Coenzyme Q10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radical scavenging property

Journal of Biological Chemistry

Volumn 278, Issue 30, 2003, Pages 28220-28228

  Papucci, Laura ^a   Schiavone, Nicola ^a   Witort, Ewa ^a   Donnini, Martino ^a   Lapucci, Andrea ^a   Tempestini, Alessio ^a   Formigli, Lucia ^a   Zecchi Orlandini, Sandra ^a   Orlandini, Giovanni ^a   Carella, Giuseppe ^b   Brancato, Rosario ^b   Capaccioli, Sergio ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; ANTIOXIDANTS; BIOLOGICAL MEMBRANES; ENZYMES; FREE RADICALS; OXIDATION; REDUCTION; ULTRAVIOLET RADIATION;

CELL DEATH;

CELLS;

ADENOSINE TRIPHOSPHATE; ANTIMYCIN A1; CASPASE 9; CERAMIDE; CYTOCHROME C; DNA FRAGMENT; FREE RADICAL; SCAVENGER; UBIDECARENONE; CASPASE; DNA; DRUG DERIVATIVE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; UBIQUINONE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BINDING SITE; CONTROLLED STUDY; CORNEA CELL; DEPOLARIZATION; ENZYME ACTIVATION; EXCIMER LASER; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; RESPIRATORY CHAIN; ULTRAVIOLET C RADIATION; ANIMAL; CELL MEMBRANE POTENTIAL; CELL SURVIVAL; CHEMICAL MODEL; CULTURE MEDIUM; DNA DAMAGE; FLUORESCENCE MICROSCOPY; KERATINOCYTE; METABOLISM; PATHOLOGY; PHYSIOLOGY; RABBIT; TIME; ULTRAVIOLET RADIATION; WESTERN BLOTTING;

ANIMALIA;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIMYCIN A; APOPTOSIS; BLOTTING, WESTERN; CASPASE 9; CASPASES; CELL SURVIVAL; CERAMIDES; CULTURE MEDIA, SERUM-FREE; DNA; DNA DAMAGE; DNA FRAGMENTATION; FREE RADICAL SCAVENGERS; KERATINOCYTES; MEMBRANE POTENTIALS; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MODELS, CHEMICAL; OXIDATION-REDUCTION; RABBITS; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; TIME FACTORS; UBIQUINONE; ULTRAVIOLET RAYS;

EID: 0042346294     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302297200     Document Type: Article

References (63)

