-
1
-
-
0030826910
-
Genetic regulation of aging
-
Osiewacz HD: Genetic regulation of aging. J Mol Med 1997;75:715-727.
-
(1997)
J Mol Med
, vol.75
, pp. 715-727
-
-
Osiewacz, H.D.1
-
2
-
-
0033406153
-
The RAS genes: A homeostatic device in Saccharomyces cerevisiae longevity
-
Jazwinski SM: The RAS genes: a homeostatic device in Saccharomyces cerevisiae longevity. Neurobiol Aging 1999;20:471-478.
-
(1999)
Neurobiol Aging
, vol.20
, pp. 471-478
-
-
Jazwinski, S.M.1
-
3
-
-
0037052454
-
Demography: Broken limits to life expectancy
-
Oeppen J, Vaupel JW: Demography: broken limits to life expectancy. Science 2002;296:1029-1031.
-
(2002)
Science
, vol.296
, pp. 1029-1031
-
-
Oeppen, J.1
Vaupel, J.W.2
-
4
-
-
0036724946
-
UV-light-induced signal cascades and skin aging
-
Rittie L, Fisher GJ: UV-light-induced signal cascades and skin aging. Ageing Res Rev 2002;1:705-720.
-
(2002)
Ageing Res Rev
, vol.1
, pp. 705-720
-
-
Rittie, L.1
Fisher, G.J.2
-
5
-
-
0022628290
-
Connective tissue biochemistry of the aging dermis: Age-related alterations in collagen and elastin
-
Uitto J: Connective tissue biochemistry of the aging dermis: age-related alterations in collagen and elastin. Dermatol Clin 1986;4:433-446.
-
(1986)
Dermatol Clin
, vol.4
, pp. 433-446
-
-
Uitto, J.1
-
6
-
-
0036845039
-
Mechanisms of photoaging and chronological skin aging
-
Fisher GJ, Kang S, Varani J, Bata-Csorgo Z, Wan Y, Datta S, Voorhees JJ: Mechanisms of photoaging and chronological skin aging. Arch Dermatol 2002;138:1462-1470.
-
(2002)
Arch Dermatol
, vol.138
, pp. 1462-1470
-
-
Fisher, G.J.1
Kang, S.2
Varani, J.3
Bata-Csorgo, Z.4
Wan, Y.5
Datta, S.6
Voorhees, J.J.7
-
7
-
-
0031963543
-
UV-irradiation depletes antioxidants and causes oxidative damage in a model of human skin
-
Podda M, Traber MG, Weber C, Yan LJ, Packer L: UV-irradiation depletes antioxidants and causes oxidative damage in a model of human skin. Free Radic Biol Med 1998;24:55-65.
-
(1998)
Free Radic Biol Med
, vol.24
, pp. 55-65
-
-
Podda, M.1
Traber, M.G.2
Weber, C.3
Yan, L.J.4
Packer, L.5
-
8
-
-
0030926244
-
Oxidative stress and in vivo chemiluminescence in mouse skin exposed to UVA radiation
-
Evelson P, Ordonez CP, Llesuy S, Boveris A: Oxidative stress and in vivo chemiluminescence in mouse skin exposed to UVA radiation. J Photochem Photobiol B 1997;38:215-219.
-
(1997)
J Photochem Photobiol B
, vol.38
, pp. 215-219
-
-
Evelson, P.1
Ordonez, C.P.2
Llesuy, S.3
Boveris, A.4
-
9
-
-
0033133397
-
Skin antioxidants: Their role in aging and in oxidative stress - new approaches for their evaluation
-
Kohen R: Skin antioxidants: their role in aging and in oxidative stress - new approaches for their evaluation. Biomed Pharmacother 1999;53:181-192.
-
(1999)
Biomed Pharmacother
, vol.53
, pp. 181-192
-
-
Kohen, R.1
-
10
-
-
0027155898
-
Mathematical morphologic analysis of aging-related epidermal changes
-
Moragas A, Castells C, Sans M: Mathematical morphologic analysis of aging-related epidermal changes. Anal Quant Cytol Histol 1993;15:75-82.
-
(1993)
Anal Quant Cytol Histol
, vol.15
, pp. 75-82
-
-
Moragas, A.1
Castells, C.2
Sans, M.3
-
11
-
-
0031466574
-
Epidermal thickness, skin pigmentation and constitutive photosensitivity
-
Lock-Andersen J, Therkildsen P, de Fine Olivarius F, Gniadecka M, Dahlstrom K, Poulsen T, Wulf HC: Epidermal thickness, skin pigmentation and constitutive photosensitivity. Photodermatol Photoimmunol Photomed 1997;13:153-158.
-
(1997)
Photodermatol Photoimmunol Photomed
, vol.13
, pp. 153-158
-
-
Lock-Andersen, J.1
Therkildsen, P.2
de Fine Olivarius, F.3
Gniadecka, M.4
Dahlstrom, K.5
Poulsen, T.6
Wulf, H.C.7
-
12
-
-
0018577872
-
Structural alterations in exposed and unexposed aged skin
-
Lavker RM: Structural alterations in exposed and unexposed aged skin. J Invest Dermatol 1979;73:59-66.
-
(1979)
J Invest Dermatol
, vol.73
, pp. 59-66
-
-
Lavker, R.M.1
-
13
-
-
0038120902
-
Cellular senescence in human keratinocytes: Unchanged proteolytic capacity and increased protein load
-
Bregegere F, Soroka Y, Bismuth J, Friguet B, Milner Y: Cellular senescence in human keratinocytes: unchanged proteolytic capacity and increased protein load. Exp Gerontol 2003;38:619-629.
