect Dis 2000;32:587-595.
179. Kloos WE, Musselwhite MS. Distribution and persistence of Staphylococcus and Micrococcus species and other aerobic bacteria on human skin. Appl Microbiol 1975;30:381-395.
180. Nobel WC. Microbiology of Human Skin. London: Lloyd-Luke, 1981, p 433.
181. Seifert H, Dijkshoorn L, Gerner-Smidt P, Pelzer N, Tjernberg I, Vaneechoutte M. Distribution of Acinetobacter species on human skin: comparison of phenotypic and genotypic identification methods. J Clin Microbiol 1997;53:2819-2825.
182. Berlau J, Aucken H, Malnick H, Pitt T. Distribution of Acinetobacter species on skin of healthy humans. Eur J Clin Microbiol Infect Dis 1999;18:179-183.
183. Ashbee HR. Update on the genus Malassezia. Med Mycol 2007;45(4):287-303.
184. Paulino LC, Tseng C-H, Strober BE, Blaser MJ. Molecular analysis of fungal microbiota in samples from healthy human skin and psoriatic lesions. J Clin Microbiol 2006;44:2933-2941.
185. Gupta AK, Kohli Y. Prevalence of Malassezia species on various body sites in clinically healthy subjects representing different age groups. Med Mycol 2004;10:125-159.
186. Lee YW, Yim SM, Lim SH, Choe YB, Ahn KJ. Quantitative investigation on the distribution of Malassezia species on healthy human skin in Korea. Mycoses 2006;49(5):405-410.
187. Leyden JJ, McGinley KJ, Nordstrom KM, Webster GF. Skin microflora. J Invest Dermatol 1987;88:65s-72s.
188. McGinley KJ, Leyden JJ, Marples RR, Kligman AM. Quantitative microbiology of the scalp in non-dandruff, dandruff, and seborrheic dermatitis. J Invest Dermatol 1975;64(6):401-405.
189. Chamberlain AN, Halablab MA, Gould DJ, Miles RJ. Distribution of bacteria on hands and the effectiveness of brief and thorough decontamination procedures using non-medicated soap. Zentralbl Bakteriol 1997;285(4):565-575.
190. Aly R, Maibach HI. Aerobic microbial flora of intertrigenous skin. Appl Environ Microbiol 1977;33(1):97-100.
191. Bojar RA, Holland KT. The human cutaneous microbiota and factors controlling colonisation. World J Microbiol Biotechnol 2002;18:889-903.
192. Somerville DA. The normal flora of the skin in different age groups. Br J Dermatol 1980;81:248-258.
193. Selwyn S. Microbiology and ecology of human skin. Practitioner 1980;224:1059-1062.
194. Le Frock JL, Ellis CA, Weinstein L. The impact of hospitalization on the aerobic fecal microflora. Am J Med Sci 1979;277:269-274.
195. Larson EL. Persistent carriage of Gram-negative bacteria on hands. Am J Infect Control 1981;9:112-119.
196. Larson EL, McGinley KJ, Foglia AR, Talbot GH, Leyden JJ. Composition and antimicrobial resistance of skin flora in hospitalized and healthy adults. J Clin Microbiol 1986;23:604-608.
197. Bickers DR, Athar M. Oxidative stress in the pathogenesis of skin disease. J Invest Dermatol 2006;126(12):2565-2575.
198. Platzek T, Lang C, Grohmann G, Gi US, Baltes W. Formation of a carcinogenic aromatic amine from an azo dye by human skin bacteria in vitro. Hum Exp Toxicol 1999;18(9):552-559.
199. Papacostas G, Gate J eds. Les associations microbiennes, leurs applications therapeutiques. Paris: Doin, 1928.
200. Barak O, Treat JR, James WD. Antimicrobial peptides: effectors of innate immunity in the skin. Adv Dermatol 2005;21:357-374.
201. Chiller K, Selkin BA, Murakawa GJ. Skin microflora and bacterial infections of the skin. J Investig Dermatol Symp Proc 2001;6:170-174.