1. Lenaz, G., Fato, R., Castelluccio, C., Genova, M. L., Bovina, C., Estornell, E., Valls, V., Pallotti, F., and Parenti Castelli, G. (1993) Clin. Investig. 71, 66-70
2. Lenaz, G., Gavazzoni, M., Genova, M. L., D'Aurelio, M., Pallotti, F., Formiggini, G., Marchetti, M., Castelli, G. P., and Bovina, C. (1998) Biofactors 8, 195-204
3. Capaccioli, S., Nucci, C., Schiavone, N., Quattrone, A., and Carella G. (1998) in Vascular Systems of the Optic Nerve and Perioptic Area (Bisantis, C., and Carella, G., eds) pp. 81-130, I.N.C. Innovation-News-Communication, Rome
4. Wilson, S. E. (1997) J. Refract Surg. 13, 171-175
5. Brancato, R., Fiore, T., Papucci, L., Schiavone, N., Formigli, L., Zecchi Orlandini, S., Gobbi, P. G., Carones, F., Donnini, M., Lapucci, A., Capaccioli, S. (2000) J. Refract Surg. 18, 135-139
6. Brancato, R., Schiavone, N., Siano, S., Lapucci, A., Papucci, L., Donnini, M., Formigli, L., Zecchi Orlandini, S., Carella, G., Carones, F., and Capaccioli, S. (2000) Eur. J. Ophthalmol. 10, 32-38
7. Lopez-Lluch, G., Barroso, M. P., Martin, S. F., Fernandez-Ayala, D. J., Gomez-Diaz, C., Villalba, J. M., and Navas, P. (1999) Biofactors 9, 171-177
8. Kelso, G, F., Porteous, C. M., Coulter, C. V., Hughes, G., Porteous, W. K., Ledgerwood, E. C., Smith, R. A., and Murphy, M. P. (2001) J. Biol. Chem. 276, 4588-4596
9. Alleva, R., Tomasetti, M., Andera, L., Gellert, N., Borghi, B., Weber, C., Murphy, M. P., and Neuzil, J. (2001) FEBS Lett. 503, 46-50
10. Tomasetti, M., Alleva, R., Borghi, B., and Collins, A. R. (2001) FASEB J. 15, 1425-1427
11. Navas, P., Fernandez-Ayala, D. M., Martin, S. F., Lopez-Lluch, G., De Caboa, R., Rodriguez-Aguilera, J. C., and Villalba, J. M. (2002) Free Radic. Res. 36, 369-374
12. Green, D. R., and Reed, J. R. (1998) Science 281, 1309-1312
13. Wang, X. (2001) Genes Dev. 15, 2922-2933
14. Crompton, M. (1999) Biochem. J. 341, 233-249
15. De Giorgi, F., Lartigue, L., Bauer, M. K., Schubert, A., Grimm, S., Hanson, G. T., Remington, S. J., Youle, R. J., and Ichas, F. (2002) FASEB J. 16, 607-609
16. Wajant, H. (2002) Science 296, 1635-1636
17. Shiozaki, E. N., Chai, J., and Shi, Y. (2002) Proc. Natl. Acad. Sci U. S. A. 99, 4197-4202
18. Desagher, S., and Martinou J. C. (2000) Trends Cell Biol. 10, 369-377
19. Fontaine, E., Eriksson, O., Ichas, F., and Bernardi, P. (1998) J. Biol. Chem. 273, 12662-12668
20. Fontaine, E., Ichas, F., and Bernardi, P. (1998) J. Biol. Chem. 273, 25734-25740
21. Fontaine, E., and Bernardi, P. (1999) J. Bioenerg. Biomembr. 31, 335-345
22. Petronilli, V., Penzo, D., Scorrano, L., Bernardi, P., and Di Lisa, F. (2001) J. Biol. Chem. 276, 12030-12034
23. Walter, L., Nogueira, V., Leverve, X., Heitz, M. P., Bernardi, P., and Fontaine, E. (2000) J. Biol. Chem. 275, 29521-29527
24. Walter, L., Miyoshi, H., Leverve, X., Bernardi, P., and Fontaine, F. (2002) Free Radic. Res. 36, 405-412
25. Di Bernardo, S., Fato, R., Casadio, R., Fariselli, P., and Lenaz, G. (1998) FEBS Lett. 426, 77-80
26. Chauvin, C., De Oliveras, F., Ronot, X., Mousseau, M., Leverve, X., and Fontaine, E. (2001) J. Biol. Chem. 276, 41394-41398
27. Armstrong, J. S., and Jones, D. P. (2002) FASEB J. 10, 1263-1265
28. Armstrong, J. S., Steinauer, K. K., Hornung, B., Irish, J. M., Lecane, P., Birrel, G. W., Peehl, D. M., and Knox, S. J. (2002) Cell Death Differ. 9, 252-263
29. Wang, J. F., Jerrels, T. R., and Spitzer, J. J. (1996) Free Radic. Biol. Med. 20, 533-542