-
(2003)
Exp Gerontol
, vol.38
, pp. 619-629
-
-
Bregegere, F.1
Soroka, Y.2
Bismuth, J.3
Friguet, B.4
Milner, Y.5
-
14
-
-
0028044767
-
The cellular and molecular biology of skin aging
-
West MD: The cellular and molecular biology of skin aging. Arch Dermatol 1994;130:87-95.
-
(1994)
Arch Dermatol
, vol.130
, pp. 87-95
-
-
West, M.D.1
-
17
-
-
0020640790
-
Age-associated changes in human epidermal cell renewal
-
Grove GL, Kligman AM: Age-associated changes in human epidermal cell renewal. J Gerontol 1983;38:137-142.
-
(1983)
J Gerontol
, vol.38
, pp. 137-142
-
-
Grove, G.L.1
Kligman, A.M.2
-
18
-
-
0023116341
-
Aged skin: A study by light, transmission electron, and scanning electron microscopy
-
s
-
Lavker RM, Zheng PS, Dong G: Aged skin: a study by light, transmission electron, and scanning electron microscopy. J Invest Dermatol 1987;88:44s-51s.
-
(1987)
J Invest Dermatol
, vol.88
-
-
Lavker, R.M.1
Zheng, P.S.2
Dong, G.3
-
19
-
-
0034767454
-
Skin aging: Postulated mechanisms and consequent changes in structure and function
-
Yaar M, Gilchrest BA: Skin aging: postulated mechanisms and consequent changes in structure and function. Clin Geriatr Med 2001;17:617-630, v.
-
(2001)
Clin Geriatr Med
, vol.17
, pp. 617-630
-
-
Yaar, M.1
Gilchrest, B.A.2
-
20
-
-
0018609894
-
Effects of aging and chronic sun exposure on melanocytes in human skin
-
Gilchrest BA, Blog FB, Szabo G: Effects of aging and chronic sun exposure on melanocytes in human skin. J Invest Dermatol 1979;73:141-143.
-
(1979)
J Invest Dermatol
, vol.73
, pp. 141-143
-
-
Gilchrest, B.A.1
Blog, F.B.2
Szabo, G.3
-
22
-
-
0025214245
-
Pigmentary changes of the ageing skin
-
Ortonne JP: Pigmentary changes of the ageing skin. Br J Dermatol 1990;122(suppl 35):21-28.
-
(1990)
Br J Dermatol
, vol.122
, Issue.SUPPL. 35
, pp. 21-28
-
-
Ortonne, J.P.1
-
23
-
-
0035052972
-
Autofluorescence of human skin is age-related after correction for skin pigmentation and redness
-
Na R, Stender IM, Henriksen M, Wulf HC: Autofluorescence of human skin is age-related after correction for skin pigmentation and redness. J Invest Dermatol 2001;116:536-540.
-
(2001)
J Invest Dermatol
, vol.116
, pp. 536-540
-
-
Na, R.1
Stender, I.M.2
Henriksen, M.3
Wulf, H.C.4
-
24
-
-
0036174828
-
Tumour necrosis factor-alpha-induced migration of human Langerhans cells: The influence of ageing
-
Bhushan M, Cumberbatch M, Dearman RJ, Andrew SM, Kimber I, Griffiths CE: Tumour necrosis factor-alpha-induced migration of human Langerhans cells: the influence of ageing. Br J Dermatol 2002;146:32-40.
-
(2002)
Br J Dermatol
, vol.146
, pp. 32-40
-
-
Bhushan, M.1
Cumberbatch, M.2
Dearman, R.J.3
Andrew, S.M.4
Kimber, I.5
Griffiths, C.E.6
-
25
-
-
0034782107
-
Chronological ageing and photoageing of dendritic cells
-
Grewe M: Chronological ageing and photoageing of dendritic cells. Clin Exp Dermatol 2001;26:608-612.
-
(2001)
Clin Exp Dermatol
, vol.26
, pp. 608-612
-
-
Grewe, M.1
-
26
-
-
0035108458
-
Inhibition of type I procollagen synthesis by damaged collagen in photoaged skin and by collagenase-degraded collagen in vitro
-
Varani J, Spearman D, Perone P, Fligiel SE, Datta SC, Wang ZQ, Shao Y, Kang S, Fisher GJ, Voorhees JJ: Inhibition of type I procollagen synthesis by damaged collagen in photoaged skin and by collagenase-degraded collagen in vitro. Am J Pathol 2001;158:931-942.
-
(2001)
Am J Pathol
, vol.158
, pp. 931-942
-
-
Varani, J.1
Spearman, D.2
Perone, P.3
Fligiel, S.E.4
Datta, S.C.5
Wang, Z.Q.6
Shao, Y.7
Kang, S.8
Fisher, G.J.9
Voorhees, J.J.10
-
27
-
-
0020049070
-
Studies in cutaneous aging. I. The elastic fiber network
-
Braverman IM, Fonferko E: Studies in cutaneous aging. I. The elastic fiber network. J Invest Dermatol 1982;78:434-443.
-
(1982)
J Invest Dermatol
, vol.78
, pp. 434-443
-
-
Braverman, I.M.1
Fonferko, E.2
-
28
-
-
0032992573
-
Degenerative processes of elastic fibers in sun-protected and sun-exposed skin: Immunoelectron microscopic observation of elastin, fibrillin-1, amyloid P component, lysozyme and alpha1-antitrypsin
-
Suwabe H, Serizawa A, Kajiwara H, Ohkido M, Tsutsumi Y: Degenerative processes of elastic fibers in sun-protected and sun-exposed skin: immunoelectron microscopic observation of elastin, fibrillin-1, amyloid P component, lysozyme and alpha1-antitrypsin. Pathol Int 1999;49:391-402.