202. Fredricks DN. Microbial ecology of human skin in health and disease. J Investig Dermatol Symp Proc 2001;6:167-169.
203. Hadaway LC. Skin flora and infection. J Infus Nurs 2003;26:44-48.
204. Hadaway LC. Skin flora: unwanted dead or alive. Nursing 2005;35(7):20.
205. Roth RR, James WD. Microbiology of the skin: resident flora, ecology, infection. J Am Acad Dermatol 1989;20:367-390.
206. Laube S, Farrell AM. Bacterial skin infections in the elderly: diagnosis and treatment. Drugs Aging 2002;19:331-342.
207. http://www.ncbi.nlm.nih.gov/pubmed/18603682?ordinalpos=1&itool= EntrezSystem2. PEntrez. Pubmed. Pubmed-ResultsPanel. Pubmed-DefaultReportPanel. Pubmed-RVDocSum" Bansal E, Garg A, Bhatia S, Attri AK, Chander J. Spectrum of microbial flora in diabetic foot ulcers. Indian J Pathol Microbiol. 2008;51(2):204-208.
208. Cogen AL, Nizet V, Gallo RL. Staphylococcus epidermidis functions as a component of the skin innate immune system by inhibiting the pathogen Group A Streptococcus. J Invest Dermatol 2007;127:S131.
209. Lyon GJ, Novick RP. Peptide signaling in Staphylococcus aureus and other Gram-positive bacteria. Peptides 2004;25:1389-1403.
210. Von Eiff C, Becker K, Machka K, Stammer H, Peters G. Nasal carriage as a source of Staphylococcus aureus bacteremia. Study Group. N Engl J Med 2001;344:11-16.
211. Von Eiff C, Peters G, Heilmann C. Pathogenesis of infections due to coagulase negative staphylococci. Lancet Infect Dis 2002;2:677-685.
212. Mainous AG III, Hueston WJ, Everett CJ, Diaz VA. Nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus in the United States, 2001-2002. Ann Fam Med 2006;4:132-137.
213. Iwatsuki K, Yamasaki O, Morizane S, Oono T. Staphylococcal cutaneous infections: invasion, evasion and aggression. J Dermatol Sci 2006;42:203-214.
214. Bokarewa MI, Jin T, Tarkowski A. Staphylococcus aureus: Staphylokinase. Int J Biochem Cell Biol 2006;38(4):504-509.
215. Wichmann S, Wirsing Von Koenig CH, Becker-Boost E, Finger H, Group JK. Corynebacteria in skin flora of healthy persons and patients. Eur J Clin Microbiol 1985;4:502-504.
216. Kaźmierczak AK, Szewczyk EM. Bacteria forming a resident flora of the skin as a potential source of opportunistic infections. Pol J Microbiol 2005;54(1):27-35.
217. Kaźmierczak AK, Szarapińska-Kwaszewska JK, Szewczyk EM. Opportunistic coryneform organisms-residents of human skin. Pol J Microbiol 2005;54(1):27-35.
218. Brüggemann H, Henne A, Hoster F, Liesegang H, Wiezer A, Strittmatter A, Hujer S, Dürre P, Gottschalk G. The complete genome sequence of Propionibacterium acnes, a commensal of human skin. Science 2004;305:671-673.
219. Mowad CM, McGinley KJ, Foglia A, Leyden JJ. The role of extracellular polysaccharide substance produced by Staphylococcus epidermidis in miliaria. J Am Acad Dermatol 1995;33:729-733.
220. Goodyear HM, Watson PJ, Egan SA, Price EH, Kenny PA, Harper JI. Skin microflora of atopic eczema in first time hospital attenders. Clin Exp Dermatol 1993;18(4):300-304.
221. Spielman AI, Zeng XN, Leyden JJ, Preti G. Proteinaceous precursors of human axillary odor: isolation of two novel odor-binding proteins. Experientia 1995;51(1):40-47.
222. Cogen AL, Nizet V, Gallo RL. Skin microbiota: a source of disease or defence? Br J Dermatol 2008;158:442-455.