30. Hannun, Y. A., and Obeid, L. M. (1997) Adv. Exp. Med. Biol. 407, 145-149
31. Meydani, M. (1995) Lancet 345, 170-175
32. Brigelius-Flohe, R., and Traber, M. G. (1999) FASEB J. 13, 1145-1155
33. Oyama, Y. (1994) Brain Res. 635, 113-117
34. Esterbauer, H., Shaur, R. J., Zollner, H. (1991) Free Radic. Biol. Med. 11, 81-129
35. van de Loosdrecht, A. A., Beelen, R. H., Ossenkoppele, G. J., Broekhoven, M. G., and Langenhuijsen, M. M. (1994) J. Immunol. Methods 174, 311-320
36. Formigli, L., Papucci, L., Tani, A., Schiavone, N., Tempestini, A., Orlandini, G. E., Capaccioli, S., and Zecchi Orlandini S. (2000) J. Cell. Physiol. 181, 41-49
37. Reers, M., Smith, T. W., and Chen, L. B. (1991) Biochemistry 30, 4480-4486
38. Ruties, S. A., van der Heijden, A., Utz, P. J., van Venrooij, W. J., and Pruijn, G. J. (1999) J. Biol. Chem. 274, 24799-24807
39. Blankenberg, F. G., Katsikis, P. D., Storrs, R. W., Beaulieu, C., Spielman, D., Chen, J. Y., Naumovski, L., and Tait, J. F. (1997) Blood 89, 3778-3786
40. Hengartner, M. O. (2002) Nature 407, 770-776
41. Curtin, J. F., Donovan, M., and Cotter, T. G. (2002) J. Immunol. Methods 265, 49-72
42. Chance, B., Sies, H., and Boveris, A. (1979) Physiol. Rev. 59, 527-605
43. Zini, R., Simon, N., Morin, C., Thiault, L., and Tillement, J. P. (1998) Life Sci. 63, 357-368
44. Guidarelli, A., Brambilla, L., Rota, C., Tomasi, A., Cattabeni, F., and Cantoni, O. (1996) Biochem. J. 317, 371-375
45. O'Donnel, V., and Burkitt, M. J. (1994) Biochem. J. 304, 707-713
46. Dhanbhoora, C. M., and Babson, J. R. (1992) Arch. Biochem. Biophys. 293, 130-139
47. Schulze-Osthoff, K., Bakker, A. C., Vanhaesebroeck, B., Beyaert, R., Jacob, W. A., and Fiers, W. (1992) J. Biol. Chem. 267, 5317-5323
48. Tzung, S. P., Kim, K. M., Basanez, G., Giedt, C. D., Simon, J., Zimmerberg, J., Zhang, K. Y., and Hockenbery, D., M. (2001) Nat. Cell Biol. 3, 183-191
49. Okazaki, T., Kondo, T., Kitano, T., and Tashima, M. (1998) Cell. Signal. 10, 685-692
50. Mathias, S., Pena, L. A., and Kolesnick, R. N. (1998) Biochem. J. 335, 465-480
51. Di Paola, M., Cocco, T., and Lorusso, M. (2000) Biochemistry 39, 6660-6668
52. Gudz, T. I., Tserng, K. Y., Hoppel, C. L. (1997) J. Biol. Chem. 272, 24154-24158
53. Siskind, L. J., and Colombini, M. (2001) J. Biol. Chem. 275, 38640-38644
54. Siskind, L. J., Kolesnick, R. N., and Colombini, M. (2002) J. Biol. Chem. 277, 26796-267803
55. Kummer, J. L., Rao, P. K., and Heidenreich, K. A. (1997) J. Biol. Chem. 272, 20490-20494
56. Colombaioni, L., Frago, L. M., Varala-Nieto I., Pesi R., and Garcia-Gil, M. (2002) Neurochem. Int. 40, 327-336
57. Jang, B. C., Sanchez, T. S., Schaefers, H. J., Trifan, O. C., Liu, C. H., Creminon, C., Huang, C. K., and Hla, T. (2000) J. Biol. Chem. 275, 39507-39515
58. Kulisz, A., Chen, N., Chandel, N. S., Shao, Z., and Schumacker, P. T. (2002) Am. J. Physiol. 282, L1324-L1329
59. Zhang, H. J., Zhao, W., Venkataraman, S., Robbins, M. E., Buettner, G. R., Kregel, K. C., and Oberley, L. W. (2002) J. Biol. Chem. 277, 20919-20926
60. Quillet-Mary, A., Jaffrezou, J. P., Mansat, V., Bordier, C., Naval, J., and Laurent, G. (1997) J. Biol. Chem. 272, 21388-21395
61. Tan, S., Sagara, Y., Liu, Y., Maher, P., and Schubert, D. (1998) J. Cell Biol. 141, 1423-1432
62. Garcia-Ruiz, C., Collel, A., Paris, R., and Fernandez-Checa, J. C. (2000) FASEB J. 14, 847-858
63. Fennell, D. A., and Cotter, F. E. (2000) Br. J. Haematol. 111, 52-60