-
(1999)
Pathol Int
, vol.49
, pp. 391-402
-
-
Suwabe, H.1
Serizawa, A.2
Kajiwara, H.3
Ohkido, M.4
Tsutsumi, Y.5
-
29
-
-
0020080377
-
Studies in cutaneous aging. II. The microvasculature
-
Braverman IM, Fonferko E: Studies in cutaneous aging. II. The microvasculature. J Invest Dermatol 1982;78:444-448.
-
(1982)
J Invest Dermatol
, vol.78
, pp. 444-448
-
-
Braverman, I.M.1
Fonferko, E.2
-
30
-
-
0030874920
-
Human ageing impairs injury-induced in vivo expression of tissue inhibitor of matrix metalloproteinases (TIMP)-1 and -2 proteins and mRNA
-
Ashcroft GS, Herrick SE, Tarnuzzer RW, Horan MA, Schultz GS, Ferguson MW: Human ageing impairs injury-induced in vivo expression of tissue inhibitor of matrix metalloproteinases (TIMP)-1 and -2 proteins and mRNA. J Pathol 1997;183:169-176.
-
(1997)
J Pathol
, vol.183
, pp. 169-176
-
-
Ashcroft, G.S.1
Herrick, S.E.2
Tarnuzzer, R.W.3
Horan, M.A.4
Schultz, G.S.5
Ferguson, M.W.6
-
31
-
-
0024498070
-
Wound healing and aging
-
Eaglstein WH: Wound healing and aging. Clin Geriatr Med 1989;5:183-188.
-
(1989)
Clin Geriatr Med
, vol.5
, pp. 183-188
-
-
Eaglstein, W.H.1
-
32
-
-
50549218525
-
The limited in vitro lifetime of human diploid cell strains
-
Hayflick L: The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965;37:614-636.
-
(1965)
Exp Cell Res
, vol.37
, pp. 614-636
-
-
Hayflick, L.1
-
33
-
-
0020573584
-
In vitro assessment of keratinocyte aging
-
s
-
Gilchrest BA: In vitro assessment of keratinocyte aging. J Invest Dermatol 1983;81:184s-189s.
-
(1983)
J Invest Dermatol
, vol.81
-
-
Gilchrest, B.A.1
-
34
-
-
0001068487
-
The relationship between in vitro cellular aging and in vivo human age
-
Schneider EL, Mitsui Y: The relationship between in vitro cellular aging and in vivo human age. Proc Natl Acad Sci USA 1976;73:3584-3588.
-
(1976)
Proc Natl Acad Sci USA
, vol.73
, pp. 3584-3588
-
-
Schneider, E.L.1
Mitsui, Y.2
-
35
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O, et al: A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995;92:9363-9367.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
Acosta, M.4
Scott, G.5
Roskelley, C.6
Medrano, E.E.7
Linskens, M.8
Rubelj, I.9
Pereira-Smith, O.10
-
36
-
-
1242299775
-
The role of telomeres in skin aging/photoaging
-
Kosmadaki MG, Gilchrest BA: The role of telomeres in skin aging/photoaging. Micron 2004;35:155-159.
-
(2004)
Micron
, vol.35
, pp. 155-159
-
-
Kosmadaki, M.G.1
Gilchrest, B.A.2
-
37
-
-
0010045614
-
Extension of lifespan by introduction of telomerase into normal human cells
-
Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S, Wright WE: Extension of lifespan by introduction of telomerase into normal human cells. Science 1998;279:349-352.
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
Holt, S.E.4
Chiu, C.P.5
Morin, G.B.6
Harley, C.B.7
Shay, J.W.8
Lichtsteiner, S.9
Wright, W.E.10
-
38
-
-
0030038104
-
Replicative senescence: Implications for in vivo aging and tumor suppression
-
Smith JR, Pereira-Smith OM: Replicative senescence: implications for in vivo aging and tumor suppression. Science 1996;273:63-67.
-
(1996)
Science
, vol.273
, pp. 63-67
-
-
Smith, J.R.1
Pereira-Smith, O.M.2
-
39
-
-
0026460896
-
Telomere length predicts replicative capacity of human fibroblasts
-
Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, Greider CW, Harley CB: Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 1992;89:10114-10118.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 10114-10118
-
-
Allsopp, R.C.1
Vaziri, H.2
Patterson, C.3
Goldstein, S.4
Younglai, E.V.5
Futcher, A.B.6
Greider, C.W.7
Harley, C.B.8
-
40
-
-
0033595684
-
Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
-
Michikawa Y, Mazzucchelli F, Bresolin N, Scarlato G, Attardi G: Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science 1999;286:774-779.
-
(1999)
Science
, vol.286
, pp. 774-779
-
-
Michikawa, Y.1
Mazzucchelli, F.2
Bresolin, N.3
Scarlato, G.4
Attardi, G.5
-
41
-
-
0031964919
-
An update on the oxygen stressmitochondrial mutation theory of aging: Genetic and evolutionary implications
-
Miquel J: An update on the oxygen stressmitochondrial mutation theory of aging: genetic and evolutionary implications. Exp Gerontol 1998;33:113-126.
-
(1998)
Exp Gerontol
, vol.33
, pp. 113-126
-
-
Miquel, J.1
-
42
-
-
0017166058
-
Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos
-
Benn PA: Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos. Am J Hum Genet 1976;28:465-473.
-
(1976)
Am J Hum Genet
, vol.28
, pp. 465-473
-
-
Benn, P.A.1
-
44
-
-
0020610696
-
Similarity between in vitro and in vivo cellular aging
-
Mets T, Bekaert E, Verdonk G: Similarity between in vitro and in vivo cellular aging. Mech Ageing Dev 1983;22:71-78.
-
(1983)
Mech Ageing Dev
, vol.22
, pp. 71-78
-
-
Mets, T.1
Bekaert, E.2
Verdonk, G.3
-
45
-
-
0027163464
-
Replicative senescence of human fibroblast-like cells in culture
-
Cristofalo VJ, Pignolo RJ: Replicative senescence of human fibroblast-like cells in culture. Physiol Rev 1993;73:617-638.
-
(1993)
Physiol Rev
, vol.73
, pp. 617-638
-
-
Cristofalo, V.J.1
Pignolo, R.J.2
-
46
-
-
0021131823
-
Selective cultivation of human melanocytes from newborn and adult epidermis
-
Gilchrest BA, Vrabel MA, Flynn E, Szabo G: Selective cultivation of human melanocytes from newborn and adult epidermis. J Invest Dermatol 1984;83:370-376.
-
(1984)
J Invest Dermatol
, vol.83
, pp. 370-376
-
-
Gilchrest, B.A.1
Vrabel, M.A.2
Flynn, E.3
Szabo, G.4
-
47
-
-
0025787643
-
Telomere loss: Mitotic clock or genetic time bomb?
-
Harley CB: Telomere loss: mitotic clock or genetic time bomb? Mutat Res 1991;256:271-282.
-
(1991)
Mutat Res
, vol.256
, pp. 271-282
-
-
Harley, C.B.1
-
48
-
-
0032911694
-
Direct activation of TERT transcription by c-MYC
-
Wu KJ, Grandori C, Amacker M, Simon-Vermot N, Polack A, Lingner J, Dalla-Favera R: Direct activation of TERT transcription by c-MYC. Nat Genet 1999;21:220-224.
-
(1999)
Nat Genet
, vol.21
, pp. 220-224
-
-
Wu, K.J.1
Grandori, C.2
Amacker, M.3
Simon-Vermot, N.4
Polack, A.5
Lingner, J.6
Dalla-Favera, R.7
-
49
-
-
0029096515
-
The RNA component of human telomerase
-
Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, Chiu CP, Adams RR, Chang E, Allsopp RC, Yu J, et al: The RNA component of human telomerase. Science 1995;269:1236-1241.
-
(1995)
Science
, vol.269
, pp. 1236-1241
-
-
Feng, J.1
Funk, W.D.2
Wang, S.S.3
Weinrich, S.L.4
Avilion, A.A.5
Chiu, C.P.6
Adams, R.R.7
Chang, E.8
Allsopp, R.C.9
Yu, J.10
-
50
-
-
0028564951
-
Specific association of human telomerase activity with immortal cells and cancer
-
Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW: Specific association of human telomerase activity with immortal cells and cancer. Science 1994;266:2011-2015.
-
(1994)
Science
, vol.266
, pp. 2011-2015
-
-
Kim, N.W.1
Piatyszek, M.A.2
Prowse, K.R.3
Harley, C.B.4
West, M.D.5
Ho, P.L.6
Coviello, G.M.7
Wright, W.E.8
Weinrich, S.L.9
Shay, J.W.10
-
51
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley CB, Futcher AB, Greider CW: Telomeres shorten during ageing of human fibroblasts. Nature 1990;345:458-460.
-
(1990)
Nature
, vol.345
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
52
-
-
0025143252
-
Telomere reduction in human colorectal carcinoma and with ageing
-
Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK, Allshire RC: Telomere reduction in human colorectal carcinoma and with ageing. Nature 1990;346:866-868.
-
(1990)
Nature
, vol.346
, pp. 866-868
-
-
Hastie, N.D.1
Dempster, M.2
Dunlop, M.G.3
Thompson, A.M.4
Green, D.K.5
Allshire, R.C.6
-
53
-
-
0028856794
-
Telomere length and replicative aging in human vascular tissues
-
Chang E, Harley CB: Telomere length and replicative aging in human vascular tissues. Proc Natl Acad Sci USA 1995;92:11190-11194.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 11190-11194
-
-
Chang, E.1
Harley, C.B.2
-
54
-
-
0030961087
-
Telomere lengthening and telomerase activation during human B cell differentiation
-
Weng NP, Granger L, Hodes RJ Telomere lengthening and telomerase activation during human B cell differentiation. Proc Natl Acad Sci USA 1997;94:10827-10832.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 10827-10832
-
-
Weng, N.P.1
Granger, L.2
Hodes, R.J.3
-
55
-
-
0034849550
-
Mitochondrial defects in neurodegenerative disease
-
Wallace DC: Mitochondrial defects in neurodegenerative disease. Ment Retard Dev Disabil Res Rev 2001;7:158-166.
-
(2001)
Ment Retard Dev Disabil Res Rev
, vol.7
, pp. 158-166
-
-
Wallace, D.C.1
-
56
-
-
0034626747
-
Genetic pathways that regulate ageing in model organisms
-
Guarente L, Kenyon C: Genetic pathways that regulate ageing in model organisms. Nature 2000;408:255-262.
-
(2000)
Nature
, vol.408
, pp. 255-262
-
-
Guarente, L.1
Kenyon, C.2
-
57
-
-
0344413416
-
Aging, from basic research to pathological applications
-
Robert L, Robert AM: Aging, from basic research to pathological applications. Pathol Biol (Paris) 2003;51:543-549.
-
(2003)
Pathol Biol (Paris)
, vol.51
, pp. 543-549
-
-
Robert, L.1
Robert, A.M.2
-
58
-
-
0035990351
-
Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease
-
Johnson TE, Henderson S, Murakami S, de Castro E, de Castro SH, Cypser J, Rikke B, Tedesco P, Link C: Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease. J Inherit Metab Dis 2002;25:197-206.
-
(2002)
J Inherit Metab Dis
, vol.25
, pp. 197-206
-
-
Johnson, T.E.1
Henderson, S.2
Murakami, S.3
de Castro, E.4
de Castro, S.H.5
Cypser, J.6
Rikke, B.7
Tedesco, P.8
Link, C.9
-
59
-
-
0034671596
-
Extended life-span conferred by cotransporter gene mutations in Drosophila
-
Rogina B, Reenan RA, Nilsen SP, Helfand SL: Extended life-span conferred by cotransporter gene mutations in Drosophila. Science 2000;290:2137-2140.
-
(2000)
Science
, vol.290
, pp. 2137-2140
-
-
Rogina, B.1
Reenan, R.A.2
Nilsen, S.P.3
Helfand, S.L.4
-
60
-
-
0035815445
-
A mutant Drosophila insulin receptor homolog that extends life span and impairs neuroendocrine function
-
Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS: A mutant Drosophila insulin receptor homolog that extends life span and impairs neuroendocrine function. Science 2001;292:107-110.
-
(2001)
Science
, vol.292
, pp. 107-110
-
-
Tatar, M.1
Kopelman, A.2
Epstein, D.3
Tu, M.P.4
Yin, C.M.5
Garofalo, R.S.6
-
61
-
-
0036237273
-
Metabolic alterations and shifts in energy allocations are corequisites for the expression of extended longevity genes in Drosophila
-
discussion 463-465
-
Arking R, Buck S, Hwangbo DS, Lane M: Metabolic alterations and shifts in energy allocations are corequisites for the expression of extended longevity genes in Drosophila. Ann NY Acad Sci 2002;959:251-262;discussion 463-465.
-
(2002)
Ann NY Acad Sci
, vol.959
, pp. 251-262
-
-
Arking, R.1
Buck, S.2
Hwangbo, D.S.3
Lane, M.4
-
62
-
-
0030724491
-
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
-
Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI: Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997;390:45-51.
-
(1997)
Nature
, vol.390
, pp. 45-51
-
-
Kuro-o, M.1
Matsumura, Y.2
Aizawa, H.3
Kawaguchi, H.4
Suga, T.5
Utsugi, T.6
Ohyama, Y.7
Kurabayashi, M.8
Kaname, T.9
Kume, E.10
Iwasaki, H.11
Iida, A.12
Shiraki-Iida, T.13
Nishikawa, S.14
Nagai, R.15
Nabeshima, Y.I.16
-
63
-
-
15844409553
-
Positional cloning of the Werner's syndrome gene
-
Yu CE, Oshima J, Fu YH, Wijsman EM, Hisama F, Alisch R, Matthews S, Nakura J, Miki T, Ouais S, Martin GM, Mulligan J, Schellenberg GD: Positional cloning of the Werner's syndrome gene. Science 1996;272:258-262.
-
(1996)
Science
, vol.272
, pp. 258-262
-
-
Yu, C.E.1
Oshima, J.2
Fu, Y.H.3
Wijsman, E.M.4
Hisama, F.5
Alisch, R.6
Matthews, S.7
Nakura, J.8
Miki, T.9
Ouais, S.10
Martin, G.M.11
Mulligan, J.12
Schellenberg, G.D.13
-
64
-
-
1842525838
-
Aging, anti-aging, and hormesis
-
Rattan SI: Aging, anti-aging, and hormesis. Mech Ageing Dev 2004;125:285-289.
-
(2004)
Mech Ageing Dev
, vol.125
, pp. 285-289
-
-
Rattan, S.I.1
-
65
-
-
0037194757
-
A lethal side-effect
-
Partridge L, Gems D: A lethal side-effect. Nature 2002;418:921.
-
(2002)
Nature
, vol.418
, pp. 921
-
-
Partridge, L.1
Gems, D.2
-
66
-
-
0028096205
-
Aging and photoaging affect gene expression in cultured human keratinocytes
-
Gilchrest BA, Garmyn M, Yaar M: Aging and photoaging affect gene expression in cultured human keratinocytes. Arch Dermatol 1994;130:82-86.
-
(1994)
Arch Dermatol
, vol.130
, pp. 82-86
-
-
Gilchrest, B.A.1
Garmyn, M.2
Yaar, M.3
-
67
-
-
0028905044
-
In vivo and in vitro SPRR1 gene expression in normal and malignant keratinocytes
-
Yaar M, Eller MS, Bhawan J, Harkness DD, DiBenedetto PJ, Gilchrest BA: In vivo and in vitro SPRR1 gene expression in normal and malignant keratinocytes. Exp Cell Res 1995;217:217-226.
-
(1995)
Exp Cell Res
, vol.217
, pp. 217-226
-
-
Yaar, M.1
Eller, M.S.2
Bhawan, J.3
Harkness, D.D.4
DiBenedetto, P.J.5
Gilchrest, B.A.6
-
68
-
-
0025052004
-
Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts
-
Seshadri T, Campisi J: Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts. Science 1990;247:205-209.
-
(1990)
Science
, vol.247
, pp. 205-209
-
-
Seshadri, T.1
Campisi, J.2
-
69
-
-
0027976669
-
Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts
-
Hara E, Yamaguchi T, Nojima H, Ide T, Campisi J, Okayama H, Oda K: Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. J Biol Chem 1994;269:2139-2145.
-
(1994)
J Biol Chem
, vol.269
, pp. 2139-2145
-
-
Hara, E.1
Yamaguchi, T.2
Nojima, H.3
Ide, T.4
Campisi, J.5
Okayama, H.6
Oda, K.7
-
70
-
-
0029812890
-
Ontogeny of growth hormone receptors in human tissues: An immunohistochemical study
-
Simard M, Manthos H, Giaid A, Lefebvre Y, Goodyer CG: Ontogeny of growth hormone receptors in human tissues: an immunohistochemical study. J Clin Endocrinol Metab 1996;81:3097-3102.
-
(1996)
J Clin Endocrinol Metab
, vol.81
, pp. 3097-3102
-
-
Simard, M.1
Manthos, H.2
Giaid, A.3
Lefebvre, Y.4
Goodyer, C.G.5
-
71
-
-
0028342664
-
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
-
Noda A, Ning Y, Venable SF, Pereira-Smith OM, Smith JR: Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 1994;211:90-98.
-
(1994)
Exp Cell Res
, vol.211
, pp. 90-98
-
-
Noda, A.1
Ning, Y.2
Venable, S.F.3
Pereira-Smith, O.M.4
Smith, J.R.5
-
72
-
-
0036182866
-
Molecular mechanisms of skin ageing
-
Jenkins G: Molecular mechanisms of skin ageing. Mech Ageing Dev 2002;123:801-810.
-
(2002)
Mech Ageing Dev
, vol.123
, pp. 801-810
-
-
Jenkins, G.1
-
73
-
-
0018347149
-
Biochemistry of the elastic fibers in normal connective tissues and its alterations in diseases
-
Uitto J: Biochemistry of the elastic fibers in normal connective tissues and its alterations in diseases. J Invest Dermatol 1979;72:1-10.
-
(1979)
J Invest Dermatol
, vol.72
, pp. 1-10
-
-
Uitto, J.1
-
74
-
-
0033889654
-
Decreased extracellular-signal-regulated kinase and increased stress-activated MAP kinase activities in aged human skin in vivo
-
Chung JH, Kang S, Varani J, Lin J, Fisher GJ, Voorhees JJ: Decreased extracellular-signal-regulated kinase and increased stress-activated MAP kinase activities in aged human skin in vivo. J Invest Dermatol 2000;115:177-182.
-
(2000)
J Invest Dermatol
, vol.115
, pp. 177-182
-
-
Chung, J.H.1
Kang, S.2
Varani, J.3
Lin, J.4
Fisher, G.J.5
Voorhees, J.J.6
-
75
-
-
0028880006
-
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
-
Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME: Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995;270:1326-1331.
-
(1995)
Science
, vol.270
, pp. 1326-1331
-
-
Xia, Z.1
Dickens, M.2
Raingeaud, J.3
Davis, R.J.4
Greenberg, M.E.5
-
76
-
-
0347537940
-
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
-
Verheij M, Bose R, Lin XH, Yao B, Jarvis WD, Grant S, Birrer MJ, Szabo E, Zon LI, Kyriakis JM, Haimovitz-Friedman A, Fuks Z, Kolesnick RN: Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 1996;380:75-79.
-
(1996)
Nature
, vol.380
, pp. 75-79
-
-
Verheij, M.1
Bose, R.2
Lin, X.H.3
Yao, B.4
Jarvis, W.D.5
Grant, S.6
Birrer, M.J.7
Szabo, E.8
Zon, L.I.9
Kyriakis, J.M.10
Haimovitz-Friedman, A.11
Fuks, Z.12
Kolesnick, R.N.13
-
77
-
-
0030297286
-
Endogenous TGF-beta activity is modified during cellular aging: Effects on metalloproteinase and TIMP-1 expression
-
Zeng G, McCue HM, Mastrangelo L, Millis AJ: Endogenous TGF-beta activity is modified during cellular aging: effects on metalloproteinase and TIMP-1 expression. Exp Cell Res 1996;228:271-276.
-
(1996)
Exp Cell Res
, vol.228
, pp. 271-276
-
-
Zeng, G.1
McCue, H.M.2
Mastrangelo, L.3
Millis, A.J.4
-
78
-
-
0028304454
-
A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during G1 progression, mitogenic stimulation, differentiation, and senescence
-
Wick M, Burger C, Brusselbach S, Lucibello FC, Muller R: A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during G1 progression, mitogenic stimulation, differentiation, and senescence. J Biol Chem 1994;269:18953-18960.
-
(1994)
J Biol Chem
, vol.269
, pp. 18953-18960
-
-
Wick, M.1
Burger, C.2
Brusselbach, S.3
Lucibello, F.C.4
Muller, R.5
-
79
-
-
0031940337
-
Reduced expression of mRNA for transforming growth factor beta (TGF beta) and TGF beta receptors I and II and decreased TGF beta binding to the receptors in in vitro-aged fibroblasts
-
Mori Y, Hatamochi A, Arakawa M, Ueki H: Reduced expression of mRNA for transforming growth factor beta (TGF beta) and TGF beta receptors I and II and decreased TGF beta binding to the receptors in in vitro-aged fibroblasts. Arch Dermatol Res 1998;290:158-162.
-
(1998)
Arch Dermatol Res
, vol.290
, pp. 158-162
-
-
Mori, Y.1
Hatamochi, A.2
Arakawa, M.3
Ueki, H.4
-
81
-
-
0030839865
-
Oxidative decay of DNA
-
Beckman KB, Ames BN: Oxidative decay of DNA. J Biol Chem 1997;272:19633-19636.
-
(1997)
J Biol Chem
, vol.272
, pp. 19633-19636
-
-
Beckman, K.B.1
Ames, B.N.2
-
82
-
-
0027171266
-
Oxidants, antioxidants, and the degenerative diseases of aging
-
Ames BN, Shigenaga MK, Hagen TM: Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 1993;90:7915-7922.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 7915-7922
-
-
Ames, B.N.1
Shigenaga, M.K.2
Hagen, T.M.3
-
83
-
-
0028216919
-
Effect of age on antioxidants and molecular markers of oxidative damage in murine epidermis and dermis
-
Lopez-Torres M, Shindo Y, Packer L: Effect of age on antioxidants and molecular markers of oxidative damage in murine epidermis and dermis. J Invest Dermatol 1994;102:476-480.
-
(1994)
J Invest Dermatol
, vol.102
, pp. 476-480
-
-
Lopez-Torres, M.1
Shindo, Y.2
Packer, L.3
-
84
-
-
0025973702
-
Assays for 8-hydroxy-2-deoxyguanosine: A biomarker of in vivo oxidative DNA damage
-
Shigenaga MK, Ames BN: Assays for 8-hydroxy-2-deoxyguanosine: a biomarker of in vivo oxidative DNA damage. Free Radic Biol Med 1991;10:211-216.
-
(1991)
Free Radic Biol Med
, vol.10
, pp. 211-216
-
-
Shigenaga, M.K.1
Ames, B.N.2
-
85
-
-
0035915750
-
Antioxidants may contribute in the fight against ageing: An in vitro model
-
Hu HL, Forsey RJ, Blades TJ, Barratt ME, Parmar P, Powell JR: Antioxidants may contribute in the fight against ageing: an in vitro model. Mech Ageing Dev 2000;121:217-230.
-
(2000)
Mech Ageing Dev
, vol.121
, pp. 217-230
-
-
Hu, H.L.1
Forsey, R.J.2
Blades, T.J.3
Barratt, M.E.4
Parmar, P.5
Powell, J.R.6
-
86
-
-
0030038103
-
Oxidative stress, caloric restriction, and aging
-
Sohal RS, Weindruch R: Oxidative stress, caloric restriction, and aging. Science 1996;273:59-63.
-
(1996)
Science
, vol.273
, pp. 59-63
-
-
Sohal, R.S.1
Weindruch, R.2
-
87
-
-
0037082103
-
Reactive oxygen species and protein oxidation in aging: A look back, a look ahead
-
Hensley K, Floyd RA: Reactive oxygen species and protein oxidation in aging: a look back, a look ahead. Arch Biochem Biophys 2002;397:377-383.
-
(2002)
Arch Biochem Biophys
, vol.397
, pp. 377-383
-
-
Hensley, K.1
Floyd, R.A.2
-
88
-
-
0032748783
-
Effects of postmenopausal hypoestrogenism on skin collagen
-
Affinito P, Palomba S, Sorrentino C, Di Carlo C, Bifulco G, Arienzo MP, Nappi C: Effects of postmenopausal hypoestrogenism on skin collagen. Maturitas 1999;33:239-247.
-
(1999)
Maturitas
, vol.33
, pp. 239-247
-
-
Affinito, P.1
Palomba, S.2
Sorrentino, C.3
Di Carlo, C.4
Bifulco, G.5
Arienzo, M.P.6
Nappi, C.7
-
89
-
-
0025217718
-
Early natural menopause and the duration of postmenopausal life: Findings from a mathematical model of life expectancy
-
Snowdon DA: Early natural menopause and the duration of postmenopausal life: findings from a mathematical model of life expectancy. J Am Geriatr Soc 1990;38:402-408.
-
(1990)
J Am Geriatr Soc
, vol.38
, pp. 402-408
-
-
Snowdon, D.A.1
-
90
-
-
0035370372
-
Insulin/IGF signalling and ageing: Seeing the bigger picture
-
Gems D, Partridge L: Insulin/IGF signalling and ageing: seeing the bigger picture. Curr Opin Genet Dev 2001;11:287-292.
-
(2001)
Curr Opin Genet Dev
, vol.11
, pp. 287-292
-
-
Gems, D.1
Partridge, L.2
-
91
-
-
0034884345
-
Genes that prolong life: Relationships of growth hormone and growth to aging and life span
-
Bartke A, Coschigano K, Kopchick J, Chandrashekar V, Mattison J, Kinney B, Hauck S: Genes that prolong life: relationships of growth hormone and growth to aging and life span. J Gerontol A Biol Sci Med Sci 2001;56:B340-B349.
-
(2001)
J Gerontol A Biol Sci Med Sci
, vol.56
-
-
Bartke, A.1
Coschigano, K.2
Kopchick, J.3
Chandrashekar, V.4
Mattison, J.5
Kinney, B.6
Hauck, S.7
-
92
-
-
0037470439
-
Steroid control of longevity in Drosophila melanogaster
-
Simon AF, Shih C, Mack A, Benzer S: Steroid control of longevity in Drosophila melanogaster. Science 2003;299:1407-1410.
-
(2003)
Science
, vol.299
, pp. 1407-1410
-
-
Simon, A.F.1
Shih, C.2
Mack, A.3
Benzer, S.4
-
93
-
-
0037470501
-
The endocrine regulation of aging by insulin-like signals
-
Tatar M, Bartke A, Antebi A: The endocrine regulation of aging by insulin-like signals. Science 2003;299:1346-1351.
-
(2003)
Science
, vol.299
, pp. 1346-1351
-
-
Tatar, M.1
Bartke, A.2
Antebi, A.3
-
94
-
-
0035378238
-
Androgen deficiency in women
-
Miller KK: Androgen deficiency in women. J Clin Endocrinol Metab 2001;86:2395-2401.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 2395-2401
-
-
Miller, K.K.1
-
96
-
-
0032442416
-
Aging and the adrenal cortex
-
Yen SS, Laughlin GA: Aging and the adrenal cortex. Exp Gerontol 1998;33:897-910.
-
(1998)
Exp Gerontol
, vol.33
, pp. 897-910
-
-
Yen, S.S.1
Laughlin, G.A.2
-
97
-
-
0030912617
-
Testosterone and the aging male
-
Tenover JL: Testosterone and the aging male. J Androl 1997;18:103-106.
-
(1997)
J Androl
, vol.18
, pp. 103-106
-
-
Tenover, J.L.1
-
98
-
-
0026645294
-
The influence of aging on plasma sex hormones in men: The Telecom Study
-
Simon D, Preziosi P, Barrett-Connor E, Roger M, Saint-Paul M, Nahoul K, Papoz L: The influence of aging on plasma sex hormones in men: the Telecom Study. Am J Epidemiol 1992;135:783-791.
-
(1992)
Am J Epidemiol
, vol.135
, pp. 783-791
-
-
Simon, D.1
Preziosi, P.2
Barrett-Connor, E.3
Roger, M.4
Saint-Paul, M.5
Nahoul, K.6
Papoz, L.7
-
99
-
-
0025884064
-
Age, disease, and changing sex hormone levels in middle-aged men: Results of the Massachusetts Male Aging Study
-
Gray A, Feldman HA, McKinlay JB, Longcope C: Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. J Clin Endocrinol Metab 1991;73:1016-1025.
-
(1991)
J Clin Endocrinol Metab
, vol.73
, pp. 1016-1025
-
-
Gray, A.1
Feldman, H.A.2
McKinlay, J.B.3
Longcope, C.4
-
100
-
-
0035140777
-
Aging-related growth hormone (GH) decrease is a selective hypothalamic GH-releasing hormone pulse amplitude mediated phenomenon
-
Russell-Aulet M, Dimaraki EV, Jaffe CA, DeMott-Friberg R, Barkan AL: Aging-related growth hormone (GH) decrease is a selective hypothalamic GH-releasing hormone pulse amplitude mediated phenomenon. J Gerontol A Biol Sci Med Sci 2001;56:M124-M129.
-
(2001)
J Gerontol A Biol Sci Med Sci
, vol.56
-
-
Russell-Aulet, M.1
Dimaraki, E.V.2
Jaffe, C.A.3
DeMott-Friberg, R.4
Barkan, A.L.5
-
101
-
-
0034583277
-
Human skin: An independent peripheral endocrine organ
-
Zouboulis CC: Human skin: an independent peripheral endocrine organ. Horm Res 2000;54:230-242.
-
(2000)
Horm Res
, vol.54
, pp. 230-242
-
-
Zouboulis, C.C.1
-
102
-
-
0034729071
-
Hormone replacement therapy and the skin
-
Brincat MP: Hormone replacement therapy and the skin. Maturitas 2000;35:107-117.
-
(2000)
Maturitas
, vol.35
, pp. 107-117
-
-
Brincat, M.P.1
-
103
-
-
0141782610
-
The effects of an estrogen and glycolic acid cream on the facial skin of postmenopausal women: A randomized histologic study
-
Fuchs KO, Solis O, Tapawan R, Paranjpe J: The effects of an estrogen and glycolic acid cream on the facial skin of postmenopausal women: a randomized histologic study. Cutis 2003;71:481-488.
-
(2003)
Cutis
, vol.71
, pp. 481-488
-
-
Fuchs, K.O.1
Solis, O.2
Tapawan, R.3
Paranjpe, J.4
-
104
-
-
0035948752
-
The influence of hormone replacement therapy on skin ageing: A pilot study
-
Sator PG, Schmidt JB, Sator MO, Huber JC, Honigsmann H: The influence of hormone replacement therapy on skin ageing: a pilot study. Maturitas 2001;39:43-55.
-
(2001)
Maturitas
, vol.39
, pp. 43-55
-
-
Sator, P.G.1
Schmidt, J.B.2
Sator, M.O.3
Huber, J.C.4
Honigsmann, H.5
-
105
-
-
0029821818
-
Treatment of skin aging with topical estrogens
-
Schmidt JB, Binder M, Demschik G, Bieglmayer C, Reiner A: Treatment of skin aging with topical estrogens. Int J Dermatol 1996;35:669-674.
-
(1996)
Int J Dermatol
, vol.35
, pp. 669-674
-
-
Schmidt, J.B.1
Binder, M.2
Demschik, G.3
Bieglmayer, C.4
Reiner, A.5
-
106
-
-
13944261231
-
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
-
Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA: Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 2005;433:760-764.
-
(2005)
Nature
, vol.433
, pp. 760-764
-
-
Conboy, I.M.1
Conboy, M.J.2
Wagers, A.J.3
Girma, E.R.4
Weissman, I.L.5
Rando, T.A.6
-
107
-
-
33746356233
-
Age-specific hormonal decline is accompanied by transcriptional changes in human sebocytes in vitro
-
Makrantonaki E, Adjaye J, Herwig R, Brink TC, Groth D, Hultschig C, Lehrach H, Zouboulis CC: Age-specific hormonal decline is accompanied by transcriptional changes in human sebocytes in vitro. Aging Cell 2006;5:331-344.
-
(2006)
Aging Cell
, vol.5
, pp. 331-344
-
-
Makrantonaki, E.1
Adjaye, J.2
Herwig, R.3
Brink, T.C.4
Groth, D.5
Hultschig, C.6
Lehrach, H.7
Zouboulis, C.C.8
-
108
-
-
12144265562
-
Whole-genome approaches for large-scale gene identification and expression analysis in mammalian preimplantation embryos
-
Adjaye J: Whole-genome approaches for large-scale gene identification and expression analysis in mammalian preimplantation embryos. Reprod Fertil Dev 2005;17:37-45.
-
(2005)
Reprod Fertil Dev
, vol.17
, pp. 37-45
-
-
Adjaye, J.1
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